Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Pakoyo Kamba Fadhiru
ID:
Elucidating the mechanism of interaction of mycobacteria rhomboid proteases with their specific substrates
REFNo: NS49ES

The goal is to elucidate the mechanism(s) of interaction of mycobacteria rhomboid proteases with their specific native substrates. There are three specific objectives: • To identify the native peptide substrates for mycobacteria rhomboid proteases. • To elucidate the substrate residues essential in interaction with mycobacteria rhomboid proteases. • To elucidate the mycobacteria rhomboid protease residues essential in interaction with their substrates.
Uganda 2018-04-30 2021-04-30 Natural Sciences Non-degree Award
Andrea  Calcagno
ID:
Using Calcaneal Quantitative Ultrasound (cQUS) and urine Retinol Binding Protein to screen HIV-infected cART-treated patients for reduced bone mineral density: a pilot study
REFNo: HS204ES

Primary objective: To compare DEXA and cQUS in predicting reduced BMD in a population of Ugandan HIV-infected individuals on long-term cART. Secondary objective: To assess the prevalence of abnormal RBP/Cr and the correlation between abnormal RBP/Cr and reduced BMD.
Italy 2018-04-30 2021-04-30 Medical and Health Sciences Non-degree Award
Michael Juma
ID:
EXAMINING THE EFFECT OF SERVICE DELIVERY FACTORS ON TIMELY INITIATION OF TUBERCULOSIS TREATMENT WITHIN PRIMARY CARE SETTINGS IN UGANDA
REFNo: HS205ES

The study goal is to examine the association between service delivery factors and timeliness of Tuberculosis treatment initiation within accredited primary care facilities in Uganda. Here service delivery factors are characteristics relating to HF structure and care delivery. The specific aims are: Aim 1: To explore the association between service-delivery factors (structural and care delivery characteristics) and process timeliness (diagnosis time, laboratory turnaround time and treatment initiation time) Aim 2: To measure the association between process timeliness and Tuberculosis treatment initiation Aim 3: Describe perspectives of healthcare workers (in-charges of outpatient departments, heads of clinical teams and heads of laboratories) within each accredited health facility on preventing delays in diagnosis and initiation of Tuberculosis treatment.
Uganda 2018-04-30 2021-04-30 Medical and Health Sciences Degree Award
Jack  Horowitz Rosengarten
ID:
Community-Driven Financial Solutions to Human-Wildlife Conflict in Uganda's Albertine Rift Eco-Region
REFNo: SS176ES

1. Policy objective: Uncover and clearly illustrate any institutional challenges of the Human-Wildlife Conflict Resilience Fund (HWCRF) project that may exist which are unique to Uganda’s Albertine rift region (UAR) in order to (a) strengthen the long-term implementation of the HWCRF project and (b) provide lessons learned for other governments and communities looking to implement human-wildlife conflict (HWC) financial instruments within similar geographies. 2. Academic objective: Contribute to the literature by bridging HWC insurance research outside of Sub-Saharan Africa with previous studies on HWC within UAR which have yet to formally analyze HWC financial instruments.
 USA 2018-04-25 2021-04-25 Social Science and Humanities Degree Award
Simon Wakwale Peter
ID:
POLITICAL DECENTRALISATION AND LOCAL GOVERNMENT PERFORMANCE: A CASE STUDY OF MBALE MUNICIPAL COUNCIL
REFNo: SS76ES

1. TO EXAMINE THE EFFECT OF DEVOLUTION OF POWERS ON TIMELY ACCOUNTABILITY IN MBALE MUNICIPAL COUNCIL 2. TO ASSESS THE EFFECT OF DEVOLUTION OF POWERS ON INFRASTRUCTURAL DEVELOPMENT IN MBALE MUNICIPAL COUNCIL 3. TO ESTABLISH THE EFFECT OF DEVOLUTION OF POWERS ON PROVISION OF SOCIAL SERVICES IN MBALE MUNICIPAL COUNCIL 4. TO FIND OUT THE EFFECT OF DEVOLUTION OF POWERS ON POLICY IMPLEMENTATION IN MBALE MUNICIPAL COUNCIL
Uganda 2018-04-24 2021-04-24 Social Science and Humanities Degree Award
CHRISTOPHER  OPIO KENNETH
ID:
Analysis of the genetic determinism of hepatocellular carcinoma (HCC)
REFNo: HS125ES

1) Determine the association between chosen genetic markers among patients with HCC compared with subjects from Uganda with advanced liver fibrosis (F4 or cirrhosis). 2) Explore additional genetic markers of HCC by selected sequencing (targeted sequencing and exome sequencing) of the genome of subjects with HCC compared to controls from Uganda. 3) Determine whether these markers correlate with the clinical stages of HCC and could be predictive of HCC progression. 4) To describe clinical outcomes of advanced liver fibrosis (F4 or cirrhosis) or HCC over the study follow-up period.
Uganda 2018-04-24 2021-04-24 Medical and Health Sciences Non-degree Award
Tiffany Basciano Nicole
ID:
No One Left Behind? A Study on the Human Rights of Women Living With HIV/AIDS in Uganda
REFNo: SS140ES

