Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Elizabeth namukwaya namukwaya
ID: UNCST-2021-R013177
Supporting undergraduate nurses palliative care education needs
REFNo: HS4672ES

To identify areas for reciprocal learning and shared learning priorities between these countries,To examine student nurses and educators experiences of palliative care education,To generate understanding of undergraduate palliative care nursing education in South Africa, Uganda, Ghana, New Zealand, Canada and the UK,
Uganda 2024-10-14 8:15:25 2027-10-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Nixon Niyonzima
ID: UNCST-2020-R014577
A Phase III, Randomized, Double-Blind, Placebo-Controlled Study Evaluating Atezolizumab and Bevacizumab, with or without Tiragolumab, in Patients with Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (IMBRAVE152)
REFNo: HS5026ES

To evaluate the immune response to tiragolumab and atezolizumab,To characterize the PK profile of atezolizumab plus bevacizumab plus tiragolumab, To evaluate the safety of atezolizumab plus bevacizumab plus tiragolumab compared with atezolizumab plus bevacizumab,To evaluate the efficacy of atezolizumab plus bevacizumab plus tiragolumab compared with atezolizumab plus bevacizumab,
Uganda 2024-10-14 8:13:47 2027-10-14 Medical and Health Sciences Clinical Trial Non-degree Award
Isaac Ebiju
ID: UNCST-2024-R003903
Assessing the Impact of Summary Clinical Guidelines (charts and wheels) on Rational Antibiotic Use and Compliance with Uganda Clinical Guidelines Among Outpatient Prescribers: A case study of Health Centres III & IV in Kampala, Uganda.
REFNo: HS4926ES

To assess the impact and sustainability of summary clinical guidelines for improving compliance of prescription patterns with treatment guidelines on antibiotic use among prescribers at health Centers III and IV in Kampala, Uganda.,To analyze factors affecting guideline utilization among prescribers at health Centers III and IV in Kampala, Uganda.,To assess the compliance and prescription patterns of the Uganda Clinical Guidelines by prescribers at health Centers III and IV in Kampala, Uganda. ,To determine if the use of summary clinical guidelines improves the rational use of antibiotics and adherence to Uganda clinical guidelines among prescribers in outpatient departments of Health Centre IIIs and IVs in Kampala, Uganda.,
Uganda 2024-10-14 8:08:10 2027-10-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Thereza Piloya Were
ID: UNCST-2019-R000491
Effects of Social Determinants of Health on Type 1 Diabetes (T1D) Care in Sub Saharan Africa; Perspectives from Uganda.
REFNo: HS5008ES

Primary
i. To describe the SDOH among the children and youths in Uganda.
ii. To determine the impact of SDoH on glycemic control of children and youths aged 6 months- 25 years in Uganda.
iii. To determine the effect of the SDoH on the physical growth of children and youths in Uganda.
Secondary
i. To set up a database of SDoH for children with T1D in Uganda.
ii. To determine the effect of the SDoH on the complications (DKA, severe hypoglycemia and hypertension) of children and youths in Uganda.

Uganda 2024-10-14 8:06:50 2027-10-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Cissy  Kityo
ID: UNCST-2021-R013663
Impact of Non-B HIV-1 Subtype on second-line Protease Inhibitor Regimens in Africa (INSPIRE)
REFNo: HS5035ES

To evaluate the effect of replicative fitness on susceptibility to PIs in patients with repeated failure in presence of known and novel Gag and Env PI-associated mutations.,To assess HIV-1 drug resistance in PI-resistant viruses using phenotypic drug susceptibility assay and recombinant viruses based on gag, pol, and env genes derived from patients failing 2L.,To determine the basis for second line (2L) treatment failures on ATV/r- and LPV/r-containing regimens in the absence and presence of protease-associated drug resistance.,To determine the effect of Non-B HIV-1 Subtype on second-line Protease Inhibitor Regimens in Africa.,
Uganda 2024-10-14 8:03:22 2027-10-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Benjamin Eyre
ID: UNCST-2024-R002750
Enumerating development: how interdisciplinary perspectives on the treatment of research officers can improve data for social transformation
REFNo: SS3327ES

