Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
BRIGHT  NDAHIRO
ID: UNCST-2024-R015220
 ECOLOGICAL RISK ASSESSMENT OF HEAVY METALS AND POTENTIAL USE OF SELECTED MACROPHYTES IN PHYTOREMEDIATION AND MANAGEMENT OF LAKE GEORGE, UGANDA
REFNo: NS1001ES

General objective
Assess the ecological risk of heavy metal contamination in selected macrophytes, associated water and sediments of Lake George, Uganda
Specific objectives
The specific objectives are to:
1.Determine the distribution and diversity of macrophytes on L. George
2.Determine the pattern of multi elemental concentration (Cu, Ni, Pb and Zn, Co and their variations in wetland plant species of different growth forms, in corresponding water and sediments of Lake George.
3.Apply ecological pollution indices to assess pollution load in the sediments and macrophytes.
4.Identify the selected macrophytes potential use as bio-indicators and for phyto-extraction and phyto-stabilization of heavy metal contamination

 Uganda 2025-08-26 15:33:18 2028-08-26 Natural Sciences Non-Clinical Trial Degree Award
Edwin Nuwagira
ID: UNCST-2021-R013488
 EFFICACY AND TOLERABILITY OF SHORT-COURSE INTERMITTENT INTRAVENOUS LIPOSOMAL AMPHOTERICIN B VERSUS ORAL POSACONAZOLE FOR CHRONIC PULMONARY ASPERGILLOSIS: A PHASE IIA, PROSPECTIVE, MULTI-CENTRE, RANDOMIZED, CONTROLLED, OPEN-LABEL, FEASIBILITY TRIAL
REFNo: HS6400ES

5. Assess recruitment and retention of patients with CPA on a trial to inform design and sample size for a definitive efficacy trial.,4. To assess adherence to posaconazole therapy,3. To evaluate the utility of different trial endpoints (change in Aspergillus IgG antibody titer, radiological improvement, step test and weight) across groups.,2. To compare 12-month all-cause mortality in each arm,1. To measure emergence of isolates of Aspergillus with resistance/reduced susceptibility to posaconazole in both arms. ,1. Compare the efficacy and tolerability of 1) short course, high dose of intravenous liposomal amphotericin B, 2) short course, high dose of intravenous liposomal amphotericin B followed by daily posaconazole, or 3) posaconazole alone for the treatment of CPA for 6 months.,
 Uganda 2025-08-26 13:48:03 2028-08-26 Medical and Health Sciences Clinical Trial Non-degree Award
Barnabas Bakamutumaho
ID: UNCST-2021-R012636
 Countrywide Enhancement of Sentinel Congenital Rubella Surveillance and Intensified Case Identification for Burden Monitoring Following Measles-Rubella Vaccine Introduction in Uganda and Neighboring Countries
REFNo: HS6410ES

Objective: The long-term goal is to sustain systematic CRS case-based sentinel surveillance countrywide to understand the burden of rubella infections causing congenital disabilities and to assess the public health control and prevention interventions such as the vaccines.

Specific aim 1: To support laboratory based CRS diagnosis in clinically suspected cases
Specific aim 2: To monitor vaccine impact in Uganda's routine immunization program
Specific aim 3: To monitor and characterize genotypes associated with CRS
Specific aim 4: To monitor molecular epidemiology of CRS in East African region

 Uganda 2025-08-26 13:35:01 2028-08-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Michael Emenyu Richard
ID: UNCST-2025-R018382
 Assessing awareness and attitudes of nurses/midwives on effective referral protocols of cleft lip and or palate children; a case study of Teso Sub-Region in Eastern Uganda
REFNo: HS5973ES

Main objective/ purpose To assess the level of awareness and attitudes of nurses/midwives on effective referral protocols for cleft lip and or palate children in Teso sub-region, Eastern Uganda. Specific Objectives i. To assess the level of awareness of nurses/midwives on effective referral protocols for cleft lip and palate children. ii. To determine the attitudes of nurses/midwives on effective referral protocols for cleft lip and palate children. iii. To assess the referral protocol/policy for cleft lip and or palate children in Uganda being implemented/used across the health facilities in Teso sub-region. iv. To determine the socio-demographics of nurses/midwives on effective referral protocols for cleft lip and or palate children.
Uganda 2025-08-26 13:23:57 2028-08-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Clara Wekesa
ID: UNCST-2021-R013282
 Correlation between particulate matter and immuno-biochemical markers among people living with HIV and fibrotic liver disease in urban Uganda
REFNo: HS6060ES

