Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Pauline Byakika-Kibwika
ID: UNCST-2019-R001206
Perceptions and acceptance of malaria vaccine among caregivers of children admitted with severe malaria in a highly endemic area in Uganda; a mixed methods study
REFNo: HS4059ES

To explore the perceptions of caregivers of children admitted with severe malaria in Tororo General Hospital about malaria vaccine,To investigate the factors associated with the acceptability of malaria vaccine among caregivers of children admitted with severe malaria in Tororo General Hospital in Uganda,To determine the proportion of caregivers of children admitted with severe malaria in Tororo General Hospital who will accept the malaria vaccine,To assess the perceptions and acceptance of malaria vaccine and associated factors among caregivers of children admitted with severe malaria in Tororo General Hospital. ,
Uganda 2024-05-14 9:01:46 2027-05-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Edith Wakida K
ID: UNCST-2019-R001225
A multi-component mHealth intervention ‘eCap-CoDe’ consisting of training, data capture and feedback tailored for improved community-based dementia care in rural Uganda: the barriers, ideating, development process
REFNo: HS4064ES

To ideate and develop a prototype for a multi-component mHealth application consisting of training, data capture and feedback to the PHC providers to improve community-based dementia care,To identify the barriers and facilitators faced by the PHC providers in rural Uganda as it relates to training, data capture and feedback on dementia assessment and management,To explore the barriers faced by the PHC providers in rural Uganda as it relates to training, data capture and feedback on dementia assessment and management, and co-design a multi-component mHealth intervention to improve community-based dementia care,
Uganda 2024-05-14 9:00:15 2027-05-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Melody Niwamanya
ID: UNCST-2019-R000928
Mid-term Evaluation Survey for Second Education Response Plan [ERP II] for refugees and host communities. Ref No: MUREC- 2024-366
REFNo: SS2610ES

To identify and document key areas of learning for partners and stakeholders engaged in the implementation of ERP II.,Examine the extent to which interventions are delivered or are likely to deliver results in an inclusive, economic, and timely manner.,To assess the relevance and coherence of planned interventions specifically examine the extent to which interventions implemented address the needs and priorities of targeted beneficiaries including complementarity of interventions, harmonization, and coordination of implementation,To assess the effectiveness of the implementation of interventions planned in ERP II by partners and stakeholders. Particularly assess progress towards implementation of planned activities and delivery of outputs aligned to ERP II objectives.,
2024-05-07 14:22:46 2027-05-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
LYDIA NAMIREMBE
ID: UNCST-2023-R006332
PREDICTORS OF HIV STATUS DISCLOURE TO INTIMATE PARTNERS AMONG HIV POSITIVE FEMALES AGED 20-49. A CROSS SECTIONAL STUDY IN BUIKWE DISTRICT, UGANDA.
REFNo: SS2570ES

iii. To explore the factors related to healthcare services that influence the inclination to disclose HIV test results to intimate partners among HIV-positive females aged 20-49 in Buikwe district.,ii. To identify the psychological factors that influence the inclination to disclose HIV test results to intimate partners among HIV-positive females aged 20-49 in Buikwe district.,i. To assess the socio-economic factors that impact the inclination to disclose HIV test results to intimate partners among HIV-positive females aged 20-49 in Buikwe district.,The primary goal of this study is to examine the factors that play a role in determining the willingness to reveal HIV test results to intimate partners among females aged 20-49 who are living with HIV in the Buikwe district.,
Uganda 2024-05-07 14:19:27 2027-05-07 Social Science and Humanities Non-Clinical Trial Degree Award
Hadijah Nansamba
ID:
INSTITUTIONALIZATION OF INFORMAL JUSTICE SYSTEM AND MITIGATION OF GENDER-BASED VIOLENCE IN BUNDIBUJYO DISTRICT IN WESTERN UGANDA
REFNo: SS2580ES

Purpose of the Study
To investigate the effect of institutionalization of informal justice systems towards Gender-Based Violence mitigation in Bundibugyo District in western Uganda

