Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Alexander Kagaha
ID: UNCST-2024-R004967
REIMAGINING MALARIAL INFECTION CONTROL IN TERMS OF PLANETARY HEALTH BOUNDARIES
REFNo: HS4005ES

To examine the performances through which regimes of malaria and malaria control consciousness conceal and privilege specific human and nonhuman elements.,To examine the shifting terrain of consciousness on malaria control and the conditions that underpin their rise. ,To explore and examine human and nonhuman elements constituted by and within consciousness boundaries of malaria and malaria control interventions. ,To investigate the boundaries of consciousness of malaria and malaria control interventions in Uganda. The boundary of consciousness here denotes the dominant forms of collective and institutional consciousness that guides, regulates, informs and mediates malaria control.,
Uganda 2024-04-26 9:45:31 2027-04-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
HENRY MBOWA STANLEY
ID:
SOCIAL MEDIA USAGE AND MARKET PERFORMANCE OF SMALL AND MEDIUM ENTERPRISES IN WAKISO DISTRICT, UGANDA
REFNo: SS2564ES

iv. To develop a model that will guide social media usage in order to improve the market performance of SMEs in the Wakiso district,iii. To investigate the challenges affecting social media usage by SMEs in the Wakiso district,ii. To examine the influence of social media usage on the market performance of SMEs in Wakiso district,i. To explore the various social media platforms used by SMEs in Wakiso district,The general objective of the study will be to establish the extent to which social media usage enhances market performance of SMEs in Wakiso district, Uganda.,
Uganda 2024-04-26 9:44:07 2027-04-26 Social Science and Humanities Non-Clinical Trial Degree Award
Faisal Kiberu
ID:
Investigation Of Burnt Clay Hollow Block Reinforced Concrete Slab Under Seismic Action
REFNo: SIR327ES

Main To evaluate the seismic behavior of reinforced concrete (RC) frame with Burnt Clay Hollow Block (BC-HB) RC slab under simulated seismic action. Specific Objectives i. To determine the mechanical properties of BC-HB and all other materials that are used in BC-HB RC slab. ii. To simulate the behavior of BC-HB RC slab under seismic action. iii. To design and construct an RC frame with an optimized BC-HB RC slab. iv. To determine the performance of the optimized BC-HB RC slab under seismic action.
Uganda 2024-04-26 9:41:58 2027-04-26 Engineering and Technology Non-Clinical Trial Degree Award
Anthony Kiwanuka N/A
ID: UNCST-2023-R005473
MENTAL HEALTH DISORDER MANAGEMENT AND BARRIERS TO ACCESSING ITS SERVICESAMONG THE RELIGIOUS IN UGANDA
REFNo: SS2517ES

iv. To assess the coping mechanisms available for optimizing mental health disorders among the religious persons. ,iii. To analyze the barriers linked to accessing mental health services faced by the religious persons,ii. To describe mental health services and factors related to stigma associated with mental illness among the people of consecrated life.,i. To explore the ways in which mental health disorder management institutes provide access to services to persons of consecrated life. ,This study will seek to explore mental health disorder management and barriers to accessing its services among the religious in Uganda.,
Uganda 2024-04-26 9:41:00 2027-04-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Peter Olds
ID: UNCST-2023-R006240
Feasibility and effectiveness of atrial fibrillation detection methods among high-risk patients in southwestern Uganda
REFNo: HS3976ES

1. Compare FitBit watch with Holter monitor in detecting the burden of atrial fibrillation among high-risk patients at MRRH. We will compare FitBit watches with the gold standard of Holter monitor for detection of atrial fibrillation among high-risk patients at the MRRH outpatient cardiology clinic. We will also calculate the prevalence of atrial fibrillation in our population and build a regression model for risk factors associated with atrial fibrillation.

2. Evaluate the feasibility and acceptability of implementing atrial fibrillation detection devices in Uganda. Embedded within our non-inferiority trial, we will evaluate the feasibility and acceptability of implementing FitBit watches and Holter monitors using implementation metrics. For primary outcome, we will use the Proctor Model to assess key implementation, service, and client outcomes.

