Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Rosalind  Parkes-Ratanshi Parkes
ID: UNCST-2019-R000717
 Characterizing STIs and antimicrobial resistance in men with urethral discharge syndrome in Uganda
REFNo: HS1338ES

Primary:
• To assess and compare the prevalence of pharyngeal STIs (gonorrhea, chlamydia) in relation to urogenital STIs, characterize the antimicrobial resistance (AMR) profile of pharyngeal and urogenital gonorrhea, and identify demographic and behavioral risk factors associated with STIs at different anatomical sites. STIs and AMR profiles will be determined using a combination of traditional laboratory methods (cultures) and molecular approaches, including, but not limited to nucleic acid amplification tests (NAATs).

Secondary:
• To assess acceptability of self-collected tests in men with UDS and pharyngeal testing for STIs in Uganda.
• To estimate the prevalence of 4 STIs in a population of men with UDS caused by the following pathogens: Chlamydia trachomatis (CT), Neisseria gonorrhoea (NG), Trichomonas vaginalis (TV), and Mycoplasma genitalium (MG) using NAATs.
• To estimate the proportion of STIs (CT/NG/MG) at multiple anatomical sites (penis and pharynx (throat))
• To assess the prevalence of HIV and syphilis, and compare HIV result to self-reported HIV status.
• To explore socio-demographic, behavioural and clinical factors associated with positive STI diagnosis and antimicrobial-resistant infections.
• To compare the antimicrobial susceptibility profiles of pharyngeal and urogenital NG isolates recovered the same participant(s).
• To compare the distribution of AMR markers in pharyngeal and urogenital NG.
• To determine the effectiveness of treatment for urogenital NG infections on pharyngeal infections.
• To explore the feasibility of detecting NG and AMR markers using a single-cell molecular approach directly from pharyngeal samples.
• To collect pharyngeal samples for future metagenomics analysis to explore the role of microbiome on pharyngeal NG infections and AMR.
• To explore the role of commensal Neisseria species on the development of AMR in NG.
To provide samples to be added to the Johns Hopkins International STI biorepository at Johns Hopkins School of Medicine, Baltimore, MD USA.


 UK 2021-06-23 2024-06-23 Medical and Health Sciences Non-degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
 Drug Interactions between Dolutegravir (DTG) and escalating-doses of Rifampicin (RIF) Study
REFNo: HS1376ES

The secondary objectives of the trial are to determine the safety and tolerability of the DTG/RIF combination, the PK of RIF, induction of PgP and CYP3A4 and effect of DTG on appetite,Primary Objective The primary objective of the study is to determine changes to the PK parameters of DTG when administered with standard, medium and high doses of RIF in HIV-negative, TB-monoinfected participants coming to the end of continuation TB therapy with standard doses of RIF and INH over a 10 week period,
 Nigeria 2021-06-23 2024-06-23 Medical and Health Sciences Clinical Trial Non-degree Award
Mark Okwir
ID: UNCST-2021-R013417
 Meningitis: Burden, Causes, Pathogenesis and Prevention in Rural Northern Uganda
REFNo: HS1420ES

Aim 1: To prospectively collect data on all patients with meningitis and meningitis symptoms who were admitted to LRRH to assess etiologies and pathogenesis of meningitis using modern diagnostic testing not previously available and evaluate the causes, burden of disease, and outcomes of meningitis. Aim 2: To perform CrAg screening of 10,000 HIV-positive patients to determine the prevalence of cryptococcal antigenemia and conduct a case control study to compare outcomes among CrAg-positive patients and CD4-matched CrAg-negative controls.
 Uganda 2021-06-23 2024-06-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Olivia Kituuka
ID:
HLA TYPING OF 5 MAJOR ETHNIC GROUPS IN UGANDA AND KNOWLEDGE AND ATTITUDES ABOUT ORGAN DONATION AND TRANSPLANTATION AMONG HEALTH CARE WORKERS, HEALTH POLICY MAKERS AND THE URBAN POPULATION IN UGANDA.
REFNo: HS1447ES

To determine the prevalence of Human Leucocyte Antigen (HLA) sub-types among individuals from five largest ethnic groups in Uganda. ,To assess Knowledge Attitudes and perceptions among urban populations and key stakeholders in Kampala city on organ transplantation in Uganda,
 Uganda 2021-06-23 2024-06-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bernard Kikaire
ID:
Perspectives of stakeholders in research on post-trial access to investigative products: The Post Trial Access (PTA) Study
REFNo: HS1449ES

General Objective
To explore the understanding and perspectives of key research stakeholders about the provision of post-trial access in clinical trials conducted in Uganda.
Specific Objectives
1.To explore research stakeholders’ knowledge of post-trial access in Uganda

2.To explore research stakeholders’ perspectives about post-trial access in clinical trials conducted in Uganda.

3.To describe the post-trial access practices and or experiences among key research stakeholders in Uganda

 Uganda 2021-06-23 2024-06-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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