Phillip Ssekamatte
ID:
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IMMUNOLOGICAL, METABOLIC AND GENETIC CHANGES AMONG PATIENTS WITH TUBERCULOSIS AND TYPE 2 DIABETES MELLITUS IN UGANDA
REFNo: HS1696ES
Study objectives
General objective
To assess the effect of type 2 DM on Mtb-specific T-cell subset functional phenotypes during metformin and isoniazid therapy, and type 2 DM on the immunological, metabolic and genetic TB responses.
Specific objectives
(i) To determine the effect of type 2 DM on frequency, function (activation and cytokine secretion), and survival of Mtb-specific T-cell subsets (CD4+ and CD8+) in patients having both type 2 DM and LTBI during metformin and isoniazid therapy.
(ii) To assess baseline differences in Mtb-specific T-cell subset functional phenotypes to LTBI between people with and without type 2 DM.
(iii) To profile baseline immune-metabolic changes among type 2 DM and LTBI patients.
(iv) To investigate baseline differences in gene expression signatures (TB Risk-11) to LTBI between people with and without type 2 DM.
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Uganda |
2022-04-21 |
2025-04-21 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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Barnabas Bakamutumaho
ID: UNCST-2021-R012636
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Maintenance and transmission of Rift Valley Fever Virus and other emerging infectious diseases in East and Central Africa: Version number: 1.0
REFNo: HS1713ES
(i) Determine whether low-level RVF virus transmission and disease among or between animals and humans occurs during the inter-epidemic periods (IEPs)
(a). To describe host immune responses to RVF infections in humans and livestock during inter-epidemic periods.
(ii) Conduct detailed niche modelling of RVF high risk and low risk ecologies to determine the important ecological risk factors associated with persistence of RVF virus and recurrence of outbreaks in animals and humans.
(iii) Investigate impact of climate change on the RVF permissive ecologies and its effect on RVF virus transmission
2.2.2 Secondary objective
(iv) Conduct pathogen discovery on human, livestock, and wildlife samples collected from ECA countries to identify other circulating emerging infectious pathogens which are of epidemic or pandemic potential.
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Uganda |
2022-04-21 |
2025-04-21 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Etheldreda Nakimuli-Mpungu
ID: UNCST-2020-R014808
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Tele-Psychotherapy for Youth using Mobile Phones during Covid-19 Pandemic
REFNo: HS2106ES
1. We aim to conduct online and community-based participatory qualitative research to obtain information on the potential usefulness of individual tele-support psychotherapy in addressing depression during the Covid-19 pandemic.
2. We will compare the effectiveness of individual tele-support psychotherapy (TSP) delivered by trained lay counsellors in combination with standard mental health services (SMHS) for depression with use of SMHS alone.
3. We aim to compare the effects of TSP combined with SMHS and SMHS alone on other psychosocial variables including self-esteem, anxiety, alcohol and substance use, social support, stigma, number of disability days, asset possession, poverty indices, and cost-effectiveness measures.
4. To conduct a process evaluation of trial activities informed by Linnan and Steckler’s process evaluation frameworks to specifically determine indicators of feasibility, acceptability, fidelity, and to explore causal mediating processes and contextual influences
5. We will also explore whether or not the effects of TSP and SMHS are moderated by alcohol and drug use.
6. We shall explore whether the strength of a therapeutic relationship will mediate the effects of TSP and SMHS on depression
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Uganda |
2022-04-21 |
2025-04-21 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Joseph Erume
ID:
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Profiling virulence markers and drivers enabling Escherichia coli to cause neo-natal and post-weaning piglet diarrhea in major pig producing districts of Uganda
REFNo: A190ES
1. To determine the adhesins in the 157 E. coli previously isolated from Kayunga and Mityana districts, Central Uganda
2. To determine the significance of E. coli species in the etiology of piglet diarrhea in the major pig producing districts of Uganda.
3. To determine drivers which underlie the dynamics and perpetuation of E. coli infections of pigs in the major pig producing districts of Uganda.
4. To molecularly characterize virulence markers of E. coli species involved in diarrheal outbreaks in piglets in the small holder pig production systems in major pig producing districts of Uganda.
5. To determine the antimicrobial susceptibility of E. coli isolates isolated from diarrheic piglets in the small holder pig production systems in selected major pig producing districts of Uganda.
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Uganda |
2022-04-21 |
2025-04-21 |
Agricultural Sciences |
Non-Clinical Trial |
Non-degree Award |
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Paula Rabaey Ann
ID:
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A seat for every child: Ensuring safe and dignified mealtimes for children with disabilities
REFNo: SS1247ES
Determine in country stakeholder interest in promoting and using the chair,Determine percent change in caregiver stress level while feeding child in the chair versus current position (without adaptive equipment),Determine ability and level of ease/difficulty with which caregivers can independently position their child correctly in the chair ,Determine change in feeding position and tolerance for using the chair (from child’s current feeding position to being fed in the chair),To pilot test SPOON Foundation’s low-cost feeding chair for acceptability, usability, and feasibility for families with a child with a disability (CWD) in Uganda. ,
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USA |
2022-04-20 |
2025-04-20 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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