USA 2024-04-26 9:37:51 2027-04-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Abel Bizimana
ID:
EFFECTS OF MEMBERSHIP IN SELF-HELP INGOBYI ASSOCIATIONS ON ACCESS TO MATERNAL HEALTH SERVICES IN THE CONTEXT OF ETHNICALLY MARGINALIZED BATWA IN KIGEZI, UGANDA: A MIXED METHOD STUDY
REFNo: HS4132ES

To determine how Ingobyi Associations affect access to maternal health services, To explore organisational and implementation dynamics within Ingobyi Associations, To determine factors that affect access to maternal health care services among the Batwa and other community members in the Kigezi sub-region.,To determine effects of membership in Ingobyi Associations in access to maternal healthcare services among the Batwa and other community members in the Kigezi sub-region, Uganda,
Uganda 2024-04-26 9:33:28 2027-04-26 Medical and Health Sciences Non-Clinical Trial Degree Award
Felix Bongomin
ID: UNCST-2020-R014224
Undiagnosed Pulmonary Aspergillosis as a Fatal Complication of Advanced HIV Disease in Uganda: An Autopsy-Based Study
REFNo: HS3378ES

The second objective is to determine the burden of co-infections of pulmonary aspergillosis with other pulmonary infections, such as tuberculosis, histoplasmosis, cryptococcosis, and pneumocystosis, among patients with advanced HIV disease who died in selected hospitals in Northern Uganda. ,The first objective is to determine the prevalence and pattern of pulmonary aspergillosis among patients with advanced HIV disease who died in selected hospitals in Northern Uganda.,
Uganda 2024-04-26 9:30:27 2027-04-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Samson Okello
ID: UNCST-2019-R001580
EsophaCap for the Detection of Early Esophageal Carcinoma
REFNo: HS3248ES

Using our POC approach to carry out a diagnostic pilot study of ESCC in Uganda,In order to achieve fully automatic high-speed biomarker assaying, to design a small,light apparatus,In order to achieve a sample-to-answer assay, to implement DNA extraction, bisulfitetreatment, and methylation-specific PCR into a magnetofluidic chip with dried reagents.,Using a sponge-capsule swallowed/tethered collection device, to construct amethylation marker-based strategy to detect ESCC,To evaluate and validate the performance of the combined sponge methylation biomarker strategy in vivo in PRoBE-compliant, among prospective live cohorts od patients with EAC/HGD, ESCC and gastric cancer and controls in Uganda.,
Uganda 2024-04-26 9:27:48 2027-04-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
David Okimait
ID: UNCST-2019-R000095
Amref Uganda 2023 - 2030 Strategic Plan Baseline Survey
REFNo: HS3697ES

To set a benchmark for Amref Uganda’s country strategy indicators for the strategic platforms and eight strategic objectives. To carry out a stakeholder analysis of access, utilization, and provision of healthcare services as well as assessing the preparedness of health facilities for public health emergencies in Uganda. To recommend actions to improve the chances of achieving Amref Uganda's 2023-2030 strategy.
Uganda 2024-04-26 9:26:30 2027-04-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Christopher Turyatunga Bernard
ID: UNCST-2023-R006842
Drivers, profiling and drugs resistance effects, outcomes and cost-effectiveness of diagnostic and Syndromic interventions among urogenital discharging patients in southwestern Uganda
REFNo: HS3796ES