Specific Objectives
i. To assess the effect of institutionalization of traditional cultural courts towards mitigation of Gender-Based Violence in Bundibugyo District.
ii. To examine the effect of institutionalization of semi-formal local council courts towards mitigation of Gender-Based Violence in Bundibugyo District.
iii. To examine the effect of institutionalization of alternative community-based systems towards mitigation of Gender-Based Violence in Bundibugyo District.
iv. To explore the stakeholder perception about the effectiveness of institutionalization of the informal justice system towards mitigation of gender-based violence in Bundibujyo District

Hypotheses
i. There is no statistically significant effect of institutionalization of traditional cultural courts towards mitigation of Gender-Based Violence in Bundibugyo District
ii. There is no statistically significant effect of institutionalization of semi-formal local council courts towards mitigation of Gender-Based Violence in Bundibugyo District
iii. There is no statistically significant effect of institutionalization of alternative community-based systems towards mitigation of Gender-Based Violence in Bundibugyo District

Research Question
i. How do stakeholders perceive the effectiveness of the institutionalization of the informal justice system toward the mitigation of gender-based violence in Bundibugyo District?

Uganda 2024-05-07 14:11:05 2027-05-07 Social Science and Humanities Non-Clinical Trial Degree Award
Andrew Mujugira
ID: UNCST-2019-R000871
Multi-level intervention for intersectional stigma reduction to improve HIV outcomes for sex workers
REFNo: HS4129ES

Aim 1: Adapt the multilevel PRISM ISD-reduction intervention to address ISD
for SW in Uganda.
Aim 2: Conduct a pilot hybrid type 1 effectiveness-implementation trial to test
the preliminary effectiveness of the adapted multilevel Ssinga Nze ISD-
reduction intervention on (a) PrEP adherence or (b) viral suppression
among SW using a status-neutral approach.
Aim 3: Evaluate implementation of Ssinga Nze using qualitative methods.
Uganda 2024-05-07 14:09:03 2027-05-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Elizabeth Nyboer Ann
ID: UNCST-2023-R005929
Using population genetics to inform sustainable aquaculture governance in Lake Victoria, Uganda
REFNo: NS798ES

Specific aims are to: (i) characterize the genetic profiles of Nile Tilapia (Oreochromis niloticus) in Ugandan fish farms, and (ii) investigate levels of admixture and introgressive hybridization among farmed and wild O. niloticus and endemic Oreochromis species.
Canada 2024-05-07 14:07:15 2027-05-07 Natural Sciences Non-Clinical Trial Non-degree Award
Jenny Löfgren
ID: UNCST-2024-R005428
Simulation based training for hernia mesh repair for novice learners – a randomized trial
REFNo: HS4176ES

b) Assess the student’s perception of the respective training methods.,a) Compare the learning outcomes regarding the ability to carry out an anterior groin hernia mesh repair on a 3D model for learners who participate in simulation-based training under supervision versus those who practice in simulation-based training without supervision.,
Sweden 2024-05-07 14:06:01 2027-05-07 Medical and Health Sciences Non-Clinical Trial Degree Award
Katherine Hill Jane
ID: UNCST-2023-R005519
MITICare: Multimorbidity in Tuberculosis and Its Impact on Patient Care
REFNo: HS3888ES

Retrospective Cohort Objectives: Primary Objective: To describe the prevalence and patterns of multimorbidity in people with TB-HIV in Kampala. Secondary Objectives: To evaluate how prevalence and patterns of multimorbidity compare between people with TB-HIV and PLWHIV who do not develop TB within the cohort timeframe. To determine the effect of multimorbidity on end of TB treatment outcomes. Cross-sectional Study Nested Within Prospective Cohort Study Objectives: Primary Objective: To describe the prevalence of multimorbidity in patients at the start of treatment for TB in Kampala. Secondary Objectives: To determine the effect of multimorbidity on clinical characteristics of TB at the start of treatment. To determine the effect of multimorbidity on TB treatment outcomes. Exploratory Objective: To determine the effect of multimorbidity on progress through TB care.
UK 2024-05-07 14:04:46 2027-05-07 Medical and Health Sciences Non-Clinical Trial Degree Award
PAUL LWEVOLA
ID:
Barriers and Facilitators to enrollment into the Community Retail Pharmacy Drug Distribution Point (CRPDDP) model and its treatment outcomes in a Peri-Urban Setting, A Case of Iganga Hospital
REFNo: HS3892ES

