Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Patrick Kagurusi Tumusiime
ID: UNCST-2021-R012687
 Exploring the Nexus of Clean Water Access and Sexual Reproductive Health among Women and Girls in Rural Uganda
REFNo: SS2829ES

1. How do socio-cultural contexts, such as traditional gender roles and community expectations, shape the challenges women and girls face when accessing clean water?
2. How do power dynamics influence the management, utilization, and involvement of women in activities related to water access?
3. What role does education play on the awareness and implementation of Sexual Reproductive Health practices among women and girls?

Uganda 2024-08-28 18:39:31 2027-08-28 Social Science and Humanities Non-Clinical Trial Non-degree Award
Hadijah Yahyah
ID:
Assessing the Environmental Sustainability Implications of Farm-Level Persistent Organic Pollutant Pesticide Use in Uganda
REFNo: SS2683ES

1. To examine the pathways for the transmission of POPs pesticides into Mukono District;
2. To evaluate the trends and characteristics of farm level use of POP pesticides into Mukono District;
3. To assess the role and level of knowledge, attitudes and practices of farmers in decision making for POPs pesticide use in Mukono District;
4. To assess the adequacy of the existing structures , tools, and approaches for the regulation of importation and farm-level use of POP pesticides in Uganda;

 Uganda 2024-08-28 18:31:37 2027-08-28 Social Science and Humanities Non-Clinical Trial Degree Award
Catherine Nakaye
ID: UNCST-2021-R013222
 FEASIBILITY, ACCEPTABILITY, AND PERSISTENCE OF COMMUNITY DRUG SHOP-BASED HIV SELF-TESTING AND ORAL PREP DELIVERY AMONG FEMALE SEX WORKERS IN KITEBI, KAMPALA CAPITAL CITY, CENTRAL UGANDA (DROP-D).
REFNo: HS4556ES

Examine FSW and community drug shop PrEP providers’ experiences, preferences, barriers, and facilitators related to the community drug shop based HIVST and oral PrEP delivery model,Assess persistence of community drug shop-based HIVST and oral PrEP delivery among FSW in Kampala,Assess the feasibility and acceptability of utilising community drug shops to offer HIVST and oral PrEP delivery among FSW in Kampala,
 Uganda 2024-08-28 18:28:21 2027-08-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ronald Semyalo Paul Ddumba
ID: UNCST-2021-R012585
 RISING INEQUALITIES OCCASIONED BY COVID-19 IMPACTS IN URBAN INFORMAL SETTLEMENT IN UGANDA (CASE STUDY OF ACCESS AND USE OF SAFE WATER IN KAMPALA SLUM AREAS)
REFNo: NS746ES

To assess microbiological and physicochemical water quality both at the source and household reserves, as well as carryout sanitation risk assessment of the different water sources in Kisenyi.,To assess the patterns of access to and utilization of safe water among households in Kisenyi, Central Division, examining the changes that occurred before, during, and after the COVID-19 pandemic.,To investigate the diverse socio-economic determinants of households in Kisenyi which influences their choice of water source and how this was impacted by COVID-19.,Examine the multifaceted impact of the COVID-19 pandemic on the exacerbation of social and economic inequalities among the urban poor, with a specific focus on access to Water, Sanitation, and Hygiene (WASH) services, as a means to gain insights and inform strategies for addressing these disparities.,
 Uganda 2024-08-28 18:19:09 2027-08-28 Natural Sciences Non-Clinical Trial Non-degree Award
ERINAH MUDONDO -
ID:
Liquidity management practices and Financial performance of banking institution in Kampala metropolitan - Uganda
REFNo: SS2872ES

To establish the influence of liquidity risk on the financial performance of banking institutions in Kampala Metropolitan.,To investigate the influence of liquidity management practices on financial performance of banking institutions in Kampala Metropolitan, Uganda.,
 Uganda 2024-08-28 18:17:15 2027-08-28 Social Science and Humanities Non-Clinical Trial Degree Award
Robert Downing George
ID: UNCST-2020-R014615
 A prospective, multi-centre study to evaluate the diagnostic sensitivity and specificity of the Determine Syphilis Advanced test.
REFNo: HS4648ES


The primary objective of this study is:
• To determine the diagnostic sensitivity and specificity of the Determine Syphilis Advanced test results using fingerstick capillary whole blood, venous whole blood, serum and venous plasma, when the test is performed by professional users.