A study on adult women living with HIV/AIDS in Uganda. The study will include an examination of how women’s rights are integrated into HIV/AIDS-related laws, policies, programs, and initiatives in Uganda. We will further examine any challenges that women may face in family life, healthcare settings, or in the workplace because of their status, as well as any distinction in the experiences of women in urban versus rural settings. We hope that this research will help support the achievement of Sustainable Development Goals (SDGs) 3 – good health and well-being and 5 gender equality.
 USA 2018-04-24 2021-04-24 Social Science and Humanities Degree Award
Specioza  Twinamasiko
ID:
Oil discovery and compensation over land: Conceptualizing risks and vulnerabilities of women's household livelihoods i Albertine Graben, Uganda
REFNo: SS147ES

i- To discover the nature of oil related land contestations in the Albertine Graben. ii- To explore the risks and vulnerabilities experienced by women after oil discovery. iii- To examine land compensation processes before and after eviction. iv- To Explore the role of women in the land compensation process. v- To examine the strategies women have put in place to improve their livelihood.
Uganda 2018-04-24 2021-04-24 Social Science and Humanities Degree Award
Richard Wamimbi Wotti
ID:
Community Systems and Practices to Prevent and Respond to Violence Against Children in Uganda: Children's perceptions and lived experiences.
REFNo: SS158ES

1.Find out the perceptions and lived experiences of children most especially girls in preventing and responding to Violence Against Children in their communities. 2.Establish what the formal (education and social welfare) and non formal (family , faith based, traditional) approaches to child protection are and how they are being applied in creating safer communities in Uganda free from violence. 3.Examine how the formal and non-formal elements of community referral and reporting mechanisms are functioning to prevent and respond to Violence Against Children. 4.Explore how girls are affected by different forms of violence and how they are supported to enable them live in an environment that is free from all forms of violence throughout their life course
Uganda 2018-04-24 2021-04-24 Social Science and Humanities Degree Award
Wilfred Kokas Aupal Kokas
ID:
Change Management Practices and Performance of Selected Local Governments in Eastern Uganda
REFNo: SS165ES

1. To establish the relationship between executive support and performance of selected Local Governments in Eastern Uganda. 2. To assess the relationship between effective communication and performance of selected Local Governments in Eastern Uganda. 3. To investigate the relationship between employee involvement and performance of selected Local Governments in Eastern Uganda
Uganda 2018-04-24 2021-04-24 Social Science and Humanities Degree Award
Michael Carter Ross
ID:
Smallholder Farmers’ Returns and Learning from Subsidized Inputs in Uganda
REFNo: SS145ES

The Government of Uganda is launching an agricultural input subsidy program through an electronic voucher and we have the opportunity to study its first implementation phase (5,000 households) and provide lessons for scaling up the full program (450,000 households) by evaluating, inter alia, how different subsidy schemes affect the spread of technology to poor households and their networks and women farmers and their networks.
 USA 2018-04-20 2021-04-20 Social Science and Humanities Non-degree Award
Jacent Kamuntu  Asiimwe Kamuntu
ID:
BASELINE ASSESSMENT OF KNOWLEDGE, ATTITUDES AND PRACTICES ON HEALTH AND NUTRITION AMONG CAREGIVERS AND PREGNANT WOMEN IN LIVING GOODS OPERATIONAL DISTRICTS
REFNo: HS192ES

To assess and document existing knowledge, attitudes and practices of caregivers and pregnant women in Living Goods’ areas of operation on, nutrition and other health seeking behaviour during pregnancy as well as infant and young child feeding – (IYCF) practices.
 Uganda 2018-04-20 2021-04-20 Medical and Health Sciences Non-degree Award
Mael Leroux
ID:
Dual articulation in the communication system of chimpanzees
REFNo: NS47ES

The emergence of combinatoriality (phonology and syntax) in human language represents one of the key evolutionary transitions in life (Maynard Smith & Szathmary 1995). Despite its significance, we know very little regarding how unique this capacity is to humans or the evolutionary progression of this trait. By searching for core features of language, such as its combinatoriality, in the communication systems of closely related species to humans, particularly the primates, it is possible to shed light on whether the components of language are de novo evolved traits in humans or whether they have their origins rooted in the primate lineage. With this project, I aim to shed light on how unique combinatorics is to human language through empirically investigating the presence of linguistic forms of phonology and syntax in our closest living relative, the chimpanzee.
France 2018-04-20 2021-04-20 Natural Sciences Degree Award
JIMMY SSEMALULU
ID:
PRESCRIPTION PRACTICES AND USE OF LABORATORY PARAMETERS TO MONITOR EFFICACY AND TOXICITY OF ANTIRETROVIRAL THERAPY (ART) AMONG HIV PATIENTS (15YEARS AND ABOVE) AT ART CLINIC IN BUTABIKA NATIONAL PSYCHIATRIC REFERRAL HOSPITAL, UGANDA.
REFNo: HS151ES

STUDY OBJECTIVES General objective To assess prescription practices and use of laboratory parameters to monitor efficacy and toxicity of ART among HIV patients (15 years and above) at ART clinic in Butabika hospital. 1.5.2 Specific objectives 1. To describe pharmaceuticals prescribed for HIV patients (15 years and above) at ART clinic in Butabika hospital. 2. To determine drug drug interactions between ARVs and other medicines prescribed to HIV patients (15 years and above) at ART clinic in Butabika hospital. 3. To identify laboratory parameters used to monitor treatment response and toxicity of ARVs among HIV patients (15 years and above) on ART in Butabika hospital.
Uganda 2018-04-11 2021-04-11 Medical and Health Sciences Degree Award
Laura Bogart
ID:
GAME CHANGERS: A PILOT INTERVENTION TO EMPOWER HIV CLIENTS AS PREVENTION ADVOCATES IN UGANDA (PHASE 2)
REFNo: SS166ES

Primary objectives include: Assessing preliminary intervention effects on: a) protective behavior of the HIV-positive clients (condom use, partner concurrency/number of partners, engagement in HIV care, ART adherence) b) diffusion of prevention messages across the network, as assessed by the content and extent of communication with network members about protective behaviors (condom use, partner concurrency/number of partners, HIV testing, engagement in HIV care, circumcision), HIV disclosure, and HIV stigma
USA 2018-04-11 2021-04-11 Social Science and Humanities Non-degree Award
CHARLES LUGERO
ID:
A global registry to study the demographics, socioeconomic and clinical factors, etiologies, pathophysiology, management, barriers to care, and outcomes of heart failure patients
REFNo: HS144ES

