Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Josef Bryja
ID:
Evolutionary diversity of small mammals in isolated mountains in north-eastern Uganda - stepping stones for colonization of the Albertine Rift and Kenyan Highlands from Ethiopia?
REFNo: NS301ES

Overall goal: To analyse genetic diversity of small mammals and their pathogens to test alternative hypotheses of colonization of Eastern Afromontane Biodiversity Hotspot (EAMBH)
Objective: Description of biodiversity patterns in EAMBH using integrative approach

Output 1: List of small mammals of isolated sky islands of north-eastern Uganda
Activity 1: Field sampling, species identification (using integrative approach)

Output 2: Phylogeographic scenarios for the colonization of EAMBH, identification of "refugia within refugia", biogeographical regionalization
Activity 2: Combination of obtained (genetic) data with other datasets from Ethiopia, Kenya, Tanzania, etc. Testing of phylogeographic hypotheses.

Czech Republic 2021-10-22 2024-10-22 Natural Sciences Non-Clinical Trial Non-degree Award
Eddy Walakira Joshua
ID: UNCST-2022-R009077
Strengthening the Effectiveness of National Children’s Care Systems: A Political Analysis of Uganda
REFNo: SS1064ES

This study will examine the effectiveness of the National Children’s Care System in Uganda focusing on the political, bureaucratic and economic forces as well as the strategies that augment the effectiveness of this system.

The study aims to use the collected data to develop an adaptable framework to achieve effective national care systems for children in Low-Income Countries (LICs).

In specific terms, the research will:
1. Examine the political, bureaucratic and economic forces shaping the effectiveness of Uganda’s national children’s care systems

2. Delineate the strategies to improve the capacity of these systems to protect children

3. Develop an adaptable framework for Uganda to analyze factors shaping children’s care systems in LICs?
Uganda 2021-10-22 2024-10-22 Social Science and Humanities Non-Clinical Trial Non-degree Award
Gorretti Nassali
ID:
Trends of Breast Cancer among patients younger than 40 years at St. Francis Hospital Nsambya: A cross section descriptive study
REFNo: HS1758ES

This study aims to describe prevalence by age, stage at diagnosis, cancer type and grade, and hormone receptor status, among women younger than 40 years at St. Francis Hospital Nsambya between 2010 and 2020.
Uganda 2021-10-21 2024-10-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Anna Ritah  Namuganga
ID:
Mycobacterium tuberculosis associated immune activation and exhaustion profiles for prediction of active pulmonary tuberculosis
REFNo: HS1201ES

Main Objectives
Determine the differential expression of immune activation and exhaustion markers to predict active TB disease among presumptive TB cases.
Primary Specific Objectives
i. To determine the levels of soluble markers of immune activation and exhaustion in serum of active PTB cases, LTBI and those with ORDs and response to treatment.
ii. To determine levels of immune activation and exhaustion associated cytokines/chemokines in serum among active PTB, LTBI and ORDs and response to treatment.
iii. Perform a phenotypic profiling of expression of markers immune activation and exhaustion in PBMCs and determine their association with active PTB, LTBI states or other respiratory diseases (ORDs).
iv. To determine the activation and exhaustion genes expression profiles in QFT Gold plus cell pellets and compare levels in active PTB cases and LTBI.

Uganda 2021-10-20 2024-10-20 Medical and Health Sciences Degree Award
Andrew Okwi Livex
ID: UNCST-2021-R013180
Unlocking the potential of thiocyanate in cassava root for management of painful crisis in sickle cell disease patients in Uganda
REFNo: HS1486ES

1. To determine the frequency of cassava consumption in the districts of Uganda with high prevalence of sickle cell disease
2. To assess the frequency of painful crisis among SCD patients in these districts.
3. To determine the levels of thiocyanate in patients with SCD in these districts
4. To determine the optimum concentration of thiocyanate that causes antisickling (in vitro studies)

Uganda 2021-10-20 2024-10-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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