Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Namajja Ketty
ID:
Quality assurance and quality control for ethical practice in clinical research conducted in southwestern Uganda
REFNo: SS2263ES

To assess the quality assurance measures employed in clinical research in Southwestern Uganda. To establish quality control procedures used by clinical researchers in Southwestern Uganda. To determine the level of adherence and factors influencing adherence to ethical practices among clinical researchers of Southwestern Uganda
 Uganda 2024-01-29 15:09:58 2027-01-29 Social Science and Humanities Non-Clinical Trial Degree Award
Andrew Mujugira
ID: UNCST-2019-R000871
 Discrete choice experiment to guide HIV prevention counseling with novel HIV prevention products
REFNo: HS3665ES

To determine preferences for attributes of HIV prevention counseling that would support young women in Uganda to initiate and sustain use of a PrEP product.
 Uganda 2024-01-29 14:58:57 2027-01-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jacob Negrey Douglas
ID:
Multisystem aging patterns in chimpanzees (Pan troglodytes schweinfurthii) living at Ngogo, Kibale National Park, Uganda
REFNo: NS727ES

To better understand the biological and ecological forces that shape primate aging, we will assess both longitudinal and cross-sectional, age-related patterns of social, physiological, and physical variation in adult chimpanzees of the notably long-lived groups at Ngogo, Kibale National Park, Uganda. This project will integrate behavioral, genetic, endocrinological, immunological, and microbial data collected from wild chimpanzees. We will combine tried-and-tried observational and laboratory analyses with innovative, noninvasive omics-based approaches to studying physiological function. The proposed research will elucidate the advantages and limitations of wild chimpanzees as models of human health and aging and build an extensive multisystem dataset for future comparative chimpanzee research. The three primary goals of this research are outlined below: 1) Characterize cross-sectional and longitudinal aging trajectories across functional domains. How do functional domains vary in the timing and rate of age-related decline? Do some systems (e.g., physical function, immune function) exhibit later onset and/or slower rates of decline than do others? 2) Determine the extent of sex biases in aging trajectories in Ngogo chimpanzees. Given that female chimpanzees at Ngogo have greater life expectancies at birth than do males [25], do female chimpanzees also show slower or delayed rates of aging across most / all functional domains? Are aging effects more pronounced in some functional domains than others, and if so, which domains show greater sex biases? 3) Develop methods to noninvasively study chimpanzee aging. Given that the study of wild chimpanzees is strictly noninvasive, we will continue to develop, validate, and implement new methods for studying aging across a range of functional domains. Notably, we will continue to refine the use of video recordings to measure walking speeds, which are an invaluable measure of physical function in humans and nonhuman primates alike [32, 33]. We will develop new urinary biomarkers for use in wild chimpanzee studies including biomarkers of neurodegeneration (e.g., Alzheimer’s-associated neuronal thread protein) and physical function (e.g., urinary pentosidine). Finally, we will validate and implement the study of genetic material from chimpanzee saliva samples, including bacterial and epigenetic information, by collecting and subsequently analyzing chimpanzee saliva samples onsite at Ngogo using transportable sequencing equipment (MinION Mk1C sequencer, Oxford Nanopore Technologies, Oxford, UK).
 USA 2024-01-29 14:57:37 2027-01-29 Natural Sciences Non-Clinical Trial Non-degree Award
joel lwasa njagala calls
ID: UNCST-2023-R006315
 ASSESSING THE IMPACT OF MEDICAL INTERNS ON HEALTHCARE DELIVERY AT KAWEMPE NATIONAL REFERRAL HOSPITAL
REFNo: SS2306ES

1.To compare hospital metrics at Kawempe National Referral Hospital when medical interns were present and when they were absent.
2.To compare patient outcomes at Kawempe National Referral Hospital when medical interns were present and when they were absent.
 Uganda 2024-01-29 14:56:29 2027-01-29 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jacqueline Kanywa Balungi
ID:
HPV Vaccine Survey: Determining reasons as to why girls have or have not received the HPV vaccine who attend the clinic at the Baylor Uganda center of excellence.
REFNo: HS3620ES

Primary objective:
To determine reasons as to why 10- to 18-year-old girls receiving health care services at the Baylor Uganda center of excellence have or have not received the HPV vaccine using a short survey during a study period of September 1, 2023 to December 31, 2023.

