Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Nicholus Nanyeenya
ID:
Infection Prevention and Control (IPC): Profiling, Barriers, Facilitators and Effectiveness of an IPC Community-of-Practice in Central Uganda
REFNo: HS4570ES

The objectives are to;
a) Characterize the uptake of IPC measures in selected health facilities in Central Uganda
b) Explore the facilitators and barriers to the uptake of IPC measures in selected health facilities in Central Uganda
c) Determine the effectiveness of an IPC community-of-practice, using peer-to-peer mentorships in enhancing the uptake of IPC measures in Central Uganda.

Uganda 2024-07-22 12:12:29 2027-07-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Grace Kisitu Paul
ID: UNCST-2024-R004102
UNIVERSAL1: Pharmacokinetic study of an optimized dose ratio of dolutegravir/emtricitabine/tenofovir alafenamide fumarate: expediting a UNIVERSAL first line regimen for all children living with HIV in Africa
REFNo: HS4280ES

Primary objective:
To evaluate the pharmacokinetics and short-term safety of DTG and FTC/TAF administered to children living with HIV using a novel dose ratio

Secondary objective:
To evaluate the short-term efficacy of DTG and FTC/TAF
formulations in children using a novel dose ratio

Uganda 2024-07-19 3:45:20 2027-07-19 Medical and Health Sciences Clinical Trial Non-degree Award
Janet Nakigudde
ID: UNCST-2019-R000444
PROMOTING MENTAL HEALTH OF TEACHERS AND CAREGIVERS USING A PERSONALIZED MHEALTH TOOLKIT IN UGANDA
REFNo: HS4431ES

3. To examine feasibility of mWEL-T and mWEL-P with parents and teachers from urban and rural regions (including examining feasibility of the implementation procedures and intervention efficacy) (n=160, 80 parents and 80 teachers from urban and rural regions).,To conduct a user-centered testing study to optimize usability of the Teacher and Parent versions of mWEL- mWEL-T and mWEL-P,1. To build a school system capacity (by establishing a cross-discipline digital health leadership & learning collaborative (n=10) and training a group of peer-community health workers (P-CHW) (n=30; 15 peer teachers and 15 peer parents) to implement the mWEL that is developed,The aim of the study is to test mWEL a newly developed mobile app and user-engagement strategies for mental health management and promotion targeting teachers and parents,
Uganda 2024-07-17 14:03:01 2027-07-17 Medical and Health Sciences Clinical Trial Non-degree Award
Emmanuel Musisi
ID: UNCST-2020-R004472
Assessing feasibility, acceptability and utility of Tuberculosis-Molecular Bacterial Load Assay for monitoring TB treatment in three HIV clinics in Kampala
REFNo: HS4475ES

iii. To innovate and describe a shortened RNA extraction protocol that will contribute to the reduction of the overall turn-around time of the TB-MBLA. This objective will support Ms. Kasinga Sharifah’s MSc in Molecular Biology at Makerere University. ,ii. Acquire knowledge about the adoptability, acceptability, feasibility, compatibility, satisfaction, and complexity of including TB-MBLA in routine TB care. This will be achieved through conducting end-of-study key informant interviews (KIIs), focus group discussions (FGDs), and surveys.,i. Understanding the baseline issues regarding the pathway to healthcare access, prior use of antibiotics and/or previous TB treatment, and socioeconomic status. This will be achieved by conducting a structured questionnaire study at different medical clinics around Kampala.,The overall objective of this study is to assess the feasibility, acceptability, and utility of the Tuberculosis-Molecular Bacterial Load Assay for monitoring TB treatment in three HIV clinics in Kampala and evaluate approaches that will reduce the turnaround time of the TB-MBLA assay.,
Uganda 2024-07-17 13:59:42 2027-07-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
NAMYENYA NAKITYO MARIAM
ID:
SELF-MANAGEMENT PRACTICES AND GLYCEMIC STATUS OF TYPE 2 DIABETES MELLITUS ADULT OUTPATIENTS ATTENDING THE DIABETES CLINIC AT KIRUDDU NATIONAL REFERRAL HOSPITAL
REFNo: HS4456ES

