Flavia Matovu Kiweewa
ID: UNCST-2021-R013337
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PURPOSE 1: GS-US-412-5624/ A Phase 3, Double-Blinded, Multicenter, Randomized Study to Evaluate Safety and Efficacy of Twice Yearly Long-Acting Subcutaneous Lenacapavir, and Daily Oral Emtricitabine/Tenofovir Alafenamide for Pre-Exposure Prophylaxis in Adolescent Girls and Young Women at Risk of HIV Infection. Version 2.0, dated 10 March 2021.
REFNo: HS1920ES
1. Primary Objectives
i) To evaluate the efficacy of LEN for HIV PrEP in AGYW at risk of HIV infection.
ii) To evaluate the efficacy of F/TAF for HIV PrEP in AGYW at risk of HIV infection.
2. Secondary Objectives/ end points
i) To compare the efficacy of LEN with F/TDF for HIV PrEP in AGYW at risk of HIV infection.
ii) To evaluate the efficacy of LEN for HIV PrEP in AGYW at risk of HIV infection in participants adherent to LEN.
iii) To evaluate the efficacy of F/TAF for HIV PrEP in AGYW at risk of HIV infection in participants adherent to F/TAF.
iv) To compare the efficacy of F/TAF with F/TDF for HIV PrEP in AGYW at risk of HIV infection.
v) To evaluate the safety and tolerability of LEN, F/TAF, and F/TDF for HIV PrEP in AGYW at risk of HIV infection.
vi) To evaluate the safety and tolerability of LEN and F/TAF for HIV PrEP in AGYW ≥ 16 to < 18 years of age who have sex with male partners and are at risk for HIV infection.
3. Exploratory objectives
i) To assess the adherence rate to LEN as assessed by on-time LEN injection
ii) To assess LEN plasma levels
iii) To assess the adherence rate to F/TAF and F/TDF using intracellular TFV-DP levels in DBS.
iv) To evaluate the acceptability of a once every 26 weeks LEN injection for HIV PrEP in AGYW at risk of HIV infection.
v) To assess LEN plasma levels during pregnancy.
vi) To explore concentrations of hormonal contraceptives in LEN participants.
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Uganda |
2021-11-25 |
2024-11-25 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Julie Teichroeb Annette
ID:
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Social decision-making in Angolan colobus (Colobus angolensis ruwenzorii) and vervet monkeys (Chlorocebus pygerythrus) at Lake Nabugabo
REFNo: NS131ES
Understanding the effects of social constraints on group size and composition, movements, and foraging decisions.
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Canada |
2021-11-24 |
2024-11-24 |
Natural Sciences |
Non-Clinical Trial |
Non-degree Award |
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Kamya Moses
ID: UNCST-2020-R014203
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Enhancing immunity to malaria in young children with effective chemoprevention
REFNo: HS1763ES
To compare the incidence of malaria from 4 weeks to 4 years of age among children born to mothers randomized to receive intermittent preventative therapy in pregnancy (IPTp) with monthly sulfadoxine pyrimethamine (SP) alone, monthly DP alone, or both monthly SP+DP.
To compare the incidence of malaria from 2-4 years of age among children randomized to receive IPT in childhood (IPTc) with monthly DP from 8 weeks to 1 year of age vs. monthly DP from 8 weeks to 2 year of age vs. no IPTc.
To compare innate and adaptive effector and regulatory responses between children randomized to different IPT arms.
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Uganda |
2021-11-24 |
2024-11-24 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Emmanuel Viga Emmanuel
ID:
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MORAL AND SOCIAL DIMENSIONS OF ACCOUNTABILITY IN CIVIC HUMANITARIANISM: RELATIONAL AID AMONGST SOUTH SUDANESE REFUGEES IN UGANDA
REFNo: SS832ES
This research will majorly attempt to answer the question How is accountability of relational aid in civic humanitarianism conceptualized and managed in protracted crisis. This will be achieved by answering the following sub questions:-
1. What differentiates civic humanitarianism from mainstream humanitarian actors?
2. What is relational aid within civic humanitarianism? and how is accountability understood within the concept of relational aid?
3. What are the accountability practices in civic humanitarian aid?
4- How do different accountability forms influence aid delivery?
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Uganda |
2021-11-23 |
2024-11-23 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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DAN NYEHANGANE
ID:
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CYCLOTIDES FROM MEDICINAL PLANTS OF UGANDA: SELECTED SOURCES, ANTIBACTERIAL ACTIVITY, AND CYTOTOXICITY
REFNo: NS258ES
Primary Objective: To identify cyclotides from selected medicinal plants in Uganda and establish their antibacterial activity and cytotoxicity, in order to provide a basis for their medical application in Uganda.
Specific Objectives
1.To determine the presence and quantities of cyclotides in different parts of selected medicinal plant species from selected families reported to express cyclotides and are used to treat bacterial infections in Uganda.
2.To characterize the activity of cyclotides from Ugandan plants in relation to sequence, size and structure
3.To determine antibacterial activities of cyclotides isolated from the different plant species stratified by the plant part extracted and season of harvesting the plant.
4.To determine the cytotoxic effect of the most active antibacterial cyclotide on mammalian cells
5.To determine the synergistic activity of the most active cyclotides against bacterial strains by using combinations of cyclotides from different plant species
6.To establish the anti-biofilm and immunomodulatory activity of the most active anti-bacterial cyclotides
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Uganda |
2021-11-23 |
2024-11-23 |
Natural Sciences |
Non-Clinical Trial |
Degree Award |
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