Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
GORRETTI BYOMIRE
ID:
Employment and Inclusive Childcare for Mothers of Children with Disabilities in Kampala, Uganda.
REFNo: SS2360ES

The objectives of the study are as follows:
1. To assess the impact of access to inclusive childcare on the workforce participation of mothers of children with disabilities.
2. To examine the relationship between access to inclusive childcare, labor market participation, and women's economic engagement.
3. To identify barriers and challenges faced by mothers of children with disabilities in accessing inclusive childcare and participating in the workforce.
4. To explore the potential multigenerational impacts of access to inclusive childcare on women's economic empowerment.
5. To generate knowledge and recommendations to promote disability inclusion in Early Childhood Care and Development (ECCD) and expand access to quality affordable inclusive childcare.
6. To inform future work on inclusive childcare and contribute to the dialogue on disability inclusion and women's economic empowerment.

Uganda 2024-06-24 0:07:53 2027-06-24 Social Science and Humanities Non-Clinical Trial Non-degree Award
SAMUEL JJUNJU
ID: UNCST-2023-R006269
PREVALENCE OF KIDNEY DISEASE AND ASSOCIATED FACTORS AMONG PATIENTS WITH CHRONIC HEPATITIS B INFECTION AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS4186ES

To determine the prevalence of kidney disease among patients with chronic hepatitis B infection attending hepatitis clinic at MRRH. To determine the factors that are associated with kidney disease among chronic hepatitis B patients. To determine the correlation between urine NGAL and serum creatinine in estimating kidney function.
Uganda 2024-06-24 0:06:00 2027-06-24 Medical and Health Sciences Non-Clinical Trial Degree Award
Francis Munyambonera Ezra
ID: UNCST-2023-R007401
Modelling Agricultural Cooperatives Uganda, A Case Study of Kigezi Region Re: KABREC-2023-19
REFNo: SS2637ES

The purpose of this study is to investigate the impacts of Agricultural Cooperatives on farmer’s market accessibility in Kigezi Sub Region, Southwestern Uganda. ,
Uganda 2024-06-24 0:04:02 2027-06-24 Social Science and Humanities Non-Clinical Trial Non-degree Award
Abner Baryaija Besigye
ID:
DECENTRALIZATION AND QUALITY PUBLIC HEALTHCARE SERVICE DELIVERY IN THE LOCAL GOVERNMENTS OF UGANDA: A CASE STUDY OF GREATER BUSHENYI DISTRICTS
REFNo: SS2347ES

(iv) To explore the stakeholders’ perception about the effectiveness and efficiency of quality public healthcare service delivery in Greater Bushenyi districts.,To assess the influence of political decentralization on quality public healthcare service delivery in Greater Bushenyi districts.,(ii) To assess association between administrative decentralization and quality public healthcare service delivery in Greater Bushenyi districts.,(i) To assess the effect of fiscal decentralization and the quality of public health care service delivery in the local governments of Greater Bushenyi districts.,The purpose of the study is to assess the relationship between the types of decentralization and the quality of public healthcare service delivery in the local governments of Uganda.,
Uganda 2024-06-21 18:14:03 2027-06-21 Social Science and Humanities Non-Clinical Trial Degree Award
Godfrey  Siu
ID: UNCST-2021-R005439
An evaluation of scaled-up implementation of the Parenting for Respectability Programme in Five Districts in Uganda
REFNo: HS4286ES

i. To evaluate the scalability and impact of the PfR programme on child maltreatment, violence against children and spousal relationships in 5 districts of Uganda
ii. To examine the factors associated with implementation success during scaled-up delivery of the PfR programme
iii. To assess the facilitators experiences, fidelity, and challenges in delivering the PfR programme during scale-up implementation
iv. Examine the cost effectiveness of PfR scale-up using incremental cost-effectiveness analyses (CEA)
v. To examine the design, perceived need, acceptability and perceived relevance of a practitioner’s course on designing and implementation of parenting interventions.

Uganda 2024-06-21 18:10:27 2027-06-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Louis Bayo Boroa
ID:
Understanding Barriers to Immunization among Zero-dose and Under-immunized children in an Urban setting: An Exploratory Case Study in Kampala, Uganda. RefNo: SPH 2024-572
REFNo: HS4298ES