Study 1. Estimate the incident rate of outcomes in HF patients in world Objectives regions and overall, and assess social and lifestyle factors (demographics, socioeconomic variables, clinical risk factors, diet, medication use, and health‐related quality of life), etiologies and variations in treatment patterns that might influence mortality and morbidity. 2. Describe determinants of different HF phenotypes (HFpEF, HFrEF, HF due to valvular disease, ALVD) in these world regions, and their management and outcomes. G‐CHF Protocol Page 3 2016‐09‐26 Version 1.2 3. Describe the potential role of biomarkers (BNP/NT‐proBNP and troponin, as available), related genetic determinants, and their relation to clinical factors, treatments, and type of HF 4. Assess non‐cardiac co‐morbidities at enrolment, their incidence during the study and how they influence outcomes from both cardiovascular and non‐cardiovascular mortality and morbidity. 5. In a sub‐study of approximately 4000‐5000 patients, perform measures of frailty, cognitive and lung function, mental health, adherence to medication, and dietary assessment, with collection of blood and urine samples for central analysis, to further understand the pathophysiologic changes in HF and their relation to outcomes. 6. Describe patient and system barriers to HF care in a global HF population.
Uganda 2018-04-04 2021-04-04 Medical and Health Sciences Non-degree Award
Clémence Bonneaud
ID:
Pant-hoot call in immature chimpanzees
REFNo: NS40ES

We will describe the age at which pant-hoot production starts. We will examine the order in which the four phases of the pant-hoot call develop. For example: is development sequential with the order of the final pant-hoot call, or do later phases (the climax) develop before early ones. We will investigate at what point multiple elements are produced within a call, and whether the sex differences seen in the pant-hoot calls of adults are also seen during development.
France 2018-04-04 2021-04-04 Natural Sciences Degree Award
Catriona  Waitt John
ID: UNCST-2019-R001068
 Clinical and genetic factors influencing variability in warfarin dose requirements in Sub-Saharan African patients: An observational study
REFNo: HS164ES

1. To determine demographic and clinical factors that determine individual daily dose requirements for warfarin in Ugandan and South African patients receiving warfarin as part of their routine care 2. To identify ethnic-specific genetic factors influencing individual daily dose requirements for warfarin in Ugandan and South African patients receiving warfarin as part of their routine care
UK 2018-04-04 2021-04-04 Medical and Health Sciences Non-degree Award
Agnes Kiragga
ID:
Locating disengaged HIV positive women on Option B+ and ascertainment of outcomes among their infants
REFNo: HS175ES

1. To describe the pregnancy outcomes and HIV care status among women (and their exposed infants) who initiate Option B+ 2. To correct 6 week and 18 month estimates of MTCT through tracing of a random sample of HIV positive women who initiated Option B+ during pregnancy and disengaged from care. 3. To identify factors associated with HIV sero-positivity among infants born to women initiated on Option B+. 4. To establish the frequency of Multiclass Resistance among HIV positive infants born to women initiated on Option B+ 5. To estimate the proportion of disengaged women with viral failure and correct estimates of viral suppression (3 rd UN 90 goal) in the facilities.
 Uganda 2018-04-04 2021-04-04 Medical and Health Sciences Non-degree Award
ANNET MAGOLO KISAKA
ID:
INFLUENCE OF ORGANISATIONAL CULTURE ON EMPLOYEE PERFORMANCE IN PUBLIC UNIVERSITIES IN UGANDA
REFNo: SS155ES

1. To examine the extent to which organizational mission influences employee performance in public Universities in Uganda 2.To assess the extent to which consistency affects employee performance in public Universities in Uganda 3. To establish how employee involvement influences performance in public universities
Uganda 2018-04-04 2021-04-04 Social Science and Humanities Degree Award
Erik Serrao
ID:
A Clinical Study to Validate the Accuracy and Usability of HemoTypeSCTM, Which is a Novel, Low-Cost, Rapid Diagnostic Test for Sickle Cell Disease
REFNo: HS158ES

The objective of this evaluation protocol is to determine the clinical accuracy of HemoTypeSC in diagnosing SCD-relevant Hb phenotypes (A/A, A/S, A/C, S/S, S/C, and C/C) as compared to “gold standard” HPLC/IEF laboratory testing methodology.
 USA 2018-03-27 2021-03-27 Medical and Health Sciences Non-degree Award
Richard Batamwita
ID:
Utilization of obulamu interventions by sex workers and men who have sex with men: a retrospective analysis of services delivery data.
REFNo: HS189ES

To determine changes in the levels of utilization of HIV and STI services by MSM and FSW before and after OBULAMU campaign in Uganda and to compare their utilisation levels with those of the general population (non-MSM and non-FSW population).
Uganda 2018-03-27 2021-03-27 Medical and Health Sciences Non-degree Award
CORDELIA MBOIJANA KATUREEBE
ID:
Developing and Validating a Pediatric and Adolescent HIV Testing Eligibility Screening Tool for Health Care Providers in Uganda
REFNo: HS155ES

General Objective 1) To develop, validate and field test a Pediatric and Adolescent HIV Testing Eligibility Screening Tool (PATEST) for use in outpatient departments within health facilities in Uganda Specific Objectives 1) To develop a Pediatric and Adolescent HIV Testing Eligibility Screening Tool (PATEST) for use in outpatient departments within health facilities in Uganda. 2) To determine the sensitivity, specificity, positive predictive value and negative predictive value of the PATEST among individuals aged 18 months to 19 years in selected study health facilities in Uganda. 3) To assess the perceptions and experiences of use of the PATETST among health care workers, caregivers and adolescents attending outpatient departments within selected study health facilities in Uganda.
Uganda 2018-03-15 2021-03-15 Medical and Health Sciences Non-degree Award
Joanne Corbin Nancy
ID:
Effects of armed conflict and displacement on men's socio-cultural and economic roles in northern Uganda
REFNo: SS119ES

