Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Johnes Obungoloch
ID: UNCST-2024-R005331
Application of Artificial Intelligence using Chest x-ray images to aid clinical care of patients with pulmonary complications in Uganda (AI4CX)
REFNo: SS2718ES

III.To develop a machine learning algorithm for automated diagnosis of pulmonary diseases from chest x-ray images,II.To establish a dataset of annotated chest x-ray images of pulmonary diseases among patients seeking pulmonary care in Mbarara City, South Western Uganda,I.To generate quality chest x-ray images of pulmonary diseases among patients seeking care in Mbarara City, South Western Uganda,●To develop an Artificial intelligence model using Chest x-ray images to aid clinical care of patients with pulmonary complications in Uganda,
Uganda 2024-08-06 17:38:06 2027-08-06 Social Science and Humanities Non-Clinical Trial Non-degree Award
ABDULAZIZ KAKOOZA
ID: UNCST-2024-R004009
INTEGRATION OF EMPLOYABILITY SKILLS IN PRE-SERVICE TEACHER TRAINING PROGRAMME IN HIGHER EDUCATION INSTITUTIONS IN UGANDA: A CASE STUDY OF KYAMBOGO UNIVERSITY
REFNo: SS2747ES

iii. To establish ways employability skills can be enhanced in the pre-service teacher training programme at Kyambogo University. ,ii. To examine the integration of employability skills in the pre-service teacher training programme at Kyambogo University.,i. To explore employability skills desired by employers from pre-service teacher training graduates at Kyambogo University.,
Uganda 2024-08-06 17:36:01 2027-08-06 Social Science and Humanities Non-Clinical Trial Degree Award
Arthur Kwizera
ID: UNCST-2021-R012928
A multicentre, prospective, registry-based intensive care quality improvement project in Uganda’s hospitals.
REFNo: HS4484ES

To inform clinical guidelines, national policies and planning for critical care services in Uganda. ,To describe the epidemiology and outcomes of intensive care patients in Uganda,To implement a national intensive care registry that can be used at both a facility, and national level to assess, report and improve quality of care for intensive care unit patients. ,
Uganda 2024-08-06 17:34:41 2027-08-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Cissy  Kityo
ID: UNCST-2021-R013663
A Phase 4, Open-Label, Rollover Study to Provide Continued Access to Cabotegravir Long-acting Injection and Rilpivirine Long-acting Injection to Participants Living with Human Immunodeficiency Virus Type 1 (HIV-1) Infection Who Participated in Long-Acting Combination Therapy Studies.
REFNo: HS4452ES

The secondary objective is to assess the long-term safety and tolerability of CAB LA + RPV LA by evaluating the incidence of serious adverse events (SAEs), pregnancies, adverse events (AEs) leading to discontinuation of CABLA +RPV LA, and AEs considered to be related to the study intervention.,The primary objective of the study is to provide continued CAB LA + RPV LA access to participants who were enrolled and treated with CAB LA + RPV LA in the parent studies, and who, at the time of roll-over, experience and are expected to continue to experience clinical benefit from this treatment.,
Uganda 2024-08-06 17:32:50 2027-08-06 Medical and Health Sciences Clinical Trial Non-degree Award
alfred bulamu
ID: UNCST-2023-R008638
Uganda Translational Breast Cancer Screening Research Center with Innovations in MRI and Genetic Testing.
REFNo: HS4689ES

