Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Esther Nakyaze
ID:
Provider Perspectives on the PrEP Ring (“ProPrEP”): views from a maternal and child health program (“BAMA”) serving young mothers in rural Uganda.
REFNo: HS4468ES

General Objective
The study will deepen our understanding of provider perspectives on use of the PrEP vaginal ring among young mothers living in rural areas of Uganda.
Specific Objectives
1. Identify preliminary areas for education and outreach to improve both provider and end-user understanding/knowledge of the new vaginal ring technology, thus increasing likelihood of quality counseling and uptake among a vulnerable population of young mothers.
2. Explore the reception by health care personnel of promotional and information/education/counseling (IEC) materials developed by the multilateral “Catalyst” study (funded by PEPFAR through USAID) for ring launch, especially in rural regions having distinct health services resources; identify areas for possible adaptation or elaboration for best uptake and use by health workers
3. Expand understanding of facilitators and barriers faced by young mothers in accessing HIV prevention information and services, especially:
a. community and peer-based stigma
b. provider attitudes
c. models of service provision linking maternal health and HIV prevention/care

Uganda 2024-08-26 18:29:44 2027-08-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
BOSCO AGABA BEKIITA
ID: UNCST-2019-R000549
Epidemiological Profile of Malaria and Molecular Characterization to Assess Presence and Potential Contribution of Emerging Parasite Populations to Malaria Epidemics in Epidemic Districts in Eastern Uganda
REFNo: HS4786ES

General objective
To describe the epidemiological profile of malaria and assess presence and potential contribution of new emerging parasite populations to persistent epidemics in malaria
epidemic districts in Eastern Uganda
Specific objectives
1. To describe the trend and epidemiological profile of malaria in five epidemic districts in Eastern
Uganda over the past 5-year period
2 . To assess presence and potential contribution of emerging parasite species to epidemics by
molecular characterization of malaria parasite populations in epidemic districts in Eastern Uganda
3 . To assess presence and potential contribution of emerging parasite populations harboring
molecular markers of artemisinin resistance to persistent epidemics in malaria epidemic districts
in Eastern Uganda
4 . To assess presence and potential contribution of emerging parasite populations harboring pfhrp2
and pfhrp3 gene deletions to the persistent epidemics in malaria epidemic districts in Eastern Uganda
Uganda 2024-08-26 18:28:33 2027-08-26 Medical and Health Sciences Non-Clinical Trial Degree Award
MUGISHA TAREMWA IVAN
ID: UNCST-2024-R004274
Assessment of Transfusion Safety and Efficacy among Cancer Patients in Uganda and Caregivers’ Perceptions on Blood Use.
REFNo: HS4848ES

Specific objectives: (i). To assess the level of bacterial contamination in stored whole blood and blood components intended for transfusion to patients with cancer at Mbarara Regional Referral Hospital and Uganda Cancer Institute. (ii). To determine the prevalence of, and the factors associated with immune sensitization among patients with hematological malignancies at Mbarara Regional Referral Hospital and Uganda Cancer Institute. (iii). To identify the specificities of anti-RBC alloantibodies in patients with hematological malignancies at Mbarara Regional Referral Hospital and Uganda Cancer Institute (iv). To determine the incidence of acute and delayed serologic or delayed hemolytic transfusion reactions among patients with cancer at Mbarara Regional Referral Hospital and Uganda Cancer Institute (v). To describe the caregivers' perceptions of blood use and availability in southwestern Uganda. Main objective: To assess transfusion safety and efficacy among patients with cancer in Uganda and caregivers’ perceptions of blood use.
Uganda 2024-08-26 18:26:57 2027-08-26 Medical and Health Sciences Non-Clinical Trial Degree Award
Edward  Tumwesige
ID: UNCST-2024-R003855
Assessing Community Willingness and Acceptance to Utilize Locally Developed Vaccines
REFNo: SS2875ES

• Assess the community's level of knowledge and awareness regarding locally developed vaccines.
• Explore trust and willingness of the community to utilise locally developed vaccines.
• Identify factors contributing to positive or negative perceptions of locally developed vaccines.
• Explore the most effective communication channels for sharing information about locally developed vaccines.