Long-term goal: To use the responses of this survey to develop educational and clinical counseling programs for increasing the uptake of the HPV vaccine among 9–13-year-old girls at the Baylor Uganda clinical center of excellence.

 Uganda 2024-01-29 14:03:23 2027-01-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Hillary Kuteesa
ID:
PROFILES, REFERRAL PATHWAYS AND REASONS FOR REFERRAL FOR PATIENTS ADMITTED TO BUTABIKA NATIONAL REFERRAL MENTAL HOSPITAL.
REFNo: HS3412ES

1. To describe the socio-demographic characteristics of patients admitted to BNRH
2. To describe the referral pathways of patients admitted to BNRH
3. To describe the reasons for referral to BNRH

 Uganda 2024-01-25 18:41:36 2027-01-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Christine Nabirye
ID:
Hand hygiene interventions in Kampala's informal settlements: public health imaginaries local health realities.
REFNo: SS2188ES

1. To trace and characterise the framing of hand hygiene messaging by public health actors in Uganda since 1980.
2. To explore and describe the factors that maintain the preference for hand hygiene messaging among public health actors in Uganda.
3. To understand and compare the lived experiences informal settlement residents with the factors that maintain the preference for hand hygiene messaging by public health actors.

 Uganda 2024-01-25 18:40:37 2027-01-25 Social Science and Humanities Non-Clinical Trial Degree Award
Juliet Kyayesimira
ID:
Development of Governor’s Plum (Flacourtia indica) Herbal Formulation for the Management of Microbial Infections in Humans
REFNo: NS661ES

4. To determine the appropriate propagation method and conditions for domestication and conservation of F. indica,3. To evaluate the efficacy of formulated prototypes Flacourtia indica extracts for the management of microbial infections,2. To quantify the major phytochemicals of medicinal value in methanolic extracts of F. indica,1. To assess the indigenous uses, genetic diversity and habitat range of Flacourtia Spp. in Uganda,
 Uganda 2024-01-25 18:38:49 2027-01-25 Natural Sciences Non-Clinical Trial Non-degree Award
Nixon Niyonzima
ID: UNCST-2020-R014577
 Utility of a Liquid Biopsy in the Detection of Metastatic Breast Cancer in Uganda
REFNo: HS3277ES

To determine whether ctDNA can be used as a sensitive and specific measure of tumor burden and response to therapy among women with breast cancer undergoing treatment at UCI,To evaluate the feasibility, sensitivity, and specificity of the liquid biopsy, via ctDNA, to detect and quantify tumor-specific molecular characteristics in patients with metastatic breast cancer at UCI,
 Uganda 2024-01-25 18:37:59 2027-01-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bosco Buruga Apparatus
ID:
Use of information and communication technologies by farmers to enhance the management of agricultural knowledge and information in West Nile Sub-Region of Uganda
REFNo: SS2084ES

Propose an ICT model for enhancing the management of agricultural and knowledge in developing countries using a case of West Nile sub-region, Uganda.,Identify the effects of challenges farmers face in the use of these ICTs for the management of agricultural knowledge.,Determine the challenges faced by farmers in the use of ICT in enhancing the management of agricultural knowledge.,Examine the factors influencing farmers in adopting and using ICTs for enhancing the management of agricultural knowledge in the West Nile sub-region, Uganda.,Find out agricultural stakeholders’ perception of the use of ICT in the management of agricultural knowledge.,Establish the status of managing agricultural knowledge management processes in the West Nile sub-region.,The purpose of the study is to investigate ways in which ICTs can be used to enhance the management of agricultural knowledge in West Nile sub-region of Uganda and to further propose a model to be adopted for enhancing access to agricultural knowledge by stakeholders. ,
 Uganda 2024-01-25 18:35:59 2027-01-25 Social Science and Humanities Non-Clinical Trial Degree Award
Agnes Kabajuni
ID:
Researching Green Activism: How to better protect minority and indigenous communities, Civil Society Organisations, Networks, and climate Change Defenders in East Africa
REFNo: SS2032ES

Overall Objective: to create an enabling environment for climate change defenders from the ethnic minorities and indigenous peoples to play their role in pushing for responsive climate actions, hold governments accountable and protection of communities adversely affected by climate change impacts in Kenya, Tanzania and Uganda
Specific Objectives: a) Generate knowledge by collecting evidence that leads to a deeper understanding of key stakeholders of the challenges faced by environmental activists from the ethnic and indigenous minorities and traditional knowledge as climate change mitigation strategies.
b) Equip environmental activists from MIPs with knowledge/ideas on how to develop successful strategies to mitigate the challenges they face as part of their work and how to meaningfully blend gender and social inclusion in their work.
c) Promote greater collaboration, cross exchange and learning between duty bearers, civil society movements for inclusive decision-making processes.

