Victoria Ndyanabangi
ID: UNCST-2021-R012645
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Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs during Pregnancy and Postpartum,DAIDS Study ID #38609,
IND #146262
REFNo: HS1023ES
Primary Objectives
Component 1:
• To describe the PK parameters during pregnancy of selected ARV drugs administered to WLHIV who are not receiving TB drugs, and to compare these parameters to (a) historical PK data from non-pregnant women and (b) each participant’s own postpartum PK data.
Component 2:
• To describe the kinetics of (a) placental and breast milk transfer of CAB LA from mother to fetus/infant and (b) infant elimination of CAB LA acquired across the placenta after maternal dosing during pregnancy.
Component 3:
• To describe the PK parameters during pregnancy and postpartum of selected ARV drugs and first-line TB treatment drugs co-administered to WLHIV.
Component 4:
• To describe the PK parameters during pregnancy and postpartum of second-line TB treatment drugs administered to WLHIV and HIV-uninfected women.
Component 5:
• To describe the kinetics of drug transfer of selected ARVs from mother to infant via breast milk.
Secondary Objectives
All Components:
• To describe maternal and infant safety and clinical outcomes.
Components 1, 3 and 4:
• To compare drug concentrations in plasma from cord blood with concentrations in maternal plasma at delivery for selected ARV and/or TB treatment drugs.
• To describe the neonatal elimination of selected ARV and/or TB treatment drugs acquired across the placenta after maternal dosing during pregnancy.
Components 3 and 4:
• To describe the kinetics of drug transfer of selected ARVs and/or TB treatment drugs from mother to infant via breast milk
Component 4:
• To describe the PK parameters of selected ARVs when co-administered with selected second-line TB treatment drugs to WLHIV during pregnancy and postpartum.
Other Objectives
• To assess plasma protein binding of highly bound ARVs and/or TB treatment drugs during pregnancy and postpartum.
• To explore genetic sources for variability in drug exposure in pregnant and postpartum women and their infants for selected ARV and/or TB treatment drugs.
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Uganda |
2021-12-16 |
2024-12-16 |
Medical and Health Sciences |
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Non-degree Award |
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Katrina Fernandez
ID:
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Determining distribution, ecology and threats of otter species in Uganda
REFNo: NS245ES
1)To confirm the presence of otter species in and around specific wetlands in Uganda.
2)Determine the ecology, habitat, behaviour and threats to otter species in Uganda.
3)Generate awareness and education to create stewardship and foster positivity towards wildlife and habitats.
4)Identifying conflict issues and threats and developing mitigation measures where necessary.
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India |
2021-12-16 |
2024-12-16 |
Natural Sciences |
Non-Clinical Trial |
Non-degree Award |
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BOSCO AGABA BEKIITA
ID: UNCST-2019-R000549
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Protocol for Regional Estimation of pfhrp2/3 gene deletion in P. falciparum parasites in Uganda (Prep)
REFNo: HS1911ES
1. Estimate the proportion of P. falciparum pfhrp2/3 gene deletions among false-negative HRP2 RDTs in the regions
2. Detect the parasite density and frequency of non-P. falciparum species in the samples
3. Identify regions in which the prevalence of pfhrp2/3 gene deletions causing false negative P. falciparum RDTs is at or above 5%, warranting a change in RDTs.
4. Assess the diagnostic field performance of the HRP2 and pan-pLDH RDTs compared to PCR as gold standard
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Uganda |
2021-12-16 |
2024-12-16 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Christine Semambo Sempebwa
ID: UNCST-2021-R011977
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A Situation Analysis Of Refugees And Migrant Families Of Children Ages 3 To 8 In Uganda
REFNo: SS1126ES
PURPOSE: To analyze the overall refugees and the host community dynamics, highlighting issues surrounding inclusion/non-discrimination, diversity, and the influence of these issues on ECCE service provision and uptake.
SPECIFIC OBJECTIVES:
1) Analyze the overall refugees and the host community dynamics, highlighting issues surrounding inclusion/non-discrimination, diversity, and the influence of these issues on ECCE service provision and uptake.
2) Assess the context and the most salient needs of 3 to 8 year old refugee and host community children and their families.
3) Investigate the factors affecting ECCE service provision and uptake of ECCE among refugee and host community populations.
4) Provide an evidence base that will inform the best ECCE programming for 3 to 8-year-olds affected by migration, along with those from the host communities.
5) Document lessons and best practices from the already existing ECCE service provision interventions that will inform Sesame Workshop’s programming.
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Uganda |
2021-12-16 |
2024-12-16 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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Andrea Felde Kronstad
ID:
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Student Politics and mobilization in a Hybrid Regime: the Case of Makerere University, Uganda
REFNo: SS1122ES
The prime outcome of the study is to explain under which conditions the political system and system linkages affecting the organization, activity and substance of institutionalized and non-institutionalized student politics at Makerere University. The study aims to compare the effects on institutionalized student politics at Makerere University. Institutionalized student politics is operationalized as the Students Guild and non-institutionalized student politics is operationalized as Student Activism. The findings will be presented in 4 articles through an article based PhD dissertation.
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Norway |
2021-12-16 |
2024-12-16 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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