Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Proscovia Nabunya
ID: UNCST-2019-R000970
Testing the Feasibility and Acceptability of a Combination Intervention to Address Mental Health among Refugee Youth in Uganda
REFNo: SS2834ES

This proposed two-year study will be conducted in two phases. The first phase seeks to understand whether the COVID-19 pandemic had differential impact on refugee youth living in different settings. The second phase will test the feasibility and acceptability of an innovative combination intervention that has not been previously tested among refugee youth to address psychological problems that have increased since the onset of the COVID-19 pandemic. Aim 1. To examine the mental health impact of COVID-19 on refugee youth living in Bidibidi refugee settlement compared to refugee youth living in urban centers (Arua town) in northern Uganda. Aim 2. To test the feasibility, acceptability and preliminary short-term impact of an innovative intervention combining the youth readiness intervention (YRI) with youth development accounts and financial literacy training (YDA-FLT) to address the mental health impact of COVID-19 among refugee youth living in Bidibidi refugee settlement in northern Uganda.
Uganda 2024-08-19 11:03:04 2027-08-19 Social Science and Humanities Clinical Trial Non-degree Award
Peter Olupot-Olupot Olupot
ID: UNCST-2020-R014798
SMAART-MAP trial Severe Malaria A Research and Trials consortium - Multisite Adaptive Platform trial
REFNo: HS4547ES

OBJECTIVES
The objective of the SMAART-MAP trial is to identify promising adjunctive therapies to take forward into a large Phase III trial in severe malaria with a mortality endpoint. The adaptive platform design enables additional domains to be added so a range of adjunctive therapies can be tested, across multiple clinical presentations of severe malaria, in a timely manner.

PRIMARY OBJECTIVE(S)
To explore within each domain the therapeutic efficacy of the intervention using an early indicator such as a biomarker or clinical assessment at 24-72 hours.

SECONDARY OBJECTIVE(S)
 To assess the impact of the interventions on clinical outcomes (readmission and
mortality) on all children 28 days and 90 days after randomization
 To assess the impact of the interventions on Grade 3 or 4 adverse events, and adverse
events of any grade related to the interventions or comparators.
 To assess the impact of proposed definitions for severe malaria based on platelet counts
≤150,000/µL and plasma pfHRP2 concentrations ≥800 ng/mL on differences between
randomized groups
 In a sub study, to determine the performance characteristics of a POC pfHRP2 test
compared with quantitative plasma pfHRP2 concentrations determined from plasma.

Uganda 2024-08-16 11:01:14 2027-08-16 Medical and Health Sciences Clinical Trial Non-degree Award
SYLVIE NAMWASE
ID: UNCST-2024-R003958
Charcoal Conflict in Climate Change’s Decarbonisation Dilemmas: Knots of Livelihood, Nutrition, Communities, Gender, Migration and Energy in East Africa. RefNo: CoBAMS-REC-2024-39
REFNo: SS2909ES

To examine the East African challenges in the context of the global political landscape of climate strategies and identify how success-criteria are derived from global dynamics, and what lessons from these local cases should be fed into global policy-making.,To identify and examine the ways in which Uganda and Tanzania have initiated local solutions to the charcoal and climate change crisis and how they can each harmonise their legal and policy framework change in a way that is responsive to their local realities while in tandem with global climate change and decarbonisation trends.,To understand the legal and policy frameworks governing the climate change, charcoal and decarbonisation dilemma in Uganda and Tanzania. ,To understand local processes of charcoal transition in Uganda and Tanzania in order to capture the impact of possible changes on livelihoods, food, nutrition and health as well as social stability, and relations among different social identity groups, where gender, youth, women and migration are particularly central. ,The main objective is to understand how global climate change mitigation policies (decarbonisation) condition charcoal politics and socio-economic dynamics in energy-stressed countries down to local levels, and how to manage conflicts.,
Uganda 2024-08-12 10:56:54 2027-08-12 Social Science and Humanities Non-Clinical Trial Non-degree Award
PATRICIA  ATUKUNDA
ID:
Staff Welfare Strategies and Performance of Healthcare Providers in Government -aided Health Facilities in Bushenyi District, Uganda
REFNo: SS2783ES

To find out the extent to which career growth strategy affects the performance of healthcare givers in government-aided health facilities in Bushenyi District, Uganda.,To determine the extent to which financial well-being strategy impacts the performance of healthcare workers in government-aided health facilities in Bushenyi District, Uganda,To establish the extent to which work-life balance strategy influences the performance of healthcare workers in government-aided health facilities in Bushenyi District, Uganda.,To assess the extent to which health and safety strategy influences the performance of healthcare givers in government-aided health facilities in Bushenyi District, Uganda.,To analyze how the well-being of staff influences the performance of healthcare givers in government-aided health facilities within Bushenyi District, Uganda.,
Uganda 2024-08-12 10:55:47 2027-08-12 Social Science and Humanities Non-Clinical Trial Degree Award
CAROLINE NAKIDDE KAVUMA
ID:
Influence of Indigenous and Contemporary Early Years’ Education Pedagogy on Development of Children’s life-skills, Masaka District-Uganda
REFNo: SS2888ES

