Stephen Okoboi
ID: UNCST-2019-R001356
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Peer Delivered HIV/Syphilis Self-Testing with Assisted Partner Notification Services for Men who Have Sex with Men (MSM) in Uganda
REFNo: HS3021ES
Estimate the cost-effectiveness of peer-delivered HIV/syphilis self-tests and partner services compared to facility-based testing.,Conduct a pilot randomized trial to pilot test the preliminary effectiveness of peer delivered HIV/syphilis self-tests and partner services versus facility-based testing., Conduct formative research to inform implementation of peer delivered self-tests for HIV and syphilis with partner services for Ugandan MSM. ,
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Uganda |
2023-10-31 19:59:00 |
2026-10-31 |
200 |
Inclusion criteria: In both arms, peers will recruit network members who are
1) aged 18 years and older,
2) Self-report of anal sexual intercourse at least once in the prior quarter
3) self-identify as MSM,
4) not tested in past 3 months or never tested for HIV or syphilis before;
5) willing to provide informed consent;
6) willing to undergo study procedures
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National Institute of health |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Prudence Beinamaryo
ID: UNCST-2023-R007239
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Efficacy of the combination ivermectin and albendazole vs albendazole alone in school-aged children infected with Trichuris trichiura: a randomized controlled trial
REFNo: HS3160ES
To evaluate the safety and tolerability of the ,To determine the CRs and ERRs of the study drugs (i.e. albendazole alone, albendazole-ivermectin) against Ascaris lumbricoides and hookworm in co-infected participants.,To determine the egg reduction rates (ERRs) of ivermectin/albendazole combination therapy compared to albendazole monotherapy against T. trichiura,To demonstrate that co-administered ivermectin (200 µg/kg) plus albendazole (400 mg) is superior to albendazole (400 mg) monotherapy in terms of CRs against T. trichiura infections assessed by Kato-Katz at 14-21 days post-treatment in individuals aged 6-12 years.,
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Kabale, Rukore
Kabale, Rukore
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Uganda |
2023-10-04 13:42:09 |
2026-10-04 |
750 |
School age children of from Age 6-12 both males and female of any tribe residing in area. |
Prof. Dr. Jennifer Keiser |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Andrew Odur
ID: UNCST-2022-R009128
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A RANDOMIZED CONTROL TRIAL TO DETERMINE THE EFFICACY OF MACHINE LEARNING MODELS TO PREDICT POSTPARTUM HEMORRHAGE
REFNo: HS3132ES
Determine whether earlier knowledge of the high-risk patient likelihood of morbidity can change clinical management to better outcomes,Demonstrate the efficacy of a mobile app prediction-based platform in informing clinical judgment,Determine the suitability of mobile app-based platform integration into the clinical workflow of African obstetricians,Determine the efficacy of ML models to predict the likelihood of pregnancy complications among African mothers,We aim to conduct a randomized control trial to determine the efficacy of machine learning models to predict postpartum hemorrhage to potentially establish a new gold standard way of screening patients in low-resource settings,
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Lira, Cathedral
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Uganda |
2023-10-02 15:32:14 |
2026-10-02 |
RCT sample size will be 200 |
The study will enroll pregnant women 18 years and older attending ANC at Lira Regional Referral Hospital intending to deliver from the same facility residing within 10 km distance from the hospital. |
INFIUSS Health, Inc |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Conrad Muzoora Kihembe
ID: UNCST-2019-R001432
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REDUCING MORTALITY IN ADULTS WITH ADVANCED HIV DISEASE (REVIVE)
REFNo: HS2892ES
To determine whether azithromycin is effective in reducing the incidence of new infection compared to placebo in adults with advanced HIV (CD4 ≤ 100 cells/mm3).,To determine whether azithromycin is effective in reducing mortality and hospitalisation at early and late timepoints (4weeks and 24weeks) compared to placebo in adults with advanced HIV (CD4 ≤ 100 cells/mm3).,To determine whether azithromycin is an effective and safe intervention to reduce excess mortality in adults with advanced HIV (CD4 ≤ 100 cells/mm3). ,
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All Districts, Not applicable
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Uganda |
2023-09-27 17:43:49 |
2026-09-27 |
8000 |
18 years and above, all sexes and all tribes |
Population Health Research Institute (PHRI) Canada |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Adoke Yeka
ID: UNCST-2021-R004300
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PLATINUM: A multi-part, multi-center PLATform study to assess the efficacy, safety, tolerability and pharmacokinetics of anti-malarial agents administered as monotherapy at multiple dose levels and/or combination therapy IN patients with Uncomplicated Plasmodium falciparum Malaria.
REFNo: HS2817ES
Part A: To assess the parasite clearance time (PCT) of oral doses of an anti- malarial agent administered as monotherapy in patients with uncomplicated
P. falciparum malaria
Part B: To assess the effect on adjusted 28-day cure rate of an anti-malarial agent administered orally as combination therapy versus the standard of care (SoC) in patients with uncomplicated P. falciparum malaria.
Part A: To assess the effect on adjusted 28-day cure rate of an anti-malarial agent administered orally as monotherapy in patients with uncomplicated
P. falciparum malaria
Part B: To assess the parasite clearance time (PCT) of oral combinations of anti-malarial agents versus SoC in patients with uncomplicated P. falciparum malaria
All parts:
To characterize PK of each anti-malarial agent administered orally as monotherapy [Part A] and/or as combination therapy [Part B] in patients with uncomplicated P. falciparum malaria
To assess the safety and tolerability of each anti-malarial agent administered orally as monotherapy [Part A] and/or as combination therapy versus SoC [Part B] in patients with uncomplicated P. falciparum malaria
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Tororo, Tororo
Tororo, Tororo
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Uganda |
2023-09-26 11:55:15 |
2026-09-26 |
Part A 12,pART b18 |
The study population will consist of male and female patients aged ≥18 years for Part A and aged ≥12 years for Part B. |
Novartis |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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