Francis Ssali
ID: UNCST-2021-R012134
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A Phase 2, Open-label, Single-arm, Multicentre Study to Evaluate the Pharmacokinetics, Safety, Tolerability, and Efficacy of Switching to RPV Plus Other ARVs in HIV-1-infected Children (Aged 2 to less than 12 years) who are Virologically Suppressed (TMC278HTX2002)
REFNo: HS1815ES
Primary Endpoints
• Area under the plasma concentration-time curve from the time of administration up to 24 hours post-dose of RPV, as derived from the intensive PK assessments.
• Incidence of grade 3/4 AEs, SAEs, HIV-related events (including acquired immune deficiency syndrome [AIDS]-defining illnesses and Stage-3-defining Opportunistic Illnesses in HIV Infection), and AEs leading to discontinuation of study intervention through 24 weeks of study treatment.
Secondary Endpoint
• Incidence and severity of AEs/HIV-related events and their relatedness to RPV through 24 and 48 weeks of study treatment.
• Change from baseline Movement.
• Viral genotype at the time of virologic failure through 24 and 48 weeks of study treatment.
• Treatment adherence, as assessed by the Pediatric European Network for the Treatment of AIDS (PENTA) adherence questionnaire and by study intervention accountability, through 24 and 48 weeks of study treatment.
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Uganda |
2021-11-22 |
2024-11-22 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Jerome Kabakyenga Kahuma
ID: UNCST-2021-R013729
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The A-Lite vein locator: “a non-invasive assistive medical device designed to improve vein visibility among patients requiring intravenous therapy.â€
REFNo: HS1547ES
Main Objective
1. To assess the efficacy, safety and impact of using an assistive medical device to aid vein visibility among patients requiring intravenous therapy.
Specific Objectives
1. To assess the safety and efficacy of the A-Lite vein locator among 10 adults in Uganda.
2. To investigate non-inferiority by assessing the performance of the A-Lite vein locator with respect to the existing standard of care among 48 adolescents in Uganda.
3. To determine the effectiveness of using the A-Lite vein locator for improving vein visibility among 156 children requiring intravenous cannulation in Uganda.
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Uganda |
2021-11-19 |
2024-11-19 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Clare Tanton Tanton
ID:
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Taking the Good School Toolkit to scale
REFNo: SS1035ES
The aim of the project is to determine the feasibility and acceptability of using Regional Resource Persons to deliver the Good Schools Toolkit in primary and secondary schools in Uganda and to relate markers of implementation to intermediate outcomes in teachers.
The specific objectives are:
1. To determine whether implementation of the Good Schools Toolkit through Regional Resource Persons can be done with fidelity and whether it is associated with attitudes towards violence against children and markers of school operating culture among teachers.
2. To understand Teacher Protagonists’ motivations, their perceptions of their role and how these evolve during intervention implementation. To understand Teacher Protagonists’ experiences and opinions of intervention mode of delivery and the support they receive from Regional Resource Persons and school administration, and their views on the main successes and challenges of this approach.
3. To understand the experiences of Regional Resource Persons in supporting schools and at different stages of intervention implementation. To understand Regional Resource Persons’ perceptions of the main successes and challenges they face during intervention implementation and how these challenges might be overcome.
4. To explore how the attitudes and behaviours of the Regional Resource Persons evolve following Good Schools Toolkit training and during their role supporting schools, and how this correlates with their performance.
5. To understand teachers’ experiences returning to school after prolonged COVID-related closures
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UK |
2021-11-19 |
2024-11-19 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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ANGELLA MUSIIMENTA
ID: UNCST-2021-R013297
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My Mobile Wallet: An Intervention to Support Access to Tuberculosis Care and medication Adherence in Rural Uganda
REFNo: HS1688ES
Assess the refined My Mobile Wallet intervention for larger scale feasibility, acceptability, and impact on TB treatment adherence and clinical outcomes. We will randomize 162 newly diagnosed TB patients (1:1:1) to SMS texts + incentives Arm A, SMS texts only B, and control Arm C (standard clinic-based TB care); follow-up will be the 6 month-treatment period. Feasibility and acceptability will be assessed per above. Impact will be based on electronically monitored medication adherence (primary), as well as treatment completion, clinic attendance, cure, and mortality (secondary).,Refine the My Mobile Wallet intervention. We will adapt the intervention to address any feasibility and accessibility issues raised in R21 findings. We will then pilot test the refined version of the intervention in 10 TB patients over two months of treatment to ensure optimal functionality. ,Assess the initial feasibility and acceptability of My Mobile Wallet. Forty patients with newly diagnosed TB will use My Mobile Wallet over their 6-month course of treatment. Feasibility will be assessed by appropriate receipt of the cash transfers and SMS texts, and intervention functionality. Acceptability will be assessed using System Usability Scale [53] and interviews based on the Unified Theory of Acceptance and Use of Technology [54].,Determine the optimal design and develop My Mobile Wallet as an intervention to support TB medication adherence. Through client-centered approaches, we will iteratively conduct focus group discussions with up to 30 TB patients to develop an optimal My Mobile Wallet intervention.,
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Uganda |
2021-11-19 |
2024-11-19 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Noeline Nakasujja
ID: UNCST-2019-R001428
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The impact of the COVID-19 pandemic and its response on the mental health of people with pre-existing mental conditions in Uganda.
REFNo: HS1781ES
5. To explore the experiences and views of people with SMI, their families/caretakers and mental health clinicians regarding the MMHC,4. To assess the effectiveness of an outreach mobile mental health clinic (MMHC)7 initiative to mitigate the care and messaging gap for people with SMI during the Covid-19 pandemic and its response.,3. To explore the experiences and viewsof people with SMI and their families/caretakers regarding COVID -19 and its response ,2. To assess the effect of COVID -19 and its response on access to care for people with SMI ,1. To assess the effect of COVID -19 and its response on the mental health of people with SMI ,
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Uganda |
2021-11-18 |
2024-11-18 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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