1.To establish the influence of indigenous pedagogy on the development of life skills among their children.
2.To investigate the influence of contemporary Early Years’ Education Pedagogy on the development of life skills among Baganda children.
3.To establish the influence of indigenous and contemporary EYE pedagogy on life skills development among children.
4.To examine the difference between the influence of IP and contemporary EYE pedagogy in development of life skills among Baganda children.

Uganda 2024-08-06 18:26:29 2027-08-06 Social Science and Humanities Non-Clinical Trial Degree Award
Julia Mwesigwa Nanteza
ID:
Perceptions, attitudes and Information needs of Stakeholder, Health Worker, and Child Caregiver to guide introduction of the Malaria Vaccine in Uganda
REFNo: SS2895ES

1. Assess participants’ awareness of the MV, including identification of Malaria Vaccine information sources. 2. Ascertain the misconceptions, fears, and rumors from the public about the Malaria Vaccine. 3. Elicit participant concerns about side effects of the Malaria Vaccine. 4. Ascertain participant expectations for Malaria Vaccine efficacy and acceptability of continued bed net use with vaccinated children. 5. Assess caregivers’ acceptability of adhering to a four-dose vaccination schedule that extends into the second year of life and may involve new vaccination visits. 6. Identify health workers’ perceived challenges for client education, provision of a four-dose schedule, tracking dose delivery, and reporting. 7. Elicit national and subnational stakeholder views and recommendations for a successful introduction of the Malaria Vaccine, including recommendations about effective ways to link and integrate UNEPI and National Malaria Control Program (NMCP) activities to promote and provide the MV.
Uganda 2024-08-06 18:24:50 2027-08-06 Social Science and Humanities Non-Clinical Trial Non-degree Award
NAKANWAGI JOSLYLINE LYDIA
ID:
A comparative analysis of adherence, retention in care, and viral suppression among PLHIV aged 50 and above and below 50 at Mulago ISS Clinic, Uganda.
REFNo: HS4587ES

To understand the psychosocial needs and challenges (stigma, social support, mental health and lifestyle adjustments faced by PLHIV aged 50 years and above attending Mulago ISS Clinic.,To determine the factors associated with adherence to ART, retention in care and viral suppression among people aged 50 years and above,o compare adherence to ART, retention in care and viral suppression of PLHIV aged 50 years and above and those below 50 years attending Mulago ISS clinic,To compare the cascade of care between people living with HIV aged 50 years and older and those below 50 years at Mulago ISS clinic in Uganda.,
Uganda 2024-08-06 18:14:04 2027-08-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
HARRIET NAMBUYA NIL
ID: UNCST-2021-R013414
World Health Organization Minimum Maternal and Newborn Health Data Set: pilot study at Jinja Regional Referral Hospital
REFNo: HS4727ES

General objective
The aim of the study is to assess the baseline capacity of collecting the data elements to inform WHO mMNHDS at hospitals in low- and middle-income countries.
Specific objectives
1.To identify which data elements of WHO mMNHDS are already incorporated into the hospitals’ existing data systems.
2.To determine which data elements of WHO mMNHDS create the largest challenges for incorporation within hospitals’ routine data collection efforts.
3.To determine which data elements can be used to inform future implementation strategy of WHO mMNHDS.
4.To determine which data elements can be used to inform subsequent revisions of the WHO mMNHDS.

Uganda 2024-08-06 18:12:03 2027-08-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Issa Ndungo
ID: UNCST-2024-R004235
The Interplay among Instructional Strategies, Learners Geometry Attitudes, and Van Hiele Levels of Geometric Reasoning: A Case Study of Selected Secondary Schools in Mid-Western Uganda.
REFNo: SS2857ES

To determine the Mediating Role of Geometry Attitudes on the relationship Between Instructional Strategies and Progression Through Van Hiele Levels,To compare the Effect of Instructional Strategies on learners’ Progression Through Van Hiele Levels,To investigate the relationship between Geometry Attitudes on learners’ Progression Through Van Hiele Levels,To compare the influence of Instructional Strategies on Learners\' Geometry Attitudes.,To investigate the relationship between instructional strategies, learners\' attitudes toward geometry, and their Van Hiele levels of geometric reasoning.,
Uganda 2024-08-06 18:10:09 2027-08-06 Social Science and Humanities Non-Clinical Trial Degree Award
jonathan sserunkuuma
ID:
Readiness of health facilities to diagnose, manage, and prevent the Ebola epidemic along Border districts in Southwestern Uganda.
REFNo: HS4575ES

