Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
AHUMUZA VIANNEY JOHNMARY
ID:
The Refugee Question In Ugandan History 1942-2010
REFNo: SS2297ES

iii. To study the evolution of the relationship between refugees and their host communities,ii. To analyse the changing push and pull factors that shaped refugee flows into and exiting post-Colony Uganda up to 2010.,i. To examine the refugee problem in colonial Uganda.,
Uganda 2024-08-22 12:54:21 2027-08-22 Social Science and Humanities Non-Clinical Trial Degree Award
Mark Okwir
ID: UNCST-2021-R013417
PREVENTION OF MOTHER-TO-CHILD TRANSMISSION OF HEPATITIS B VIRUS BY ESTABLISHING AN ANTENATAL SCREENING AND VIRAL LOAD TESTING UNIT AND TENOFOVIR DISOPROXIL FUMARATE TREATMENT IN LIRA, NORTHERN UGANDA
REFNo: HS3861ES

To assess the viral load and effectiveness of the TDF therapy.,To assess and enhance knowledge and perceptions of hepatitis B, with the aim of reducing stigma and improving awareness among pregnant women. ,To optimise linkage to care and engagement in the recommended care after receiving a positive HBsAg test during the antenatal period.,To determine the prevalence and risk factors associated with hepatitis B virus infection among pregnant women attending the antenatal clinic in Lira University Hospital and Lira Regional Referral Hospital. ,To assess the implementation of the HBV DNA viral load threshold of ≥10,000 IU/mL for initiating TDF treatment in pregnant women during gestation week 24 or beyond in order to prevent HBV mother-to-child transmission in Lira, Northern Uganda.,
Uganda 2024-08-22 12:33:06 2027-08-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Francis Mutekanga
ID: UNCST-2020-R014725
GEC II Uganda Project
REFNo: SS3024ES

What were the implementation factors behind the GEC-T projects\' success or lack of success? ,To what extent and how did external contextual factors for different projects across the GEC-T portfolio influence their performance?,What were the unexpected or unintended results across the GEC-T portfolio?,What intermediate outcomes did the GEC-T portfolio deliver?,What results did the GEC-T portfolio deliver between the baseline and end line?,The primary objective of the Effectiveness Evaluation will be to assess the effectiveness of the GEC II projects that were designed and implemented through the GEC-T Window. ,
Uganda 2024-08-22 12:28:28 2027-08-22 Social Science and Humanities Non-Clinical Trial Non-degree Award
Grace Kisitu Paul
ID: UNCST-2024-R004102
Universal2: Pharmacokinetics, safety and acceptability of a solid paediatric fixed-dose combination of darunavir/ritonavir (DRV/r) 120/20mg for children living with HIV
REFNo: HS4762ES

To evaluate the pharmacokinetics and safety of DRV/r 120/20 mg tablets in children greater than or equal to 3 years of age and weighing 10 to less than 25 kg

To evaluate the pharmacokinetics and safety of DRV/r 120/20 mg tablets in children greater than or equal to 3 years of age and weighing 10 to Less than 25 kg

To evaluate the acceptability of DRV/r tablets in children greater than or equal to 3 years of age and weighing 10 to less than 25 kg

To evaluate the short-term efficacy of the DRV/r 120/20 mg tablets in children greater than or equal to 3 years of age and weighing 10 to less than 25 kg

To describe RTV PK parameters as well as darunavir unbound plasma concentrations.

Uganda 2024-08-22 11:45:22 2027-08-22 Medical and Health Sciences Clinical Trial Non-degree Award
Ioana Lungu
ID: UNCST-2024-R004378
Study protocol for baseline data collection on sexual and reproductive health outcomes in Wakiso district
REFNo: SS3049ES

At baseline and prior to the intervention, assess the uptake of HIV testing, ART and PrEP for AYP in our sample in study locations.,At baseline and prior to the intervention, assess the knowledge, perceived norms and attitudes towards contraception and HIV services (testing, ART and PrEP) for AYP in our sample in study locations.,At baseline and prior to the intervention, assess the modern Contraceptive Prevalence Rate (mCPR) for young women and girls in our samplein study locations.,At baseline and prior to the intervention, assess the level of access to high quality, youth friendly health services for AYP in our sample in study locations.,At baseline and prior to the intervention, assess the share of unintended pregnancies for our sample.,
Romania 2024-08-22 11:39:54 2027-08-22 Social Science and Humanities Non-Clinical Trial Non-degree Award
Agaba Katureebe Ishmael
ID: UNCST-2024-R004089
Getting a GRIP on Hypertension in Uganda: Giving Repetitive Isometric Exercise for Blood Pressure Control (GRIP in Uganda)
REFNo: HS4712ES

