Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Santo Ocii
ID:
Management of students' discipline in the post corporal punishment era in Uganda secondary schools - Northern Uganda
REFNo: SS2471ES

4- To assess the extent to which school’s environment shapes the discipline of students in a school that have demonstrated good practice of discipline in the post corporal punishment era.,3- To provide a description of how head teachers and board of governors support teachers in managing discipline in post corporal punishment era.,2- To examine the disciplinary measures and support used by teachers in managing students’ discipline in the post corporal punishment era.,1- To explore the students’ perspective on the management of school discipline in the post corporal punishment era,The purpose of this study is to understand better ways of managing students’ discipline without using corporal punishment by studying good practices from schools that are exemplary in discipline management that can be copied by other schools still using corporal punishment,
 Uganda 2024-06-05 17:12:19 2027-06-05 Social Science and Humanities Non-Clinical Trial Degree Award
ANTHONY NUWA
ID: UNCST-2022-R011102
 Host Immune dynamics following seasonal malaria chemoprevention in African children
REFNo: HS4350ES

Main Objective
1. To understand the dynamics of host immunity in settings implementing seasonal malaria chemoprevention.
Specific Objectives
1. To comprehensively profile antibody immune responses in individuals before and after single and multiple rounds of SMC.
2. To comprehensively profile the innate and adaptive cellular immune response in individuals living in an area with sustained SMC.
 Uganda 2024-06-05 17:10:29 2027-06-05 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Olive  Kabaguma
ID: UNCST-2023-R005849
 PSYCHOSOCIAL FACTORS AND WELLNESS OF MIDLIFE RELIGIOUS SISTERS IN UGANDA
REFNo: SS2503ES

To establish the association between psychosocial factors and wellness among religious sisters in Uganda.,
 Uganda 2024-06-05 17:03:18 2027-06-05 Social Science and Humanities Non-Clinical Trial Non-degree Award
Rachel McMullan
ID:
Tackling Antimicrobial Resistance Through Professional Learning: Open Societal Challenge
REFNo: SS2650ES

Aim: To synthesise knowledge around the work practices and behaviours required for effective antimicrobial stewardship and identify which of these could be strengthened by professional learning programmes and training. Objectives: 1. To describe health professionals’ practices and behaviours around antibiotics and related tools, processes, networks and challenges 2. To understand the impacts of AMS-related change on health professionals’ practices and behaviours in the work place 3. To identify how health professionals engage with learning opportunities for AMS/AMR, and associated knowledge gaps 4. To identify the AMS-related behaviour(s) in need of change that could be supported in a future intervention 5. To assess current antimicrobial prescribing practices in healthcare facilities across Eastern Uganda.
 UK 2024-06-04 7:28:02 2027-06-04 Social Science and Humanities Non-Clinical Trial Non-degree Award
Godfrey  Siu
ID: UNCST-2021-R005439
 Adaptation and Piloting of the Parenting for Respectability Programme for Hybrid Disability Inclusive Parenting Study; Feasibility, Process, and Lessons from Uganda
REFNo: HS4054ES

Research objective
The study aims to adapt and test the feasibility and acceptability of the PfR programme for parents with disabilities and parents of children with disabilities.

Specific objectives
i.To assess the extent to which existing national policies respond to the needs of parents and children with disabilities
ii.Qualitatively assess knowledge, attitudes and practices on parenting among parents and children with disabilities
iii.To adapt and pilot the existing Parenting for Respectability programme manual for facilitator-assisted WhatsApp group-based delivery in order to assess accessibility, functionality, inclusivity, and examine facilitating and hindering factors around disability inclusive parenting

Uganda 2024-05-31 18:34:28 2027-05-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sarah Zalwango Karen
ID: UNCST-2021-R005660
 Title:Evaluating the Burden of Post-Tuberculosis Morbidity Among TB Disease Survivors in Uganda: A Pilot Feasibility Study
REFNo: HS4037ES

The objective of the proposal is to conduct a pilot feasibility study on post-tuberculosis (TB) survivors as a preliminary step in planning for a future large cohort study to broadly evaluate post-TB morbidity. ,
 Uganda 2024-05-31 18:33:32 2027-05-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Phiona Arineitwe
ID:
Institutional Support and Teacher Competence Mediated by Organisational Learning in Government-Aided Secondary Schools in South Western Uganda, Uganda.
REFNo: SS2518ES

