Jenny Löfgren
ID: UNCST-2024-R005428
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Simulation-based training for mesh inguinal hernia repair under local anaesthesia - a randomized trial
REFNo: HS4058ES
Assess the learning curve of mesh inguinal hernia repair for novice learners and how it is affected by simulation based training prior to supervised surgery on patients.
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Soroti,
Mubende,
Iganga,
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Sweden |
2024-05-02 12:38:06 |
2027-05-02 |
440 |
Trainees: intern doctors with an interest in surgery and who are not already routinely performing inguinal hernia mesh repair
Patients: Adult (18 years and above), otherwise healthy (ASA 1-2) men with primary, reducible, groin hernia |
Karolinska Institutet |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
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Christopher Turyatunga Bernard
ID: UNCST-2023-R006842
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Drivers, profiling and drugs resistance effects, outcomes and cost-effectiveness of diagnostic and Syndromic interventions among urogenital discharging patients in southwestern Uganda
REFNo: HS3796ES
Establish the aetiology and sensitivity profile of urogenital discharges among patients in south western Uganda. ,5. Evaluate the Comparative cost effectiveness of diagnostic and Syndromic approaches in the management of patients with urogenital discharges in south western Uganda.,4. Compare the treatment outcomes between syndromic and diagnostic approaches in the management of patients with urogenital discharges in south western Uganda.,3. Determine the drivers of drugs resistance among patients with urogenital discharges in south western Uganda. ,2. Determine the effect of drugs’ resistance on the management of patients with urogenital discharges in south western Uganda.,This study is aimed at establishing the drivers, profiling and effect of drugs resistance, comparative treatment outcomes and cost-effectiveness of diagnostic and Syndromic interventions on patients with urogenital discharges in southwestern Uganda, and it is a parallel randomized intervention at STI clinics of Kabale and Mbarara Regional Referral Hospitals and Kisiizi Mission Hospital.,
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Uganda |
2024-04-26 9:21:22 |
2027-04-26 |
476 |
Females and males Participants aged 15 to 60 years, with urethral and abnormal vaginal discharges void of HIV/AIDS, Diabetes Mellitus and pregnancy who have sought treatment more than once in the previous three months. |
MUST and STUDY Participants |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
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Fred Ssewamala
ID: UNCST-2020-R014060
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Bridges2Scale: Testing Implementation Strategies for an intervention among young people affected by AIDS
REFNo: SS2488ES
Bridges2Scale will use a two-arm Hybrid III effectiveness-implementation cluster randomized clinical trial, where we will compare two multifaceted strategies (standard vs. enhanced) for scaling the Bridges interventions (consisting of financial literacy training, peer mentorship, family income-generating , and youth development accounts). The standard implementation strategy has been applied in our prior and ongoing studies and involves educational meetings that prepare staff members to deliver Bridges with minimal disruption to site workflow. This will be compared to an enhanced strategy that will be developed using Implementation Mapping, a systematic protocol for developing implementation strategies using theory, evidence, and stakeholder input.
Aim 1: Compare the implementation effectiveness of the standard implementation strategy vs. an enhanced implementation strategy.
Aim 2: Determine the clinical effectiveness of Bridges implemented via a standard vs. enhanced implementation strategy.
Aim 3: Explore implementation processes, mechanisms, and determinants.
Aim 4: Compare the cost and cost-effectiveness of the two implementation strategies.
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Masaka, Kimaanya
Rakai, Kakuuto
Kyotera, Kyotera TC
Lwengo, Lwengo
Kalungu, Kasaali
Sembabule, Parish ward
Bukomansimbi, Mbiriizi
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Uganda |
2024-04-19 18:42:54 |
2027-04-19 |
1440 |
Inclusion and Exclusion Criteria:
Adolescent Inclusion Criteria: (1) ages 13-17 years; (2) a student at one of the 48 public primary schools included in the study; (3) living within a family and not an institution/orphanage.
Caregiver Inclusion Criteria: A caregiver would be eligible if they are (1) self-identified and confirmed by the AY as primary caregiver of the AY; and (2) capable of providing informed consent.
Schools’ inclusion criteria: The 48 public (government) primary schools would be eligible if they are (1) located in one of the seven districts in the greater Masaka region – on secondment from the Ministry of Education or local government representative (District Education Officer [DEO]), and (2) willing and able to participate in study implementation.