Uganda 2024-08-26 18:25:34 2027-08-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
ASUMAN KHAMIS SHAFI
ID:
Timing Of Neurosurgical Intervention And Short-term Outcome Of Patients With Traumatic Brain Injury Admitted To Mulago Hospital Emergency Department
REFNo: HS4610ES

1. To determine the average decision-to-intervention time among patients with TBI admitted at MNRH ED. 2. To determine factors associated with the neurosurgical intervention among patients with TBI admitted to the MNRH ED. 3. To determine the 72-hour outcome mong patients with TBI requiring neurosurgical intervention admitted to MNRH ED.
Uganda 2024-08-26 18:24:09 2027-08-26 Medical and Health Sciences Non-Clinical Trial Degree Award
Patience Kinengyere Bemanya
ID: UNCST-2024-R004964
PROJECT EVALUATION FOR THE INCREASING EQUITABLE ACCESS TO EFFECTIVE CATARACT SERVICES IN WEST, SOUTH, AND SOUTH-WESTERN UGANDA PROJECT
REFNo: SS2923ES

6. To evaluate the impact on the broader health system, including the referral system and the ability to handle increased demand for eye health services. ,5. To analyse the efficiency of operational processes within the project, including infrastructure development, capacity-building initiatives, and improvements in surgical procedures. ,4. To assess the extent of integrating health services for women with eye care services, its merits and demerits, challenges encountered, and the factors for scalability/sustainability. ,3. To evaluate the project’s success in promoting equity and inclusivity in health service delivery, mainly focusing on gender-specific barriers and access challenges marginalised populations face. ,2. To examine the effectiveness of community engagement strategies and awareness activities in increasing eye health awareness, improving access to services, increasing uptake of eye care services and reducing barriers to access to eye health services.,1. To evaluate overall project impact and effectiveness in terms of increasing equitable access to adequate services, improving service quality, achieving gender equity in eye health and reducing cataract-related blindness in the project area. ,To assess the extent to which the project\'s two components have met their objectives, key outputs, outcomes, and overall impact. It will also validate the monitoring data collected by in-country program teams during implementation. It will contribute to improvement by extracting valuable lessons from each part of the project. These insights will be instrumental in enhancing current and future programming within the region, guiding the development of future projects, and evaluating the potential scalability of the project to improve eye health.,
Uganda 2024-08-26 18:22:11 2027-08-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Timothy  Muwonge Ronald
ID: UNCST-2020-R014680
Tailoring community ART delivery to the needs and preferences of people living with HIV in refugee settlements in Uganda
REFNo: HS4193ES

The overarching objective of the proposed study is to evaluate how community ART delivery can be optimized for people living with HIV (PLHIV) in refugee settlements in Uganda.
Specific aims:
Aim 1A: To identify key barriers to community antiretroviral therapy (ART) delivery participation and implementation in refugee settlements experienced by PLHIV, health workers, and expert clients.
Aim 1B: To characterize perspectives of PLHIV, health workers, and expert clients on the optimal design of community ART delivery for refugee settlements.
Aim 2: To quantify community ART delivery preferences among PLHIV in refugee settlements and identify demographic groups with similar preference profiles.

Uganda 2024-08-26 18:17:13 2027-08-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
FREDDIE SSENGOOBA Peter
ID: UNCST-2021-R011834
Estimating the cost of introduction, delivery and budget impact of malaria vaccine introduction in Uganda (A prospective projection)
REFNo: HS4096ES

4. To determine the budget impact of introducing and delivering Malaria vaccine among children under five years in Uganda. ,3. To estimate and compare the cost of delivering the malaria vaccine under different vaccination modalities/approaches,2. To estimate the additional resource requirements for the introduction and rollout of the malaria vaccine into Uganda’s routine immunizations programme.,1. To explore perspectives of key stakeholders on Uganda’s plan to introduce the malaria vaccine among children under five years.,To estimate the incremental resources (cost) and budget impact of introducing the new malaria vaccine in Uganda to inform the country decision-making regarding the introduction, delivery, national scale-up, as well as impact of the malaria vaccine on other vaccines in the routine immunization system.,
Uganda 2024-08-26 18:14:03 2027-08-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kisembo Vincent
ID: UNCST-2024-R003679
NATURAL RESOURCE GOVERNANCE AND HUMAN-ECOLOGICAL WELLBEING IN THE OIL AND GAS SUB SECTOR IN BUNYORO SUB-REGION
REFNo: SS2971ES

the study's main objective is to assess natural resource governance and human-ecological wellbeing in the oil and gas sub sector in Bunyoro sub-region, specifically in the districts of Hoima, Kikuube and Buliisa.
Specifically, the study aims to;
1. To analyse the established legal and institutional framework for oil natural resource governance in ensuring the well-being of human -ecological wellbeing in Buliisa, Hoima and Kikuube districts
2. To examine the policies on human wellbeing to the communities in the Oil and Gas sub sector in Buliisa, Hoima and Kikuube districts
3. To analyze the implications of oil and gas sub sector activities on ecological wellbeing in Buliisa, Hoima and Kikuube districts.
4. To examine social and environmental challenges emanating from Oil and gas activities in Buliisa, Hoima and Kikuube districts