The reference test will be Elecsys® Syphilis test (Roche). This test is an electrochemiluminescence immunoassay for the qualitative determination of total antibodies against Treponema pallidum. Samples with a negative Elecsys Syphilis result will be considered reference test-negative. Samples with a positive Elecsys Syphilis result will be confirmed by Treponema Pallidum Particle Agglutination (TPPA) testing. The TPPA result must be positive for the sample to be considered reference test-positive. Samples with a positive Elecsys Syphilis result but a negative or indeterminate TPPA result will be considered indeterminate and excluded from the study analyses. Potential discrepant result resolution using the Abbott Architect i1000SR Syphilis chemiluminescent microparticle immunoassay may be conducted for study reference test-positive or reference test-negative samples with discrepant investigational test results. The results from potential discrepant result resolution testing will be presented as table footnotes only. In addition to these treponemal tests, non-treponemal RPR testing will also be conducted for the reference test-positive participants, and the results may be stratified also by RPR status. All discrepant specimens shall be repeated using the same lot of RDT, and then on all available lots and any variability noted.

Another primary study objective is to compare the performance of the Determine Syphilis Advanced test with two commercially available similar tests, to meet the regulatory requirements in Japan. These two commercially available tests will be the TPPA test (SERODIA-TPPA, Fujirebio, Japan) and the Determine Syphilis TP test (Abbott). This analysis will be performed using 60 reference test-positive samples and 60 reference test-negative samples. The testing will be performed using plasma.

One study secondary objective is to evaluate the usability through completion of a user experience questionnaire (healthcare and laboratory staff).

Another study secondary objective is to determine the stability of venous whole blood, serum and plasma samples for use with Determine Syphilis Advanced, after refrigeration of the venous whole blood, serum and plasma at 2-8 degrees Celsius during 7 days before testing.

 UK 2024-08-28 17:34:38 2027-08-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Hillary Agaba
ID:
Understanding experiences of participating in a farmer research network from multiple perspectives in the Agroecology - Landscape project in Eastern Uganda
REFNo: SS2707ES

Provide an overview of the diversity of experiences across the Collaborative Resilient Food Systems (CRFS) countries, and different projects within countries, in ESAf. ,Gain more understanding of how FRN groups have developed and are functioning from the perspectives of those involved, ,Document the experience of participating in Farmer Research network (FRN) from multiple perspectives: farmers, researchers, NGO field staff and extension workers;,
 Uganda 2024-08-28 17:32:34 2027-08-28 Social Science and Humanities Non-Clinical Trial Non-degree Award
Dennis Muhanguzi
ID: UNCST-2019-R001101
 Comparing the Diagnostic Performance of the Rapid Tick Exposure Test (RaTexT®) and Larval Packet Test [LPT] for Acaricide Resistance Management in Uganda
REFNo: NS843ES

The general objective of this study will be to determine the diagnostic performance of RaTexT® compared to larval packet technique, test a mobile application for its ability to capture acaricide resistance data generated by RaTexT® and transmit it to end users as dynamic maps of acaricide resistance as well as determine the gender roles that are likely to underpin successful RaTexT® introduction. The specific objectives of this acaricide study will be to determine:
i.Laboratory and field diagnostic performance [specificity, sensitivity, negative and positive predictive values] of RaTexT® when used to detect acaricide resistance in tick populations isolated from different agro-ecological zones of Uganda.
ii. Possibility of integrating RaTexT® -generated acaricide resistance | susceptibility data into a mobile phone app to allow end-users to create dynamic maps of acaricide resistance in different African ecologies.
iii.Gender-based drivers of successful introduction and sustainable utilisation of RaTexT®

 Uganda 2024-08-28 17:31:08 2027-08-28 Natural Sciences Non-Clinical Trial Non-degree Award
Ruth Namazzi
ID: UNCST-2020-R014305
 Zinc for Infection Prevention in Sickle cell anemia ZIPS-2
REFNo: HS4824ES