To explore the facilitators and barriers to enrollment into the CRPDDP model at Iganga Hospital in East Central Uganda.,To determine retention, viral load suppression, and associated factors among PLHIV enrolled in CRPDDP at Iganga Hospital in East Central Uganda.,To explore Barriers and Facilitators to enrollment into the Community Retail Pharmacy Drug Distribution Point (CRPDDP) model and its treatment outcomes in a Peri-Urban Setting.,
Uganda 2024-05-07 14:03:28 2027-05-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jacqueline Kyosiimire-Lugemwa
ID: UNCST-2022-R005393
AN In-vitro PROTOCOL TO ASSESS SAFETY and EFFICACY OF NATURAL/HERBAL INVESTIGATIONAL THERAPEUTIC PRODUCTS IN UGANDA
REFNo: HS4041ES

SPECIFIC OBJECTIVES:
1) To determine bacterial/ fungal sterility of the natural products
2) To determine the cytotoxicity of the natural products
3) To determine the in-vitro anti-virus activity of natural products
4) To determine the in-vitro anti-bacterial activity of the natural products.
5) To determine the in-vitro anti-fungal activity of the natural products.
6) To determine the in-vitro anti-diabetic activity of the natural products.
7) To determine the in-vitro anti-cancer activity of the natural products.
8) To determine the in-vitro anti-inflammatory/ antioxidant activity of the natural products.
9) To determine the in-vitro anti (condition/disease) activity of the natural products, whereby innovation might be addressing a condition or disease might be of relevancy in Uganda, e.g. conditions like alcohol overuse which causes liver damage, or a disease like malaria. This protocol takes care of other innovative solutions that will come up in future. Thus, the protocol is not limited to the above conditions only.
10) For successful products, to design experiments that will contribute to other mechanism identification (examples are to assess presence of ACE2 blockers (proteins that prevent the SARS COV2 from binding the ACE2 receptor)/ ACE2 Decoys.

Uganda 2024-05-07 14:00:29 2027-05-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Nabbanja Teddy
ID:
A Model for eHealth Care Service Adoption for Mental Health Systems in Central Uganda. Case study: Butabika Referral Mental Hospital (BRMH)
REFNo: SIR305ES

Main Objective
The aim of this study is to develop a model for eHealth care service adoption that will enhance mental health service provision for health systems in Central Uganda.
Specific objectives
i) To examine the mental health care services provided by Butabika Hospital.
ii) To evaluate the existing mental health system for care services provision in Butabika Hospital.
iii) To design an e-Health Service Care Model for mental health service provision in Butabika Hospital.
iv) To validate the e-Health Service Care Model for mental health service provision in Butabika Hospital.

Uganda 2024-05-07 13:54:04 2027-05-07 Engineering and Technology Non-Clinical Trial Degree Award
Soumya Mishra
ID:
Examining PRC-associated Economic Development Zones in Africa: local impacts and the implications for host states
REFNo: SS2384ES

(1) What narratives and Sino-African interactions accompany the establishment of PRC-associated EDZs in Sub-Saharan Africa?(2) To what extent do PRC-associated EDZs meet their stated aims in terms of industrialisation, employment creation and other economic impacts? (3) What are the broader social, economic, political and environmental impacts of PRC-associated EDZs?
India 2024-05-07 13:52:47 2027-05-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
Josephine Najjuma Nambi
ID: UNCST-2021-R013717
Developing and testing a simulation-based intervention to improve stroke nursing care in Mbarara Regional Referral Hospital
REFNo: HS3535ES

