Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
JAMES  SSENFUUMA THOMAS
ID: UNCST-2023-R005484
 RESILIENCE OF REFUGEES EXPERIENCING WFP FOOD AID CUTS IN KYAKA II SETTLEMENT, KYEGEGWA DISTRICT, UGANDA
REFNo: SS2412ES

1. To assess the effects of food reductions by WFP on the social-economic wellbeing of refugees in Kyaka II Settlement, Kyegegwa district


2. To explore the effects of food aid cuts by WFP on social cohesion of refugees in Kyaka II Settlement, Kyegegwa district

3. To explore the survival strategies (protective factors) employed by refugees affected by WFP food aid cuts in Kyaka II settlement, Kyegegwa district, Uganda
 Uganda 2024-02-29 16:43:51 2027-03-01 Social Science and Humanities Non-Clinical Trial Degree Award
Nobert Bongo
ID: UNCST-2023-R008651
 TeamUp Uganda project Research Protocol
REFNo: SS1940ES

3. To assess the role and contribution of public-private partnerships (PPPs) model in improving the quality of life for the youth in Uganda,2. To assess and analyse the extent to which across-sector collaboration efforts by TeamUp Project implementing partner have contributed to improved quality of life for the youth ,1. To establish the impact of three TeamUp interventions; (water, agriculture and Sexual reproductive health) on the youth quality of life,
 Uganda 2024-02-29 16:40:45 2027-03-01 Social Science and Humanities Non-Clinical Trial Non-degree Award
Hellen Opolot
ID: UNCST-2019-R001724
 The Effect of Public Health Emergencies on the Research Regulatory Systems: A Qualitative Study of COVID-19 In Uganda.
REFNo: SS2192ES

1. To explore the effects of COVID-19 pandemic on NRAs/RECs/researchers’ operations in Uganda.
2. To examine the effectiveness of national policies and guidelines on the conduct of research regulation in Uganda.
3. To describe the coping strategies of researchers, NRAs and RECs amidst the COVID-19 pandemic.

 Uganda 2024-02-28 17:57:26 2027-02-28 Social Science and Humanities Non-Clinical Trial Non-degree Award
Martin Origa Jobson Ariel
ID: UNCST-2022-R010809
 The Every Woman Study in Low- and Middle-Income Countries: Identifying challenges and opportunities to improve survival and quality of life for women with ovarian cancer.
REFNo: HS3730ES

To obtain country level reports from the lead clinicians (CL) summarising the environment in which they work to diagnose and treat women, and to interview at least one woman per participating country who might be considered to have a common experience, and who would be willing to be involved in developing advocacy efforts.,To explore the variations in experience of women in their particular country versus the group of respondents as a whole, with a view at looking for opportunities for progress.,To gather sufficient survey responses at a country level to make robust statements about the experiences of ovarian cancer at a national, and larger regional level, and for women in lower- and middle-income countries as a whole.,
 Uganda 2024-02-26 14:03:58 2027-02-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Immaculate  Mbwali
ID: UNCST-2023-R008116
 Care and support after a miscarriage in Eastern Uganda: a grounded theory exploration
REFNo: HS3543ES

To develop a theory grounded in the data, of care and support for women after experiencing a miscarriage in Uganda. ,To explore the healthcare providers’ and other potential groups’ perceptions and practices of offering care and support to women after a miscarriage in Eastern Uganda.,To explore the experiences of women and their male partners after a miscarriage in Eastern Uganda.,To conduct a metasynthesis to critically reinterpret the existing qualitative literature surrounding experiences of women after a miscarriage.,To understand the social processes surrounding care and support after a miscarriage in Eastern Uganda from the perspectives of women, partners/families, and health workers and to develop a theory of care and support that could inform future research and practice of the care and support for women after experiencing a miscarriage. ,
 Uganda 2024-02-26 13:56:17 2027-02-26 Medical and Health Sciences Non-Clinical Trial Degree Award
Agnes TURYAMUBONA
ID:
Prevalence of protective levels of Anti-Hepatitis B Surface Antigen Antibody titers among Ugandan adolescents living with HIV
REFNo: HS3679ES