To assess the capacity and readiness of primary healthcare centers to diagnose Ebola virus disease in Southwestern Uganda.To assess the capacity and readiness of primary healthcare centers to manage Ebola virus disease in Southwestern Uganda.To assess the capacity and readiness of primary healthcare centers to prevention Ebola virus disease in Southwestern Uganda.
Uganda 2024-08-06 18:07:39 2027-08-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Josephine Ninsiima Connie
ID:
Prevalence, Predictors, and Outcomes of Non-Communicable Diseases (Hypertension, Diabetes Mellitus, Obesity and Mental Health Disorders) among Persons Living with HIV in Uganda
REFNo: HS4621ES

To document the health-system-related strengths, opportunities, and challenges in the provision of NCDs services among PLHIV in Uganda,To describe the HIV and NCD outcomes for PLHIV with the selected NCDs in Uganda.,To document factors that are associated with selected NCDs among PLHIV in Uganda.,To describe cascades of care for selected NCDs among PLHIV in Uganda.,To describe the burden, predictors and outcomes of NCDs among PLHIV in Uganda, and assess the capacity of the Ugandan health system to offer NCDs services to PLHIV.,
Uganda 2024-08-06 18:04:20 2027-08-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
VINCENT MUBANGIZI
ID: UNCST-2024-R004232
Opti-MaP (Optimising Implementation of Maternal and Perinatal Death Surveillance and Response to prevent avoidable future deaths in Uganda
REFNo: HS4630ES

To review existing tools, develop and adapt a harmonised toolbox of resources to optimise MPDSR implementationTo co-design customised an "intervention package" using the toolboxTo evaluate effectiveness and cost-effectiveness of the "customised intervention package" to reduce perinatal and maternal mortalityTo develop and adapt a harmonised toolbox of resources to optimise MPDSR implementation
Uganda 2024-08-06 18:02:24 2027-08-06 Medical and Health Sciences Clinical Trial Non-degree Award
Rawlance  Ndejjo
ID: UNCST-2022-R010993
City-based interventions to stimulate active movement for health (CITY-MOVE) in Kampala city, Uganda
REFNo: HS4566ES

5. To assess the effects of selected city interventions on physical activity and population health and wellbeing. ,4. To document population & spatial data availability and assess utilization of routine physical activity data in Kampala city.,3. To identify stakeholder needs, preferences, and feasibility of selected early-phase city-GAPPA interventions to support their successful implementation through action research in LLs. ,2. To describe selected GAPPA interventions in Kampala city and evaluate their implementation process. ,1. To develop a comprehensive theory of change and operationalized measures for stakeholder engagement and context analysis in Kampala city,The primary aim of this study is to comprehensively evaluate the impact and long-term viability of city-GAPPA interventions aimed at promoting active movement and generate evidence on implementation, evaluation, and scalability as well as best implementation practices and transferability of city-GAPPA interventions,
Uganda 2024-08-06 17:55:51 2027-08-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ezekiel  Musasizi
ID: UNCST-2024-R005085
DETERMINANTS OF ADHERENCE TO NICOTINE REPLACEMENT THERAPY AMONG PEOPLE LIVING WITH HIV USING SMOKELESS AND SMOKED TOBACCO IN ARUA AND MOROTO DISTRICTS OF UGANDA
REFNo: HS4478ES

4. To explore experiences of People Living with HIV on ART in using Nicotine Replacement Therapy patches,3. To determine the interpersonal and intrapersonal factors associated with adherence to NRT among PLWH on ART who use smokeless and smoked tobacco enrolled to the Quit4Life+ trial. ,2. To explore the organizational and community factors influencing smokeless and smoked tobacco use among PLWH on ART in Arua and Moroto districts in Uganda ,1. To determine the intrapersonal and interpersonal factors influencing smokeless and smoked tobacco use among People Living with HIV on ART in Arua and Moroto districts in Uganda ,To determine the intrapersonal, interpersonal, organizational, and community determinants of smokeless and smoked tobacco use and NRT adherence among People Living with HIV on ART in Arua and Moroto districts in Uganda,
Uganda 2024-08-06 17:52:34 2027-08-06 Medical and Health Sciences Non-Clinical Trial Degree Award
Edgar Mulogo Mugema
ID: UNCST-2023-R008170
Epidemiology of Acute Respiratory Illness in Southwestern Uganda: A Retrospective Review
REFNo: HS4543ES

The primary objective of this study is to retrospectively document epidemiological and ecological trends in both outpatient and inpatient cases of ARI in five districts in southwestern Uganda. These data will inform the establishment of a network of healthcare facilities to conduct research on preventing and improving the management of ARI in this region.,
Uganda 2024-08-06 17:47:55 2027-08-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
David  Mwambari
ID:
Traveling Memories, Silences and Secrets (TMSS): Life narratives of Violence Among Refugees from Africa’s Great Lakes Region – A case of Uganda
REFNo: SS2424ES

