Nadine Schubert
ID:
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Genetically-based social communication in an inbred group-living wild mammal
REFNo: NS273ES
The aim is to investigate the role of immune genes of the major histocompatibility complex (MHC) in affecting odour cues used for social communication in banded mongooses. Furthermore, we want to investigate the link between MHC composition of an individual and fitness parameters as well as the impact of the MHC on microbiota communities. Last, it is crucial to test the ability of banded mongooses to discriminate MHC-based differences in odour cues in a natural setting.
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Germany |
2021-10-05 |
2024-10-05 |
Natural Sciences |
Non-Clinical Trial |
Degree Award |
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Christine Wiltshire Sekaggya
ID: UNCST-2019-R000578
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Clinical Predictors of 3-Months Isoniazid Rifapentine (3HP)- Related Adverse Drug Reactions (ADR) During Tuberculosis Preventive Therapy
(PAnDoRA-3HP study)
REFNo: HS1582ES
Primary Objectives
1.To describe the safety profile of 3HP among people receiving tuberculosis preventive therapy.
2.To describe the effect of adverse drug reactions on tuberculosis preventive therapy completion rates
Secondary Objective
1.To describe the pharmacokinetic and pharmacogenomic determinants of ADRs among people receiving tuberculosis preventive therapy in Uganda
2.To determine the efficacy of 3HP when used for tuberculosis preventive therapy.
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Uganda |
2021-10-04 |
2024-10-04 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Joseph Lutaakome
ID: UNCST-2020-R008323
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An International Multicenter, Randomized, Double-Blind, PlaceboControlled Trial of the Safety and Efficacy of Anti-Coronavirus Hyperimmune Intravenous Immunoglobulin for the Treatment of Adult Outpatients in Early Stages of COVID-19
REFNo: HS1715ES
Primary Objective
Primary objective: Among outpatients with recently diagnosed SARS-CoV-2 infection to compare the safety and efficacy of a single infusion of hIVIG (pooled for the 2 hIVIG
products) versus placebo, each given with SOC, on clinical status after seven days. Two hypotheses will be tested to address this primary objective, which compares the primary endpoint among two study populations: 1) participants where neutralizing MAb was not specified as part of SOC treatment (stratum 1, see Section 6.1 Overall Study Design); and 2) all randomized participants (stratum 1 and stratum 2 combined). hIVIG will be considered superior to placebo if either of the two hypotheses are rejected.
Secondary Objectives and Endpoints
Secondary objectives, including subgroup analyses and safety outcomes, will be addressed for all randomized participants and for those in stratum 1 and 2 separately.
Secondary Endpoints
The clinical status as classified on the ordinal outcome scale will be assessed with a number of additional analyses comparing hIVIG (pooled for the 2 hIVIG products) with placebo, among the overall study population as well as for the key subgroup of those not receiving anti-SARS-CoV-2 monoclonal antibodies as part of SOC (stratum 1), including:
1. All-cause hospitalization or death through 28 days.
2. All-cause mortality through 28 days.
3. Significant disease progression through 28 days, using a time to event analysis with outcome defined by fulfilling criteria for category 4 or 5 on the ordinal scale.
4. Distribution of ordinal scale outcome at Day 4, 14, and 28.
5. The proportion of participants with any disease progression at Day 7, using a sliding dichotomous scale progression defined by a categorization on the ordinal scale that is worse than the status at entry
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Uganda |
2021-10-04 |
2024-10-04 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Joyce Nankumbi
ID:
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The status of OFSP production, utilization and the nutritional status and welfare of sweet potato growing households in northern and eastern Uganda
REFNo: A152ES
1. To characterise the consumption of vitamin A rich foods among households in the selected northern and eastern districts of Uganda 2. What is the food security status in the households in the selected northern and eastern districts in Uganda? 3. To document the production and consumption of orange-fleshed sweet potato among households in the selected northern and eastern districts in Uganda? 4. To identify infant feeding practices of women in the selected districts of northern and eastern regions in Uganda? 5. To identify water, hygiene and sanitation practices of households in the selected northern and eastern districts in Uganda 6. To establish the knowledge, attitudes and perception on the consumption of beta carotene-rich orange-fleshed sweet potatoes/ vitamin A-rich foods among households in the northern and eastern regions in Uganda,To determine status of orange-fleshed sweet potato production, utilization and the nutritional status and welfare of sweet potato growing households. in northern and eastern Uganda ,
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Uganda |
2021-10-01 |
2024-10-01 |
Agricultural Sciences |
Non-Clinical Trial |
Non-degree Award |
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Arthur Nuwagaba
ID:
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TOP MANAGEMENT TEAM CHARACTERISTICS AND PERFORMANCE OF UGANDAN STATE AGENCIES
REFNo: SS999ES
iv. Establish the joint effect of top management team characteristics, strategy implementation and external environment on the performance of Ugandan state agencies.,iii. Determine the moderating effect of the external environment on the relationship between top management team characteristics and the performance of Ugandan state agencies.,ii. Establish the mediating effect of strategy implementation on the relationship between top management team characteristics and performance of Ugandan state agencies.,i. Determine the influence of top management team characteristics on the performance of Ugandan state agencies.,The main objective of the study is to determine the influence of strategy implementation and external environment on the relationship between the TMT characteristics and the performance of state agencies in Uganda.,
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Uganda |
2021-10-01 |
2024-10-01 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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