Implementation of breast MRI with genetic testing as BC screening method for women at high risk of BC by July 2029 (Phase 6) , Continuous Trainings for radiologists, radiographers and laboratory staffs on the modern technologies of MRI and Genetic testing (phase 3 to phase 6) ,Evaluating the feasibility of screening BC using MRI and genetic testing for high risk women by December 2028 (phase 5),Large scale education of the community about BC by July 2028 (phase 3 and phase 4).,Large scale determination of the utility of genetic testing as a screening modality for BC in Uganda by perform mutational genetic analysis for women at high-risk aged19 years to 80 years by July 2028 (phase 3 and phase 4) , Large scale determination of the utility of quantitative breast MRI for screening women at high risk BC aged 19 years to 80 years by July 2028 (phase 3 and phase 4) ,Training of the users on equipment i.e. Radiologists, Radiographers and laboratory staffs by 2025 (phase 2) ,Securing and installation of lab equipment for genetic testing by 2025 (Phase 2,Securing and installation of MRI with Breast coils by July 2025 (Phase 2),To build capacity for 20 laboratory health care workers in genetic testing technologies by December 2023 (phase 1).,To build capacity for 30 radiology health professionals in modern breast Imaging with MRI by December 2023 (Phase 1),To determine the utility of quantitative breast MRI for screening women at high risk breast cancer aged 19 years to 80 years by July 2024 (phase 1),To determine the utility of genetic testing as a screening modality for BC in Uganda by perform mutational genetic analysis for women at high-risk of BC aged 19 years to 80 years, by July 2024 (phase1),To build a long-lasting infrastructure for research, clinical screening in Uganda and training using modern technologies. ,To offer improved access to Breast Cancer screening in Uganda through quantitative MRI and genetic testing research center,
Uganda 2024-08-06 17:27:31 2027-08-06 Medical and Health Sciences Clinical Trial Non-degree Award
Edward Nahurira
ID: UNCST-2022-R009739
Comparative Phytochemical Studies of Callus Regenerated from Leaf Explant of Prunus Africana (Hook F. Kalkman) and Stem Bark of the Same Mother Plant
REFNo: HS2434ES

1. To develop callus culture from the explant of P. africana leaf and stem bark.

2. To evaluate the phytochemical constituents of the callus extracts of P. africana leaf and stem bark explant.

3. To develop and compare the TLC and HPLC fingerprints of each extract for their identification.

Uganda 2024-08-06 17:22:37 2027-08-06 Medical and Health Sciences Non-Clinical Trial Degree Award
ANITA ARINDA
ID: UNCST-2020-R014158
Intellectual Disability in Children and Adolescents with Epilepsy in Mulago and Butabika National Referral Hospitals: Prevalence and Associated Factors
REFNo: HS4589ES

2. To determine the factors associated with ID in children and adolescents with epilepsy attending Mulago and Butabika National Referral Hospitals.,1. To determine the prevalence of ID in children and adolescents with epilepsy attending Mulago and Butabika National Referral Hospitals.,To determine the prevalence of and factors associated with ID in children and adolescents with epilepsy attending Mulago and Butabika National Referral Hospitals.,
Uganda 2024-08-05 14:04:37 2027-08-05 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Moses Oketch
ID: UNCST-2024-R004313
Long-Term Impacts of Improved Childhood Literacy
REFNo: SS2796ES

Economic situation,
UK 2024-08-05 14:01:33 2027-08-05 Social Science and Humanities Clinical Trial Non-degree Award
Jonathan Mayito
ID: UNCST-2019-R000490
Detection of Mycobacterium tuberculosis in blood of tuberculosis patients and their contacts in Uganda
REFNo: HS4553ES

To determine whether Mtb strains isolated from the sputum/blood of index cases with pulmonary TB are genetically identical to those detected in the blood of their contacts,To establish whether detection of Mtb in blood using the methods above associates with either of the following biomarkers of host immune response: - QFT-Plus - Blood RNA signatures for incipient tuberculosis,To determine whether Mtb can be detected in the blood of TB patients and their contacts, recruited in Kampala, Uganda, using any of the following methods: - GeneXpert® MTB/RIF Ultra (Cepheid) - Fluorescence microscopy - Blood culture - Targeted Next-Generation Sequencing,The primary objective of this study is to determine whether Mtb DNA can be detected in the blood of TB patients and their contacts, recruited in Kampala, Uganda, using digital PCR,
Uganda 2024-08-05 13:49:07 2027-08-05 Medical and Health Sciences Non-Clinical Trial Non-degree Award
OKELLO DAMOI JOSEPH
ID: UNCST-2022-R011560
Construction and Validation of a Poverty Assessment Survey Tool to Inform Ambulatory Care and Surgery Cost Waiver or Subsidization in a Developing Country
REFNo: HS4463ES