6. Pilot test the simulation-based nursing intervention for feasibility, acceptability, functionality, quality of life, and preliminary health outcomes among stroke patients at MRRH. ,5. Develop a simulation-based stroke training packet/intervention for nurses to improve stroke care and management at Mbarara Regional Referral Hospital,4. Explore the barriers and facilitators for stroke management, and training among health care professionals at Mbarara Regional Referral Hospital ,The general objective of the study is to develop and pilot a simulation-based stroke intervention to improve stroke management at MRRH ,
Uganda 2024-05-07 13:49:58 2027-05-07 Medical and Health Sciences Clinical Trial Degree Award
David Guwatudde
ID: UNCST-2021-R008522
Research network for design and evaluation of adolescent health interventions and policies in Sub-Saharan Africa (DASH)
REFNo: HS4116ES

The overarching and long-term goal for the DASH research activities is to boost adolescent health in SAA through rigorous population-based surveillance, intervention and policy research in seven SSA countries including Burkina Faso, Ethiopia, Ghana, Nigeria, South Africa, Tanzania and Uganda (henceforth referred to as the ‘African DASH partner countries’). The key functions to address these objectives are to combine the efficient collection and use of important adolescent health data, and the employment of robust quantitative and qualitative methods of data collection and evaluation with local domain-specific expert and stakeholder knowledge on the health domains nutrition & physical activity, sexual & reproductive health, and mental health & violence (henceforth referred to as the ‘DASH health domains’).,To examine and assess transportability of DASH interventions and population-level policies (Transportability), in order to context relate to adolescent and young adult health, with the aim to understand how this context moderates the impact of interventions and policies; subsequently we will aim to transport the evidence on impact, generated within DASH, to other contexts in SSA,To evaluate population-level policies (Policy evaluation) with the aim to prioritize and select multiple population-level policies, related to the DASH health domains, which likely affect the health of adolescents and young adults, and to subsequently evaluate and understand the impact and mechanisms of these policies in Ghana, South Africa and Tanzania,To evaluate the impact of the DASH interventions (Intervention evaluation), their impact and performance,To co-design DASH interventions (Co-Design) with the aim to gain an understanding of local intervention needs and will co-design and pilot test interventions to improve nutrition & physical activity in South Africa, sexual & reproductive health in Uganda, and mental health & violence in Tanzania; these designed interventions will then be locally adapted in each African DASH partner country,To implement and test multiple light-touch interventions, which are relatively non-invasive, resource non-intensive interventions that aim to influence intentions, motivations and behaviors related to the three DASH health domains,To conduct surveillance of health and health-related risks (Surveillance) in order to determine trends and changes in adolescent and youth health, well-being and behaviors, particularly related to the three DASH health domains.,
Uganda 2024-05-07 12:44:23 2027-05-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
REBECCA NANTANDA
ID: UNCST-2019-R001533
Improving access to Asthma Care among Children and Adolescents in Uganda
REFNo: HS4136ES

To assess the feasibility, acceptability, and effectiveness of routine screening for asthma symptoms, healthcare worker needs-directed training and mentorship and asthma education in improving diagnosis and management of children and adolescents with asthma in Uganda. Specific objectives The study is divided into 4 sub-studies, and each of them has specific objectives as outlined below. Sub-study 1: Routine screening for asthma symptoms Objectives 1. To evaluate the clinical and cost-effectiveness of routine screening for asthma symptoms among children and adolescents with respiratory illnesses in identification of patients with undiagnosed asthma 2. To assess the feasibility and acceptability of routine screening for asthma symptoms among children and adolescents with respiratory illnesses. Sub-study 2: Healthcare workers’ needs-directed training and mentorship Objectives 1. To evaluate the clinical and cost-effectiveness of needs-directed healthcare workers’ training and mentorship in improving asthma outcomes in children and adolescents. 2. To assess the feasibility and acceptability of implementing a needs-directed healthcare workers’ training and mentorship intervention for improving asthma outcomes in children and adolescents. Sub-study 3: Community Health Worker-led asthma education Objectives 1. To assess the clinical and cost-effectiveness of community health worker-led asthma education in improving asthma outcomes among children and adolescents. 2. To assess the feasibility and acceptability of community health worker-led asthma education among children and adolescents, and their caregivers. Sub-study 4: Psychosocial challenges of asthma Objective 1. To explore the psychosocial challenges faced by children and adolescents with asthma, and their caregivers.
Uganda 2024-05-07 12:43:04 2027-05-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ounyesiga Living
ID: UNCST-2024-R005177
MODELING, SIMULATION AND OPTIMIZATION OF SOLAR POWER GENERATION AND TRANSMISSION IN UGANDA
REFNo: SIR322ES