Primary objectives:
• To examine the relationship between PM exposure and serum levels of biochemical and haematological parameters (liver chemistry profile, platelet count, fasting blood glucose, glycated hemoglobin and lipid profiles)
• To examine the relationship between PM exposure and serum levels of pro-fibrotic cytokines
Secondary objectives:
• Correlation coefficient between PM and fatty liver change measurements
• Correlation coefficient between PM and fatty liver stiffness measurements

 Uganda 2025-08-26 13:19:27 2028-08-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kirabo Suubi
ID: UNCST-2023-R005659
 RESPOND – Rethinking access and utilization of reproductive healthcare and domestic violence services among women with disabilities in Uganda
REFNo: SS3965ES

To explore the perspectives of reproductive healthcare (RHC) workers in providing reproductive health services to WWDs and their perspectives on the health system’s capacity to deliver reproductive health services to WWDs.,2. To explore the perspective of providers of domestic violence (DV) services in providing DV services to WWDs and their perspectives on the systems’ capacity to deliver domestic violence services to WWDs.,1. To explore the perspectives of WWDs on access and utilization of reproductive healthcare and domestic violence services. ,The purpose of this research is to provide a better understanding of the impact of disability on access, utilization, and delivery of reproductive healthcare and domestic violence services among WWDs, to inform responses to the needs of WWDs in low-income countries. ,
 Uganda 2025-08-26 13:15:25 2028-08-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Helen Naiga Nelly
ID: UNCST-2025-R016871
 Uptake of Sickle Cell Screening and Exploring Knowledge, Attitudes, and Beliefs towards sickle cell screening among Young Adults in Bugweri district
REFNo: HS6109ES

• To determine the uptake of sickle cell screening among young adults aged 18-49 years in Bugweri district
• To determine the knowledge levels, attitude and beliefs of young adults aged 18-49 years in Bugweri district regarding sickle cell disease and screening
• To establish the factors influencing the uptake of sickle cell screening among young adults aged 18-49 years in Bugweri district

 Uganda 2025-08-26 11:41:44 2028-08-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kazibwe Herman
ID: UNCST-2025-R017099
 STUDY TITLE: APPROPRIATENESS & USABILITY OF A DISCHARGE PLANNING PROTOCOL FOR PHYSIOTHERAPY OF PATIENTS WITH TRAUMATIC BRAIN INJURY FOR PROVIDERS AT MBARARA REGIONAL REFERRAL HOSPITAL AND MULAGO NATIONAL REFERRAL HOSPITAL
REFNo: HS6191ES

Research Question: Is an interdisciplinary referral protocol intervention for TBI patients, expanded for inclusion of occupational and speech therapy, appropriate and usable at a national & regional hospital? Objectives 1.To assess appropriateness of the discharge planning protocol, revised to include occupational and speech therapy, to concurrently meet the needs for decision-making by individual users and a multidisciplinary care team. 2.To assess usability of the revised discharge planning protocol and paper interface in healthcare practice for individual users and multidisciplinary team communication
Uganda 2025-08-26 11:40:11 2028-08-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Satoru Mikami
ID: UNCST-2019-R000358
 The Effects of a Hands-off Approach and Information Empowerment on Adherence to HWTS: Evidence from a Multi-Arm Randomized Field Experiment in Northern Wakiso, Uganda
REFNo: SS4167ES

This study aims to test two hypotheses on how to improve adherence to HWTS, especially focusing on the regular cleaning of water containers: (1) whether a hands-off approach, such as a conditional cash transfer, is more effective than a conventional hands-on approach, and/or (2) whether information empowerment—specifically, visually exposing the inside of water containers—can promote adherence under challenging conditions.
 Japan 2025-08-25 13:41:19 2028-08-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
Nathan Kenya-Mugisha
ID: UNCST-2021-R013752
 Assessing different deployment models for small-scale tsetse control using Tiny Targets
REFNo: NS1013ES

The aim of this study is to evaluate three different models of Tiny Target deployment: top-down regular; top-down intensive; community-based, that could be used for future reactive vector control. The data that will be generated in the study will enable policy makers, implementers and funders to make an informed decision about how to implement reactive vector control. The aim will be achieved by the following objectives: Objective 1: to determine which deployment model achieves the greatest reduction in tsetse densities Objective 2: to compare the resource requirements of each deployment model Objective 3: to ascertain the acceptability of the different deployment models to the communities Objective 4: to compare the coverage and quality of Tiny Target deployments between models Objective 5: to assess community knowledge of tsetse habitat and human-tsetse contact areas Methods: Study sites:
Uganda 2025-08-19 13:22:12 2028-08-19 Natural Sciences Non-Clinical Trial Non-degree Award
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