To generate new knowledge on FOs perspectives in relation to their work practices and conditions with a particular focus on how they see this affecting the quality of the data they produce. ,To explore challenges FOs negotiate, including low salaries, precarious employment contracts, pressure to perform quickly, working in dangerous environments, and negotiating knowledge hierarchies.,To document the lived experience of FOs working in the behavioural economics research sector in Uganda. Their work involves conducting surveys, experiments, and RCTs in informal urban settlements, peri-urban, and rural areas. ,
UK 2024-10-14 8:02:17 2027-10-14 Social Science and Humanities Non-Clinical Trial Non-degree Award
Rosalind  Parkes-Ratanshi Parkes
ID: UNCST-2019-R000717
Providing Rapid HIV viral Diagnostics at Point of Care (The PROmPT) study.
REFNo: HS4881ES

Primary:
To evaluate quantitative performance of the HIV self-testing platform in a resource-limited setting (Uganda) compared to a laboratory-based, gold-standard FDA-approved HIV VL test (Roche Cobas Quantitative HIV-1 RNA, or Abbott Real Time HIV-1 assay, or similar) in PLHIV who have both viral suppression and non-suppression.

Secondary:
To evaluate patient acceptability of the HIV self-testing platform compared to gold standard VL assay
To compare the Turnaround Time (TaT) of the HIV VL self-testing assay and lab-based VL assay
To compare the assay performance of the HIV self-testing platform to lab-based testing by sex, age group, HIV viral load, HIV clade, and HIV risk group

UK 2024-10-08 18:13:17 2027-10-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Mohamed Abouaziza
ID:
Evaluating Impact of Financial Incentives on Agri-Businesses in Uganda
REFNo: A520ES

The specific objectives are to determine whether access to incentivized loans generates increased credit for SMEs, and whether this additional credit subsequently leads to higher revenues, profits, and downstream outcomes for these businesses,The main objective of this research is to examine the effects of financial incentives offered to lenders on agricultural Small and Medium Enterprises (SMEs) while identifying and understanding the challenges these enterprises encounter. Specifically, the study aims to assess whether exposure to these incentives influences the volume of agricultural loans at the bank level and to understand the effects of these incentives on SME growth and performance at the SME level.,
Egypt 2024-10-08 18:11:59 2027-10-08 Agricultural Sciences Non-Clinical Trial Non-degree Award
Josephine  Prynn Elsie Sunman
ID: UNCST-2024-R002840
Nested case control study of prevalence and aetiology of dementia in a rural Ugandan population, and a situational analysis of services available for affected families.
REFNo: HS4827ES

1) Evaluate the prevalence of dementia. 2) Establish the causes and associated factors of dementia to inform risk reduction strategies. 3) Understand the formal support available for people living with dementia and their families.
UK 2024-10-08 17:59:00 2027-10-08 Medical and Health Sciences Non-Clinical Trial Degree Award
OKELLO DAMOI JOSEPH
ID: UNCST-2022-R011560
Impact of the Global Laparoscopic Advancement Pro Training Program on the Fundamentals of Laparoscopic Surgery (FLS) Test Pass Rate among COSECSA Trainees and Members in Sub-Saharan African Countries
REFNo: HS4898ES

To evaluate the impact the GLAP Pro program on the FLS test pass rates among COSECSA trainees and members in Sub-Saharan African countries,To determine the factors associated with the FLS pass rate among intervention (GLAP Pro) group and the control (conventional training),To determine the FLS pass rate among COSECSA Trainees and members in sub-Saharan African countries, following GLAP pro training reception and conventional laparoscopic training,To evaluate the impact of global laparoscopic advancement pro training program on fundamentals of laparoscopic surgery (FLS) test passing rate among COSECSA Trainees and members in sub-Saharan African countries,
Uganda 2024-10-08 17:55:54 2027-10-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Madison Lindeman
ID: UNCST-2023-R006228
The Lived Menstrual Experiences of Women in Western Uganda
REFNo: SS3304ES

