Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
VINCENT MUBANGIZI
ID: UNCST-2024-R004232
Opti-MaP (Optimising Implementation of Maternal and Perinatal Death Surveillance and Response to prevent avoidable future deaths in Uganda
REFNo: HS4630ES

To review existing tools, develop and adapt a harmonised toolbox of resources to optimise MPDSR implementationTo co-design customised an "intervention package" using the toolboxTo evaluate effectiveness and cost-effectiveness of the "customised intervention package" to reduce perinatal and maternal mortalityTo develop and adapt a harmonised toolbox of resources to optimise MPDSR implementation
Uganda 2024-08-06 18:02:24 2027-08-06 Medical and Health Sciences Clinical Trial Non-degree Award
Rawlance  Ndejjo
ID: UNCST-2022-R010993
City-based interventions to stimulate active movement for health (CITY-MOVE) in Kampala city, Uganda
REFNo: HS4566ES

5. To assess the effects of selected city interventions on physical activity and population health and wellbeing. ,4. To document population & spatial data availability and assess utilization of routine physical activity data in Kampala city.,3. To identify stakeholder needs, preferences, and feasibility of selected early-phase city-GAPPA interventions to support their successful implementation through action research in LLs. ,2. To describe selected GAPPA interventions in Kampala city and evaluate their implementation process. ,1. To develop a comprehensive theory of change and operationalized measures for stakeholder engagement and context analysis in Kampala city,The primary aim of this study is to comprehensively evaluate the impact and long-term viability of city-GAPPA interventions aimed at promoting active movement and generate evidence on implementation, evaluation, and scalability as well as best implementation practices and transferability of city-GAPPA interventions,
Uganda 2024-08-06 17:55:51 2027-08-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ezekiel  Musasizi
ID: UNCST-2024-R005085
DETERMINANTS OF ADHERENCE TO NICOTINE REPLACEMENT THERAPY AMONG PEOPLE LIVING WITH HIV USING SMOKELESS AND SMOKED TOBACCO IN ARUA AND MOROTO DISTRICTS OF UGANDA
REFNo: HS4478ES

4. To explore experiences of People Living with HIV on ART in using Nicotine Replacement Therapy patches,3. To determine the interpersonal and intrapersonal factors associated with adherence to NRT among PLWH on ART who use smokeless and smoked tobacco enrolled to the Quit4Life+ trial. ,2. To explore the organizational and community factors influencing smokeless and smoked tobacco use among PLWH on ART in Arua and Moroto districts in Uganda ,1. To determine the intrapersonal and interpersonal factors influencing smokeless and smoked tobacco use among People Living with HIV on ART in Arua and Moroto districts in Uganda ,To determine the intrapersonal, interpersonal, organizational, and community determinants of smokeless and smoked tobacco use and NRT adherence among People Living with HIV on ART in Arua and Moroto districts in Uganda,
Uganda 2024-08-06 17:52:34 2027-08-06 Medical and Health Sciences Non-Clinical Trial Degree Award
Edgar Mulogo Mugema
ID: UNCST-2023-R008170
Epidemiology of Acute Respiratory Illness in Southwestern Uganda: A Retrospective Review
REFNo: HS4543ES

The primary objective of this study is to retrospectively document epidemiological and ecological trends in both outpatient and inpatient cases of ARI in five districts in southwestern Uganda. These data will inform the establishment of a network of healthcare facilities to conduct research on preventing and improving the management of ARI in this region.,
Uganda 2024-08-06 17:47:55 2027-08-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
David  Mwambari
ID:
Traveling Memories, Silences and Secrets (TMSS): Life narratives of Violence Among Refugees from Africa’s Great Lakes Region – A case of Uganda
REFNo: SS2424ES

The study will be guided by the following objectives: 1. Empirically: (a) to map and examine how the life narratives of refugees evolve from contexts of origin to countries of transition and destination (Burundi⇒Tanzania⇒USA;
DRC⇒Uganda⇒Belgium; Rwanda⇒Kenya⇒South Africa); (b) to investigate the evolution
of the memories, silences, and secrets that AGLR refugees carry in their trajectories of
migration.
2. Theoretically: to analyse (a) how space and time transform these life narratives on the move, and (b) how these transformed life narratives shape relationships within refugee communities and relationships with host communities in countries of transition and destination.
3. Epistemologically: (a) to develop a set of innovative interdisciplinary perspectives and
methodological approaches that can be used in researching the memory dynamics and mobility
that originate from Global South lived experiences; (b) to foster collaboration between a diverse multidisciplinary, international team of researchers involved in the TMSS project.
4. Policy: to explore how (a) our understanding of life narratives on the move can transform policy-making at local, regional, and international levels; and (b) how this understanding shapes practitioners’ work with refugees in countries of transition and destination.
Belgium 2024-08-06 17:46:31 2027-08-06 Social Science and Humanities Non-Clinical Trial Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
Implementation research on the tailored, multidisciplinary Non-Communicable Disease prevention package targeting air pollution exposure in mid- to late adolescents in Uganda: FRESHAIR-4-LIFE
REFNo: SS2485ES