1. To investigate the influence of institutional support on teacher competence in government-aided secondary schools in South Western Uganda.
2. To establish the influence of institutional support on organisational learning in government-aided secondary schools in South Western Uganda.
3. To determine the influence of organisational learning on teacher competence in government-aided secondary schools in South Western Uganda.
4. To test the mediating effect of organisational learning on the influence of institutional support on teacher competence in government-aided secondary schools in South Western Uganda

 Uganda 2024-05-31 18:31:51 2027-05-31 Social Science and Humanities Non-Clinical Trial Degree Award
Herbert Kiwalya
ID: UNCST-2024-R004872
 Electronic healthcare registries: An evaluation of current practices, stakeholder perceptions and implementation effectiveness.
REFNo: HS4359ES

Evaluate the effectiveness and usability of an electronic registry implemented to enhance the availability and accessibility of patient-level data for quality improvement and decision-making.,Describe the implementation requirements for an electronic healthcare registry in Uganda and identify barriers that may be encountered during its’ setup and utilisation.,Assess the current practices and challenges in documenting, accessing and using patient-level, registry-based healthcare data in eastern Uganda.,Describe stakeholder perceptions of electronic healthcare registries to facilitate quality improvement, clinical benchmarking and research at local, regional, national and international levels of the healthcare system in Uganda, Ethiopia, and South Africa.,We aim to understand current views of stakeholders in three African countries about the use of electronic healthcare registries. This will include developing a detailed understanding of the local context from eastern Uganda. Following implementation of an integrated electronic registry to support quality improvement work we will conduct a process evaluation that will allow us to reflect on the effectiveness of our registry in this setting.,
 Uganda 2024-05-31 18:30:37 2027-05-31 Medical and Health Sciences Non-Clinical Trial Degree Award
Alice Endra Ezuru
ID:
Access and Application of digital technologies among fishing communities in Uganda: a case of Lake Victoria community
REFNo: SS2677ES

i). To examine the information needs (personal, trade, health, fishing inputs, technology) of the fishing communities of Lake Victoria, Uganda.
ii). To establish the digital technologies used in information access by the fishing communities of Lake Victoria, Uganda.
iii). To determine the access and application of digital technologies in information dissemination within the fishing communities and managers of Lake Victoria in Uganda.
v). To examine challenges (if any) in access and application of digital technologies among the fishing communities of Lake Victoria in Uganda.

 Uganda 2024-05-31 18:29:42 2027-05-31 Social Science and Humanities Non-Clinical Trial Degree Award
Ali Kudamba
ID:
Anticancer activity and safety of Rhoicissus tridentata (L.f) Wild & R.B. Drumm. as used in the treatment of prostate cancer in the Elgon sub-region, Uganda
REFNo: HS3007ES

To determine the effect of aqueous, methanol, & total crude of Rhoicissus tridentata (Lf.) Wild & R.B. Drumm. on the antiproliferative activity (% growth inhibition or cell viability) of the prostate cancer cell line,To assess the effect of aqueous, methanol, and total crude extracts from Rhoicissus tridentata (Lf.) Wild & R.B. Drumm. on the apoptotic index of the prostate cancer cell line. ,To assess the effect of methanol, aqueous, and total crude extracts Rhoicissus tridentata (Lf.) Wild & R.B. Drumm. on sub-acute toxicity in Wistar albino rats. ,To assess the effect of methanol, aqueous, and total crude extracts Rhoicissus tridentata (Lf.) Wild & R.B. Drumm. on acute toxicity in female Wistar albino mice. ,To determine the phytochemical compositions of aqueous and methanol extracts of Rhoicissus tridentata (Lf.) Wild & R.B. Drumm. harvested from the volcanic soils of mountain Elgon slopes.,To describe the medicinal plants used in the treatment of cancers with emphasis on prostate cancer,The study is aimed at assessing the anticancer activity and safety of Rhoicissus tridentata (L.f.) Wild & R.B. Drumm used in the treatment of prostate cancer in the Elgon sub-region. ,
 Uganda 2024-05-31 18:28:36 2027-05-31 Medical and Health Sciences Non-Clinical Trial Degree Award
Lauren Wolf
ID:
The Spatial Ecology of the Red Colobus Monkeys
REFNo: NS808ES