To synthesize learnings to inform division and Kampala district Reaching Every District (RED) micro-plans and the UNEPI’s Urban Immunization Strategy.,To document challenges, strategies, and lessons learned to reach zero-dose and under-immunized children among health workers and division health teams.,To describe beliefs, attitudes, and health-seeking behaviors of caregivers with zero-dose or under-immunized children in Kampala City, and their solutions to zero-dose or under-immunization.,To describe the socio-demographic characteristics of zero-dose or under-immunized children and their caregivers in Kampala City.,To profile the contextual characteristics of missed communities in Kampala.,The overall goal is to identify reasons why children in Kampala are zero-dose or under-immunized and what kind of interventions can be used to reach them effectively to inform division, district, and national immunization strategies.,
Uganda 2024-06-21 18:07:50 2027-06-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Fred Abila
ID:
PREVALENCE AND RISK FACTORS ASSOCIATED WITH PLASMODIUM FALCIPARUM HISTIDINE-RICH PROTEINS 2/3 GENOMIC LOCI DELETIONS IN LANGO AND ACHOLI SUB-REGIONS, NORTHERN UGANDA
REFNo: HS4067ES

3. To determine the risk factors associated with PfHRP2/3 gene deletions among patients with confirmed P. falciparum malaria cases in selected health facilities in the sub regions.,2. To determine the parasite density among patients with confirmed PfHRP2/3 genes deletion in selected health facilities in Lango and Acholi Sub region, Northern Uganda,1. To determine the prevalence of suspected false-negative PfHRP2 RDT results and PfHRP2/3 genes deletion among patients with confirmed P. falciparum malaria cases in health facilities in Lango and Acholi sub regions, Northern Uganda.,To assess the prevalence and factors associated with PfHRP23 gene deletions leading to false negative PfHRP2/3 RDT results among patients with confirmed malaria in selected health facilities in Lango and Acholi Sub regions, Northern Uganda,
Uganda 2024-06-21 18:01:59 2027-06-21 Medical and Health Sciences Non-Clinical Trial Degree Award
Stavia Turyahabwe Stavia
ID: UNCST-2022-R011373
Tuberculosis (TB) Differentiated Service Delivery (DSD) approaches to support continuity of essential services during COVID and beyond in Uganda
REFNo: HS3122ES

5. To improve IPT coverage among children <5 years who are contacts of index TB clients in select health facilities in Kampala and Soroti regions,4. To improve identification of contacts of index TB clients in select health facilities in Kampala and Soroti regions, and improve their access to comprehensive diagnostic workup ,3. To improve TB treatment success (lower death rates, lower interruption rates, higher completion/cure rates) through implementation of DSD approaches in select health facilities in Kampala and Soroti regions ,2. To improve TB treatment initiation for newly identified TB cases through timely commencement of TB treatment in select health facilities in Kampala and Soroti regions ,1. To design and implement DSD models, to evaluate the models’ ability to effectively provide TPT and TB treatment, and to inform national TB/TPT DSD guidelines,To implement and evaluate innovative approaches and client care models to improve health care access, increase TB case detection and strengthen TB service delivery through DSD models. ,
Uganda 2024-06-21 18:00:08 2027-06-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Charles Mukundane Godfrey
ID:
Gendered Power Relations, Food Production and Socioeconomic Livelihoods of Female Headed Households in Ankole Region
REFNo: SS2293ES

1. To examine how gendered power relations has affected food production among female headed households in Ankole Region. 2. To determine the mediating effect of food production on socioeconomic livelihoods of female headed households in Ankole Region. 3. To examine how gendered power relations has affected socioeconomic livelihoods of female headed households in Ankole Region.,To examine how gendered power relations influence food production and socioeconomic livelihoods of female headed households in Ankole Region.,
Uganda 2024-06-21 17:58:16 2027-06-21 Social Science and Humanities Non-Clinical Trial Degree Award
Andrew Katumba
ID:
A Machine Learning-aided Platform for Point-of-Care Pregnancy Risk Assessment from 2D Ultrasound
REFNo: HS4144ES

1. To develop a predictive ML model based on ultrasound, clinical, and demographic data to categorize pregnancy risk and enable the community health worker to make appropriate and timely intervention recommendations.
2. To integrate the ML model in the image processing pipeline of a hand-held portable ultrasound system.
3. To pilot and evaluate the efficacy of the predictive and diagnostic models in managing high-risk pregnancies.

Uganda 2024-06-21 17:54:02 2027-06-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Martin Bikorwomuhangi
ID:
INCIDENCE, INDICATIONS AND SHORT-TERM OUTCOMES OF NON-CONVENTIONAL INTRA-ABDOMINAL DRAINS AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: SS2689ES