To address the burden of NCDs by gaining knowledge, resources and capacity to optimize the implementation of tailored preventive intervention packages, targeting adolescents’ exposure to risk factors like tobacco (use) and AP in disadvantaged populations worldwide. In Uganda, we will focus on air pollution.,
Uganda 2024-08-06 17:44:22 2027-08-06 Social Science and Humanities Non-Clinical Trial Non-degree Award
Aurelius  Ssali Ssettunba
ID: UNCST-2023-R005538
CHARISMS OF INSTITUTES OF CONSECRATED LIFE AND THE MISSIONS OF CONSECRATED PERSONS OF THE SELECTED FOUR INSTITUTES IN UGANDA.
REFNo: SS2647ES

specific objectives of the study The study seeks to focus on.the following objectives 1. To find out whether the four institutes of the Concreted life in Uganda do assimilate their founders’ Charisms. 2. To evaluate the areas of pastoral activities that fulfillstheir Founders’Charisms. 3. To identify challenges experienced by the different institutions in their fulfillment of their founders Charisms.,To identify the relationship between charism and mission in the consecrated institutions.,To evaluate the areas of pastoral activities that fulfills their Founders‟Charisms.,To find out whether Personal charism leads to Restore God‟s glory among people in the charism institution. ,Basing on the study, it will establish whether the four members institutes of the consecrated do effectively assimilate their Charism to effectively do their mission,
Uganda 2024-08-06 17:42:37 2027-08-06 Social Science and Humanities Non-Clinical Trial Non-degree Award
Abubaker Kawooya
ID:
PHAGE-MEDIATED BIOCONTROL OF THE DOMINANT PATHOGENIC BACTERIA STRAIN IN READY-TO-EAT VEGETABLE SALADS SOLD IN KAMPALA CITY
REFNo: HS3986ES

To study the safety of phages by analyzing the entire genome sequence for unwanted genes,To determine the lytic activity of phages against the dominant pathogenic bacteria isolated from ready-to-eat vegetable salads,To establish the diversity and genetic relatedness of bacteria in ready-to-eat vegetable salads,This study aims to evaluate the effectiveness of Phages in maintaining the microbial quality of ready-to-eat vegetable salads in Kampala.,
Uganda 2024-08-06 17:40:09 2027-08-06 Medical and Health Sciences Non-Clinical Trial Degree Award
Ismail  Draguma Legason
ID: UNCST-2021-R012130
Immunohistochemical assessment of Epstein Barr virus-encoded nuclear antigen (EBNA-1)and selected lymphoma markers for Burkitt Lymphoma diagnosis in resource-restricted settings
REFNo: HS4755ES

To determine the combined sensitivity, specificity, and predictive values of EBNA-1immunohistochemistry with CD10, BCL2, and Ki67 for the diagnosis of Burkitt lymphoma.,To determine the sensitivity, specificity, and predictive values of EBNA-1 protein immunohistochemistry for diagnosing Burkitt lymphoma. ,To evaluate EBNA -1 and selected lymphoma markers for Burkitt lymphoma diagnosis in resource-limited settings. ,
Uganda 2024-08-06 17:39:05 2027-08-06 Medical and Health Sciences Non-Clinical Trial Degree Award
Johnes Obungoloch
ID: UNCST-2024-R005331
Application of Artificial Intelligence using Chest x-ray images to aid clinical care of patients with pulmonary complications in Uganda (AI4CX)
REFNo: SS2718ES

