Dickens Akena Howard
ID: UNCST-2019-R000179
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Rethinking the Use of Race, Ethnicity, and Ancestry in Genomics: Including Global Voices
REFNo: HS7222ES
1.To explore the perspectives of genome scientists and study participants from within the African continent on: (i) the use of population descriptors in genomics; and (ii) the risks and potential benefits of genomic research.
2.To determine and assess participants and researchers’ views on the use of population descriptors in genomics, the risks, and potential benefits of genomic research
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Uganda |
2026-06-12 16:02:49 |
2029-06-12 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Deogratius Ssemwanga
ID: UNCST-2025-R021563
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Mpox Genomic Characterization, Viral Evolution and Host Response in Uganda: A multi-Omics Investigation of Transmission, Immune Evasion and Disease Severity
REFNo: HS7619ES
Main Objective:
To characterize the genomic, transcriptomic, epigenomic and proteomic profiles of MPXV infection in symptomatic cases and their contacts to inform improved diagnostic, control and management strategies.
Specific Objectives:
Objective 1: Viral Evolution and Transmission of the MPXV. This objective seeks to characterize MPXV genomic diversity and identify mutations associated with viral load, transmission clustering and infection duration. This involves identifying genetic variants driving adaptation, transmission and pathogenesis, sequencing viral genome for real-time evolution tracking, defining transmission dynamics among Mpox cases and their contacts, and collecting data on transmission risk factors for improved transmission control.
Objective 2: Host transcriptional Expression. We’ll identify host gene expression signatures associated with Mpox severity, immune evasion, clearance, and progression by comparing cases, contacts, and healthy controls (HCs). HCs will provide baseline host gene expression profiles.
Objective 3: Epigenetic regulation. Assess whether MPXV infection alters chromatin accessibility and interferon-stimulated gene regulation in infected individuals. Host chromatin architecture and epigenetic markers in both asymptomatic and symptomatic Mpox infections will be defined enabling us to dissect and understand chromatin remodeling mechanism driving infection and disease progression.
Objective 4: Comparative Proteomic Analysis. To characterize proteomic signatures in Mpox suspected patients, close contacts, and healthy controls, leading to identification of potential biomarkers for infection detection and an understanding of host response in Mpox.
Objective 5: Integrated Multi-Omics Analysis. Integrate viral genomics, transcriptomics, proteomics and epigenomics to identify mechanisms of immune evasion and predictors of transmission success.
Objective 6: Living with Mpox Experience. To explore healthcare workers' and survivors' perspectives on the impact of Mpox diagnosis and management on physical, emotional, and social well-being in Uganda.
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Uganda |
2026-06-11 13:36:41 |
2029-06-11 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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ANGELLINE KISAAKYE
ID: UNCST-2026-R023482
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INFLUENCE OF GENDER ROLES ON FOOD AVAILABILITY AND ACCESSIBILITY IN KAABONG DISTRICT, UGANDA.
REFNo: SS5216ES
(i) To establish the gender roles terrain in the context of food security in Kaabong West Sub-county, Kaabong district.
(ii) To investigate the influence of gender roles on food availability in Kaabong West sub-county, Kaabong district.
(iii) To analyse how gender roles shape patterns of food accessibility in Kaabong West sub-county, Kaabong district.
(iv) To examine strategies for mitigating gender-based vulnerabilities to enhance food security in Kaabong West sub-county, Kaabong district.
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Uganda |
2026-06-11 13:35:07 |
2029-06-11 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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Michael Byamukama
ID:
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Modelling HIV/AIDS Transmission in the Era of Biomedical Prevention: A Policy Oriented Mathematical Approach
REFNo: NS1268ES
1. To develop a deterministic compartmental model incorporating HIV progression and biomedical interventions (ART, PrEP, PEP).
2. To compute and analyse the effective reproduction number under various intervention scenarios.
3. To estimate model parameters using national data, conduct sensitivity and uncertainty analyses in order to determine impactful parameters.
4. To simulate realistic intervention scenarios and project long-term outcomes in prevalence and incidence.
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Uganda |
2026-06-11 13:31:21 |
2029-06-11 |
Natural Sciences |
Non-Clinical Trial |
Non-degree Award |
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Joseph Rujumba Rujumba
ID: UNCST-2022-R011160
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Post-Discharge Malaria Chemoprevention (PDMC) in Children with Severe Acute Malnutrition (SAM): A Qualitative Study of Acceptability and Use in Malawi and Uganda
REFNo: HS7633ES
1. To explore health workers’ and caregivers’ initial perceptions, knowledge, and attitudes towards PDMC-SAM before full implementation (prospective phase).
2. To examine the experiences of health workers and caregivers during trial implementation, including perceived benefits, burdens, and challenges of PDMC-SAM (retrospective phase).
3. To assess health workers’ and caregivers’ reflections after trial completion regarding the acceptability, feasibility, and sustainability of PDMC-SAM, and to identify anticipated adaptations required for scale-up (retrospective phase)
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Uganda |
2026-06-11 13:27:59 |
2029-06-11 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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