Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
AHEEBWA ROGGERS COLLINS
ID: UNCST-2025-R017036
Tax Policies And Financial Performance Of Small & Medium Enterprises (SMEs) in Uganda: A Case Of SMEs in Kabale District
REFNo: SS3844ES

i. To examine the effect of tax compliance costs on the financial performance of small and medium enterprises in Kabale district
ii. To examine the effect of tax incentives on the financial performance of small and medium enterprises in Kabale district.
iii. To examine the effect of tax rates on the financial performance of small scale and medium enterprises in Kabale district.


Uganda 2025-06-02 17:15:52 2028-06-02 Social Science and Humanities Non-Clinical Trial Degree Award
Kamya Moses
ID: UNCST-2020-R014203
A case-control study to assess the effectiveness and safety of the R21/matrix-M malaria vaccine
REFNo: HS6009ES

To assess the Vaccine Effectiveness (VE) of R21/Matrix-M vaccine against severe malaria caused by Plasmodium falciparum.

To assess the Vaccine Effectiveness (VE) of the R21/Matrix-M vaccine against clinical malaria in high-transmission perennial areas caused by Plasmodium falciparum.

To assess if the R21/Matrix-M vaccine recipients are at an increased risk of death (all-cause).
Uganda 2025-06-02 17:04:40 2028-06-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
PROTOCOL FOR THE PERFORMANCE EVALUATION OF ALINITY M HIV-1 ASSAY USING DRIED BLOOD SPOT SPECIMENS HIV VIRAL LOAD ASSAY FOR WHO PREQUALIFICATION ASSESSMENT
REFNo: HS6061ES

• To assess the Alinity m HIV-1 DBS assay’s agreement with a cobas HIV-1 Quantitative nucleic acid test for use on the cobas 6800/8800 Systems (Roche Diagnostics GmbH) on clinical specimens, including:
o Quantitative assessment of bias, limits of agreement and correlation
o Misclassification above or below the clinical threshold (1000 copies/mL)
• To assess the analytical performance of the Alinity m HIV-1 assay using DBS:
o Precision (repeatability and within-laboratory reproducibility)
o Linear range on the main subtypes
o Limit of detection
o Cross-contamination
• To describe the operational characteristics and ease of use of the Alinity m HIV-1 assay using DBS and its suitability for use in countries with limited infrastructure.

Uganda 2025-05-29 17:20:17 2028-05-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
STANDARDTM M10 HR-HPV: Evaluation of Clinical Performance and Usability in the hands of untrained users.
REFNo: HS6022ES

Demonstration of usability of the STANDARDTM M10 Hr-HPV assay. ,Demonstration of sample type equivalence for the STANDARDTM M10 Hr-HPV assay: ThinPrep® PreservCyt® Solution (Hologic) vs. BD SurePathTM Collection Vial (Becton, Dickinson and Company),Determination of the relative diagnostic sensitivity and specificity i.e. compared with the Roche Cobas HPV assay (used according to the current standard of care at the study site).,Determination of clinical accuracy i.e. absolute diagnostic sensitivity for CIN2+ and CIN3+ and absolute diagnostic specificity for ≤ CIN1.,To demonstrate the clinical performance of the STANDARDTM M10 Hr-HPV assay when used by healthcare professionals in a laboratory setting or health institution (i.e. intended use setting), the following objectives have been defined.,
Uganda 2025-05-29 17:19:03 2028-05-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Anatoli Mawanda
ID: UNCST-2024-R015927
GENETIC AND MOLECULAR DETERMINANTS OF BREAST CANCER DISPARITY AMONG AFRICAN, AFRICAN AMERICAN AND WHITE POPULATIONS
REFNo: HS6015ES

To study the genetic, molecular, and biological regulators of breast cancer in Ugandan
women and compare them with African American and white women.
Uganda 2025-05-29 17:17:31 2028-05-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Christabel Gero Anyango
ID: UNCST-2025-R017108
Perspectives of Child Domestic Workers and Their Employers: A Qualitative Study in Kampala, Uganda
REFNo: SS3860ES

• To establish patterns of entry into, exit out of and conditions of child domestic work in the Ugandan setting, including patterns that constitute human trafficking. Entry patterns will include decision making and influences to enter domestic work, while exit will encompass strategies used to transition to other work roles and the types of work roles entered following domestic work. • To understand employers’ perceptions of and views on child domestic workers, including reasons for recruiting younger workers, strategies to recruit CDWs, views on the benefits, drawbacks and development needs of younger workers, treatment and remuneration of CDWs, and awareness of laws and policies related to young workers, among others.
Kenya 2025-05-29 17:15:05 2028-05-29 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jeya Sushimitha Jawahar Kanth
ID: UNCST-2024-R016269
Evaluating the Impact of Social Media Influencers on Tobacco Use Among Urban Youth in Africa: A Comparative Mixed Methods Study Across Kampala, Nairobi, and Lagos
REFNo: SS3850ES

Main Objective
1. To explore and compare the role of social media influencers in shaping tobacco use behaviors among urban youth (ages 18-29) residing in Kampala, Nairobi, and Lagos by examining tobacco use prevalence, influencer messaging, and youth perspectives.
Specific Objectives
1. To determine the prevalence of tobacco use among urban youth (18-29 years) in Nairobi, Lagos, and Kampala.
2. To assess the relationship between exposure to influencer content and tobacco use behaviors among urban youth.
3. To analyze the content and reach of pro-tobacco messages shared by social media influencers among the target youth population.
4. To investigate urban youth perceptions of how influencers impact their decisions and attitudes toward tobacco use.
India 2025-05-29 17:14:22 2028-05-29 Social Science and Humanities Non-Clinical Trial Non-degree Award
Denis Nansera
ID: UNCST-2024-R004002
Improving HIV testing among Children under five in Rural Uganda
REFNo: HS5829ES

The main objective of this study is to develop a traditional healer facilitated paediatric HIV testing program to improve access to paediatric HIV testing. To do this, we will first use qualitative study methods to determine factors that influence HIV testing among paediatric clients of TH and guide adaptation of the TH-facilitated HIV testing program for children. We will then implement a pilot study to evaluate offering paediatric HIV testing at traditional healer locations in southwestern Uganda.
Uganda 2025-05-29 17:12:49 2028-05-29 Medical and Health Sciences Clinical Trial Non-degree Award
Nanyonga Elizabeth Monica
ID: UNCST-2025-R018232
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REFNo: SIR516ES

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Uganda 2025-05-27 9:30:38 2028-05-27 Engineering and Technology Clinical Trial Non-degree Award
Justine  Komunyena Tumusiime
ID: UNCST-2023-R008465
“Exploring Acceptability: Expanding Family Planning Services in Pharmacies and drug shops in Uganda.”
REFNo: HS5733ES

a. To assess the acceptability of family planning including implant provision through pharmacies and drug shops among key stakeholders in Uganda.
b. To examine the role of non-monetary incentives (e.g., training, certification, recognition) in motivating pharmacy and drug shop operators to provide FP services.
c. To explore the willingness and capacity of pharmacy and drug shop providers to comply with government reporting requirements for FP service provision.
d. To identify perceived potential facilitators and challenges to the successful implementation of implant provision in pharmacies and drug shops in Uganda.

Uganda 2025-05-27 11:03:29 2028-05-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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