To assess knowledge, attitudes, and practices (KAP) about HTN and experience with IHT (if applicable) ,To measure HTN medication adherence for those prescribed HTN medication during their follow-up, which will be measured through pill counting (counting the remaining amount of pills for prescribed medication).,To assess the need for HTN medication at endline, as per clinical and MOH guidelines, which will be measured through changes in BP levels at week 12,To evaluate the effects of Isometric Hand Training (IHT) on resting diastolic Blood Pressure when compared to standard care after 12 weeks ,To evaluate the effects of Isometric Hand Training (IHT) on resting Systolic Blood Pressure when compared to standard care after 12 weeks ,To determine the efficacy of Isometric Hand Training (IHT) in a population of Hypertension (HTN) patients compared to standard care after 12 weeks of care,
Uganda 2024-08-22 11:38:26 2027-08-22 Medical and Health Sciences Clinical Trial Non-degree Award
JOSELYN RWEBEMBERA
ID: UNCST-2021-R013915
ASSESSING THE CONTEMPORARY ECHOCARDIOGRAPHIC DIAGNOSIS AND SECONDARY PROPHYLAXIS OF EARLY-STAGE RHEUMATIC HEART DISEASE
REFNo: HS4694ES

a) To determine the diagnostic accuracy of the 2023 World Heart Federation (WHF) echocardiographic screening criteria for RHD, estimate the cost of RHD screening using the WHF 2023 active case finding algorithm, and a cost analysis of two RHD screening models in Uganda; b) To compare patient-reported outcomes (i.e, treatment adherence, treatment satisfaction and health-related quality of life) among children receiving intramuscular and oral forms of penicillin prophylaxis; and c) To evaluate the cost effectiveness of oral versus intramuscular penicillin for treating early-stage RHD.
Uganda 2024-08-22 11:35:35 2027-08-22 Medical and Health Sciences Non-Clinical Trial Degree Award
Wilson Mathembele
ID:
School Inspection and the Quality of Education in Secondary Schools in Uganda: A case Study of Kasese District
REFNo: SS2957ES

To assess the influence of school inspection on the quality of education in secondary schools in Kasese District,To evaluate the quality of education in secondary schools in Kasese District ,To examine the quality of inspection in the secondary schools in Kasese District,The purpose of this study is to determine the effectiveness of school inspection in ensuring the quality of education in secondary schools in Kasese District in order to improve educational standards and quality outcomes.,
Uganda 2024-08-22 11:30:39 2027-08-22 Social Science and Humanities Non-Clinical Trial Degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
Assessment of Longitudinal Lung Function and Sleep Disordered Breathing in COPD Patients in Uganda
REFNo: HS4817ES

1.Assess longitudinal lung function and respiratory symptoms among adults with COPD in Uganda.

2.Determine whether baseline radiographic imaging and inflammatory markers can predict exacerbations at one year among those with COPD.

3.Assess nocturnal sleep patterns and the association between sleep disordered breathing and quality of life.


Uganda 2024-08-22 11:27:08 2027-08-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Proscovia Nabunya
ID: UNCST-2019-R000970
Testing the Feasibility and Acceptability of a Combination Intervention to Address Mental Health among Refugee Youth in Uganda
REFNo: SS2834ES

This proposed two-year study will be conducted in two phases. The first phase seeks to understand whether the COVID-19 pandemic had differential impact on refugee youth living in different settings. The second phase will test the feasibility and acceptability of an innovative combination intervention that has not been previously tested among refugee youth to address psychological problems that have increased since the onset of the COVID-19 pandemic. Aim 1. To examine the mental health impact of COVID-19 on refugee youth living in Bidibidi refugee settlement compared to refugee youth living in urban centers (Arua town) in northern Uganda. Aim 2. To test the feasibility, acceptability and preliminary short-term impact of an innovative intervention combining the youth readiness intervention (YRI) with youth development accounts and financial literacy training (YDA-FLT) to address the mental health impact of COVID-19 among refugee youth living in Bidibidi refugee settlement in northern Uganda.
Uganda 2024-08-19 11:03:04 2027-08-19 Social Science and Humanities Clinical Trial Non-degree Award
Peter Olupot-Olupot Olupot
ID: UNCST-2020-R014798
SMAART-MAP trial Severe Malaria A Research and Trials consortium - Multisite Adaptive Platform trial
REFNo: HS4547ES

OBJECTIVES
The objective of the SMAART-MAP trial is to identify promising adjunctive therapies to take forward into a large Phase III trial in severe malaria with a mortality endpoint. The adaptive platform design enables additional domains to be added so a range of adjunctive therapies can be tested, across multiple clinical presentations of severe malaria, in a timely manner.