• To examine the impact of armed conflict and internal displacement on men’s socio-cultural and economic roles in Northern Uganda. • To examine this phenomenon from subjective experiences. • To explore the adaptations that men have made to deal with any socio-cultural and economic impacts from armed conflict and internal displacement. • To disseminate the findings from this study in appropriate venues as recommended by Ugandan colleagues and produce an article on the results of this research.
USA 2018-03-14 2021-03-14 Social Science and Humanities Non-degree Award
Innocent Besigye Kabahena
ID: UNCST-2019-R001025
 Identifying gaps in screening, diagnosis, clinical practice guidelines and improving hypertension management in primary care facilities in Tororo District
REFNo: HS176ES

1. To identify the gaps in the health facility minimum requirements for successful screening, diagnosis and management of hypertension in Tororo district primary care facilities. 2. To establish the gap between hypertension management guidelines and clinical practice in Tororo district primary care facilities 3. To describe what needs to change for improved care of hypertension in primary care facilities in Tororo District.
Uganda 2018-03-14 2021-03-14 Medical and Health Sciences Non-degree Award
Julie  Nabweteme
ID:
A Post Mortem review of hospital-based suspected Hepatocellular cancer deaths in Uganda to examine the relationship with Schistosomiasis
REFNo: HS116ES

Primary: • To investigate the prevalence of schistosomiasis based on histopathology findings among suspected hepatocellular carcinoma cases. Secondary: • To validate the diagnosis of hepatocellular carcinoma (HCC) among cases of the larger study, which is defined by clinician’s suspicion of HCC and/or presence of liver masses on ultra sound scan with liver mass histopathology obtained at the time of autopsy. • To pathologically correlate the level of liver fibrosis due to schistosomiasis among the HCC deaths adjusting for geographical location and HIV co-infection.
Uganda 2018-03-12 2021-03-12 Medical and Health Sciences Non-degree Award
Chienwen Kao Jennifer
ID:
Mapping Social Networks of Child Caregiving in Uganda: A Formative Mixed Methods Study
REFNo: SS137ES

1. Use qualitative interviews to better understand the caregiving networks of female Ugandan child caregivers 2. Pilot and receive feedback on a novel social network measure designed to measure caregiving networks quantitatively 3. A preliminary exploration of how the captured social network relates to the caregiver’s depression
Taiwan 2018-03-12 2021-03-12 Social Science and Humanities Degree Award
Charles Namisi Patrick
ID: UNCST-2019-R001073
 DEVELOPMENT OF A MEASURE TO EMPOWER ADULT PEOPLE WITH HIV IN STIGMA MANAGEMENT, UGANDA
REFNo: SS146ES

This study is conceptualised within empowerment framework, with the purpose to develop and evaluate a measure for empowering adult people in stigma management in Uganda. Specifically, the study will address the three related objectives below; Objective 1, to determine the prevalence and associated factors for Internalized HIV-related stigma among adult PLHIV (Sub study 1). Objective 2, to develop a measure for empowering people living with HIV in stigma management among adults with HIV (sub study 2). Objective 3 a) to evaluate psychometric properties of the Empowerment Questionnaire for HIV-related Stigma Management (EQ-HSM) (Sub study 3).
 Uganda 2018-03-09 2021-03-09 Social Science and Humanities Degree Award
Philipp Trotter
ID:
Optimal energy planning in Uganda
REFNo: SIR7ES

There are three major aims of the study: 1. Understand the electricity consumption patterns and current energy situation for Ugandan households in different regions in Uganda 2. Understand the requirements and desires of Ugandan households with regards to Uganda’s energy future 3. Construct an optimization model of the Ugandan electricity infrastructure which analyses different energy future pathways
UK 2018-03-06 2021-03-06 Engineering and Technology Degree Award
Patricia NAHIRYA Ntege Nahirya
ID: UNCST-2019-R001117
 HPTN 084 - A Phase 3 Double Blind Safety and Efficacy Study of Long-Acting Injectable Cabotegravir Compared to Daily Oral TDF/FTC for Pre-Exposure Prophylaxis in HIV-Uninfected Women
REFNo: HS147ES

Primary Objectives • Efficacy: To evaluate the relative efficacy of oral CAB/CAB LA (oral run-in and injections, Steps 1 and 2) vs. daily oral TDF/FTC for HIV prevention (Steps 1 and 2). • Safety: To evaluate the relative safety of oral CAB/CAB LA (oral run-in and injections, Steps 1 and 2) vs. daily oral TDF/FTC for HIV prevention (Steps 1 and 2). Secondary Objectives • To compare HIV incidence among participants receiving oral CAB/CAB LA vs. daily oral TDF/FTC (Steps 1, 2 and 3). • To evaluate relative efficacy of oral CAB/CAB LA vs. oral TDF/FTC in subgroups defined by the baseline factors of: age, herpes simplex virus-2 (HSV-2) serostatus, contraceptive method, and body mass index (BMI). • To describe and model the relationship between HIV incidence and drug concentration, within each arm. • To describe the distribution and correlates of drug concentration, within each arm. • To compare the acceptability of and preferences for CAB LA vs. oral TDF/FTC. Tertiary Objectives • To estimate and compare sexual risk behaviors, as measured by self-report and rates of incident sexually transmitted infections (STIs), between study arms. • To compare Grade >2 AE rates in women with baseline BMI
Uganda 2018-03-06 2021-03-06 Medical and Health Sciences Non-degree Award
Simon  Sensalire
ID:
Assessment of Effectiveness and Cost-effectiveness of the Quality Improvement Guide on Maternal and Newborn Care in Uganda
REFNo: HS162ES

