Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
SHAFIC MAKUMBI
ID:
Voluntary Consent to Research on Children: A sub-study of the CHAPAS-4 and ODYSSEY Trial
REFNo: SS677ES

1.2 Overall objective
The aim of this study is to assess parental perception of voluntariness of consent in Paediatric HIV clinical trials and associated factors.

1.4 Specific objectives
1.4.1. To describe the process in which parents and guardians consent for their children to be enrolled in two pediatric HIV Clinical Trials.
1.4.2. To measure the level of perceived voluntariness of consent using the voluntariness ladder
1.4.3. To identify the social demographic, situational and external control factors that influence parental perception of the voluntariness of their consent

 Uganda 2021-01-20 2024-01-20 Social Science and Humanities Degree Award
Rhoda Wanyenze
ID: UNCST-2021-R013352
 Impact of Masks on Community Spread of COVID-19: Evidence from Uganda
REFNo: HS1124ES

2.1 General Objective

The aim of this study is to provide policy makers with the first population-based estimate of the extent to which face coverings reduce the spread of SARS-CoV-2. We also intend to provide evidence to the Ministry of Health in Uganda (and public health officials more generally) with evidence about effective communication and education tools for increasing the proper use of masks in the general population.


2.2 Specific Aims

The specific objectives of our study are as follows:

Aim 1: To test whether free mask distribution increases the proper use of masks in intervention communities
Aim 2: To test whether combining free mask distribution with education and communication about masks and COVID-19 increases the proper use of masks in intervention communities Aim 3: To evaluate whether increased mask use affects seroprevalence of SARS-CoV-2
Aim 4: To evaluate potential spillovers, or whether higher mask use in intervention communities affect mask use and probability of infection in neighboring non-intervention communities

 Uganda 2021-01-20 2024-01-20 Medical and Health Sciences Non-degree Award
Kamya Moses
ID: UNCST-2020-R014203
 COVID-19 sydromic and sero-surveillance using established Uganda malaria surveillance sites.
REFNo: HS1125ES

To establish COVID-19 syndromic surveillance through existing Uganda Malaria Surveillance sites by collecting additional data on COVID-19 specific symptoms.

To perform enhanced surveillance for COVID-19 and assess for serological evidence of past infection with SARS-CoV-2 in patients, in order to estimate disease burden and map the geographic spread of the epidemic.

 Uganda 2021-01-20 2024-01-20 Medical and Health Sciences Non-degree Award
Edgar Agaba
ID:
One Nutrition in Complex Environments (ONCE), a cluster-randomized trial of nutrition education and access to simple supportive technologies in improving agricultural practices and water quality management
REFNo: HS492ES

Aim 1: Implement and test a social and behavior change (NIPP) program alone (free-standing) and in combination with a “value-added” approach (NIPP+). The latter includes access to innovative low-cost tools and technologies relating to WASH and agriculture.

Aim 2: Identify best-practices emerging from the implementation of both approaches through process and program monitoring for effective integration, implementation, scale-up, and uptake of multi-sectoral and multi-level packages in complex environments to ascertain potential for scale up.

Aim 3: Study the sustained impact of the NIPP approach and the “value added” package (NIPP+) on knowledge and practices by gender within participating households, environmental risk factors, child health and nutritional status through a rigorous impact evaluation and longitudinal monitoring system.
 Uganda 2021-01-12 2024-01-12 Medical and Health Sciences Non-degree Award
Henry Ddungu
ID: UNCST-2019-R000966
 A Phase 2b Study to Evaluate the Safety and Efficacy of IMR-687 in Subjects with Sickle Cell Disease.
REFNo: HS1078ES

Primary Objectives:
(a)To evaluate the fetal hemoglobin (HbF) response to IMR-687 versus placebo
(b)To evaluate the safety of IMR-687 versus placebo.
Secondary Efficacy Objectives
(a)To evaluate the effect of IMR-687 versus placebo on HbF-associated biomarkers
(b)To evaluate the effect of IMR-687 versus placebo on indices of red cell hemolysis
(c)To evaluate the effect of IMR-687 versus placebo on indices of white blood cell (WBC)
adhesion
(d)To evaluate the effect of IMR-687 versus placebo on the incidence of vaso-occlusive crises(VOCs)
(e)To evaluate the effect of IMR-687 versus placebo on quality of life measures

Pharmacokinetic Objectives
(i)To evaluate the PK of IMR-687 and any major circulating metabolites

Exploratory Efficacy Objectives
(ii)To evaluate the effect of IMR-687 versus placebo on changes in red blood cell (RBC)
characteristics and total Hb
(iii)To evaluate the effect of IMR-687 versus placebo on renal function
(iv)To evaluate the effect of IMR-687 versus placebo on indices associated with
cardiovascular pathophysiology and ischemic stroke risk.
 Uganda 2021-01-12 2024-01-12 Medical and Health Sciences Non-degree Award
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