PRIMARY OBJECTIVE(S)
To explore within each domain the therapeutic efficacy of the intervention using an early indicator such as a biomarker or clinical assessment at 24-72 hours.

SECONDARY OBJECTIVE(S)
 To assess the impact of the interventions on clinical outcomes (readmission and
mortality) on all children 28 days and 90 days after randomization
 To assess the impact of the interventions on Grade 3 or 4 adverse events, and adverse
events of any grade related to the interventions or comparators.
 To assess the impact of proposed definitions for severe malaria based on platelet counts
≤150,000/µL and plasma pfHRP2 concentrations ≥800 ng/mL on differences between
randomized groups
 In a sub study, to determine the performance characteristics of a POC pfHRP2 test
compared with quantitative plasma pfHRP2 concentrations determined from plasma.

Uganda 2024-08-16 11:01:14 2027-08-16 Medical and Health Sciences Clinical Trial Non-degree Award
SYLVIE NAMWASE
ID: UNCST-2024-R003958
Charcoal Conflict in Climate Change’s Decarbonisation Dilemmas: Knots of Livelihood, Nutrition, Communities, Gender, Migration and Energy in East Africa. RefNo: CoBAMS-REC-2024-39
REFNo: SS2909ES

To examine the East African challenges in the context of the global political landscape of climate strategies and identify how success-criteria are derived from global dynamics, and what lessons from these local cases should be fed into global policy-making.,To identify and examine the ways in which Uganda and Tanzania have initiated local solutions to the charcoal and climate change crisis and how they can each harmonise their legal and policy framework change in a way that is responsive to their local realities while in tandem with global climate change and decarbonisation trends.,To understand the legal and policy frameworks governing the climate change, charcoal and decarbonisation dilemma in Uganda and Tanzania. ,To understand local processes of charcoal transition in Uganda and Tanzania in order to capture the impact of possible changes on livelihoods, food, nutrition and health as well as social stability, and relations among different social identity groups, where gender, youth, women and migration are particularly central. ,The main objective is to understand how global climate change mitigation policies (decarbonisation) condition charcoal politics and socio-economic dynamics in energy-stressed countries down to local levels, and how to manage conflicts.,
Uganda 2024-08-12 10:56:54 2027-08-12 Social Science and Humanities Non-Clinical Trial Non-degree Award
PATRICIA  ATUKUNDA
ID:
Staff Welfare Strategies and Performance of Healthcare Providers in Government -aided Health Facilities in Bushenyi District, Uganda
REFNo: SS2783ES

To find out the extent to which career growth strategy affects the performance of healthcare givers in government-aided health facilities in Bushenyi District, Uganda.,To determine the extent to which financial well-being strategy impacts the performance of healthcare workers in government-aided health facilities in Bushenyi District, Uganda,To establish the extent to which work-life balance strategy influences the performance of healthcare workers in government-aided health facilities in Bushenyi District, Uganda.,To assess the extent to which health and safety strategy influences the performance of healthcare givers in government-aided health facilities in Bushenyi District, Uganda.,To analyze how the well-being of staff influences the performance of healthcare givers in government-aided health facilities within Bushenyi District, Uganda.,
Uganda 2024-08-12 10:55:47 2027-08-12 Social Science and Humanities Non-Clinical Trial Degree Award
CAROLINE NAKIDDE KAVUMA
ID:
Influence of Indigenous and Contemporary Early Years’ Education Pedagogy on Development of Children’s life-skills, Masaka District-Uganda
REFNo: SS2888ES

1.To establish the influence of indigenous pedagogy on the development of life skills among their children.
2.To investigate the influence of contemporary Early Years’ Education Pedagogy on the development of life skills among Baganda children.
3.To establish the influence of indigenous and contemporary EYE pedagogy on life skills development among children.
4.To examine the difference between the influence of IP and contemporary EYE pedagogy in development of life skills among Baganda children.

Uganda 2024-08-06 18:26:29 2027-08-06 Social Science and Humanities Non-Clinical Trial Degree Award
Julia Mwesigwa Nanteza
ID:
Perceptions, attitudes and Information needs of Stakeholder, Health Worker, and Child Caregiver to guide introduction of the Malaria Vaccine in Uganda
REFNo: SS2895ES

