Afiz Kibuuka Kibuuka
ID: UNCST-2021-R012755
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A Phase 2b Study to Evaluate the Safety and Efficacy of IMR-687 in Subjects with Sickle Cell Disease
REFNo: HS1150ES
Objectives:
Primary Objectives
• To evaluate the fetal hemoglobin (HbF) response to IMR-687 versus placebo
• To evaluate the safety of IMR-687 versus placebo Seconduy Efficacy Objectives
• To evaluate the effect of IMR-687 versus placebo on HbF-associated biomarkers
• To evaluate the effect ofIMR-687 versus placebo on indices of red cell hemolysis
• To evaluate the effect ofIMR-687 versus placebo on indices of white blood cell (WBC) adhesion
To evaluate the effect of IMR-687 versus placebo on the incidence of vaso-occlusive crises (vocs)
• To evaluate the effect of IMR-687 versus placebo on quality of life measures Pharmacokinetic•Óbjectives
• To evaluate the PK ofIMR-687 and any major circulating metabolites
Exploratory Efficacy Objectives
To evaluate the effect of IMR-687 versus placebo on changes in red blood cell (RBC) characteristics and total Hb e To evaluate the effect of IMR-687 versus placebo on renal function
• To evaluate the effect of IMR-687 versus placebo on indices associated with cardiovascular pathophysiology and ischemic stroke risk
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Uganda |
2021-02-11 |
2024-02-11 |
Medical and Health Sciences |
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Non-degree Award |
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Casim Tolo Umba
ID: UNCST-2021-R012658
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Action Towards Reducing Aquatic snail-borne Parasitic diseases (ATRAP)
REFNo: NS128ES
The main objective of the project is to improve Health through the prevention and mitigation of risks that originate at the interface between humans, animals and the environment. In this project we want to increase the capacity to prevent infections by snail-borne diseases in western Uganda. The strategic objectives are as follows:
1. To strengthen scientific research capacity.
2. To strengthen physical and virtual diffusion of scientific research
results to the larger scientific community
3. To raise awareness about snail borne diseases to the general public.
4. To support good governance, based on the scientific results.
5. To develop synergies and complementary activities among partners through multi-partner governance and coordination
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Uganda |
2021-02-10 |
2024-02-10 |
Natural Sciences |
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Degree Award |
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MIRIAM NAKALEMBE
ID: UNCST-2019-R000824
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Designing and Piloting of a Mobile-based Transport Technology linking Mothers to Health Facilities to Reduce Maternal and New-born Deaths in Uganda during the COVID-19 Pandemic.
REFNo: HS1148ES
1. To identify the existing automated maternal services apps and assess the extent to which they provide near real-time information and communication between mothers and the transporters at community level.
2. To develop a mobile-based transport technology that improves two-way communication between mothers and the transporters at community levels
3. To pilot the mobile-based transport technology for its usability and acceptability
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Uganda |
2021-02-10 |
2024-02-10 |
Medical and Health Sciences |
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Non-degree Award |
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Anthony Nuwa
ID:
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Evaluating the feasibility, acceptability and protective efficacy of seasonal malaria chemoprevention in two districts in Karamoja, Uganda
REFNo: HS1182ES
Objective 1: To document the adaptation of SMC in Karamoja region in Uganda
Objective 2: To Assess the process of implementing SMC in Uganda, with regards to coverage and quality of implementation
Objective 3: To assess the acceptability of SMC among policy makers, implementers, and beneficiaries.
Objective 4: To determine the impact of SMC on malaria incidence and prevalence among children under 5 years in the Karamoja region and assess the protective efficacy of SPAQ
Objective 5: To analyse cost of SMC delivery to children 3-59 months in Karamoja region
Objective 6: Monitor the safety of sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ) when used in SMC among children 3-59 months in Karamoja region.
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Uganda |
2021-02-10 |
2024-02-10 |
Medical and Health Sciences |
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Non-degree Award |
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Noah Kiwanuka
ID: UNCST-2021-R010125
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Capturing spatial patterns of new M. tuberculosis infection in Kampala, Uganda
REFNo: HS1230ES
To map the geo-spatial incidence of Mtb infections in a prospective community cohort study of HIV+ and HIV- adults in Kampala Uganda. GPS tracking technology will be used to trace and map subjects to locate areas of high Mtb transmission, or hotspots. Study participants without tuberculous infection will be followed for IGRA/TST conversion for up to 2 years with serial plasma samples taken quarterly.
To determine and validate whether a defined plasma signature found in other studies can identify recent Mtb infection in persons who developed LTBI. Using a paired analysis, we will evaluate baseline and follow-up samples within individuals to determine whether changes associated with new Mtb infection in the community can be detected in plasma with published and newly developed biomarkers. Using a nested case control design, we will compare incident infections with randomly selected controls from the cohort who did not convert
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Uganda |
2021-02-10 |
2024-02-10 |
Medical and Health Sciences |
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Non-degree Award |
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