The overall goal of this project is to comprehensively understand the ecological and social determinants that influence the spatial behavior of the Ashy Red Colobus Monkey.
USA 2024-05-31 18:27:17 2027-05-31 Natural Sciences Non-Clinical Trial Degree Award
SHANNA NANTUME AGNES
ID: UNCST-2024-R004915
 CHILD MALTREATMENT,SOCIAL SUPPORT AND PSYCHOLOGICAL WELL-BEING AMONG ADOLESCENTS IN NAGURU REMAND HOME
REFNo: SS2642ES

1. To identify the best predictor of psychological well-being among adolescents in a remand home. 2. To determine the relationship between child maltreatment and social support among these adolescents. 3. To assess the relationship between social support and psychological well-being among adolescents. 4. To examine the relationship between child maltreatment and psychological well-being among adolescents.
 Uganda 2024-05-31 18:26:39 2027-05-31 Social Science and Humanities Non-Clinical Trial Degree Award
Karen Setty Elizabeth
ID:
Tracking the Ripple Effects of Water Quality Information Sharing among Household Consumers, Water Managers, and Local Officials
REFNo: SS2609ES

1. Characterize actual information uses and applications that might affect water management practices and policies. - Follow up with participants through surveys and qualitative interviews after each information-sharing event. - Individually deliver a series of water quality reports containing solution-oriented messages. - Evaluate the uses and impact of water quality data among local government, water management, and household decision-makers. 2. Tailor a water quality information delivery intervention through a user-centered design process. - Establish good practices for water quality information sharing in small water supply systems in low-resource settings.
 USA 2024-05-31 18:25:09 2027-05-31 Social Science and Humanities Non-Clinical Trial Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
 AIr Pollution Effects on Transmission of Mycobacterium tuberculosis in Urban Slum Communities in Uganda.
REFNo: HS3084ES

Overall, the purpose of the study is to ensure the development team have a deep understanding of the considerations surrounding use of a respiratory treatment device. This includes the most significant challenges and opportunities in use of a respiratory treatment device. As such, the present study will form the foundation of concept ideation for a respiratory treatment device. Specific study objectives include the following: (1) Capture potential end user needs in both urban and rural locations (2) Capturing participant’s COVID-19 pandemic experience (3) Gaining an understanding of the COVID-19 pandemic response, and (4) Gaining an understanding of the healthcare system in which a respiratory device may be distributed/prescribed/administered/used/disposed.,4.2.2 Specific objectives I. To enroll subjects with active pulmonary TB (index cases) and assess their source strength in an urban slum community in Uganda II. To enroll household contacts (HC) of index cases and measure Mtb transmission to Mtb-naïve (those with negative Mtb infection tests) household contacts (people living in the same home as the index case) in an urban slum community in Uganda III. To characterize exposures to air pollution in both TB index cases and their household contacts in an urban slum community in Uganda,Main Objective The overall purpose of this study is to determine the extent to which particulate matter (PM) air pollution exposure affects the source strength (quantity of Mtb (Mycobacterium tuberculosis) in respiratory aerosol) of persons with active tuberculosis (TB) and the susceptibility to infection with Mycobacterium tuberculosis in their contacts. Both source strength and susceptibility determine transmission of Mtb in the community,
 Uganda 2024-05-31 18:24:06 2027-05-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isidore Dorpenyo Kafui
ID:
Exploring local literacies, pedagogies, and teacher perceptions in Ugandan university writing courses.
REFNo: SS2614ES

This study has two main goals: a) it explores the local pedagogies in Uganda's university Academic English writing courses and b) it explores the attitudes that English writing instructors and curriculum designers have toward Academic English writing.
Ghana 2024-05-31 18:21:59 2027-05-31 Social Science and Humanities Non-Clinical Trial Degree Award
Samuel Kyobe
ID: UNCST-2019-R000108
 DSpace: Utilizing Data Science to Predict and Improve Health Outcomes in Pediatric HIV
REFNo: HS4003ES

Use explainable machine learning algorithms to integrate multi-omics data with temporal EHRs to improve the diagnosis of active TB in HIV-infected children,Use machine learning to integrate temporal EHRs with genomic data to predict the longitudinal risk of MetS among African children on life-long ART,How can Data Science be utilized to integrate large temporal electronic health records with multiomics data to predict and improve health outcomes of HIV-infected children in Africa.,
 Uganda 2024-05-31 18:19:52 2027-05-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Godfrey  Siu
ID: UNCST-2021-R005439
 An Evaluation of the Effectiveness of the Parenting for Respectability Programme on Early Childhood Development among Children aged 0-6 years in Uganda
REFNo: HS4168ES

Main Objective
To conduct an effectiveness trial of an adapted (shorter) version of the PfR programme on ECD outcomes nested within wide scale implementation.
Specific Objectives
1.To estimate the effectiveness of the Parenting for Respectability programme on improving ECD specific outcomes (gross motor, fine motor, language and social development) among children aged 0-6 years after 6 months of intervention.
2.To estimate the observed improvement in parental knowledge, practices and parent-child relationships after 6 months of PfR programme interventions.