III.To develop a machine learning algorithm for automated diagnosis of pulmonary diseases from chest x-ray images,II.To establish a dataset of annotated chest x-ray images of pulmonary diseases among patients seeking pulmonary care in Mbarara City, South Western Uganda,I.To generate quality chest x-ray images of pulmonary diseases among patients seeking care in Mbarara City, South Western Uganda,●To develop an Artificial intelligence model using Chest x-ray images to aid clinical care of patients with pulmonary complications in Uganda,
Uganda 2024-08-06 17:38:06 2027-08-06 Social Science and Humanities Non-Clinical Trial Non-degree Award
ABDULAZIZ KAKOOZA
ID: UNCST-2024-R004009
INTEGRATION OF EMPLOYABILITY SKILLS IN PRE-SERVICE TEACHER TRAINING PROGRAMME IN HIGHER EDUCATION INSTITUTIONS IN UGANDA: A CASE STUDY OF KYAMBOGO UNIVERSITY
REFNo: SS2747ES

iii. To establish ways employability skills can be enhanced in the pre-service teacher training programme at Kyambogo University. ,ii. To examine the integration of employability skills in the pre-service teacher training programme at Kyambogo University.,i. To explore employability skills desired by employers from pre-service teacher training graduates at Kyambogo University.,
Uganda 2024-08-06 17:36:01 2027-08-06 Social Science and Humanities Non-Clinical Trial Degree Award
Arthur Kwizera
ID: UNCST-2021-R012928
A multicentre, prospective, registry-based intensive care quality improvement project in Uganda’s hospitals.
REFNo: HS4484ES

To inform clinical guidelines, national policies and planning for critical care services in Uganda. ,To describe the epidemiology and outcomes of intensive care patients in Uganda,To implement a national intensive care registry that can be used at both a facility, and national level to assess, report and improve quality of care for intensive care unit patients. ,
Uganda 2024-08-06 17:34:41 2027-08-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Cissy  Kityo
ID: UNCST-2021-R013663
A Phase 4, Open-Label, Rollover Study to Provide Continued Access to Cabotegravir Long-acting Injection and Rilpivirine Long-acting Injection to Participants Living with Human Immunodeficiency Virus Type 1 (HIV-1) Infection Who Participated in Long-Acting Combination Therapy Studies.
REFNo: HS4452ES

The secondary objective is to assess the long-term safety and tolerability of CAB LA + RPV LA by evaluating the incidence of serious adverse events (SAEs), pregnancies, adverse events (AEs) leading to discontinuation of CABLA +RPV LA, and AEs considered to be related to the study intervention.,The primary objective of the study is to provide continued CAB LA + RPV LA access to participants who were enrolled and treated with CAB LA + RPV LA in the parent studies, and who, at the time of roll-over, experience and are expected to continue to experience clinical benefit from this treatment.,
Uganda 2024-08-06 17:32:50 2027-08-06 Medical and Health Sciences Clinical Trial Non-degree Award
alfred bulamu
ID: UNCST-2023-R008638
Uganda Translational Breast Cancer Screening Research Center with Innovations in MRI and Genetic Testing.
REFNo: HS4689ES

Implementation of breast MRI with genetic testing as BC screening method for women at high risk of BC by July 2029 (Phase 6) , Continuous Trainings for radiologists, radiographers and laboratory staffs on the modern technologies of MRI and Genetic testing (phase 3 to phase 6) ,Evaluating the feasibility of screening BC using MRI and genetic testing for high risk women by December 2028 (phase 5),Large scale education of the community about BC by July 2028 (phase 3 and phase 4).,Large scale determination of the utility of genetic testing as a screening modality for BC in Uganda by perform mutational genetic analysis for women at high-risk aged19 years to 80 years by July 2028 (phase 3 and phase 4) , Large scale determination of the utility of quantitative breast MRI for screening women at high risk BC aged 19 years to 80 years by July 2028 (phase 3 and phase 4) ,Training of the users on equipment i.e. Radiologists, Radiographers and laboratory staffs by 2025 (phase 2) ,Securing and installation of lab equipment for genetic testing by 2025 (Phase 2,Securing and installation of MRI with Breast coils by July 2025 (Phase 2),To build capacity for 20 laboratory health care workers in genetic testing technologies by December 2023 (phase 1).,To build capacity for 30 radiology health professionals in modern breast Imaging with MRI by December 2023 (Phase 1),To determine the utility of quantitative breast MRI for screening women at high risk breast cancer aged 19 years to 80 years by July 2024 (phase 1),To determine the utility of genetic testing as a screening modality for BC in Uganda by perform mutational genetic analysis for women at high-risk of BC aged 19 years to 80 years, by July 2024 (phase1),To build a long-lasting infrastructure for research, clinical screening in Uganda and training using modern technologies. ,To offer improved access to Breast Cancer screening in Uganda through quantitative MRI and genetic testing research center,
Uganda 2024-08-06 17:27:31 2027-08-06 Medical and Health Sciences Clinical Trial Non-degree Award
Edward Nahurira
ID: UNCST-2022-R009739
Comparative Phytochemical Studies of Callus Regenerated from Leaf Explant of Prunus Africana (Hook F. Kalkman) and Stem Bark of the Same Mother Plant
REFNo: HS2434ES

