Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Kamya Moses
ID: UNCST-2020-R014203
Impact of long-lasting insecticidal nets (LLINs) treated with pyrethroid plus pyriproxyfen vs LLINs treated with pyrethroid plus piperonyl butoxide on malaria incidence in Uganda: a cluster-randomised trial
REFNo: HS1097ES

Primary Objective:
To evaluate the impact of LLINs treated with a pyrethroid insecticide plus pyriproxyfen (PPF LLINs), as compared to LLINs treated with a pyrethroid plus piperonyl butoxide (PBO LLINs), on malaria incidence in Uganda. We will test the hypothesis that malaria incidence will be lower in intervention clusters (randomised to receive PPF LLINs) than in control clusters (randomised to receive PBO LLINs).

Secondary Objectives:
To evaluate the impact of PPF LLINs vs PBO LLINs on parasite prevalence, anaemia, and vector density.
To estimate the cost-effectiveness of delivering PPF LLINs, as compared to PBO LLINs
To assess net durability, survivorship and use of PPF LLINs vs PBO LLINs.

Uganda 2021-01-11 2024-01-11 Medical and Health Sciences Non-degree Award
Robert Opika Opoka
ID: UNCST-2021-R014036
The Influence of Comprehensive Follow-Up in Pediatric Sickle Cell Disease in an African Setting: a retrospective cohort Study
REFNo: HS636ES

General Objectives: To compare a set of sickle cell-related outcomes (mortality, stroke, blood transfusions, and hospitalizations) between children with SCA on a comprehensive follow up schedule under clinical trials setting and that of a cohort of children with SCA receiving routine care at a specialized sickle cell clinic.


Primary Objective: To compare sickle cell-related outcomes in the NOHARM children who were on the placebo arm to those of children of similar age group from the MHSCC who fulfilled the inclusion criteria for the NOHARM study at the time the study was recruiting patients but who were not enrolled.

Secondary Objectives: To assess the added effect of hydroxyurea therapy (in addition to comprehensive follow up schedule) on sickle cell-related outcomes. This shall be done by comparing sickle cell related outcomes in
1) NOHARM children randomized to hydroxyurea arm and that of the cohort of non-study MHSCC children with SCA over the time period of the NOHARM study (calendar years 2015-17).
2) NOHARM children on the MTD dose of hydroxyurea to that of the cohort of non-study MHSCC children with SCA over the time period of the MTD study (calendar years 2018-19).

Uganda 2021-01-08 2024-01-08 Medical and Health Sciences Non-degree Award
JANE  BWIRUKA FRIDA
ID:
Student teachers Narratives on Pedagogical Practices that inform their Competences at Makerere University, Uganda
REFNo: SS518ES

1)Explore the narratives of student teachers on teaching practices that inform their competences at Makerere University.
2)Explore the narratives of student teachers on mentoring practices that inform their competences at Makerere University.
3)Explore the narratives of student teachers on supervision practices that inform their competences at Makerere University.
Uganda 2021-01-08 2024-01-08 Social Science and Humanities Degree Award
ANNETTEE NAKIMULI OLIVIA
ID: UNCST-2022-R011194
Using new genomic approaches to investigate causes of maternal sepsis among women delivering in sub-Saharan Africa
REFNo: HS969ES

Primary objectives
1)To compare the pathogen profiles using routine microbiology (blood cultures, urinalysis, malaria tests, complete blood count) among women with fever at delivery and those without fever at KNRH
2)To compare the prevalence of Streptococcus agalactiae in placental samples using qPCR among women with fever at delivery and those without fever at KNRH

Secondary objectives
1)To compare the composition and diversity of the nasal and ano-vaginal microbiota among women with fever at delivery and those without fever at KNRH
2)To compare the composition and diversity of the nasal and ano-vaginal microbiota among newborns of women with fever at delivery and the newborns of those without fever at KNRH
3)To compare the single-cell RNA-seq transcriptome of the placentae of women with placental malaria and those without placental malaria at Kawempe National Referral Hospital (KNRH).


Uganda 2021-01-08 2024-01-08 Medical and Health Sciences Non-degree Award
Moreen Kiiza
ID:
The Right to Rehabilitation for the Survivors of Torture: A Case Study of Urban Refugees in Katwe-Kinyolo, Kampala-Uganda
REFNo: SS630ES

1. To assess the adequacy of the legal and policy framework governing rehabilitation for refugee survivors of torture in Uganda.
2. To ascertain the rehabilitation needs of refugee survivors of torture in Uganda.
3. To establish the adequacy of available mechanisms for the rehabilitation of refugee survivors of torture in Uganda.
4. To establish the challenges to the rehabilitation of refugee survivors of torture in Uganda.

Uganda 2021-01-08 2024-01-08 Social Science and Humanities Degree Award
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