Establish the aetiology and sensitivity profile of urogenital discharges among patients in south western Uganda. ,5. Evaluate the Comparative cost effectiveness of diagnostic and Syndromic approaches in the management of patients with urogenital discharges in south western Uganda.,4. Compare the treatment outcomes between syndromic and diagnostic approaches in the management of patients with urogenital discharges in south western Uganda.,3. Determine the drivers of drugs resistance among patients with urogenital discharges in south western Uganda. ,2. Determine the effect of drugs’ resistance on the management of patients with urogenital discharges in south western Uganda.,This study is aimed at establishing the drivers, profiling and effect of drugs resistance, comparative treatment outcomes and cost-effectiveness of diagnostic and Syndromic interventions on patients with urogenital discharges in southwestern Uganda, and it is a parallel randomized intervention at STI clinics of Kabale and Mbarara Regional Referral Hospitals and Kisiizi Mission Hospital.,
Uganda 2024-04-26 9:21:22 2027-04-26 Medical and Health Sciences Clinical Trial Degree Award
David Kabugo
ID: UNCST-2023-R005971
An Evaluation of the Caring for Caregiver (CFC) Intervention on caregiver emotional wellbeing, social support, and parenting stress in two rural districts of Uganda
REFNo: SS2385ES

1. To determine whether exposure to Caring for Caregiver (CFC) standardized training and supervision results in improvements in FLW counselling capacities and leads to fidelity in the application of CFC skills, tools, activities.
2. To determine whether exposure to CFC skills, tools, activities result in positive changes to emotional-wellbeing, social support and parenting stress in an intervention group relative to a comparison group.
3. To assess whether FLW emotional wellbeing, social support, and perceived stress, before, during and after training, implementation and supervision, influences caregiver and/or FLW outcomes.

Uganda 2024-04-26 9:17:45 2027-04-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Louis Kamulegeya Henry
ID:
Assessing the role of micro-nutrient deficiency and Immune system dysfunction among HIV-positive adults with pulmonary Tuberculosis at a public health facility in Uganda.
REFNo: HS3933ES

To determine the relationship between micro and macro nutrient status with pulmonary tuberculosis treatment response (symptom improvement).,To determine the association between micro and macro nutrient status and TB specific Immune responses among HIV infected TB patients,To assess the association between macro and micro nutrient status with severity of pulmonary tuberculosis among HIV/TB infected patients,To determine the levels of macro and micro nutrients among HIV-infected pulmonary tuberculosis patients at a public health facility,To assess how nutritional status (macro and micro) among HIV-positive patients co-infected with pulmonary tuberculosis correlates with the severity of symptoms, immune response and treatment outcome at a public health facility in Uganda,
Uganda 2024-04-26 9:15:09 2027-04-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sarah Zalwango Karen
ID: UNCST-2021-R005660
Qualitative assessment of Facilitators and barriers to using wearable GPS watches as a device for collecting research data.
REFNo: SIR326ES

The objective is to assess the facilitators and barriers to wearing a GPS watch among individuals with no previous infection of M. tuberculosis in Kampala, Uganda. ,
Uganda 2024-04-26 9:12:25 2027-04-26 Engineering and Technology Non-Clinical Trial Non-degree Award
Mercyline Ong'ayo Jerusa
ID:
Antecedents to participation and performance of collective action initiatives amongst the smallholder farmers in Northern Uganda
REFNo: SS2507ES

To contribute to improved performance of farmer organizations by unraveling participation dynamics in collective action initiatives undertaken by FOs in Northern Uganda., iv. To determine the influence of farmer participation and socio-economic environment on the perceived performance of CAIs.,iii. To determine the influence of farmer motivation on participation in CAIs provided by farmer organizations. ,ii. To analyze the relationship between entrepreneurial orientation and farmer participation in CAIs.,i. To determine the relationship between socio-economic environment and farmer participation intensity in CAIs provided by farmer organizations. ,
Kenya 2024-04-26 9:09:58 2027-04-26 Social Science and Humanities Non-Clinical Trial Degree Award
Arianna Pacifico
ID:
Political Economy Analysis of Refugee Education Financing within the Context of the Inclusion Agenda
REFNo: SS2571ES