To determine the predictors of glycemic status among T2DM adult outpatients attending the diabetes clinic at KNRH.,To establish the relationship between self-management practices and glycemic status of T2DM adult outpatients attending the diabetes clinic at KNRH.,To evaluate the self-management practices of T2DM adult outpatients attending the diabetes clinic at KNRH.,To assess the glycemic status of T2DM adult outpatients attending the diabetes clinic at KNRH.,To investigate the self-management practices and the glycemic status of T2DM adult outpatients attending the diabetes clinic at KNRH.,
Uganda 2024-07-17 13:49:23 2027-07-17 Medical and Health Sciences Non-Clinical Trial Degree Award
Leo Okoya
ID: UNCST-2024-R004171
Socio-ecological and cultural factors in the use of pesticides in Smallholder Agri-food system in Koch Goma Sub- County, Northern Uganda
REFNo: SS2759ES

General Objective
- To examine the social, cultural and ecological factors in the use of pesticides in smallholder agrifood systems and its effects on humans and the environment
Specific objectives
1.To examine how tomato production positioned within smallholder agrifood production systems in Koch Goma Sub-County.
2.To assess the community perceptions of traditional pest and disease management practices vis a vis the current practices in tomato production in Koch Goma sub-county
3.To explore the discourses and knowledge circulating about the socio-ecological effects of pesticides in tomato production in Koch Goma Sub- County.
4.To examine the social lives of selected pesticides used in tomato production in Koch Goma Sub- County.

Uganda 2024-07-17 13:46:53 2027-07-17 Social Science and Humanities Non-Clinical Trial Degree Award
Moses Nasinyama Makoha
ID:
Approaches to Knowledge Translation and Management for Public Revenue Mobilization in Pallisa District, Uganda
REFNo: SS2709ES

Purpose of the study
To examine how approaches of Knowledge Translation support the management for Public Revenue Mobilization in Pallisa District, Uganda.

1.3.1 Objectives of the Study
The specific objectives of the study are to:
1. Assess the nature and methods (both local and modern) used for knowledge development to support the management for PRM in Pallisa.
2. Analyze the process and methods used in knowledge development to accelerate innovation in public revenue knowledge design in Pallisa.
3. Assess the institutional structures in place to support public revenue knowledge transfer in Pallisa.
4. Explore the role of key stakeholders in public revenue knowledge generation and management in Pallisa.


Uganda 2024-07-17 12:42:18 2027-07-17 Social Science and Humanities Non-Clinical Trial Degree Award
Julius Ssendiwala
ID:
Evaluation of the National PMTCT Group Antenatal Care/ Postnatal Care Differentiated Service Delivery model: Uganda 2021-2023
REFNo: SS2873ES

To estimate the cost of delivering the G-ANC/PNC DSD model of care as part of MCH service delivery for PBF AGYW and their infants by health facility level,To determine the acceptability, enablers and barriers of implementing the G-ANC/PNC model of care for PBF AGYW and their infants.,To determine the effectiveness of G-ANC/PNC DSD model of care on maternal and infant health outcomes across the continuum of care for mother-infant pairs, including retention rates.,To assess the uptake of G-ANC/PNC DSD model of care among PBF AGYWs,To measure the uptake, effectiveness and cost of the G-ANC/PNC DSD model of care for PBF AGYW and their infants for program improvement.,
Uganda 2024-07-17 12:07:59 2027-07-17 Social Science and Humanities Non-Clinical Trial Non-degree Award
Philip Rwezawula
ID: UNCST-2024-R003279
Probiotics and Bacteriophages as Biocontrol Agents of Motile Aeromonad Septicaemia in Nile Tilapia: A Holistic Approach to Disease Management in Aquaculture
REFNo: A451ES

To evaluate the synergistic effects of combining lytic phages with local probiotic Bacillus spp. on the growth performance and survival rates of Nile tilapia in the field under conditions of Aeromonas hydrophila exposure ,To evaluate the synergistic effects of combining lytic phages and local probiotic Bacillus spp. under lab conditions to prevent and/or cure MAS in Nile tilapia,To verify the potential of local lytic bacteriophages and probiotic Bacillus spp. to prevent or mitigate Motile Aeromonad Septicaemia (MAS) in farmed Nile tilapia under lab conditions,Isolation and characterization of local probiotic Bacillus spp. and local lytic bacteriophages,to assess the potential of bacteriophages and probiotics as biocontrol agents of Motile Aeromonad Septicaemia (MAS) in farmed Nile tilapia (Oreochromis niloticus). ,
Uganda 2024-07-17 12:06:50 2027-07-17 Agricultural Sciences Non-Clinical Trial Degree Award
Faith Nawagi
ID: UNCST-2021-R013751
AFREhealth-FAIMER Interprofessional Education Student Exchange Program Evaluation Plan.
REFNo: HS4461ES

