Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Rita Nakalega
ID: UNCST-2019-R000599
Exploring Neuro-Vascular Biomarkers in Young Adults with lifelong HIV and without HIV in Uganda: Insights from Carotid Ultrasound
REFNo: HS6038ES

Exploratory objectives/aims: To determine the prevalence of and relationships between HIV infection, carotid pathology, neurological and neurocognitive function, and serum markers of cardiovascular health and inflammation in a population of young adults living with HIV in Uganda who acquired the infection perinatally as well as uninfected age-matched controls,Secondary objective (Aim 2): To determine the prevalence of cognitive dysfunction, as determined by a battery of cognitive evaluations, of a population of young adults living with HIV in Uganda who acquired the infection perinatally, relative to uninfected age-matched controls.,Primary objective (Aim 1): To determine the prevalence of carotid pathology, as determined by ultrasound-based measurement of intima-media thickness (IMT), in a population of young adults living with HIV in Uganda who acquired the infection perinatally, relative to uninfected age-matched controls.,
Uganda 2025-06-20 9:22:24 2028-06-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kiel McGowan
ID: UNCST-2025-R017284
Prevalence and patterns of coinfection with malaria and soil transmitted helminths among school-aged children in rural Northern Uganda: A cross-sectional study
REFNo: HS6039ES

To measure the prevalence of coinfection with malaria and STH among school-aged children and to identify factors that may be associated with infection.
USA 2025-06-20 9:16:14 2028-06-20 Medical and Health Sciences Non-Clinical Trial Degree Award
MARY AGUNLOYE OLAOLUWA
ID: UNCST-2024-R003434
EVALUATION OF THE ACTIVITIES OF LEAF EXTRACTS OF AVOCADO (Persea americana Mill.) IN HIGH-FAT DIET/ LOW- DOSE STREPTOZOTOCIN - INDUCED TYPE 2 DIABETES MELLITUS IN WISTAR RATS
REFNo: HS5401ES

1. To screen aqueous, ethyl acetate, and ethanol leave extracts of p. americana Mill for anti-hyperglycemic activity
2. To assess the anti-diabetic potential of selected extract in high-fat diet/low-dose streptozotocin-induced T2DM in Wistar rats in a dose dependent pattern, and identify it mechanism of action
3. To perform phytochemical screening and metabolite profiling of the selected bioactive extracts through integrated FT-IR, LC-MS and GC-MS
4. To assess the in silico interactions of compounds of avocado leaf with selected drug targets in type II diabetes.
5. To evaluate the biological activities of the in silico hit compounds using in vitro and in vivo analyses

Nigeria 2025-06-20 9:03:03 2028-06-20 Medical and Health Sciences Non-Clinical Trial Degree Award
GEOFFREYEDWIN SEMAMBO
ID: UNCST-2024-R015519
prevalence and factors associated with Adverse maternal outcomes among emergency obstetric referrals delivered at Mbarara regional referral Hospital
REFNo: HS5740ES

To determine the factors associated with adverse maternal outcomes among emergency obstetric referrals at Mbarara Regional Referral Hospital,To describe the adverse maternal outcomes among emergency obstetric referrals delivered at Mbarara Regional Referral Hospital,To determine the prevalence of adverse maternal outcomes among emergency obstetric referrals delivered at Mbarara Regional Referral Hospital, To determine the prevalence and factors associated with adverse maternal outcomes among emergency obstetric referrals delivered at Mbarara Regional Referral Hospital,
Uganda 2025-06-20 8:55:52 2028-06-20 Medical and Health Sciences Non-Clinical Trial Degree Award
Gloria Lubega
ID: UNCST-2025-R017180
Understanding HIV vertical transmission in Uganda in a population of urban mothers in the era of Dolutegravir based antiretroviral therapy(VERT)
REFNo: HS6095ES

Quantitative Objectives I. To identify level of utilisation of PMTCT and EID services among mothers living with HIV. II. To assess the factors associated with utilization of PMTCT services and EID services among mothers living with HIV. III. To identify factors associated with HIV vertical transmission in the era of Dolutegravir based therapy among mothers living with HIV. IV. To determine the proportion of pregnant women diagnosed with HIV that were linked to care and the time taken from HIV diagnosis to linkage to care among mothers living with HIV. Qualitative Objectives 1. To explore the experiences of women in the PMTCT program, including. • Barriers and facilitators for utilizing the program. • Adherence to instructions such as breastfeeding practices. • And the role of close relationships (partner, family and community members) in supporting women’s participation in PMTCT. 2. To obtain suggestions that can potentially improve the implementation of the PMTCT program
Uganda 2025-06-20 8:53:57 2028-06-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Annah Tugaineyo
ID: UNCST-2024-R016504
WORKPLACE EQUITY, PARTICIPATION IN STAFF COMMITTEES, STAFF WELFARE AND JOB SATISFACTION OF ACADEMIC STAFF IN PUBLIC AND PRIVATE UNIVERSITIES IN WESTERN UGANDA
REFNo: SS3835ES

-To examine the differences in workplace equity between academic staff in public and private universities in Western Uganda.