Objectives of the Study
General Objective. The main objective of the study is to model, simulate and optimize solar power generation and transmission in Uganda.
Specific Objectives
The specific objectives are as follows:
(i) To modify the traditional power loss objective function in order to minimize electric power losses on Ugandan electricity transmission lines
(ii) To develop a mathematical models for coupled and uncoupled transmission lines, which can simulate lossy and lossless transmission parameters of current, voltage and temperature.
(iii) To formulate a differential equation for solar power generation and multiple empirical models for improving Photo Voltaic (PV) system design and operations.

Uganda 2024-05-07 12:37:34 2027-05-07 Engineering and Technology Non-Clinical Trial Degree Award
ANTHONY ONONO JAMES
ID:
FACTORS ASSOCIATED WITH HEALTH CARE WASTE MANAGEMENT PRACTICES AMONG HEALTHCARE WORKERS IN GULU CITY
REFNo: HS4009ES

3. To identify healthcare system factors associated with effective healthcare management practices among healthcare workers in Gulu city, located in Northern Uganda.,2. To assess individual factors associated with the management of healthcare waste by healthcare staff in Gulu city, located in the northern region of Uganda.,1. To assess the healthcare waste management practices among healthcare workers in Northern Uganda\'s Gulu city.,To assess factors associated with healthcare waste management practices among health care workers in Gulu city. ,
Uganda 2024-05-07 12:36:35 2027-05-07 Medical and Health Sciences Non-Clinical Trial Degree Award
Ntirandekura  Moses
ID: UNCST-2023-R005665
GOOD GOVERNANCE AND WOMEN ECONOMIC EMPOWERMENT IN SELECTED DISTRICTS OF SOUTH WESTERN UGANDA: A STUDY OF UGANDA WOMEN ENTREPRENEURSHIP PROGRAMME (UWEP)
REFNo: SS2612ES

i. To establish the effect of accountability in implementation of UWEP on women economic empowerment in Kisoro and Kabale Districts of South Western Uganda. ii. To examine the extent to which transparency in implementation of UWEP affects women economic empowerment in Kisoro and Kabale Districts of South Western Uganda. iii. To determine the influence of participation in implementation of UWEP on women economic empowerment in Kisoro and Kabale Districts of South Western Uganda. iv. To identify how equitability and inclusiveness in implementation of UWEP affect women economic empowerment in Kisoro and Kabale Districts of South Western Uganda. v. To determine the relationship between gender regulatory policies and women economic empowerment in Kisoro and Kabale Districts of South Western Uganda.
Uganda 2024-05-07 12:35:04 2027-05-07 Social Science and Humanities Non-Clinical Trial Degree Award
Alison Comfort
ID: UNCST-2022-R011501
Social networks and their role in early initiation of antenatal care by HIV serostatus in Uganda
REFNo: HS4061ES

Through a quantitative survey data collection using a prospective cohort design, this study aims to: 1) Understand whether there exists an association between social network characteristics and early ANC initiation; 2) Explore whether visualizing social network characteristics differentially affects care-seeking intentions at delivery; 3) Characterize the social network characteristics of pregnant women seeking ANC and assess whether differences exist by serostatus; 4) Assess whether network characteristics are differentially associated with early ANC initiation depending on serostatus, with similar analyses for other perinatal care indicators (e.g., facility-based delivery, post-partum care and infant HIV testing if applicable)
USA 2024-05-07 12:25:25 2027-05-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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