To determine the weights of each attribute per item, in the constructed and validated tool that can be used to inform ambulatory care and surgery cost waiver or subsidization in a developing country,To construct a validated ambulatory care and surgery-context poverty assessment survey tool that can be used to inform ambulatory care and surgery cost waiver or subsidization in a developing country,To analyze the data earlier collected using the ambulatory care and surgery-context poverty assessment survey tool at KSC, for principal components,To conduct content validity and reliability testing of the ambulatory care and surgery- context poverty assessment survey tool, previously developed with adaption of some items from the simple poverty score tool for Uganda,To construct and validation of a poverty assessment survey tool that can be used to inform ambulatory care and surgery cost waiver or subsidization in a developing country,
Uganda 2024-08-05 13:12:56 2027-08-05 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Vesall Nourani
ID: UNCST-2022-R009221
Impact of on-demand irrigation service : Evidence from Uganda
REFNo: SS2112ES

Do certain intermediaries (providers of agricultural inputs) facilitate efficient information aggregation and dissemination of farming knowledge between farmers?,
USA 2024-08-05 13:11:25 2027-08-05 Social Science and Humanities Non-Clinical Trial Non-degree Award
Lawrence Okidi
ID:
NUTRITIONAL QUALITY AND MICROBIAL SAFETY OF SELECTED INDIGENOUS FOODS FOR CHILDREN UNDER FIVE: A CASE STUDY OF KARAMOJA SUB-REGION OF UGANDA
REFNo: A51ES

1.3 Objectives
1.3.1 General objective
To contribute to food security by investigating the nutritive quality and safety of indigenous foods for children under five in Karamoja sub-region.
1.3.2 Specific objectives
i. To assess household handling practices of selected indigenous foods for children under five in Karamoja sub-region
ii. To determine the nutritional quality of selected indigenous foods for children under five in Karamoja sub-region
iii. To determine the microbial load and diversity of selected indigenous foods for children under five in Karamoja sub-region
iv. To determine the dietary exposure risk of children under five to pathogenic microorganisms from selected indigenous foods in Karamoja sub-region

Uganda 2024-08-02 17:46:01 2027-08-02 Agricultural Sciences Degree Award
Charles Masembe Kikubo
ID: UNCST-2019-R001092
Investigating the dynamics and clinical outcome of African swine fever infection at pig farms in an endemic livestock wildlife setting in Uganda
REFNo: A355ES

1) Assess the spatial distribution of pig farmers in the study areas and recruit them
2) Determine the ASF virus molecular characteristics in apparently healthy domestic pigs
3) Determine the genetic characteristics and relationships of ASFV isolated from domestic pigs
4) Determine the full genome characteristics of the unique lineages obtained from domestic pigs
5) To establish an ASF biobank of clinical materials that are curated with clinical outcomes
6) Establish Ugandan Genotype IX repository at PIADC - for genomics and vaccine research
7) Build rapid ASF whole genome sequencing capacity in endemic settings

Uganda 2024-08-01 16:54:11 2027-08-01 Agricultural Sciences Non-Clinical Trial Non-degree Award
David Kibirige
ID:
DESIGN AND IMPLEMENTATION OF A PV SYSTEM FOR EMERGENCY SITUATION IN HEALTH FACILITIES IN RWEBISENGO UGANDA
REFNo: SIR363ES

4. To carryout hardware design and field test of the PV system,3. To design an improved inverter system for both AC single phase and three phase for PV application.,2. To model a PV power system circuit using Proteus software as well as carrying out its dynamic modeling using Simulink,1. To carry out Electrical and thermal analysis of a PV system to be used during the study,The aim of this research is to design a PV system that can be utilized during emergency situation in health facilities in Rwebisengo Uganda.,
Uganda 2024-08-01 16:05:23 2027-08-01 Engineering and Technology Non-Clinical Trial Degree Award
EDWINAH ATUSINGWIZE
ID: UNCST-2023-R007893
Exploring Stakeholder perspectives of the social determinants of malaria in Uganda
REFNo: HS4271ES

