Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Sarah Zalwango Karen
ID: UNCST-2021-R005660
Identifying adolescents at high risk of neurocognitive disorder: Development and validation of composite risk index.
REFNo: HS1532ES

a. To develop a CRI by combining intake data on nutrition, immune parameters and HIV status and their interactions and perform internal and external validation of CRI as predictor of ND at 12 months. We hypothesize that the CRI evaluated at intake will successfully predict progressive/incident ND 12 months later.

b. To further internally and externally validate CRI for “out-of-time-window” prediction from 24 to 36 months. We hypothesize that the CRI developed at intake but evaluated at 24 months will successfully predict progressive/incident ND at 36 months.

c. For HEU and HIV-infected children, to refine CRI into CRI-HEU and CRI-HIV, respectively, by including type of maternal ART, viral genome parameters, current cART regimen/adherence (as applicable), and their interactions. We hypothesize that the CRI-HEU and CRI-HIV developed at intake and evaluated at intake and 24 months will successfully predict ND and ND/HAND respectively, 12 months later.

Uganda 2021-08-04 2024-08-04 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Mary Goretti Nakabugo Goretti
ID: UNCST-2021-R013051
DEVELOPING SUSTAINABLE MODELS FOR COMMUNITY-BASED PRESCHOOLS IN UGANDA
REFNo: SS714ES

The purpose of this study is to identify and refine models of ECCE provision which can help to increase its availability and enhance its quality in the context of Uganda. It is intended that these models should involve community ownership and management as far as possible and should be suitable for public subsidy in the future.

The main research questions are as follows and will apply to a variety of cases selected for in-depth and comparative study:

1. What structures, practices and resources can enable the preschool to be controlled by, and accountable to, representatives of a local community or other relevant community?

2. What structures, resources and system of funding can help to make the preschool accessible and affordable to all or most households in the locality? How far can these elements be sourced within the community?

3. What are the essential human and physical resources for the preschool to be of acceptable quality and how should the standards for these be stated for purposes of management and evaluation? How far can the community provide these resources?

4. Given the existing provision of resources, what should be the priorities for improving leadership, teaching and care in the preschool?

5. How can the preschool best be linked with schools, health and social welfare services and existing demand-side interventions?

Uganda 2021-08-03 2024-08-03 Social Science and Humanities Non-degree Award
ANN NANTEZA SENGENDO
ID:
Assessment of integrated control of East Coast fever (ECF) by induction of acquired immunity in Ankole cattle after natural infection by early diagnosis and early treatment
REFNo: A134ES

Mainobjective
To investigate the performance of early diagnosis and early treatment of ECF as a method of reducing calf mortality and enhancing conditions for the development of endemic stability
Specific objectives
i. To determine the prevalence of ECF based on microscopic, ELISA and PCR methods.
ii. To determine the efficiency of early symptom diagnosis and early chemotherapy approach in treating natural ECF cases and induction of protective immunity against ECF in Ankole cattle in an endemic area.
iii. To design a diagnostic regimen/protocol that farmers can use to minimize cattle losses due to ECF by integrating early case symptom detection and early treatment in the routine control strategy in an endemic area.


Uganda 2021-08-03 2024-08-03 Agricultural Sciences Non-Clinical Trial Non-degree Award
Kenneth Rubango
ID:
Feasibility Study of Nanomedicine in Uganda
REFNo: HS1485ES

Design a nanomedicine promotion package that will be shared with Makerere University, the Ministry of Health and the other healthcare providers. ,Study and evaluate the effectiveness of nanomedicine towards the existing medical education in the selected medical schools. Under this aim, the teaching staff e.g Assistant lecturers, Lecturers, Associate Professors or Professors will be interviewed for the necessary information.,Engage employers and employees in designing the feasibility study towards nanomedicine at their workplaces. Under this aim, the employers e.g Administrators, Principals or Human resource managers will be interviewed for the necessary information.,Assess employer’s willingness to support interventions geared at promoting nanomedicine at their workplaces. Under this aim, the employers e.g Administrators, Principals or Human resource managers will be interviewed for the necessary information.,Conduct formative research to assess existing and needed support for nanomedicine in the selected medical schools. Under this aim, the Key Informant person from each medical school will be interviewed. ,To design and evaluate the feasibility study of nanomedicine in the selected Ugandan medical schools.,
Uganda 2021-08-03 2024-08-03 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Cally Tann
ID: UNCST-2023-R008021
Transitioning a Bundle for Early Detection and Intervention for Children with Developmental Disability to Scale for Low-Resource Settings
REFNo: SS910ES

WS1: To develop harmonised training materials to promote and support high fidelity implementation of the PDC and ABAaNA EIP at scale.
WS2: To further develop the Ubuntu multi-media web platform including development of a pilot mobile tablet application to promote programme accessibility and fidelity.
WS3: To identify existing approaches to livelihood support for caregivers of children with developmental disability in low- and middle-income countries to inform the development of a livelihoods component to the EIP.
WS4: To develop a scale-up strategy, business model and marketing strategy to disseminate the PDC and EIP approaches to a wider audience.
WS5: To define a sustainable monitoring, evaluation and learning strategy to track implementation of the PDC and EIP at scale

UK 2021-08-03 2024-08-03 Social Science and Humanities Non-Clinical Trial Non-degree Award
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