Uganda 2024-01-25 18:32:52 2027-01-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
Susan  Nabadda
ID: UNCST-2020-R014331
 Field Pilot Study for Histoplasmosis and Aspergillosis testing among patients with Advanced HIV Disease in Uganda.
REFNo: HS2803ES

To determine the integration needs of the Clarus Histoplasma Galactomannan Enzyme Immuno Assay (HGM201) and Sōna Aspergillus Galactomannan Lateral Flow Assay (AGM LFA) in the routine screening, testing and management processes for AHD patients in Uganda. To assess the operational characteristics such as usability and acceptability of the Sōna Aspergillus Galactomannan Lateral Flow Assay (AGM LFA) in the public health context. To assess the operational characteristics such as usability and acceptability of the Clarus Histoplasma Galactomannan Enzyme Immuno Assay (HGM201) in the public health context. To determine the prevalence of invasive aspergillosis in Advanced HIV Disease patients in Uganda. To determine the prevalence of disseminated histoplasmosis in Advanced HIV Disease patients in Uganda.
 Uganda 2024-01-25 18:23:34 2027-01-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
EDITH  NAKKU-JOLOBA NAKKU
ID: UNCST-2021-R013931
 Point of Care (POC) based Interventions to Improve sexual partner testing and tracking for Chlamydia Trachomatis (CT) and Neisseria Gonorrhoea (NG) in Kampala metropolitan STD clinics (POC-PIKAM STUDY)
REFNo: HS1448ES

To estimate the prevalence of commonly occurring causal organisms for genital discharge in men and women (N. gonorrhea and C. trachomatis T. Vaginalis and Gardnerella) infections in men and women attending outpatient clinics in Kampala using molecular diagnostic tests (Xpert) and other point of care tests,To assess the feasibility and reliability of participant self-collection for POC CT/NG tests (Xpert and Binx io CT/NG tests) and evaluate accuracy of the Binx io CT/NG Test against clinician provider and the Laboratory gold standard among persons presenting with genital discharge attending outpatient clinics in Kampala metropolitan .,To describe the perceptions and practices of persons regarding self-collection and self-testing for STD, and STD partner notification among persons with genital discharge attending outpatient STD clinics in Kampala, Uganda.,To evaluate the use of self-collection and self-testing of swabs in increasing the proportion of individuals and partners that get tested and treated for STI among persons presenting with genital discharge attending outpatient clinics in Kampala, Uganda. ,Our overall goal is to evaluate the effect of an intervention that includes; self-collection and partner notification on the proportion of partners of persons with vaginal and urethral discharge who return to the clinic for partner follow up and treatment at outpatient clinics in Kampala district and on management of NG and CT in this population.,
 Uganda 2024-01-25 18:21:26 2027-01-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
HARRIET NABIRYE
ID: UNCST-2023-R006463
 Adoption, Compliance and Effectiveness of MOH-Recommended Biosafety Practices and Guidelines at Public Health Laboratories in Central Uganda: A Cross-Sectional Survey.
REFNo: HS3437ES

1. To evaluate the adoption and compliance of MoH recommended biosafety practices and guidelines at PHLs in Central Uganda

2. To evaluate the effectiveness of MoH recommended biosafety practices and guidelines at Public Health Laboratories (PHLs) in Central Uganda

 Uganda 2024-01-25 18:19:01 2027-01-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Catherine Atuhaire
ID: UNCST-2021-R013090
 Perceived Maternal Social Support and Perinatal Depression among women in Public health facilities, Mbarara district, south western Uganda (PEMPED)
REFNo: HS3525ES

Aim 1: To determine the prevalence of antepartum depression and its associated factors among pregnant women in latent labor in Mbarara district, south western Uganda

Aim 2: To determine the prevalence of maternity blues at six hours and six days postpartum and its associated factors among mothers in Mbarara district, south western Uganda

Aim 3: To examine the association between perceived maternal social support and postpartum depression among mothers in Mbarara district, south western Uganda