-To assess the underlying factors that stimulate job satisfaction among academic staff in public and private universities in western Uganda

-To analyze the differences in participation in staff committees between academic staff in public and private universities in Western Uganda.

-To determine the influence of workplace equity on job satisfaction among academic staff in public and private universities in western Uganda.

-To assess the mediating role of participation in staff committees in the relationship between workplace equity and job satisfaction in public and private universities in western Uganda.

-To investigate the mediating role of staff welfare in the relationship between workplace equity and job satisfaction in public and private universities in western Uganda.

Uganda 2025-06-20 8:47:35 2028-06-20 Social Science and Humanities Non-Clinical Trial Degree Award
Anne Mette Kjaer
ID: UNCST-2024-R015303
The Political Economy of Local Food System Governance: Impacts on climate -Vulnerable communities in Lake Victoria Border Region
REFNo: SS3899ES

1. Understanding and mapping national food governance ie policy initiatives, decisions and processes affecting food and livelihood security of climate-vulnerable communities in lake Victoria border region (WP1)
2. Understanding the implementation processes of these food system policies and decision with a focus on the effect of local government autonomy and capacity to address the food and livelihood of climate-vulnerable communities, and the nature of state-community encouters in these processes (WP2)
3. Understanding the lived experiences of food and livelihood security among the climate-vulnerable communities in Lake Victoria region, the perceptions they have of local and national food system policies, and the role these communities play in food system governance
Denmark 2025-06-20 8:43:55 2028-06-20 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jolly  Kamugisha G.K.
ID: UNCST-2023-R005715
Performance and Factors Affecting the Implementation of the Integrated Management of Acute Malnutrition Programme: A Study of Kampala, Mukono, Wakiso and Kayunga Districts
REFNo: HS6084ES

5. To document the lessons learnt and best practices during implementation of the IMAM program in the four target districts during the calendar year 2022 and 2023.,4. To establish factors that affect the utilization of IMAM services in the four target districts.,3. To determine factors influencing treatment outcomes of children with wasting in the four target districts.,2. To determine the performances of the integrated management of acute malnutrition program in the four target districts during the calendar year 2022 and 2023.,1. To identify the communities contributing to a high burden of childhood wasting caseload in health facilities in four target districts (Kampala, Mukono, Wakiso and Kayunga),The overall objective of this study is to assess the nutrition service delivery and factors influencing utilization of the IMAM programme in Kampala, Mukono, Wakiso and Kayunga districts,
Uganda 2025-06-20 8:41:29 2028-06-20 Medical and Health Sciences Clinical Trial Non-degree Award
Evan Borkum
ID: UNCST-2025-R016987
Evaluation of cash and cash plus intervention in Nakivale refugee settlement, Uganda
REFNo: SS3849ES

The non-profit organization GiveDirectly plans to implement a cash-plus program in Nakivale refugee settlement, which will supplement a large unconditional cash transfer with demand-driven skills training and apprenticeship; business coaching, mentoring, and entrepreneurship support; and access to financial services and financial literacy training. The objective of the study is to rigorously assess the impact of the program on household wellbeing through a randomized controlled trial.
Italy 2025-06-20 8:36:56 2028-06-20 Social Science and Humanities Non-Clinical Trial Non-degree Award
Christine Nalwadda Kayemba
ID: UNCST-2020-R014220
EVALUATION OF A PILOT PROJECT TO EXPAND ACCESS TO THE IMPLANT FAMILY PLANNING METHOD THROUGH COMMUNITY HEALTH EXTENSION WORKERS IN SELECTED DISTRICTS IN UGANDA
REFNo: HS5966ES

3. To determine competence of the CHEWs regarding insertion and removal of implants following training.,2. To assess the acceptability of the community-based implant by CHEWs among the stakeholders (health workers at the facility, FP clients in the community) ,1. To explore the perceptions of the stakeholders towards the implant provision task shifting to the CHEWs (stakeholders including the CHEWs, clients, health workers/ professionals and policy makers) ,The overall objective is to evaluate the implementation of a community-based implant intervention through training CHEWs on how to insert and remove implants, in order to understand the perceptions and acceptability of stakeholders towards task shifting the implants service provision to CHEWS, and determine the CHEWs attainment of competencies to insert and removal implants in the selected districts in Uganda,
Uganda 2025-06-20 8:34:40 2028-06-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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