To determine the prevalence of acute, chronic and resolved hepatitis B infections from archived Plasma samples of adolescent PLWH at CPHL between January-to- September, 2023. , To determine the prevalence of protective antibody titers against HBV from Plasma samples at CPHL, Uganda obtained from adolescents living with HIV.,To determine the prevalence of Anti-HBs, acute, chronic and resolved HBV infections among adolescents living with HIV at CPHL between Jan to Sept 2023,
 Uganda 2024-02-26 13:53:35 2027-02-26 Medical and Health Sciences Non-Clinical Trial Degree Award
Rhoda Wanyenze
ID: UNCST-2021-R013352
 Evaluation of interventions to mitigate effects of adolescent pregnancy and promote maternal and child health in selected districts of Uganda: Uptake, implementation processes, experiences and immediate outcomes
REFNo: HS3874ES

Primary objectives 1. To identify coverage of the interventions to mitigate effects of adolescent pregnancy and promote maternal and child health in the adolescentCOP21 PEPFAR funded districts of Uganda. 2. To determine uptake of interventions by adolescent girls who received pregnancy and motherhood support to mitigate effects of pregnancy and promote maternal and child health adolescentin the COP21 PEPFAR funded districts of Uganda. To measure immediate outcomes within one year of the interventions to mitigate effects of adolescent pregnancy and promote maternal and child healthadolescent in the COP21 PEPFAR funded districts of Uganda. 3. adolescentTo assess implementation processes and dynamics of the interventions to mitigate effects of adolescent pregnancy and promote maternal and child health adolescentin the COP21 PEPFAR funded districts of Uganda . To explore experiences and perceptions of adolescent girls who received pregnancy and motherhood support and implementers towards interventions to mitigate effects of adolescent pregnancy and promote maternal and child health in the COP21 PEPFAR funded districts of Uganda. Secondary objective 1. To identify other existing interventions in place to prevent and respond to adolescent pregnancies adolescent in the COP21 ARPA funded districts. 2. To compare immediate outcomes and effects of adolescent pregnancy between DREAMS and non-DREAMS COP21 ARPA funded districts.
Uganda 2024-02-26 13:52:20 2027-02-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
LILLIAN MBABAZI
ID:
Storytelling Among the Bakiga of Uganda: Changing Form, Character and Performance Contexts Between 1930 – 2009
REFNo: SS2359ES

To examine the changing form, character, and performance contexts in storytelling among the Bakiga between 1930 and 2009.
To explore the function of storytelling among the Bakiga.
To assess the changing themes, structure, and settings for storytelling among the Bakiga in times of Christianity and formal schooling.
To examine how migration shaped the content, processes and form(s) of storytelling among the Bakiga.
To analyse how commercialisation influenced the composition and performance of storytelling among the Bakiga.
Uganda 2024-02-26 13:49:42 2027-02-26 Social Science and Humanities Non-Clinical Trial Degree Award
Winfred  Tugumisirize
ID:
Participatory Budgeting and Financial Sustainability in the Local Government in Uganda: A Case Study of Kabale District
REFNo: SS2353ES

4. To establish the relationship between participatory budgeting and financial sustainability in Kabale District Local Government.,3. To assess the relationship between budget implementation and financial sustainability in Kabale District Local Government.,2. To analyze the impact of budget approval on financial sustainability in Kabale District Local Government.,1. To examine the influence of budget formulation on financial sustainability in Kabale District Local Government . ,The main objective of the study is to examine the relationship between participatory budgeting and financial sustainability of Local Governments in Uganda.,
 Uganda 2024-02-26 13:47:53 2027-02-26 Social Science and Humanities Non-Clinical Trial Degree Award
LILLIAN BYERETA HAPPY
ID: UNCST-2021-R012144
 To utilize simplified instruments for geriatric assessment for specialized routine care of Old People Living with HIV (HIV –OLD, HOPE)
REFNo: HS3704ES

2. To evaluate the feasibility of self-collection (with the support of a research assistant) through tablets of simplified validated tools for Quality of life, Instrumental activities of daily living (IADL), history of falls, screening for depression, and incontinence. 1. To utilize simplified instruments for geriatric assessment of OPLWH which can be potentially scaled up in routine care, particularly for the assessment of frailty, sarcopenia , physical and cognitive function. ,The overall goal of the proposal is to validate simplified tools for specialized routine care of OPLWH. ,
 Uganda 2024-02-26 13:45:25 2027-02-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kamoga Ronald
ID: UNCST-2019-R001524
 VAGUS NERVE STIMULATION IN A RAT MODEL OF ALZHEIMER’S DISEASE-LIKE SYMPTOMS: MORPHOLOGICAL, IMMUNOHISTOCHEMICAL, MOLECULAR AND BEHAVIORAL CHANGES
REFNo: HS3781ES