The AFREhealth-FAIMER IPE program evaluation aims to assess the key process factors required for implementation of an IPE elective program, impact and the outcomes of the program at the student, faculty, institutional, and AFREhealth Network levels.,4. To document the key process factors of developing and implementing the AFREhealth-FAIMER IPE elective program. ,3. To identify the outcomes of the AFREhealth–FAIMER IPE elective program on the participating institutions and AFREhealth as an organization at large.,2. To evaluate the participating faculty, students, program managers, institutional leaders, and AFREhealth leaders’ perspectives on the AFREhealth-FAIMER IPE elective program curriculum. ,1. To establish the IPECP skills gained by the students participating in the AFREhealth-FAIMER IPE elective program. ,
Uganda 2024-07-17 12:04:18 2027-07-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Anxious   Niwaha Jackson.
ID: UNCST-2023-R008010
Patho-physiologic and metabolic characterisation of Lean Diabetes in Uganda (LEAN-D study)
REFNo: HS4533ES

1. To establish the principal cause of hyperglycemia in lean SSA diabetes. (Hyperglycemia is high blood sugar)
2. To determine the association between biomarkers of beta cell function, and body composition and lean type 2 diabetes.
3. To establish if Persistent Organic Pollutants are present in sufficient levels in individuals with lean SSA diabetes to contribute to the process of developing diabetes.
4. To translate knowledge products into formats that are accessible and usable by key stake holders to enhance lean diabetes diagnosis, and inform policy and intervention strategies.

Uganda 2024-07-15 8:24:33 2027-07-15 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Allan Kalungi
ID: UNCST-2022-R009843
Genetic, Biological and Psychosocial predictors of Incident and Persistent Internalizing Mental Disorders among Ugandan Children and Adolescents living with HIV: A Machine Learning Approach.
REFNo: HS4521ES

1. To build a machine learning model for prediction of prevalent, incident, and persistent cases of Internalizing Mental Disorders among Ugandan children and adolescents living with HIV.
2. To evaluate the performance of the machine learning model (developed in 1 above) based on each of genetic, biological, and psychosocial factors respectively.
3. To evaluate the performance of the machine learning model based on the combination all the three factor domains of genetic, biological, and psychosocial factors.

Uganda 2024-07-15 8:22:11 2027-07-15 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sheila Balinda Nina
ID: UNCST-2021-R013804
Advancing Vaccine Development: Harnessing Multiple Antigenic Epitopes for Crimean-Congo Hemorrhagic Fever in Humans and Animals
REFNo: HS4493ES

Overall objective To develop and evaluate an adenovector CCHFV vaccine candidate. Sub-study general objectives i) To design the CCHFV immunogens and construct an adenovector CCHF vaccine candidate by conjugating the immunogens into the adenovector backbone. ii) To conduct preclinical studies of the CCHF vaccine in mice and non-human primates (animal models). iii) To translate knowledge products into formats that are accessible and usable by key stakeholders to enhance CCHF vaccine discovery and scale up.
Uganda 2024-07-15 8:16:36 2027-07-15 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jolly  Kamugisha G.K.
ID: UNCST-2023-R005715
Evaluation of The Early Childhood Nutrition Programme In The Karamoja Region, Uganda. RefNo: JCRC-2024-78:
REFNo: HS4490ES

To assess ECD centre readiness to implement integrated early childhood nutrition interventions in order to inform programming that fosters early childhood development in the Karamoja regionTo determine the early childhood developmental status of children aged 0-24 months in the Karamoja region. To determine the contextual barriers and facilitators to implementation of comprehensive nutrition interventions in ECD centres and their catchment communities in the Karamoja region To determine the effect of comprehensive early childhood nutrition interventions on Early Childhood Developmental status among children aged 24-59 months in the Karamoja region
Uganda 2024-07-12 14:50:24 2027-07-12 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Mamerito Nturanabo
ID: UNCST-2024-R004377
Social Equity Interventions and Maternal health outcomes in Bugiri District, Eastern Uganda
REFNo: SS2781ES