1. Assess participants’ awareness of the MV, including identification of Malaria Vaccine information sources. 2. Ascertain the misconceptions, fears, and rumors from the public about the Malaria Vaccine. 3. Elicit participant concerns about side effects of the Malaria Vaccine. 4. Ascertain participant expectations for Malaria Vaccine efficacy and acceptability of continued bed net use with vaccinated children. 5. Assess caregivers’ acceptability of adhering to a four-dose vaccination schedule that extends into the second year of life and may involve new vaccination visits. 6. Identify health workers’ perceived challenges for client education, provision of a four-dose schedule, tracking dose delivery, and reporting. 7. Elicit national and subnational stakeholder views and recommendations for a successful introduction of the Malaria Vaccine, including recommendations about effective ways to link and integrate UNEPI and National Malaria Control Program (NMCP) activities to promote and provide the MV.
Uganda 2024-08-06 18:24:50 2027-08-06 Social Science and Humanities Non-Clinical Trial Non-degree Award
NAKANWAGI JOSLYLINE LYDIA
ID:
A comparative analysis of adherence, retention in care, and viral suppression among PLHIV aged 50 and above and below 50 at Mulago ISS Clinic, Uganda.
REFNo: HS4587ES

To understand the psychosocial needs and challenges (stigma, social support, mental health and lifestyle adjustments faced by PLHIV aged 50 years and above attending Mulago ISS Clinic.,To determine the factors associated with adherence to ART, retention in care and viral suppression among people aged 50 years and above,o compare adherence to ART, retention in care and viral suppression of PLHIV aged 50 years and above and those below 50 years attending Mulago ISS clinic,To compare the cascade of care between people living with HIV aged 50 years and older and those below 50 years at Mulago ISS clinic in Uganda.,
Uganda 2024-08-06 18:14:04 2027-08-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
HARRIET NAMBUYA NIL
ID: UNCST-2021-R013414
World Health Organization Minimum Maternal and Newborn Health Data Set: pilot study at Jinja Regional Referral Hospital
REFNo: HS4727ES

General objective
The aim of the study is to assess the baseline capacity of collecting the data elements to inform WHO mMNHDS at hospitals in low- and middle-income countries.
Specific objectives
1.To identify which data elements of WHO mMNHDS are already incorporated into the hospitals’ existing data systems.
2.To determine which data elements of WHO mMNHDS create the largest challenges for incorporation within hospitals’ routine data collection efforts.
3.To determine which data elements can be used to inform future implementation strategy of WHO mMNHDS.
4.To determine which data elements can be used to inform subsequent revisions of the WHO mMNHDS.

Uganda 2024-08-06 18:12:03 2027-08-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Issa Ndungo
ID: UNCST-2024-R004235
The Interplay among Instructional Strategies, Learners Geometry Attitudes, and Van Hiele Levels of Geometric Reasoning: A Case Study of Selected Secondary Schools in Mid-Western Uganda.
REFNo: SS2857ES

To determine the Mediating Role of Geometry Attitudes on the relationship Between Instructional Strategies and Progression Through Van Hiele Levels,To compare the Effect of Instructional Strategies on learners’ Progression Through Van Hiele Levels,To investigate the relationship between Geometry Attitudes on learners’ Progression Through Van Hiele Levels,To compare the influence of Instructional Strategies on Learners\' Geometry Attitudes.,To investigate the relationship between instructional strategies, learners\' attitudes toward geometry, and their Van Hiele levels of geometric reasoning.,
Uganda 2024-08-06 18:10:09 2027-08-06 Social Science and Humanities Non-Clinical Trial Degree Award
jonathan sserunkuuma
ID:
Readiness of health facilities to diagnose, manage, and prevent the Ebola epidemic along Border districts in Southwestern Uganda.
REFNo: HS4575ES

To assess the capacity and readiness of primary healthcare centers to diagnose Ebola virus disease in Southwestern Uganda.To assess the capacity and readiness of primary healthcare centers to manage Ebola virus disease in Southwestern Uganda.To assess the capacity and readiness of primary healthcare centers to prevention Ebola virus disease in Southwestern Uganda.
Uganda 2024-08-06 18:07:39 2027-08-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Josephine Ninsiima Connie
ID:
Prevalence, Predictors, and Outcomes of Non-Communicable Diseases (Hypertension, Diabetes Mellitus, Obesity and Mental Health Disorders) among Persons Living with HIV in Uganda
REFNo: HS4621ES

To document the health-system-related strengths, opportunities, and challenges in the provision of NCDs services among PLHIV in Uganda,To describe the HIV and NCD outcomes for PLHIV with the selected NCDs in Uganda.,To document factors that are associated with selected NCDs among PLHIV in Uganda.,To describe cascades of care for selected NCDs among PLHIV in Uganda.,To describe the burden, predictors and outcomes of NCDs among PLHIV in Uganda, and assess the capacity of the Ugandan health system to offer NCDs services to PLHIV.,
Uganda 2024-08-06 18:04:20 2027-08-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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