1. To develop callus culture from the explant of P. africana leaf and stem bark.

2. To evaluate the phytochemical constituents of the callus extracts of P. africana leaf and stem bark explant.

3. To develop and compare the TLC and HPLC fingerprints of each extract for their identification.

Uganda 2024-08-06 17:22:37 2027-08-06 Medical and Health Sciences Non-Clinical Trial Degree Award
ANITA ARINDA
ID: UNCST-2020-R014158
Intellectual Disability in Children and Adolescents with Epilepsy in Mulago and Butabika National Referral Hospitals: Prevalence and Associated Factors
REFNo: HS4589ES

2. To determine the factors associated with ID in children and adolescents with epilepsy attending Mulago and Butabika National Referral Hospitals.,1. To determine the prevalence of ID in children and adolescents with epilepsy attending Mulago and Butabika National Referral Hospitals.,To determine the prevalence of and factors associated with ID in children and adolescents with epilepsy attending Mulago and Butabika National Referral Hospitals.,
Uganda 2024-08-05 14:04:37 2027-08-05 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Moses Oketch
ID: UNCST-2024-R004313
Long-Term Impacts of Improved Childhood Literacy
REFNo: SS2796ES

Economic situation,
UK 2024-08-05 14:01:33 2027-08-05 Social Science and Humanities Clinical Trial Non-degree Award
Jonathan Mayito
ID: UNCST-2019-R000490
Detection of Mycobacterium tuberculosis in blood of tuberculosis patients and their contacts in Uganda
REFNo: HS4553ES

To determine whether Mtb strains isolated from the sputum/blood of index cases with pulmonary TB are genetically identical to those detected in the blood of their contacts,To establish whether detection of Mtb in blood using the methods above associates with either of the following biomarkers of host immune response: - QFT-Plus - Blood RNA signatures for incipient tuberculosis,To determine whether Mtb can be detected in the blood of TB patients and their contacts, recruited in Kampala, Uganda, using any of the following methods: - GeneXpert® MTB/RIF Ultra (Cepheid) - Fluorescence microscopy - Blood culture - Targeted Next-Generation Sequencing,The primary objective of this study is to determine whether Mtb DNA can be detected in the blood of TB patients and their contacts, recruited in Kampala, Uganda, using digital PCR,
Uganda 2024-08-05 13:49:07 2027-08-05 Medical and Health Sciences Non-Clinical Trial Non-degree Award
OKELLO DAMOI JOSEPH
ID: UNCST-2022-R011560
Construction and Validation of a Poverty Assessment Survey Tool to Inform Ambulatory Care and Surgery Cost Waiver or Subsidization in a Developing Country
REFNo: HS4463ES

To determine the weights of each attribute per item, in the constructed and validated tool that can be used to inform ambulatory care and surgery cost waiver or subsidization in a developing country,To construct a validated ambulatory care and surgery-context poverty assessment survey tool that can be used to inform ambulatory care and surgery cost waiver or subsidization in a developing country,To analyze the data earlier collected using the ambulatory care and surgery-context poverty assessment survey tool at KSC, for principal components,To conduct content validity and reliability testing of the ambulatory care and surgery- context poverty assessment survey tool, previously developed with adaption of some items from the simple poverty score tool for Uganda,To construct and validation of a poverty assessment survey tool that can be used to inform ambulatory care and surgery cost waiver or subsidization in a developing country,
Uganda 2024-08-05 13:12:56 2027-08-05 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Vesall Nourani
ID: UNCST-2022-R009221
Impact of on-demand irrigation service : Evidence from Uganda
REFNo: SS2112ES

Do certain intermediaries (providers of agricultural inputs) facilitate efficient information aggregation and dissemination of farming knowledge between farmers?,
USA 2024-08-05 13:11:25 2027-08-05 Social Science and Humanities Non-Clinical Trial Non-degree Award
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