Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Adeodata Rukyalekere Kekitiinwa
ID: UNCST-2019-R000799
BREATHER Plus: A randomized open-label 2-arm, 96-week trial evaluating the efficacy, safety and acceptability of short cycle (five days on, two days off) dolutegravir/tenofovir-based triple antiretroviral therapy (ART) compared to daily dolutegravir/tenofovir- based triple ART in virologically suppressed HIV-infected adolescents aged 12 to 19 years of age in sub-Saharan Africa, Version 2.0, Dated 18-Mar-2020; ISRCTN #: 85058577
REFNo: HS1822ES

Major Objective: A randomized open-label 2-arm, 96-week trial evaluating the efficacy, safety and acceptability of short cycle (five days on, two days off) dolutegravir/tenofovir-based triple antiretroviral therapy (ART) compared to daily dolutegravir/tenofovir-based triple ART in virologically suppressed HIV-infected adolescents aged 12 to 19 years of age in sub- Saharan Africa
Specific Objectives
To evaluate an innovative and contemporary ART strategy in HIV-infected adolescents to provide choice for young people facing life-long treatment. Output from this RCT will provide evidence on efficacy, safety and acceptability of a novel treatment approach in HIV-infected adolescents in sub-Saharan Africa
To evaluate the virological efficacy, safety, acceptability and Quality of Life of DTG-based Short-cycle Therapy with weekends off compared with Continuous Therapy with a DTG- based ART regimen
To optimize treatment for HIV-infected adolescents in sub-Saharan Africa

Uganda 2021-11-15 2024-11-15 Medical and Health Sciences Clinical Trial Non-degree Award
Mvuyo Sikhondze Maqhawe
ID:
DIABETIC FOOT ULCERS: SURGICAL CHARACTERISTICS, TREATMENT MODALITIES AND SHORT-TERM TREATMENT OUTCOMES AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS1857ES

General Objective
To describe the surgical characteristics, treatment modalities and short-term treatment outcomes of diabetic foot ulcers at Mbarara Regional Referral Hospital.

Specific Objectives
1. To describe the surgical characteristics of diabetic foot ulcers observed at Mbarara Regional Referral Hospital.
2. To describe the treatment modalities of diabetic foot ulcers at Mbarara Regional Referral Hospital.
3. To document the short-term treatment outcomes of patients with diabetic foot ulcers at Mbarara Regional Referral Hospital.
Eswatini 2021-11-15 2024-11-15 Medical and Health Sciences Non-Clinical Trial Degree Award
Sabine, Willemina, Johanna Luning
ID:
Gold Matters: Transformations to Sustainability in Artisanal and Small Scale Gold Mining in Uganda
REFNo: SS716ES

1. To consider whether a transformative approach toward sustainability can arise in Artisanal and Small Scale Gold Mining (ASGM).
2. To explore new notions of sustainability and transformations.
3. To contribute to a better understanding of the dynamic, heterogeneous reality of ASGM.
Netherlands 2021-11-11 2024-11-11 Social Science and Humanities Degree Award
Jessica Perkins M
ID: UNCST-2021-R013564
Perceptions of Social Norms and Personal Propensity to Engage in HIV Testing: A Mixed Methods Study and Intervention in Rural Uganda
REFNo: SS812ES

We propose a study to assess norms and perceptions about HIV prevention and related topics. This includes assessing village norms (i.e., the behaviours or attitudes of more than 50% of the adult population), perceived norms, how people form their perceptions, which social reference groups are the most meaningful, and the difference between actual norms and individuals’ perceptions of what most others do or believe. We will also examine whether perceptions are associated with personal behaviours and attitudes. Project 1 Aim: To engage in secondary analysis of quantitative data about perceived social norms and actual population norms around HIV prevention behaviours and related topics across different social reference groups. Aim 1: We will assess the prevalence of perceived and actual behavioural norms. We will do this both at the village-level and across various sociodemographic and health indicators. We will consider a behaviour the village norm if it is reported by more than 50% of adults. Aim 2: Because the parent study includes nearly all adults living in Nyakabare Parish, we can compare the actual village norm (assessed in Aim 1) to perceptions of the village norm. The parent study asked participants about their perceptions of what most other adults in the village do or think. Aim 3: Using the self-reported behaviours, attitudes, and norm perceptions, we will test whether individuals’ perceptions of what is normative is related to their personal attitudes and behaviours. Project 2 Aim: To use qualitative research methods to understand the nuances of HopeNet participants’ perceptions about local norms and design valid survey questions that elicit perceived social norms about HIV testing within different reference groups. Aim 1: Through in-depth interviews, scenarios related to HIV prevention attitudes and behaviours and perceived norms about salient social reference groups will be discussed. Aim 2: Based on results from Aim 1, survey questions using different ways of assessing norms will be developed to assess perceived social norms around HIV-related prevention behaviours and attitudes among different reference groups. Aim 3: Through cognitive interviews, the content validity of these survey questions to elicit perceptions of social norms about HIV-related attitudes and behaviours among specific social reference groups will improve.
USA 2021-11-11 2024-11-11 Social Science and Humanities Non-Clinical Trial Non-degree Award
SIMON EWASU -
ID:
EXPLORING THE INFLUENCE OF SCHOOL LEADERSHIP ON STUDENTS’ ACADEMIC PERFORMANCE: A COMPARATIVE STUDY OF TWO PRIMARY SCHOOLS’ IN OMODOI SUB-COUNTY-UGANDA
REFNo: SS980ES

1. To explore how school leadership influences learners’ academic performance in schools’?
2. What school leaders do to improve on the students’ academic performance in schools
3. To find out the teachers’ and students’ perceptions on the school leadership on students’ academic performance.
4. To find out the strategies school leaders employ to support their own teams to improve on the learner’s academic performance?

Uganda 2021-11-11 2024-11-11 Social Science and Humanities Non-Clinical Trial Degree Award
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