Uganda 2024-08-26 15:11:29 2027-08-26 Social Science and Humanities Non-Clinical Trial Degree Award
Teopista Akoyi Kevin
ID: UNCST-2024-R004534
AfriFoodLinks Project - Mbale City Research
REFNo: SS2990ES

d. Actively engage government actors, creating a project feedback mechanism. ,c. Engage other project work packages towards constructing positions on multi-level governance, agri-food system entrepreneurship and innovation and urban food environments,b. Actively contribute to development of urban food system researcher network in partner African cities,a. Support the generation of new and path-leading urban food systems knowledge,to generate scientific evidence to inform actions geared towards transforming urban food systems in such a manner that tackles the systemic foundations of food insecurity and environmental impact.,
Uganda 2024-08-26 15:00:52 2027-08-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Herbert Ainamani Elvis
ID: UNCST-2020-R014674
The Impact of Self Help Plus and Climate Smart Agriculture on Mental Health and Food Security in the Rhino and Nakivale Refugee Settlements of Uganda
REFNo: HS4691ES

To compare the uptake of HGI between the mothers in the combined intervention group (HGI & SH+) with those in the HGI group living in Nakivale refugee settlement,To assess the effect of SH+ on the development of children aged 3-6 years belonging to participating mothers living in Rhino and Nakivale refugee settlements,To assess the effect of SH+ on the mental health of mothers with children aged 3-6 years living in Rhino and Nakivale refugee settlements ,To assess the perceptions and attitudes towards a home gardening intervention (HGI) among participating mothers living in Nakivale refugee settlement,To assess the effectiveness of Self Help Plus (SH+) and home gardening on maternal mental health, food security and child development in the Rhino and Nakivale refugee settlements of Uganda,
Uganda 2024-08-26 14:58:27 2027-08-26 Medical and Health Sciences Clinical Trial Non-degree Award
Richard Mayanja Weazher
ID:
cultural practice and consumption of indigenous iron artifacts of the Baganda people in Uganda
REFNo: SS2942ES

3. To analyze the extent to which indigenous knowledge of ironworks of the Baganda in Central and Southern Uganda has survived.,2. To examine the historical and contemporary relevance of Indigenous iron implements to the Baganda in Central and Southern Uganda.,1. To document the indigenous knowledge embedded in the design production of the indigenous ironworks of the Baganda in Central and Southern Uganda.,The purpose of this study is to document the cultural practice and consumption of the indigenous iron art forms of the Baganda in central and southern Uganda for posterity. ,
Uganda 2024-08-26 14:55:51 2027-08-26 Social Science and Humanities Non-Clinical Trial Degree Award
Claire Norcross Valerie
ID: UNCST-2024-R004641
An observational study evaluating archived and emergent HIV drug resistance in people with a history of sub-optimal HIV control in East and Southern Africa
REFNo: HS4761ES

1. To describe archived resistance mutation patterns (major/minor mutations and minority variants) in adults in East and Southern Africa with a recent history of sub-optimal adherence to dolutegravir-based ART; through next-generation sequencing of pro-viral DNA 2. To describe emergent resistance patterns (major/minor mutations and minority variants) in people living with HIV (PLWH) who fail treatment with long-acting injectable cabotegravir/rilpivirine (LAI-CAB/RPV) and the implications for future treatment, and in those who experience blips on LAI-CAB/RPV, through next-generation sequencing on stored plasma 3. To identify predictors of treatment failure on LAI-CAB/RPV in PLWH in East and Southern Africa, and consider how these predictors can influence policy
UK 2024-08-26 14:52:18 2027-08-26 Medical and Health Sciences Non-Clinical Trial Degree Award
David Okimait
ID: UNCST-2019-R000095
We Can Work Baseline for Youth With Disability
REFNo: SS3023ES