1 Evaluate the change in QI-related actions (defined as; establishing improvement team, identifying gaps in quality of care and particular barriers causing the gap, deciding what to improve, plan, test and implement interventions to address identified gap, routinely monitor the progress of improvement and institutionalize improvement and successful changes in the facility) and knowledge among health care providers and managers from targeted health facilities using different implementation strategies vs business as usual (control group). 2 Determine the change in quality of maternal and newborn care processes (defined as every patient receiving the recommended services every time it is appropriate) and outcomes from pre-intervention to post-intervention in health facilities which have been exposed to the three different implementation strategies. 3 Determine the incremental cost-effectiveness ratio of the different implementation strategies in terms of expenditure per unit of patient care improvement achieved by the implementation strategy to each other and the control group with no incremental costs related to particular control group strategy. 4 Explore key informants perceptions of and experiences with the different intervention strategies.
Uganda 2018-03-06 2021-03-06 Medical and Health Sciences Non-degree Award
Susan Whyte Reynolds
ID:
Aging as a Human Condition: Radical Uncertainty and the Search for the Good (Old) Life
REFNo: SS150ES

Through a comparative ethnographic research design, we explore the universal and the culturally specific in experiences of aging, with an eye to how local cultural resources and social structures can both afford and constrain people’s search for the good life in later years. The specific objectives are to explore experiences of four main themes: the mindful body, intimate others, time lived, and home space
USA 2018-03-06 2021-03-06 Social Science and Humanities Non-degree Award
Aya Tsubota
ID:
Work empowerment of Health Care Workers in the Republic of Uganda
REFNo: HS172ES

This research aims to identify effective factors of work empowerment for health care workers in the Republic of Uganda using the Focus Group Interview method.
 Japan 2018-03-06 2021-03-06 Medical and Health Sciences Degree Award
KYALIMPA Paul
ID:
LEADERSHIP COMPETENCIES AND SUSTAINABLE FUNDING OF NON-GOVERNMENTAL ORGANISATIONS IN UGANDA
REFNo: SS156ES

1.To determine the competences of Nocal NGO (LNGO) leaders in Uganda; 2.To establish the level of LNGO financial sustainability in Uganda; and 3.To establish the influence of competences of LNGO leaders on sustainable funding of LNGOs in Uganda.
Uganda 2018-03-06 2021-03-06 Social Science and Humanities Degree Award
John Sentongo Luyimbazi
ID:
Increasing Efficiency and Improving Quality of Secondary Education in Sub Saharan Africa: A Case Study of Uganda
REFNo: SS163ES

Review and document evidence, background literature and policies on school efficiency in the secondary education context, 2. Develop a theoretical framework to structure evidence and approaches to improving school level efficiency, 3. Assess how secondary schools are governed, managed, resourced, monitored and how resources are allocated and utilized against a benchmark or a framework, 4. Identify opportunities to increase the efficiency and effectiveness of secondary schools through implementation of local solutions and actionable interventions, and 5. Recommend contextually relevant and innovative school efficiency measures to empower schools to sustainably finance, effectively govern, and improve the quality of secondary education.
Uganda 2018-03-06 2021-03-06 Social Science and Humanities Non-degree Award
Vitaliano Cama
ID:
Evaluation of the Diagnostic Tests in Areas Hypoendemic for Onchocerciasis –Uganda
REFNo: HS90ES

) Evaluate the distribution of anti-OV-16 antibody and other markers of O. volvulus infection in multiple age groups. Data from this study may allow to determine the force of infection (rate at which susceptible individuals acquire an infection) using catalytic models
USA 2018-02-21 2021-02-21 Medical and Health Sciences Non-degree Award
Payal Chakraborty
ID:
Characterizing Treatment/Management and Patient Outcomes of Epilepsy in Uganda: A Prospective Cohort Study
REFNo: HS99ES

1. Characterize management of epilepsy in Mulago National Referral Hospital (MNRH), Butabika National Mental Hospital (BNMH), and Mbarara Regional Referral Hospital (MRRH). 1a. To assess treatment options available for epilepsy patients by site (MNRH, BNMH, and MRRH). 1b. To assess knowledge, attitudes, and other factors associated with treatment barriers. 2. Characterize treatment outcomes in hospital-based epilepsy care, specifically at MNRH, BNMH, and MRRH. 2a. To determine etiological risk factors and common seizure patterns associated with epilepsy that present in patients at study sites. 2b. To determine the seizure severity, quality of life, and seizure outcomes among patients with epilepsy. 2c. To determine the adherence levels and factors associated with non-adherence of anti-epileptic drugs.
USA 2018-02-21 2021-02-21 Medical and Health Sciences Degree Award
Alicia Rich Michelle
ID:
Chimpanzee Highways: Gene Flow and Connectivity at Itwara Forest Reserve
REFNo: NS36ES