The study will be guided by the following objectives: 1. Empirically: (a) to map and examine how the life narratives of refugees evolve from contexts of origin to countries of transition and destination (Burundi⇒Tanzania⇒USA;
DRC⇒Uganda⇒Belgium; Rwanda⇒Kenya⇒South Africa); (b) to investigate the evolution
of the memories, silences, and secrets that AGLR refugees carry in their trajectories of
migration.
2. Theoretically: to analyse (a) how space and time transform these life narratives on the move, and (b) how these transformed life narratives shape relationships within refugee communities and relationships with host communities in countries of transition and destination.
3. Epistemologically: (a) to develop a set of innovative interdisciplinary perspectives and
methodological approaches that can be used in researching the memory dynamics and mobility
that originate from Global South lived experiences; (b) to foster collaboration between a diverse multidisciplinary, international team of researchers involved in the TMSS project.
4. Policy: to explore how (a) our understanding of life narratives on the move can transform policy-making at local, regional, and international levels; and (b) how this understanding shapes practitioners’ work with refugees in countries of transition and destination.
Belgium 2024-08-06 17:46:31 2027-08-06 Social Science and Humanities Non-Clinical Trial Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
Implementation research on the tailored, multidisciplinary Non-Communicable Disease prevention package targeting air pollution exposure in mid- to late adolescents in Uganda: FRESHAIR-4-LIFE
REFNo: SS2485ES

To address the burden of NCDs by gaining knowledge, resources and capacity to optimize the implementation of tailored preventive intervention packages, targeting adolescents’ exposure to risk factors like tobacco (use) and AP in disadvantaged populations worldwide. In Uganda, we will focus on air pollution.,
Uganda 2024-08-06 17:44:22 2027-08-06 Social Science and Humanities Non-Clinical Trial Non-degree Award
Aurelius  Ssali Ssettunba
ID: UNCST-2023-R005538
CHARISMS OF INSTITUTES OF CONSECRATED LIFE AND THE MISSIONS OF CONSECRATED PERSONS OF THE SELECTED FOUR INSTITUTES IN UGANDA.
REFNo: SS2647ES

specific objectives of the study The study seeks to focus on.the following objectives 1. To find out whether the four institutes of the Concreted life in Uganda do assimilate their founders’ Charisms. 2. To evaluate the areas of pastoral activities that fulfillstheir Founders’Charisms. 3. To identify challenges experienced by the different institutions in their fulfillment of their founders Charisms.,To identify the relationship between charism and mission in the consecrated institutions.,To evaluate the areas of pastoral activities that fulfills their Founders‟Charisms.,To find out whether Personal charism leads to Restore God‟s glory among people in the charism institution. ,Basing on the study, it will establish whether the four members institutes of the consecrated do effectively assimilate their Charism to effectively do their mission,
Uganda 2024-08-06 17:42:37 2027-08-06 Social Science and Humanities Non-Clinical Trial Non-degree Award
Abubaker Kawooya
ID:
PHAGE-MEDIATED BIOCONTROL OF THE DOMINANT PATHOGENIC BACTERIA STRAIN IN READY-TO-EAT VEGETABLE SALADS SOLD IN KAMPALA CITY
REFNo: HS3986ES

To study the safety of phages by analyzing the entire genome sequence for unwanted genes,To determine the lytic activity of phages against the dominant pathogenic bacteria isolated from ready-to-eat vegetable salads,To establish the diversity and genetic relatedness of bacteria in ready-to-eat vegetable salads,This study aims to evaluate the effectiveness of Phages in maintaining the microbial quality of ready-to-eat vegetable salads in Kampala.,
Uganda 2024-08-06 17:40:09 2027-08-06 Medical and Health Sciences Non-Clinical Trial Degree Award
Ismail  Draguma Legason
ID: UNCST-2021-R012130
Immunohistochemical assessment of Epstein Barr virus-encoded nuclear antigen (EBNA-1)and selected lymphoma markers for Burkitt Lymphoma diagnosis in resource-restricted settings
REFNo: HS4755ES

To determine the combined sensitivity, specificity, and predictive values of EBNA-1immunohistochemistry with CD10, BCL2, and Ki67 for the diagnosis of Burkitt lymphoma.,To determine the sensitivity, specificity, and predictive values of EBNA-1 protein immunohistochemistry for diagnosing Burkitt lymphoma. ,To evaluate EBNA -1 and selected lymphoma markers for Burkitt lymphoma diagnosis in resource-limited settings. ,
Uganda 2024-08-06 17:39:05 2027-08-06 Medical and Health Sciences Non-Clinical Trial Degree Award
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