To provide relevant recommendations and insights that will further inform the program design and adaptation during the implementation period.,To measure all goal, outcome, and output level indicators as a benchmark for purposes of setting performance targets and measurement of the program progress,The overall purpose of this baseline survey is to establish a benchmark of the program indicators across all five outcomes to inform implementation. This will enable systematic measurement of progress towards the intended results annually and at final evaluation,
Uganda 2024-08-26 14:45:41 2027-08-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
FREDRICK MAKUMBI
ID:
Rapid Assessment of Bottlenecks Inhibiting the Scale-up of Evidence-based Family Planning Practices in Uganda
REFNo: HS4723ES

Broad objective To understand enablers and inhibitors to the scale-up of three EBPs (PPFP, task sharing/expansion, and SBCC) and FP broadly through a BNA approach to inform strategies that can accelerate the uptake of family planning services and programme implementation in Uganda. Specific objectives 1.To synthesize what is known about scaling up FP EBPs and broader FP in Uganda, including implementation status, alignment of guidance with national and international standards, and the lessons learned from successful implementation (including approaches that aim to address gender norms and inequalities) 2.To understand the perspectives of key stakeholders (policymakers, programme managers, healthcare managers, service providers and civil society) on the various health systems factors inhibiting the scale-up of the EBPs. 3.Build consensus among key stakeholders on the most important bottlenecks to EBP scale-up and on solutions that address the root causes inhibiting scale-up
Uganda 2024-08-26 14:41:30 2027-08-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Clare Bangirana Ahabwe
ID: UNCST-2021-R012842
What works to prevent and respond to childhood sexual violence in resource-constrained settings: The Case of the 3RT Model implemented by The Remnant Generation in Uganda
REFNo: SS3005ES

4. To study the contribution of girls’ agency in promoting social norms change to prevent childhood sexual violence.,3. To identify critical enablers for effective implementation of interventions to prevent and respond to childhood sexual violence.,2. To explore the role of communities in leading sustainable change for safe environments free from childhood sexual violence. ,To document the effectiveness of the 3RT model in preventing and responding to childhood sexual violence among adolescents in Uganda.,To scientifically examine what works in preventing and responding to childhood sexual violence in resource-constrained settings using the 3RT model of the Remnant Generation as a case. ,
Uganda 2024-08-26 14:40:04 2027-08-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Warren Aryeija
ID:
Experiences of People with Infertility in Uganda: Empirical Study of Couples with Infertility Challenges at Selected Hospitals in Kampala City
REFNo: SS2807ES

1. Assess knowledge about the causes of infertility among infertile male and female couples. 2. Identify socio-economic challenges experienced by infertile male and female couples. 3. Examine the psycho-emotional impact of infertility on infertile male and female couples. 4. Explore Coping strategies used by infertile male and female couples in living and dealing with infertility. 5. Determine the Socio-demographic correlates of Coping Strategies adopted by infertile male and female couples.
Uganda 2024-08-26 14:21:31 2027-08-26 Social Science and Humanities Non-Clinical Trial Degree Award
Monicah Agaba
ID: UNCST-2024-R004221
The Health-Beauty Paradox among Women in Mbarara City Uganda
REFNo: HS4708ES

iii. To characterise the cardio-metabolic profile of WRA.,ii. To document the risk behaviours and their factors related to these societal beauty perceptions.,i. To document societal beauty perceptions and their determinants.,To understand what, why and how the health-beauty paradox is so deeply entrenched in the culture.,
Uganda 2024-08-26 10:18:37 2027-08-26 Medical and Health Sciences Clinical Trial Degree Award
George William Ddaaki
ID: UNCST-2022-R009216
Exploring perceptions, concerns, and perceived benefits of pregnant women and those intending to become pregnant towards participating in HIV cure research.
REFNo: SS2866ES

a) To identify concerns and perceived benefits among women in south central Uganda regarding their participation in HIV cure studies.
b) To explore the perceptions and attitudes of pregnant women and those intending to become pregnant in south central Uganda towards participating in a study focused on impact of pregnancy on the HIV viral reservoir and HIV cure.

Uganda 2024-08-26 10:14:01 2027-08-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Kamya Moses
ID: UNCST-2020-R014203
Implementing comprehensive malaria surveillance at sentinel sites in Uganda
REFNo: HS4692ES

To monitor geographic and temporal trends in malaria burden and assess the impact of population level control interventions across a range of epidemiological settings in Uganda.
Uganda 2024-08-26 10:12:47 2027-08-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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