4.To determine the association between different types of non-conventional intra-abdominal drains and short-term outcomes among patients who undergo intra-abdominal surgery at Surgical ward MRRH,3.To describe the different short-term outcomes among patients with non-conventional intra-abdominal drains among patients who undergo intra-abdominal surgery at Surgical ward MRRH,2.To document the various indications of non-conventional intra-abdominal drains among patients who undergo intra-abdominal surgery at Surgical ward MRRH,1.To determine the incidence of non-conventional intra-abdominal drains among patients who undergo intra-abdominal surgery at Surgical ward MRRH,To determine the incidence, indications and short-term outcomes of non-conventional intra-abdominal drains among patients who undergo intra-abdominal surgery at Surgical ward MRRH,
Uganda 2024-06-21 17:53:08 2027-06-21 Social Science and Humanities Non-Clinical Trial Degree Award
Stevens Bechange
ID: UNCST-2022-R009190
Eye Health Systems Assessment – Uganda
REFNo: HS4368ES

Examine how the above components of the eye health system recognise and address the needs of groups identified as vulnerable to exclusion from services,Assess the available eye care infrastructure,Assess the information system for eye health,Determine available medical products, vaccines and technologies for eye care,Determine available human resources for eye health,Describe eye care service delivery ,Assess the health financing mechanisms in operation,Describe the governance and leadership function ,The overall objective of this study is to examine and document the strengths and weaknesses of all components of the eye health care delivery system and health system linkages – thus providing a basis for targeted programmatic work to strengthen the eye health systems infrastructure and improving outcomes for eye conditions in Uganda.,
Uganda 2024-06-21 17:51:54 2027-06-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
George Kasule William
ID: UNCST-2023-R006891
EVALUATION OF NON-SPUTUM-BASED DIAGNOSTICS AND BIOMARKERS FOR DETECTION OF M. TUBERCULOSIS AMONG CHILDREN AND PEOPLE LIVING WITH HIV
REFNo: HS4344ES

To assess literature review of Mycobacterium tuberculosis biomarkers in non-invasively collected non-sputum samples of the Oral-Gut and Nasal pharynx parts of humans. To determine the diagnostic performance of novel stool-based biomarkers for detecting tuberculosis in children and among PLHIV using stool samples.To determine the diagnostic performance of breath-based biomarkers for detecting tuberculosis in children and among PLHIV.To determine the diagnostic performance of novel urine-based biomarkers for detecting tuberculosis in children and among PLHIV.To explore health workers’ and policymakers’ perceptions on the use of non-sputum-based assays for detecting tuberculosis in children and among PLHIV in Uganda.
Uganda 2024-06-21 17:50:21 2027-06-21 Medical and Health Sciences Non-Clinical Trial Degree Award
Rose Nabirye Chalo
ID: UNCST-2020-R014645
DEVELOPMENT OF AN INTER-PROFESSIONAL EDUCATIONAL PROGRAMME FOR THE ASSESSMENT OF MENTAL HEALTH OF PREGNANT TEENAGERS
REFNo: SS2691ES

The proposed project seeks to promote inter-professional education by developing an educational programme that will be used for inter-professional training of students in the health professions on the mental health assessment of pregnant teenagers.,
Uganda 2024-06-21 17:48:53 2027-06-21 Social Science and Humanities Non-Clinical Trial Non-degree Award
Daniel Iraguha Ndungutse
ID: UNCST-2024-R003686
DETECTION OF PAROXYSMAL ATRIAL FIBRILLATION AMONG RHEUMATIC HEART DISEASE REGISTRY PATIENTS AT THE UGANDA HEART INSTITUTE, A PREVENTIVE STRATEGY AGAINST STROKE
REFNo: HS4389ES

• To determine the prevalence of paroxysmal
atrial fibrillation using ambulatory ECG
monitoring among participants with severe
RHD in the Uganda Heart registry
• To determine factors associated with
paroxysmal atrial fibrillation among
participants with severe RHD in the Uganda
RHD registry

Uganda 2024-06-21 17:47:52 2027-06-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jonathan Izudi
ID: UNCST-2019-R000469
Integrating Tuberculosis Treatment into Community Pharmacies to improve TB/HIV outcomes in Uganda: the Community Pharmacy Tuberculosis Treatment (COPHAT) study
REFNo: HS4397ES

To evaluate the implementation and preliminary effectiveness of integrating TB treatment into community pharmacies among people with TB/HIV.,To adapt a person-centered strategy for integrating TB treatment into community pharmacies using a human-centered design methodology.,To explore the barriers and facilitators to integrating TB treatment into community pharmacies among people with TB/HIV.,The main objective of this Community Pharmacy Tuberculosis Treatment (COPHAT) study is to develop and pilot an implementation strategy focused on integrating TB treatment into community pharmacies among people with TB/HIV in Kampala, Uganda. ,
Uganda 2024-06-21 17:46:35 2027-06-21 Medical and Health Sciences Clinical Trial Non-degree Award
JUSTINE MUKALERE
ID:
CONNECTING COMMUNITIES TO HEALTH SYSTEMS THROUGH VILLAGE HEALTH TEAMS: A TECHNOLOGY-ENABLED FRAMEWORK. A CASE OF BUGWERI, BULAMBULI, KIBUKU DISTRICTS
REFNo: SIR284ES