- To understand how menstruation impacts women in their daily lives to develop solutions and policy interventions rooted in women’s experiences to improve menstrual health in Uganda. - To explore the structural conditions, resources, and sociocultural discourses that surround menstruation and how these impact women’s embodied experiences. - To understand how women in Mbarara, Uganda experience and navigate menstruation in their everyday lives.
USA 2024-10-08 17:52:55 2027-10-08 Social Science and Humanities Non-Clinical Trial Degree Award
Gilbert Akampurira
ID: UNCST-2024-R003558
PREVALENCE AND FACTORS ASSOCIATED WITH EPISIOTOMY EXTENSION INTO THIRD- OR FOURTH-DEGREE PERINEAL TEARS AMONG WOMEN DELIVERING AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS5072ES

1. To determine the prevalence of episiotomy extension into third or fourth-degree perineal tears among women delivering at Mbarara Regional Referral Hospital.
2. To determine the factors associated with episiotomy extension into third or fourth-degree perineal tears among women delivering at Mbarara Regional Referral Hospital.

Uganda 2024-10-08 17:49:03 2027-10-08 Medical and Health Sciences Non-Clinical Trial Degree Award
John Rek
ID: UNCST-2024-R004373
Training of machine learning algorithms to detect bednet use in Busia Uganda
REFNo: HS4850ES

The objective of this study is to train a comprehensive platform for highly accurate remote monitoring of LLIN use and other behaviors related to malaria risk. We will:
1) gather real-life data about how LLINs are hung and used in the community,
2) train the machine learning algorithms based off pre-defined protocols informed by actual practice and
3) test the accuracy of the machine learning algorithms in real-life settings.

Uganda 2024-10-08 17:48:05 2027-10-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
George Opiyo Otieno
ID: UNCST-2022-R009824
Assessment of Early Childhood Education (ECE) supported by development partners in 12 Refugee Hosting Districts in Uganda
REFNo: SS3188ES

What are the similarities and differences in “what worked” for boys and girls across settings and to what extent can “what worked” be ported to new contexts (i.e. “what works”)?,What factor/s can be leveraged to improve learning for boys and girls through ECE programming?,To what extent are children school-ready in their final year of pre-primary and how did contextual factors, learning environmental factors, student characteristics and programmatic interventions work together to shape learning outcomes?,What are the main challenges to implementation of programmes?,What are the main types of programmatic approaches across select ECE implementing partners in refugee hosting districts of Uganda?,The main objective of the study is to provide information to stakeholders and incentivize future studies on the extent to which children are school ready in the final year of pre-primary education, what factors affect higher or lower learning outcomes and how to adapt support to ECE centres to improve learning for all children.,
Kenya 2024-10-08 17:46:20 2027-10-08 Social Science and Humanities Non-Clinical Trial Non-degree Award
Wilfred Opobo
ID:
APPROPRIATENESS OF MALARIA CONTROL POLICY AND FACTORS ASSOCIATED WITH PUBLIC COMPLIANCE IN GULU DISTRICT, UGANDA. A QUALITATIVE STUDY
REFNo: SS3130ES

General objective of the study.
• To examine the factors that influence citizens’ compliance with malaria control policy guidelines in Uganda.

Specific objectives of the study.
• To explore how lay perceptions and understandings of malaria control and prevention measures influence citizens’ compliance with malaria control policy.
• To examine the effectiveness of the national information, education, and communication strategies used to promote citizens’ compliance with malaria control policy guidelines.
• To assess the effectiveness of the district malaria governance structures in promoting citizens’ compliance with malaria control policy guidelines.