This study will focus on a chimpanzee metapopulation, which likely spans several protected areas in western Uganda by utilizing Itwara Forest Reserve (hereafter ‘Itwara’) as a connective corridor. Contrasting environments characterize at least two of those areas; closed-forest habitat dominates Itwara Forest Reserve (Howard 1991), while closely neighboring Toro-Semliki is usually described as an “open habitat,” (Hunt and McGrew 2002). Initial observations suggest that chimpanzees utilize a connective corridor of ~4 km between those two reserves, not only for rare dispersal events, but also for regular ranging within a single community’s territory (Rich et al. in prep). Here we are proposing to test whether chimpanzees do use a connective corridor between the two reserves, where the chimpanzee-selected corridor is, and what motivates travel through it (i.e. dispersal, foraging, etc.). We will examine the evolutionary and conservation-based implications of corridor-use by Toro-Semliki/Itwara chimpanzees and lay the groundwork for long term, multi-species connectivity research in and around Itwara Forest Reserve using indirect methods. If chimpanzees are using this corridor, then we will expand our research to examine other potential connective corridors that extend from Itwara Forest Reserve into other protected areas such as Kibale National Park and Muhangi Forest Reserve.
 USA 2018-02-21 2021-02-21 Natural Sciences Non-degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
 Pharmacokinetic and pharmacodynamic evaluation of etonogestrel dose escalation with efavirenz-based antiretroviral therapy in HIV-infected Ugandan women (DoublET)
REFNo: HS163ES

Primary objective: To compare the rate of ovulation (by weekly endogenous progesterone at months 3, 6, and 12) when women receive two 68 mg ENG implants (dose-escalated) compared to one 68 mg ENG implant (standard dose) in combination with EFV-based ART. Secondary objectives: 1. To determine cervical mucus quality (by collecting weekly WHO cervical mucus scores at months 3, 6, and 12) when women receive two 68 mg ENG implants (dose-escalated) compared to one 68 mg ENG implant (standard dose) in combination with EFV-based ART. 2. To compare the PK parameters of two ENG implants (136 mg total) with combined EFV use versus the standard dose 68 mg ENG implant with no ART (historical controls in the same population using the same laboratory1) over 6 months of combined use. 3. To evaluate the safety and tolerability of two ENG implants with combined EFV-based ART use. 4. To describe the relationship between ENG concentrations and participant specific variables, specifically body weight, albumin, sex hormone binding globulin, pharmacogenetic polymorphisms, and ART concentrations. 5. To describe the long term feasibility and tolerability of increased dose ENG (136mg) subdermal implant use in HIV-infected women receiving EFV-based ART after weeks 96 and 144 of combined use.
Nigeria 2018-02-21 2021-02-21 Medical and Health Sciences Non-degree Award
Emmanuel Isingoma
ID: UNCST-2019-R001057
 Prevalence of Brucella antibodies in livestock in Karamoja, northeastern Uganda
REFNo: A28ES

1. To determine by district the prevalence of Brucella antibodies in cattle, goats and sheep in Karamoja sub-region 2. To determine the distribution of Brucella antibodies by sex of the different species of livestock 3. To determine the distribution of Brucella antibodies by age of the different species of livestock
Uganda 2018-02-21 2021-02-21 Agricultural Sciences Degree Award
Karolina Werner
ID:
From Statebuilding to Localized Governance: Exploring African governance structures
REFNo: SS56ES

The project focuses on understanding the legal integration of informal/traditional authorities into the governance of states in sub-Saharan Africa. The objective is to better understand the unique systems of governance present on the continent, providing a comparative study of four countries (Uganda, Zambia, Mozambique, Botswana) with varying degrees of integration.
 Canada 2018-02-13 2021-02-13 Social Science and Humanities Degree Award
Godfrey Zari Rukundo Zari
ID: UNCST-2019-R001500
 Implementation and Adaptation of a Web-Based Clinical Education Program for Mental Health Providers in Uganda
REFNo: HS59ES

The objective of the study is to assess the acceptability and utility a of western-developed online CBT course in advancing knowledge of cognitive-behavioral interventions among staff and graduate students in the department of psychiatry at Mbarara University/Mbarara Hospital in southwestern Uganda. Because this is the first time the course is being offered in this manner in Uganda, it is necessary to first pilot and adapt the training modules to our local setting.
 Uganda 2018-02-13 2021-02-13 Medical and Health Sciences Non-degree Award
Anna Stadelman Michelle
ID:
Assessing Lung Function and Quality of Life in Ugandans after Completion of Multi-Drug Resistant Tuberculosis Treatment (ALFU-MDR TB)
REFNo: HS122ES

To evaluate the impact of MDR TB and its treatment on pulmonary function in survivors of MDR TB. To establish the impact of MDR TB and its treatment on the quality of life of MDR TB survivors. To assess the effect of HIV and MDR TB co-infection on pulmonary function in MDR TB survivors.
 USA 2018-02-13 2021-02-13 Medical and Health Sciences Non-degree Award
Yahaya Gavamukulya
ID: UNCST-2019-R001017
 Green Synthesis and Biochemical Evaluation of Anticancer Activities of Silver Nanoparticles Conjugated Ethanolic Extracts of Leaves of Annona muricata (Graviola)
REFNo: NS43ES

General Objective To undertake green synthesis and biochemical evaluation of anticancer activities of AgNPs-conjugated ethanolic extracts of leaves of Annona muricata (Graviola). Specific Objectives 1. To conduct LCMS analysis of the ethanolic extracts of leaves of Annona muricata and undertake green synthesis and characterization of the extracts’ mediated AgNPs. 2. To investigate the effects of the AgNPs-conjugated ethanolic extracts of leaves of Annona muricata on the biological properties (morphology, migration, growth, and death) of selected cancer cell lines using selected assays. 3. To evaluate the effects of the AgNPs-conjugated ethanolic extracts of leaves of Annona muricata on the transcriptome for expression of cancer associated genes in selected cancer cell lines using RNA-Seq analysis. 4. Evaluation of the in vivo anticancer activities of the AgNPs-conjugated ethanolic extracts of leaves of Annona muricata against chemically induced tumours in mice models.
Uganda 2018-02-13 2021-02-13 Natural Sciences Degree Award
Helen Liebling Jane
ID:
Sexual and Gender-Based Violence and Torture Experiences of South Sudanese Refugees in Northern Uganda: Health and Justice Responses
REFNo: SS126ES