3. To explore barriers and facilitators to addressing the social determinants of malaria.,2. To examine how the social determinants of malaria are addressed in policy making and practice. ,1. To explore stakeholder perspectives of the social determinants of malaria.,The overall aim of this study is to explore stakeholder perspectives and experiences of the social determinants of malaria in Uganda in order to inform malaria prevention policy and practice. ,
Uganda 2024-07-26 16:04:20 2027-07-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Alen Musisi
ID: UNCST-2022-R009338
Knowledge, Attitude, and Practice on Radiation Protection Among Radiation Safety Officers in Uganda.
REFNo: HS4617ES

To determine the radiation protection knowledge level among RSOs
To determine the level of attitudes of RSOs towards radiation protection and safety
To determine radiation protection practices among RSOs

Uganda 2024-07-26 16:03:08 2027-07-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jean Damascene Niyonsenga
ID:
Role of PT in Ugandan Neurosurgical Transitional Care
REFNo: HS4400ES

This study aims to determine acceptability and feasibility of utilizing an interdisciplinary discharge planning protocol to improve team communication and increase patient referral to outpatient rehabilitation services in two public Ugandan hospitals.
Rwanda 2024-07-26 16:01:48 2027-07-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Mbisi Muhindo Enosh
ID:
HOST COMMUNITIES’ RELATIONS AND REFUGEE ADAPTABILITY AT KYAKA II AND KYANGWALI SETTLEMENTS IN WESTERN UGANDA
REFNo: SS2953ES

To examine the role of social cohesion within host communities in facilitating refugee adaptability at Kyaka II and Kyangwali settlements,To investigate how Attitudes and Perceptions of host communities influence Refugee Adaptability at Kyaka II and Kyangwali settlements,To assess the socio-economic and political factors contributing to refugee adaptability at Kyaka II and Kyangwali settlements,To examine the impact of legal and policy framework on Refugee Adaptability within Host communities at Kyaka II and Kyangwali settlements in Uganda,To examine the dynamics and factors influencing the relationship between host communities and refugees, and to understand the impact of this relationship on the adaptability and integration of refugees at Kyaka II and Kyangwali settlements,
Uganda 2024-07-26 15:59:56 2027-07-26 Social Science and Humanities Non-Clinical Trial Degree Award
Doris Kwesiga
ID:
Implementer’s Voices: An input to the Lancet Commission on Evidence-based Implementation in Global Health
REFNo: HS4408ES

To examine the insights and experiences of LMIC health sector implementers on the use of evidence in their work, so as to identify barriers and enablers and design interventions to increase evidence-based implementation.,ii. What are the gaps between evidence and implementation, and how can these be closed?,i. How and why, do (or don’t) implementers use evidence? ,
Uganda 2024-07-26 15:58:42 2027-07-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ismail  Draguma Legason
ID: UNCST-2021-R012130
Molecular profiling of Epstein-Barr virus genome and expression in endemic Burkitt Lymphoma (EBVL study)
REFNo: HS4198ES

1. The main goal of the study is to examine the molecular architecture of EBV, its expression pattern, and the determinants of viral pathogenesis in endemic Burkitt lymphoma. ,Perform differential gene expression and protein analysis on formalin fixed-paraffin embedded BL tissues using RT- PCR or NanoString and analyse the data for: i) differentially expressed genes and proteins ii) gene and protein expression levels iii) correlation with tumour stage and viral strains ,Perform whole genome sequencing of EBV from clinical samples (ctDNA for eBL and plasma for healthy controls) and analyse data for: i) viral strains and co-infection ii) Mutations (SNVs, Indels, and structural variants) and compare frequencies iii) mutational signatures iv) viral population structure -phylogenetics and decomposition matrices to infer evolutionary relatedness with publicly available strains. ,
Uganda 2024-07-26 15:56:08 2027-07-26 Medical and Health Sciences Non-Clinical Trial Degree Award
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