Uganda 2024-10-08 17:44:59 2027-10-08 Social Science and Humanities Clinical Trial Degree Award
Eric Jjemba
ID: UNCST-2024-R004780
Uganda Ethnic Dance Pedagogy in Higher Institution of Learning: Transformation and Formalization
REFNo: SS2433ES

1. To examine how Ugandan ethnic dance forms are taught and learned at university levels of education.
2. To explore teachers' and learners' perceptions about Ugandan ethnic dance teaching and learning at university levels of education.
3. To design a standardized teaching manual for Ugandan ethnic dance teaching and learning at university levels of education.
4. To establish the pedagogical transformation of Ugandan ethnic dance at university level
of education.
5. To formalize Ugandan ethnic dance teaching and learning at higher institutions of learning.
Uganda 2024-10-08 17:42:36 2027-10-08 Social Science and Humanities Non-Clinical Trial Degree Award
Andrew Kazibwe
ID: UNCST-2024-R004007
Baseline Survey (Evaluation) for health facility performance, project beneficiary knowledge, health facility readiness, and enablers for the Triple Elimination Project (TEP) - in Acholi and Teso regions of Uganda
REFNo: HS4414ES

6. To examine the pathways to accessing TEP services at different health facilities,5. To describe the facilitators and barriers to uptake of the package of services for TEP among pregnant, breastfeeding women, and their sexual partners ,4. To explore the facilitators and barriers to provision of the package of services for TEP among health service providers ,3. To establish the percentage readiness of target health facilities to deliver a package of health services for TEP,2. To measure the median knowledge score among health service providers (facility health workers and community health workers), district leaders, and; pregnant, breastfeeding women, and their sexual partners on prevention of vertical transmission of HIV, Hepatitis B infection and syphilis,1. To determine the pre-intervention (1st April 2023 – 31st March 2024) health facility performance against TEP indicators in the target health facilities ,The purpose of this survey is to establish baseline performance on TEP outcomes and receive stakeholder input in project design,
Uganda 2024-10-08 17:38:26 2027-10-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Irene  Wobusobozi
ID:
UTILIZATION OF LABORATORY TESTS TO GUIDE ANTIBIOTIC PRESCRIPTION: A CASE STUDY OF MUKONO GENERAL HOSPITAL
REFNo: HS4785ES

1. To determine the proportion of patients for whom biomarker tests were done. 2. To determine the proportion of patients with antibiotic prescriptions based on biomarker test results 3. To assess the turnaround time for the processing and referring microbial samples 4. To explore the barriers and facilitators of using laboratory tests to guide antibiotic prescription in Mukono Hospital. ,
Uganda 2024-10-08 17:36:15 2027-10-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Deogratias Yiga
ID:
EXTERNAL LEARNING REVIEW OF CHILD SAFEGUARDING WORK SUPPORTED BY PORTICUS AFRICA
REFNo: SS3070ES

i. Assess the progress made by partner organisations towards institutionalizing child safeguarding within their systems (Effectiveness)
ii. Examine the extent to which the activities under all three Porticus challenges in the Faith sector have strengthened each other toward institutionalizing child safeguarding in partner organisations (Coherence).

Uganda 2024-10-08 17:33:06 2027-10-08 Social Science and Humanities Non-Clinical Trial Non-degree Award
TEBAJANGA JOHN
ID: UNCST-2024-R003694
prevalence of kidney dysfunction and associated factors among rheumatic heart disease patients in Uganda
REFNo: HS4868ES

General objective; To determine the prevalence of kidney dysfunction and associated factors among rheumatic heart disease patients in Uganda
specific objective 1; To determine the prevalence of kidney dysfunction among rheumatic heart disease patients in Uganda
specific objective 2; To determine factors associated with kidney dysfunction among rheumatic heart disease in Uganda
Uganda 2024-10-08 17:29:31 2027-10-08 Medical and Health Sciences Non-Clinical Trial Degree Award
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