Youth-serving NGOs will be invited if they are: (1) registered with the government of Uganda; (2) willing to work with the study team; and (3) have a history of implementing micro-finance EE interventions.
Exclusion criteria: Adolescents will be ineligible if: 1) they are unable to understand study procedures and participant rights as assessed during informed consent/assent process with the adolescent and parent. 2) If the adolescent or adult caregiver presents with emergency needs (e.g., hospitalization), needed care will be secured, rather than study participation.
Facilitator Recruitment. The leaders of public schools and youth-serving NGOs will help us select the facilitators based on their interest in the intervention and willingness to work with study participants.
Standard Implementation Strategy (SIS) condition. we will meet with both NGO and school staff to gauge their interest in partnering on study implementation and describe roles and responsibilities.
Enhanced Implementation Strategy (EIS) condition. The headmaster of each school in the EIS will identify at least 2 teachers per school to be enrolled in the study and deliver the intervention—as implementation champions. We expect to recruit at least 48 teachers in EIS (2 teachers/school x 24 schools). Similar procedures will be followed for NGO staff. Specifically, we will recruit at least 8 facilitators from NGOs and 8 facilitators from community (including PTA members) to serve as trainers for implementation champions.
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Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
Social Science and Humanities |
Clinical Trial |
Non-degree Award |
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Patricia NAHIRYA Ntege Nahirya
ID: UNCST-2019-R001117
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Long-Term Follow-Up of CAB LA for Participants in HPTN 083 and HPTN 084 CAB PrEP Studies at Risk of HIV Acquisition.
REFNo: HS3876ES
Primary Objective
• To describe new HIV infections in adult and adolescent participants at risk of HIV acquisition included in the HPTN 084 studies and their associated sub-studies.
Secondary Objective
• To describe any serious adverse events (SAEs), Grade 3 and Grade 4 ISRs, and AEs leading to withdrawal in adult and adolescent participants included in the HPTN 084 studies and their associated sub-studies.
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Kampala, Mulago
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Uganda |
2024-04-04 8:20:33 |
2027-04-04 |
146 |
Participants must be currently enrolled and ongoing in one of the following studies:
• HPTN 083
• HPTN 084
• HPTN 083 and HPTN 084 adolescent and pregnancy sub-studies
Participants who have permanently withdrawn from prior CAB PrEP studies cannot enroll into this study.
2. Evidence of continued benefit (HIV negative and at risk) from CAB LA during participation in the parent study/sub-study.
3. Participants must have a nonreactive HIV test at Screening (rapid test, antigen/antibody test and HIV-1 RNA from the parent study/sub-study) and Day 1 (a rapid test and HIV Immunoassay [Antigen/Antibody test])
Males and Females:
All participants who are engaging in sexual activity should be counselled on safer
sexual practices including the use and benefit/risk of effective barrier methods (e.g.,
male condom) and on the risk of acquiring HIV and other STIs.
Females:
Cisgender female participants who are of childbearing potential and who are engaging in sexual activity that could lead to pregnancy, must talk to the investigator about recommended contraception options (Section 11.1). Contraception will be optional in this study. Condoms are recommended in addition, because their appropriate use is the only contraception method effective for preventing HIV-1 transmission.
Pregnant participants from the HPTN 084 study are eligible to enroll into this study f they meet all eligibility criteria |
ViiV Healthcare UK Limited |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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KANIKA Jean-Claude MASSAMBA
ID:
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effectiveness of vaginal misoprostol versus vaginal dinoprostone among pregnant women undergoing labor induction at Jinja regional Referral Hospital.
(REC Approval: BSU-REC-2023-244)
REFNo: HS4007ES
To assess the Peripartum fetal complications as well as the maternal obstetrics outcomes in vaginal misoprostol group versus vaginal dinoprostone group at Jinja Referral Regional Teaching-Hospital maternity ward. ,The main goal of this study is to compare the effectiveness of vaginal misoprostol to vaginal dinoprostone and identify the feto-maternal complications in women undergoing labor induction at Jinja Referral Regional Teaching-maternity Hospital\'s unit.,
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Jinja, Jinja
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Democratic Republic of Congo |
2024-03-28 18:36:47 |
2027-03-28 |
136 |
Pregnant women between 37 weeks + 0 day to 41 weeks + 6 days of gestation attending antenatal clinic at Jinja RRH and who have indications of labor induction and consent to participate in the study. |
Principal Investigator |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
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