iii. To evaluate the designed framework to establish its applicability in connecting communities to health systems.,ii. To design a technology-enabled framework that will connect villages to health systems through Village Health Teams,i. To study the challenges faced by Village Health Teams in Kibuku, Bulambuli and Bugweri districts based on the existing framework and generate requirements,To enhance the connectivity between communities and the health systems through Village Health Teams based on a technology-enabled framework.,
Uganda 2024-06-21 17:45:14 2027-06-21 Engineering and Technology Non-Clinical Trial Degree Award
Leticia Kyohangirwe
ID: UNCST-2024-R004144
Determining the effect of psychiatric disorders on clinical outcomes among adolescents with HIV in Uganda over a one-year period.
REFNo: HS4120ES

The overall objective is to determine effect of psychiatric disorders on clinical outcomes among adolescents with HIV in Uganda using a longitudinal analysis approach.
Uganda 2024-06-19 15:57:59 2027-06-19 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kearsley Stewart
ID: UNCST-2021-R011830
Addressing Sickle Cell Disease in Uganda: A Multi-Sectoral Approach
REFNo: HS4276ES

Aim 3: We aim to assess the current digital capacity (smart mobile phone access, internet access, data security, access to data) of KHCIV sickle cell patients, their caregivers, and KHCIV clinic staff in order to understand their preparedness for using mobile applications to improve sickle cell disease care. We seek to identify facilitators and barriers to uptake of mHealth tools and interventions, including Nanbar Health for patients and SCD Toolbox for KHCIV providers. In addition, we aim to determine the feasibility of using the Nanbar Health and SCD Toolbox mobile applications in Kalangala District and propose solutions for adaptation to enhance sickle cell care and improve outcomes beyond Kalangala District for others in Uganda. ,Aim 2: We aim to improve clinical monitoring of home-based adherence to hydroxyurea by exploring the feasibility and acceptability of using a rapid point-of-care electrophoresis sickle cell test (Gazelle) to monitor fetal hemoglobin for sickle cell patients taking hydroxyurea at their quarterly clinic visits to KHCIV. In addition, we aim to understand the facilitators and barriers to successful home-based adherence to hydroxyurea through a home visit to interview patient and caregivers about their adherence-related behaviors and observe conditions in the home that directly influence adherence to hydroxyurea, such as pill storage. ,Aim 1: We aim to explore the facilitators and barriers to uptake of newborn screening at KHCIV at a time when the Government of Uganda is scaling up newborn sickle cell testing across the country. We will describe the challenges for staff at a remote government health care facility to scale up newborn sickle cell testing. We will study parental perspectives on newborn sickle cell testing and their experiences with the current standard-of-care (dried blood spots) sent by KHCIV to the Central Public Health Laboratory in Kampala.,This study aims to reduce the burden of SCD in Uganda through a multi-sectoral study of the facilitators and barriers to: scale-up of universal newborn screening, adherence to treatments such as hydroxyurea, and improved access to sickle cell health education through mHealth digital apps. ,
USA 2024-06-18 11:20:00 2027-06-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Fred Nalugoda
ID: UNCST-2021-R013343
The Rakai Orphans in Communities (ROC)
REFNo: SS2744ES

The specific aims are to:
1. Define, over time, the potentially changing impact of orphanhood on HIV risk factors and HIV infection among AYA from RCCS Rounds 6-23 (1999-2027).
2. Explore issues related to mechanism and measurement to better understand the population burden of orphanhood among AYA. Key issues include 1-timing of orphaning (i.e., age they became an orphan), 2-influence of orphanhood vs. parental absence from the household, 3-the burden of orphanhood over time among children 0-14 years, and 4-validating the route of transmission (behavioral vs. perinatal) among adolescents first entering the RCCS.
3. Through life history interviews, explore the mechanisms by which orphanhood and age at orphaning may influence HIV risk among AYA and adolescent social outcomes and to assess how programs can be tailored to meet the needs of this vulnerable population. Interviews will be conducted with youth and their adult caretakers; each should be able to differentially report on events and circumstances of the orphaning period.
4. Estimate the economic impact of declining HIV-related orphanhood on youth, families, and communities. In a cost-benefit analysis, we will examine benefits of declining orphanhood (decreased adult mortality, decreased orphanhood, increased educational status, decreased HIV infection among youth) and costs (costs for ART, MMC).
Uganda 2024-06-17 11:41:08 2027-06-17 Social Science and Humanities Non-Clinical Trial Non-degree Award
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