Ezekiel Mupere
ID: UNCST-2023-R008637
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Earlier prime-BOOST schedule to improve MEasles protection in high burden settings (BoostME)
REFNo: HS2883ES
Safety Objectives
1.To assess the safety and reactogenicity profile of the vaccine when given at different ages
2.To assess the number of measles infections throughout the study.
Primary Objectives
1.To compare protective measles antibody concentrations at 2.5 years of age in infants receiving an early (6 months) compared to standard (9 month) dose of MCV, and a booster dose at 18 months of age.
2.To compare protective measles antibody concentrations one month after a second dose of MCV given at 12 months (early) compared to standard (18 months), in those who received an early (6 months) first dose.
Secondary Objectives
•To describe the measles antibody concentrations one month after first dose in infants receiving an early (6 months) compared to standard (9 month) dose of MCV.
•To describe the effect of maternal antibodies on infant humoral and cellular immune response to first and second doses in children vaccinated under different schedules.
•To describe the effect of maternal HIV infection on infant antibody responses post MCV1 and MCV2 given at different schedules
•To describe the impact of different vaccination schedules on responses to the rubella component of the vaccine.
Community Objectives
To assess the effect of a measles vaccination clinical trial on public perceptions of measles immunisation
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Kampala, Kawaala
Kampala, Kisenyi
Kampala, Komamboga
Kampala, Mulago
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Uganda |
2023-06-23 7:46:04 |
2026-06-23 |
450 infants |
Any infant aged 6 months (23-28 weeks) at screening visit and has
not received prior vaccination against measles |
University of Oxford Research Governance, Ethics and Assurance Joint Research Office Boundary Brook House Churchill Drive Headington Oxford OX3 7GB United Kingdom, and funded by Bill and Melinda Gates Foundation. |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Tonny Kiyimba
ID:
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Efficacy of polyphenols from Tamarindus indica fruit juice on cardiometabolic health of patients living with HIV and elevated triglycerides: A study protocol
REFNo: HS2923ES
3. To establish dose response dynamics of long-term intake of T. indica fruit juice polyphenols on selected cardiometabolic risk markers of PLWH.,2. To assess the effect of an acute, single-dose intake of T. indica fruit juice on vascular function, lipid profile and plasma levels of procyanidin metabolites.,1. To produce and evaluate the sensory acceptability of T. indica fruit juice.,To determine the efficacy of T. indica fruit juice on selected cardiometabolic risk markers of PLWH in HIV community care model in Wakiso district, Uganda.,
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Wakiso, Kajjansi
Wakiso, Kajjansi
|
Uganda |
2023-06-20 11:05:36 |
2026-06-20 |
240 |
Participants will be adult(30-50 years) male and female patients living with HIV (PLWH) managed under the community-based model (Community Drug Distribution Points-CDDPs) in Wakiso district, central Uganda. The district encircles Kampala, Uganda's capital city with an estimated population of over 2.9 million people. The district has the highest prevalence (10%) of HIV in Uganda. Over 3,801 PLWH are currently receiving the HIV care from CDDPs in Wakiso District. The study inclusion and exclusion criteria are presented in Table 1. |
VLIROUS |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
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Betty Mwesigwa
ID: UNCST-2020-R014667
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SABIN-002: A Phase 2, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Safety, Tolerability, and Immune Responses of an Investigational Monovalent Chimpanzee Adenoviral-Vectored Marburg Virus Vaccine in Healthy Adults
REFNo: HS2838ES
To evaluate the safety and tolerability of
cAd3-Marburg vaccine
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Kampala, Nakasero
|
Uganda |
2023-06-14 11:06:46 |
2026-06-14 |
80 |
Male and female adults, 18-70 Years |
Sabin Vaccine Institute |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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NANKWASA SAILAS
ID:
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RANDOMIZED CONTROLLED FOR NON USE OF ANTIBIOTIC AFTER UNCOMPLICATED VAGINAL BIRTH AND POST-PARTUM ENDOMETRITIS AT ST FRANCIS HOSPITAL NSAMBYA
REFNo: HS2768ES
3. To determine the factors that may predict the likelihood of infection after uncomplicated vaginal birth at St. Francis Nsambya Hospital,2. To determine the incidence of perineal tear/episiotomy wound breakdown among women who received antibiotic and those who do not at St. Francis Nsambya Hospital,1. To determine the incidence of post-partum endometritis after uncomplicated vaginal birth in women who receive antibiotic compared to those who do not at St. Francis Nsambya Hospital,To determine whether not providing an antibiotic after uncomplicated vaginal birth is associated with increased incidence of post-partum endometritis at St. Francis Nsambya Hospital,
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Kamuli, Nsambya
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Uganda |
2023-06-06 7:53:44 |
2026-06-06 |
260 participants |
adult post delivery mothers with uncomplicated vaginal birth |
NANKWASA SAILAS |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
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RICHARD MPANGO STEPHEN
ID:
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Adaptation and Evaluation of the New Forest Parenting Program (NFPP) in the
management of ADHD among Children and Adolescents infected with HIV (CA-HIV) in
Uganda (Formative phase)
REFNo: SS1721ES
i) To adapt and evaluate the effectiveness of the NFPP in the management of ADHD among Children and adolescents infected with HIV (CA-HIV).
ii) To evaluate the acceptability and feasibility of NFPP in the management of ADHD among CA-HIV.
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Masaka, NOT APPLICABLE
Kampala, NOT APPLICABLE
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Uganda |
2023-05-29 20:36:58 |
2026-05-29 |
44 |
Twenty-two (22) participants; ten (10) Child and adolescent mental health specialists’ and HIV clinicians (representing a range of professional disciplines including psychiatrists, psychologists, psychiatric clinical officers, psychiatric nurses, experienced HIV counsellors and HIV clinicians); ten (10) parents / grandparents / teachers /day-mothers / guardians / caregivers; two (2) facilitators |
CHILD Global Research |
Social Science and Humanities |
Clinical Trial |
Degree Award |
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