To support international donors and refugee hosting education systems achieve adequate and sustainable financing for refugee education in national systems.,
USA 2024-04-26 9:08:09 2027-04-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Joan Atim
ID:
Prevalence of Lower Extremity Arterial Disease and Associated Factors Among HIV-infected Adults on Antiretroviral treatment at Mildmay Uganda.
REFNo: HS2912ES

ii. To determine the factors associated with lower extremity arterial disease among HIV-positive patients on ART at Mildmay Uganda.,i. To determine the prevalence of lower extremity arterial disease among HIV-positive patients on ART at Mildmay Uganda.,To determine the prevalence and factors associated with lower extremity arterial disease among HIV-positive patients on ART at Mildmay Uganda.,
Uganda 2024-04-26 9:04:25 2027-04-26 Medical and Health Sciences Non-Clinical Trial Degree Award
Yahaya Gavamukulya
ID: UNCST-2019-R001017
Formulation and Pre-clinical Evaluation of Herbal Toothpaste/ Mouth Wash for Management of Oral Diseases: STI-OP Dental Solutions Project
REFNo: HS4022ES

General objective/ Purpose of the study To formulate a herbal toothpaste/ mouth wash and undertake preclinical studies on its use in management of oral diseases Specific objectives 1. To formulate herbal toothpaste/ mouth wash from extracts of selected plants for management of oral diseases. 2. To evaluate the organoleptic and physical properties of the formulated herbal toothpaste / mouth wash as per specified standards. 3. To evaluate the antimicrobial activity of the formulated herbal remedy against selected oral pathogens, Streptococcus mutans and Staphylococcus aureus. 4. To produce one batch of the fully tested herbal remedy for subsequent field testing.
Uganda 2024-04-22 6:35:14 2027-04-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Michael Okot
ID: UNCST-2023-R005793
FACTORS INFLUENCING ACCESS AND UTILISATION OF ELIMINATION OF MOTHER TO CHILD TRASMISSION (EMTCT) OF HIV SERVICES IN ACHOLI SUB REGION, UGANDA.
REFNo: HS3996ES

To determine the enabling factors affecting access and utilization of the EMTCT services by the pregnant and breastfeeding women in Acholi Sub Region, Uganda.,To identify the predisposing factors affecting access and utilization of the EMTCT services by the pregnant and breastfeeding women in Acholi Sub Region, Uganda.,To explore and analyses the factors influencing the access and utilisation of the EMTCT services by pregnant women including those in high-risk groups in Acholi Sub Region.,
Uganda 2024-04-22 6:25:27 2027-04-22 Medical and Health Sciences Non-Clinical Trial Degree Award
Justine  Komunyena Tumusiime
ID: UNCST-2023-R008465
STAKEHOLDER ACCEPTABILITY AND USABILITY OF A MICROARRAY PATCH FOR PEDIATRIC ANTIRETROVIRAL TREATMENT IN UGANDA
REFNo: HS3928ES

To observe and interview stakeholders who would be potential users of the pediatric ARV MAP in Uganda
Uganda 2024-04-22 6:21:28 2027-04-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Fred Ssewamala
ID: UNCST-2020-R014060
Bridges2Scale: Testing Implementation Strategies for an intervention among young people affected by AIDS
REFNo: SS2488ES

Bridges2Scale will use a two-arm Hybrid III effectiveness-implementation cluster randomized clinical trial, where we will compare two multifaceted strategies (standard vs. enhanced) for scaling the Bridges interventions (consisting of financial literacy training, peer mentorship, family income-generating , and youth development accounts). The standard implementation strategy has been applied in our prior and ongoing studies and involves educational meetings that prepare staff members to deliver Bridges with minimal disruption to site workflow. This will be compared to an enhanced strategy that will be developed using Implementation Mapping, a systematic protocol for developing implementation strategies using theory, evidence, and stakeholder input. Aim 1: Compare the implementation effectiveness of the standard implementation strategy vs. an enhanced implementation strategy. Aim 2: Determine the clinical effectiveness of Bridges implemented via a standard vs. enhanced implementation strategy. Aim 3: Explore implementation processes, mechanisms, and determinants. Aim 4: Compare the cost and cost-effectiveness of the two implementation strategies.
Uganda 2024-04-19 18:42:54 2027-04-19 Social Science and Humanities Clinical Trial Non-degree Award
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