1. To conduct a scoping review of literature on vagus nerve stimulation in Alzheimer's-disease and related dementias.
2. To determine behavioral changes associated with vagus nerve stimulation in a rat model of Alzheimer-like symptoms.
3. To evaluate the morphological, Immunohistochemical and molecular changes in the Hippocampus, prefrontal cortex and medial temporal cortex associated with chronic stimulation of the vagus nerve in a rat model of Alzheimer’s-like disease.

 Uganda 2024-02-26 13:43:22 2027-02-26 Medical and Health Sciences Clinical Trial Degree Award
Mallory Holding Anne
ID:
Play Our Part (PoP) project primary data collection on effective engagement strategies with policymakers to support Learning through Play (LtP) in Early Childhood Education (ECE)
REFNo: SS2399ES

To gather data to help answer the PoP CoP learning question 3A: Which Engagement Strategies with Policymakers lead to the creation of enabling environments for LtP in Centre-based systems. ,Identify which advocacy approaches policymakers have found most effective.,Determine the way in which partners are currently engaging in national level advocacy activities and their definition of effectiveness.,Identify effective strategies for engaging policymakers on LtP in ECCE systems. ,
 USA 2024-02-26 13:42:34 2027-02-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Sarah Lofgren
ID: UNCST-2019-R001647
 Supervised Treadmill intervention to Reduce Inflammation and Depression through Exercise in HIV: The STRIDE Pilot Study
REFNo: HS3358ES

The objective of this study is to determine the feasibility and acceptability of an aerobic intervention via a treadmill among individuals with HIV and depression in Uganda.
3.1 Primary Endpoint: Feasibility and acceptability of Exercise as a treatment for depression in Ugandans with HIV. This will be measured by:
-Percent completion of the prescribed aerobic exercise intervention, as assessed by research staff logging participation.

3.2 Secondary Endpoint(s)/ Outcome(s):
- acceptability of the intervention assessed via a post intervention survey
-feasibility and acceptability of using a wearable exercise tracker to assess the volume of exercise, based on calories burned and steps achieved, during the intervention period among Ugandans with HIV and depression.
- measure the mean and standard deviation of baseline and 8-week serum BDNF and IL-6 level to estimate an effect size and power a future study.
- measure the mean and standard deviation of baseline and 8-week depression score via PHQ-9 to estimate an effect size and power a future study.
- measure the mean and standard deviation in aerobic fitness baseline and at 8 weeks measured via METS/watts achieved and total time/distance to estimate the effect size for a future intervention.
USA 2024-02-26 13:41:23 2027-02-26 Medical and Health Sciences Clinical Trial Non-degree Award
Waiswa Peter
ID: UNCST-2020-R014921
 Intervention Study on Unintended Pregnancy among Teenagers in Busoga
REFNo: SS2284ES

The implementation objective is to evaluate intervention acceptability and scalability in Uganda,The intervention objective is to evaluate a novel model to reach unmarried teenagers and assess its effectiveness in reducing unmet needs for modern contraceptives among the target population,
 Uganda 2024-02-26 13:39:25 2027-02-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Miriam Nakalembe
ID: UNCST-2021-R014040
 Cervical Cancer Screening Utilizing Image Capture and Machine Learning to Identify Precancerous Cervical Lesions
REFNo: HS3743ES

Using pathological confirmation of CIN 2/3+ as the reference standard for pre-cancer, determine if the sensitivity and specificity of image capture of the cervix and artificial intelligence/deep machine learning/interpretation is superior to VIA, the current standard of care for cervical cancer screening in sub-Saharan Africa. ,Evaluate the quality of the cervical images captured in the clinics for use in artificial intelligence/deep machine learning.,Establish an informatics and data management infrastructure for cervical cancer that utilizes the IeDEA data platform and will allow for images and biologic data to be stored and characterized with the AIDS and Cancer Specimen Resource (ACSR) and the National Library of Medicine (NLOM). ,
 Uganda 2024-02-26 13:37:44 2027-02-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
NELSON NSEREKO
ID:
FROM STANDARD SWAHILI TO THE SWAHILI VARIETY SPOKEN IN UGANDA: EVOLUTION AND MORPHOSYNTACTIC VARIATIONS
REFNo: SS2348ES

i) Describe the morphosyntax of the Kiswahili variety spoken in Uganda
ii) Compare and contrast the morphosyntax of Standard Kiswahili with that of the
Kiswahili spoken in Uganda
iii) Account for the emergence of the Kiswahili variety spoken in Uganda