To establish the effect of legislation on the maternal Health in Bugiri District, Eastern Uganda,To establish the civic education effect on maternal health in Bugiri District, Eastern Uganda.,To establish Health provision effect on maternal health in Bugiri District, Eastern Uganda,To assess the relationship between social equity interventions and maternal health outcomes in Bugiri District, Eastern Uganda.,
Uganda 2024-07-10 13:41:35 2027-07-10 Social Science and Humanities Non-Clinical Trial Degree Award
Shamirah Najjinda
ID:
Family support, entrepreneurial resources, resilience and entrepreneurial wellbeing of women entrepreneurs in the hospitality and tourism industry of Uganda
REFNo: SS2842ES

To determine the levels of understanding of entrepreneurial wellbeing by women entrepreneurs in Uganda.To establish the relationship between family support and entrepreneurial wellbeing of women entrepreneurs in the hospitality and tourism industry of Uganda.To examine the relationship between entrepreneurial resources and entrepreneurial wellbeing of women entrepreneurs in the hospitality and tourism industry of Uganda.To explore the influence of entrepreneurial resilience on the entrepreneurial wellbeing of women entrepreneurs in the hospitality and tourism industry of Uganda.
Uganda 2024-07-10 13:40:22 2027-07-10 Social Science and Humanities Non-Clinical Trial Degree Award
Lucas Ampaire
ID:
DIGITIZED CBC RESULTS TRANSMISSION TO SHORTEN TURN AROUND TIME AT MBARARA REGIONAL REFERRAL HOSPITAL (dCRT STUDY)
REFNo: HS4264ES

To design a mobile app as an intervention to shorten delay for CBC results transmission from the Mbarara Regional referral hospital Laboratory to the requesting clinician,To determine the perceived contributing factors to CBC results delay at Mbarara regional referral Hospital,To establish the prevalence of CBC results delays at Mbarara regional referral Hospital:,
Uganda 2024-07-10 13:38:14 2027-07-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Patricia Nabwami Esther
ID:
Evaluating the Health Systems Preparedness for Ebola Virus Disease outbreak in Mubende and Kassanda Districts in Uganda
REFNo: SS2828ES

3. To establish the existing capacities for management of EVD outbreaks containment at the local health facilities. ,To determine the status of stock piling levels for Ebola Virus Disease in health facilities.,1. To establish the level of preparedness among health care workers’ for containment of Ebola Virus Disease.,To evaluate the preparedness levels of health system for Ebola outbreak response in Mubende and Kassanda Districts in Uganda. ,
Uganda 2024-07-10 13:37:12 2027-07-10 Social Science and Humanities Non-Clinical Trial Degree Award
Ellen Forsman Larsson
ID:
“Have you been saved?” Ecstatic exorcism as therapeutic healing
REFNo: SS2494ES

This project focuses on the Balokole church, aiming to produce an ethnographic analysis of the movement. The purpose of this research is to understand how the movement interacts with global Christianity while simultaneously inflecting local practices. In particular, It will look at the types of worship undertaken in the church, and how they are experienced within the congregation. The members of this movement commonly experience so-called ‘deliverances’ - where congregants are exorcised and cleansed of demons and evil spirits. Those who undergo deliverances tell of its healing effects. The ultimate aim of the project is to understand what deliverance is, and what happens to a person when they undergo it. It will also explore the personal transformation that happens when a person is ‘born again’, to better understand the therapeutic effects which conversion, deliverance and other rituals can have.
Sweden 2024-07-10 13:35:12 2027-07-10 Social Science and Humanities Non-Clinical Trial Degree Award
Jonathan Kitonsa
ID:
Assessing the knowledge, perceptions, and uptake of HPV vaccine and evaluation of vaccine delivery strategies among non-school-going girls in southwestern Uganda
REFNo: HS4559ES

Quantitative study objectives 1. To assess knowledge, attitudes, and perceptions about the HPV vaccine among non-school going girls between 9 and 20 years. 2. To determine HPV uptake, willingness, and barriers to use HPV vaccines among nonschool going girls between 9 and 20 years. 3. To determine favourable vaccine delivery strategies for non-school going girls. Qualitative study objectives 1. To explore the willingness and acceptability of taking up an HPV vaccine among nonschool going girls between 9 and 20 years. 2. To explore the knowledge, attitudes, and perceptions about HPV vaccine among nonschool going girls, parents/care givers, and healthcare providers. 3. To describe the facilitators and barriers to the uptake of HPV vaccine among non-school going girls, parents/care givers, and healthcare providers.
Uganda 2024-07-10 13:31:20 2027-07-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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