Specific objectives are to:(1) examine the experiences of South Sudanese refugees and impact of Sexual and Gender-Based Violence (SGBV) and torture on their lives (2) analyse reproductive and psychological health,and justice needs of refugees from their own and service providers’ perspectives and (3) evaluate responses to refugees by state justice, health services and key stakeholders.
UK 2018-02-13 2021-02-13 Social Science and Humanities Non-degree Award
Helen Byakwaga
ID: UNCST-2019-R001168
 Study of Newly Diagnosed Kaposi's Sarcoma
REFNo: HS157ES

1) Describe the clinical and laboratory characteristics of HIV-infected patients who develop KS. 2) Determine survival after KS occurrence in both ART-treated and ART-untreated HIV-infected patients.
Uganda 2018-02-13 2021-02-13 Medical and Health Sciences Non-degree Award
Stephen Kyakulumbye
ID:
A framework for developing citizen-centric e-government applications in developing contexts: The design-reality gap
REFNo: IS9ES

To document a feasible participatory design methodology for citizen e-government applications.
 Uganda 2018-02-13 2021-02-13 Social Science and Humanities Degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
 Steady-state pharmacokinetics of efavirenz (Sustiva/Stocrin) 400 mg once daily in the presence of rifampicin and isoniazid (Rifinah or the local generics)
REFNo: HS161ES

Primary Objective: To evaluate the steady-state pharmacokinetics of efavirenz (Sustiva/Stocrin) 400 mg once daily during co-administration with rifampicin and isoniazid (Rifinah or local generic) Secondary Objectives: 1. To assess the safety and tolerability of efavirenz (Sustiva/Stocrin) 400 mg once daily during co-administration with rifampicin and isoniazid (Rifinah or local generic) 2. To investigate the association between genetic polymorphisms in drug disposition genes and drug exposure.
Nigeria 2018-02-06 2021-02-06 Medical and Health Sciences Non-degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
 A PHARMACOKINETIC EVALUATION OF ETONOGESTREL IMPLANT IN HIV-INFECTED WOMEN ON DARUNAVIR VERSUS RIPILVIRINE-BASED ANTIRETROVIRAL THERAPY (DRIVE-I)
REFNo: HS145ES

Primary objective: To compare the PK of ENG (68 mg) contraceptive implant over 6 months in Ugandan HIV-infected women receiving DRV-based ART or RPV-based ART versus historical controls Secondary objectives: (1) To predict the disposition of ENG over the subsequent 2.5 years of intended use through PK modeling of ENG concentrations beyond 12 months of use in HIV-infected women using DRV- or RPV-based ART (2) To describe the PK exposure over 12 months of ENG contraceptive implant in Ugandan HIV-infected women receiving DRV-based ART or RPV-based ART (3) To describe the pharmacokinetics of DRV 12 hours post-dose (C12) and RPV 24 hours post-dose (C24) prior to and during 12 months of combined use with ENG. (4) To describe the safety and tolerability of combined use of DRV/RTV or RPV and ENG during 12 months of combined use. (5) To describe the relationship between ENG concentrations and participant specific covariates including body weight, albumin, sex-hormone binding globulin and pharmacogenetic factors.
Nigeria 2018-01-29 2021-01-29 Medical and Health Sciences Non-degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
 A PHARMACOKINETIC EVALUATION OF LEVONORGESTREL IMPLANT IN HIV-INFECTED WOMEN ON DARUNAVIR VERSUS RIPILVIRINE-BASED ANTIRETROVIRAL THERAPY (DRIVE-II)
REFNo: HS146ES

Primary objective: To compare the PK of LNG (150 mg) contraceptive implant over 6 months in Ugandan HIV-infected women receiving DRV-based ART or RPV-based ART versus historical controls. Secondary objectives: (1) To compare the PK of LNG over 12 months among women receiving DRV-based ART or RPV-based ART versus historical controls (2) To predict the disposition of LNG over the subsequent 4 years of intended use through PK modeling of LNG concentrations beyond 12 months of use in HIV-infected women using DRV- or RPV-based ART (3) To describe the pharmacokinetics of DRV 12 hours post-dose (C12) and RPV 24 hours post-dose (C24) prior to and during 12 months of combined use with LNG. (4) To describe the safety and tolerability of combined use of DRV/r or RPV and LNG during 12 months of combined use. (5) To describe the relationship between LNG concentrations and participant specific covariates including body weight, albumin, sex-hormone binding globulin and pharmacogenetic factors.
Nigeria 2018-01-29 2021-01-29 Medical and Health Sciences Non-degree Award
Charlotte Hawkins
ID:
The Anthropology of Smartphones and Smart Ageing
REFNo: SS141ES

This project will investigate fundamental changes in people’s relationship to age and health associated with the global rise of the smartphone. The aim is to combine an intellectual challenge in understanding the contemporary nature of age and the impact of new media, with an applied challenge to use this knowledge to help make mHealth (mobile health) interventions more effective. mHealth has potential both for helping those with limited access to professional care but also threatens to bypass and undermine professional medical services. Our aim is to complement technology-led mHealth interventions with ethnography-led participatory design, consisting of a three-way collaboration between mHealth professionals, our ethnographically informed team and our informants in the field. We aim to demonstrate how such collaborations can lead to more culturally appropriate mHealth interventions and more effective improvements in people’s lives.
UK 2018-01-29 2021-01-29 Social Science and Humanities Degree Award
Rose Gawaya
ID:
Challenges faced by women’s organisations in the AID space: Case studies in South Africa and Uganda
REFNo: SS90ES