 Uganda 2024-02-26 13:35:31 2027-02-26 Social Science and Humanities Non-Clinical Trial Degree Award
Julian Adong
ID: UNCST-2021-R013487
 Retention through mHealth for adolescents and young adults with HIV in care
REFNo: HS3722ES

Test the acceptability, feasibility, and preliminary impact of the developed adolescent-tailored mHealth intervention for retention in care of AYWH who are new to or newly re-engaging in care,Iteratively develop a social media-based adolescent-tailored mHealth intervention to improve retention in care for AYWH who are new or newly re-engaging in care,Define the cognitive, environmental, and behavioural challenges and their impact on behavioural intention for AYWH who are new or newly re-engaging in HIV care,To develop and test an mHealth intervention for retention in care for adolescents and young adults with HIV,
 Uganda 2024-02-26 13:34:00 2027-02-26 Medical and Health Sciences Clinical Trial Non-degree Award
alfred andama andama
ID: UNCST-2022-R011051
 TONGUE SWAB TUBERCULOSIS DIAGNOSTIC YIELD STUDY
REFNo: HS3761ES

Aim 1. To determine the proportion of people presenting to primary health centers with signs and symptoms of TB who: a. can provide a sample for TB testing (sputum vs. tongue swab) b. have a valid molecular test result (sputum vs. tongue swab) c. are detected as TB-positive (sputum vs. tongue swab) d. prefer providing a sputum vs. tongue swab sample
Uganda 2024-02-26 13:32:44 2027-02-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
 SOLIDARITY TRIAL-A phase I/II Randomized Placebo controlled trial to evaluate the Safety and Immunogenicity of Sudan Ebolavirus in Uganda
REFNo: HS3190ES

Phase I (rVSV-SUDV)
1. To determine the safety of rVSV-SUDV candidate SUDV vaccine among adult healthy volunteers in Uganda.
2. To determine the immunogenicity of rVSV-SUDV candidate SUDV vaccine.

Phase II (ChAdox1, CAd3 and rVSV-SUDV)
Primary objectives
1. To determine the safety of ChAdox1, CAd3 and rVSV-SUDV candidate SUDV vaccines among healthy volunteers and persons with stable comorbidities.
2. To determine the immunogenicity of ChAdox1, CAd3 and rVSV-SUDV candidate SUDV vaccines.
Secondary objectives
1. To determine the durability of SUDV-specific induced immune responses following vaccination.
2. To determine the factors associated with optimal vaccine-induced immune responses.
3. To determine the putative cross reactivity by the SUDV vaccine candidates against other ebolaviruses (e.g. Bundibugyo ebolavirus (BUDV) and EBOV).

Exploratory objectives
1. To determine the effect of SUDV vaccines on host gene expression.
2. To determine the T and B cell specific responses and immune profiling in response to vaccination.
3. To determine the effect of SUDV vaccines on the host metabolome.
4. To determine the effect of SUDV vaccines on host innate immune responses.

 Uganda 2024-02-26 13:31:25 2027-02-26 Medical and Health Sciences Clinical Trial Non-degree Award
Rhona Mijumbi M
ID: UNCST-2023-R006843
 Building a Culture of Evidence-informed Policy-Making in Uganda (B-CuE)
REFNo: SS2257ES

3) To improve collaboration for better coordinated and complementary support to EIDM in Uganda.,2) To design a sustainable and relevant capacity-building program for pre- and in-service training to ensure individuals and institutions acquire relevant and adequate knowledge and skills to support timely EIDM.,1) To scale-up the activities of the Center for Rapid Evidence Synthesis as a knowledge brokerage institution to strengthen support for timely EIDM in Uganda.,
 Uganda 2024-02-26 13:23:45 2027-02-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
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