 Uganda 2024-05-31 18:18:53 2027-05-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JUDITH AKELLO
ID: UNCST-2024-R003967
 Unpacking the Influence of Women's Economic Empowerment Initiatives through Uganda Women’s Entrepreneurship Program on Livelihoods and Cultural Dynamics, Amolatar Sub-Region
REFNo: SS2635ES

Main objective
To explore whether and how economic impact of women's entrepreneurship program initiatives, is influenced by cultural norms and traditions on their engagement in entrepreneurial activities, in Amolatar sub-region.
Specific objectives
1. Analyse the economic impact of women's entrepreneurship programme initiatives in Amolatar sub-region. This involves tracking changes in women's income levels, employment opportunities, and access to financial services as a result of participating in these programs. The study will also evaluate the sustainability of economic improvements over time.
2. Explore the influence of cultural norms and traditions on women's engagement in women entrepreneurship programme activities within Amolatar sub-region. This will involve interviews to understand how cultural beliefs, roles, and expectations shape women's economic opportunities and choices. This study will also examine any shifts in these norms resulting from entrepreneurship program initiatives.
3. Establish the complex interplay between women's entrepreneurship program initiatives and cultural dynamics in Amolatar sub-region. This objective will involve a comparative analysis of the data gathered under the first two objectives to identify areas of alignment and tension between economic empowerment efforts and cultural norms. Additionally, we will investigate the strategies and mechanisms used by empowerment programs to navigate and influence these cultural dynamics.

 Uganda 2024-05-31 18:05:38 2027-05-31 Social Science and Humanities Non-Clinical Trial Non-degree Award
ERIC WOBUDEYA
ID: UNCST-2019-R001047
 Shortened RegiMen for Drug-susceptIbLE TB in Children
REFNo: HS4030ES

Primary
1. To determine if an 8-week HPZM regimen in children with presumed drug-susceptible TB disease has non-inferior efficacy to 8-weeks of HRZ(E) plus 8- or 16-weeks of HR(E) for achieving treatment success.
2. To evaluate the safety of the 8-week HPZM regimen in comparison to the 16- or 24- week HRZ(E) regimen among children with and without HIV.
Secondary
1. To evaluate the tolerability of the 8-week HPZM regimen in comparison to the 16- or 24- week HRZ(E) regimen among children with and without HIV.
2. To determine the weight-banded dosing of rifapentine and moxifloxacin taken as part of the HPZM regimen.
3. To evaluate the palatability and acceptability of the 8-week HPZM regimen in comparison to the 16- or 24-week HRZ(E) regimen among children with and without HIV.
4. To evaluate adherence to the 8-week HPZM regimen in comparison to the 16- or 24- week HRZ(E) regimen among children with and without HIV.
5. To evaluate clinical and laboratory characteristics and drug exposures associated with unsuccessful treatment outcomes (treatment failure or death).
6. To evaluate the cost and cost-effectiveness of the 8-week HPZM regimen relative to the 16- or 24-week HRZ(E) standard of care regimen, using a societal approach.
Exploratory
1. To characterize rifapentine and moxifloxacin PK parameters in malnourished children.
2. To evaluate the effect of rifapentine or rifampin, taken as part of the HPZM or HRZ(E) regimen, on the PK of dolutegravir.
3. To evaluate virologic control (less than 200 copies/mL) at 24- and 48-weeks among children with HIV taking a dolutegravir-based ARV treatment regimen co-administered with either HPZM or HRZ(E).
4. To collect and store biospecimens from consented participants for the purpose of future TB research.

 Uganda 2024-05-31 18:02:19 2027-05-31 Medical and Health Sciences Clinical Trial Non-degree Award
Bernard Kikaire
ID:
Improving identification of new HIV infections and primary drug resistance among adolescents' girls, young women and their sexual partners in Uganda.
REFNo: HS4283ES

To improve identification of HIV infection, describe transmitted drug resistance mutations and HIV transmission network among AGYW and their sexual partners in Uganda.
 Uganda 2024-05-31 17:57:30 2027-05-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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