The purpose of the research is to explore how women’s organisations access and utilise development aid. Access and utilisation of development aid impact on how women’s organisations achieve their organisational goals to address problems faced by women. The specific study objectives are to: 1.Determine how women’s organisations define and respond to the development aid space. 2.Identify what functions determine the participation of women in the development aid space. 3.Examine how access and utilisation of development aid contributes to feminist agendas.
Uganda 2018-01-16 2021-01-16 Social Science and Humanities Degree Award
Charles Okuonzi
ID:
Follower Voice Behavior and Leadership Competencies of Owner-managers in SMEs in Uganda
REFNo: SS142ES

The objective of thestudy is to establish the relationship between follower voice behaviour and leadership competencies of Ugandan SME owner-managers. The study is purely academic and shall involve owner-managers from 65 SMEs and 500 of their followers as respondents
 Uganda 2018-01-11 2021-01-11 Social Science and Humanities Degree Award
Afra Nuwasiima
ID:
Incentives for Increased Access to Comprehensive Family Planning for Urban Youth Using a Benefits Card: A Pilot Study
REFNo: HS98ES

1) To evaluate the effectiveness of the FPBC program in increasing uptake of comprehensive family planning services among urban youth aged 18 to 30 years. 2) To evaluate the acceptability and usability of the FPBC program among the urban youth aged 18 to 30 years 3) To estimate the cost-effectiveness and potential budget impact of the FPBC program on the taxpayer. 4) To pilot test a corporate social responsibility financing model that will pay for and potentially sustain the FPBC program.
Uganda 2018-01-08 2021-01-08 Medical and Health Sciences Non-degree Award
Jeroen  Lorist
ID:
(Re-)ordering Meaning and Masculinities in Holland and Uganda: the Gender Transformative Approach
REFNo: SS127ES

For many years research and development interventions towards gender equality have focused on women and their empowerment. Recently discourse seems to have shifted to include the engagement of men and boys towards gender equality. Through multi-sited ethnography this project examines how the idea of the Gender Transformative Approach travels and is (re-)ordered between different nodes of a distributed knowledge network. Rutgers, a Dutch NGO, acts as a major node in this global knowledge network and is the main ethnographic site (i.e. organizational ethnography of the NGO in Holland). Other research sites are Uganda and Malawi, where Rutgers' development partners operationalise GTA through various development interventions. Objective of the study is to find out, through multi-sited ethnography, what the Gender Transformative Approach really does. Is the engagement of men for gender equality really changing gender relations to be more equal, as it claims it is, or is it old wine in new bottles as some within the women’s movement claim (i.e. is it doing more than women’s empowerment?). The study will also hold a critical development perspective and will critically look at any unintended effects of the interventions.
Netherlands 2018-01-08 2021-01-08 Social Science and Humanities Degree Award
Jennifer Driscoll Jane
ID:
Child Protection arrangements in sub-Saharan African states: a preliminary investigation into the interaction between informal child protection arrangements and formal intervention services and the effect of formal systems and agency interventions on indi
REFNo: SS94ES

a) preliminary investigations to gather the views of community leaders, local government officials, representatives of (I)NGOs, and (if possible) policy-makers from national government as to i) the key issues in relation to the protection of children at community level in Uganda; ii) particular challenges identified in relation to the interaction of formal child protection systems, community arrangements and (I)NGO interventions in the communities participating in the study; iii) examples of best practice and innovative work which has proven successful in promoting effective joint local arrangements in those communities; and b) to seek participants’ specific advice as to the focus and methods that should be employed in development of a larger bid and the geographical area of study (within sub-Saharan Africa).
UK 2017-12-20 2020-12-20 Social Science and Humanities Non-degree Award
Phoebe Donnelly
ID:
Gendered Decisions and Dynamics in Eastern Africa
REFNo: SS109ES

This research is for my PhD dissertation and potentially a book or articles. My central research question asks how the attitudes and behavior of non-state armed organizations (NSAOs) towards women and girls relate to the NSAO’s broad strategy. My framework will examine four aspects of gendered strategy: 1) the role women and girls fill within NSAOs; 2) whether NSAOs use forced marriage or other regulations of relationships as a strategy; 3) how the treatment of civilian women and girls, specifically the use of gender-based violence (GBV), relates to the objectives of the NSAO; and 4) how these organizations discuss gender in their external communications. My two case studies are al-Shabaab formed in Somalia and the Lord's Resistance Army in Uganda.
 USA 2017-12-20 2020-12-20 Social Science and Humanities Degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
 Dolutegravir in Pregnant HIV Mothers and their Neonates DolPHIN-2
REFNo: HS106ES

To evaluate dolutegravir (DTG) efficacy in late-presenting pregnant HIV-infected women
 Nigeria 2017-12-20 2020-12-20 Medical and Health Sciences Non-degree Award
Jane Katusiime
ID:
A usable security model for mobile health systems in developing countries
REFNo: IS8ES

i. To investigate design and social technical challenges of mHealth systems in developing countries and determine requirements of a system that is usable by illiterate and semi-illiterate people. ii. To review and analyze the current security models and their suitability for usage in mobile health systems in developing countries iii. To design a hybrid security model that is usable in mobile health care systems in developing countries iv. To design and develop a tool that supports maternal health care and is also usable by illiterate and semi-illiterate people based on the hybrid model developed in (v). v. To evaluate the usability of the model based on the test utilization of the tool developed in vi by key stakeholders in maternal health.
Uganda 2017-12-20 2020-12-20 Social Science and Humanities Degree Award
Helen Byakwaga
ID: UNCST-2019-R001168
 Understanding the HIV Care Provider Workforce in Africa
REFNo: HS138ES

1) Describe the sociodemographic and professional characteristics of health care workers providing HIV care as well as their perspectives, beliefs and attitudes towards practice. 2) Describe the kinetics of the HIV-dedicated health care workforce.
Uganda 2017-12-20 2020-12-20 Medical and Health Sciences Non-degree Award
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