Aim 4: To explore perceived psychosocial support practices, types and preferences by postpartum mothers in Mbarara district, south western Uganda

 Uganda 2024-01-25 18:14:54 2027-01-25 Medical and Health Sciences Non-Clinical Trial Degree Award
Fanny Fauli Laessoee
ID:
Agrarian Change – How traditional agricultural knowledge and narratives of the future influence agricultural adaptation to climate change amongst smallholders in Acholiland, Northern Uganda
REFNo: A383ES

3. To explore how narratives of the future influence changing agricultural practices, 2. To examine the role of Traditional Agricultural Knowledge in agrarian change, 1. To identify how small-scale farming practices have changed over time Overall research objective: How are traditional agricultural knowledge and Narratives of the future influencing agricultural adaptation to climate change amongst smallholders in Acholiland, Northern Uganda? ,
 Denmark 2024-01-25 18:13:00 2027-01-25 Agricultural Sciences Non-Clinical Trial Degree Award
Kamada Lwere
ID: UNCST-2022-R009359
 THE RECRUITMENT AND RETENTION OF ALZHEIMER’S DISEASE DIVERSITY GENETIC COHORTS IN THE ALZHEIMER’S DISEASE SEQUENCING PROJECT(READD-ADSP)
REFNo: HS3097ES

Perform genomic analyses,Management of all phenotype, genomic and biomarker data. ,Process, store, and assay biomaterials for the genomics resource including DNA isolation, plasma, and RNA for future gene expression studies,Adjudication and Harmonization of clinical and neurocognitive data,Develop a large genomics resource for the study of AD in individuals with AF and HL ancestry,The overall goal of this proposal is to build a resource that greatly expands the presentation of currently underrepresented African ancestry (African American (AA) and Africans (AF)) and Hispanic/Latinx (HL) individuals in AD genetic studies.,
 Uganda 2024-01-25 18:00:36 2027-01-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Nixon Niyonzima
ID: UNCST-2020-R014577
 Feasibility Assessment of a Comprehensive Treatment Approach for Advanced Breast Cancer using Innovative Cancer Medicines in a Low Resource Setting in Uganda.
REFNo: HS3006ES

a. Primary objectives
The primary objectives of the study are to:

I. To measure the number of patients, out of those who are eligible, who are willing to begin immunotherapy within the recruitment period if perceived barriers are removed
II. To determine the proportion of patients who drop out over the duration of the study period

b. Secondary objectives
I. To describe the incidence of adverse events in patients on immunotherapies
II. To elucidate reasons for discontinuation of patients on immunotherapy treatment
III. To determine the factors associated with the acceptability of patients and healthcare workers for immunotherapy
IV. To describe the quality of life of breast cancer patients on immunotherapy

Uganda 2024-01-25 17:55:55 2027-01-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JAMES  KAYIMA
ID:
The development and testing of a low-cost mHealth intervention to improve blood pressure control in Uganda
REFNo: HS3060ES

1) To assess the level of BP control among ambulatory patients attending the hypertension clinic at Kiruddu National Referral Hospital.
2) To explore the perspectives of patients and providers on the acceptability of a mHealth (mobile app) and enhanced self-care strategy and elicit preferred features of a mHealth strategy for BP control.
3) To develop a mobile app for low-cost phones applying a user-centered design process among patients and providers at Kiruddu National Referral Hospital for control of blood pressure.
4) To assess the feasibility of using the m-health app among patients, community health care workers, and clinicians in Kiruddu National Referral Hospital, focusing on acceptability, practicality, demand, adaptation, and pilot the efficacy of the intervention on BP control.

 Uganda 2024-01-25 17:52:25 2027-01-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Edward Mokooza Kibikyo
ID: UNCST-2020-R014923
 PREVALENCE AND DETERMINANTS OF SUBSTANCE USE AMONG UNDERGRADUATE STUDENTS AT THE UGANDA CHRISTIAN UNIVERSITY
REFNo: HS3577ES

1. To describe the current model of substance use care and assistance for UCU students.

2. To measure the point prevalence of substance use among undergraduate students at UCU main campus in the January/May semester of 2024.

3. To determine the effect of faith (knowing), religion (doing) and spirituality (Being) on substance use among UCU students

 Uganda 2024-01-25 17:43:59 2027-01-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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