The primary objective of the study is to determine if zinc supplementation at 20mg daily is safe and efficacious at reducing all-cause infection in Ugandan children 1.00-4.99 years of age with SCA.Secondary objectives 1. To determine the incidence of adverse events requiring discontinuation of study drug in children ages 1-4.99 supplemented with 20mg of daily zinc vs placebo 2. To determine the incidence of stroke or death in children ages 1-4.99 supplemented with 20mg of daily zinc vs placebo 3. To determine the incidence of infections requiring hospitalization in children ages 1-4.99 supplemented with 20mg of daily zinc vs placebo 4. To determine the incidence of vaso-occlusive crises in children ages 1-4.99 supplemented with 20mg of daily zinc vs placebo 5. To determine the change in transcranial Doppler (TCD) velocity from enrollment to 6-month study endpoint in children ages 1-4.99 supplemented with 20mg of daily zinc vs placebo 6. To determine change in serum zinc deficiency status from enrollment to 6-month study endpoint in children ages 1-4.99 supplemented with 20mg of daily zinc vs placebo 7. To determine the incidence of serious adverse events in children ages 1-4.99 supplemented with 20mg of daily zinc vs placebo 8. To determine the incidence of adverse events in children ages 1-4.99 supplemented with 20mg of daily zinc vs placebo
Uganda 2024-08-28 17:29:12 2027-08-28 Medical and Health Sciences Clinical Trial Non-degree Award
Esther Nakyaze
ID:
Provider Perspectives on the PrEP Ring (“ProPrEP”): views from a maternal and child health program (“BAMA”) serving young mothers in rural Uganda.
REFNo: HS4468ES

General Objective
The study will deepen our understanding of provider perspectives on use of the PrEP vaginal ring among young mothers living in rural areas of Uganda.
Specific Objectives
1. Identify preliminary areas for education and outreach to improve both provider and end-user understanding/knowledge of the new vaginal ring technology, thus increasing likelihood of quality counseling and uptake among a vulnerable population of young mothers.
2. Explore the reception by health care personnel of promotional and information/education/counseling (IEC) materials developed by the multilateral “Catalyst” study (funded by PEPFAR through USAID) for ring launch, especially in rural regions having distinct health services resources; identify areas for possible adaptation or elaboration for best uptake and use by health workers
3. Expand understanding of facilitators and barriers faced by young mothers in accessing HIV prevention information and services, especially:
a. community and peer-based stigma
b. provider attitudes
c. models of service provision linking maternal health and HIV prevention/care

Uganda 2024-08-26 18:29:44 2027-08-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
BOSCO AGABA BEKIITA
ID: UNCST-2019-R000549
 Epidemiological Profile of Malaria and Molecular Characterization to Assess Presence and Potential Contribution of Emerging Parasite Populations to Malaria Epidemics in Epidemic Districts in Eastern Uganda
REFNo: HS4786ES

General objective
To describe the epidemiological profile of malaria and assess presence and potential contribution of new emerging parasite populations to persistent epidemics in malaria
epidemic districts in Eastern Uganda
Specific objectives
1. To describe the trend and epidemiological profile of malaria in five epidemic districts in Eastern
Uganda over the past 5-year period
2 . To assess presence and potential contribution of emerging parasite species to epidemics by
molecular characterization of malaria parasite populations in epidemic districts in Eastern Uganda
3 . To assess presence and potential contribution of emerging parasite populations harboring
molecular markers of artemisinin resistance to persistent epidemics in malaria epidemic districts
in Eastern Uganda
4 . To assess presence and potential contribution of emerging parasite populations harboring pfhrp2
and pfhrp3 gene deletions to the persistent epidemics in malaria epidemic districts in Eastern Uganda
 Uganda 2024-08-26 18:28:33 2027-08-26 Medical and Health Sciences Non-Clinical Trial Degree Award
MUGISHA TAREMWA IVAN
ID: UNCST-2024-R004274
 Assessment of Transfusion Safety and Efficacy among Cancer Patients in Uganda and Caregivers’ Perceptions on Blood Use.
REFNo: HS4848ES

Specific objectives: (i). To assess the level of bacterial contamination in stored whole blood and blood components intended for transfusion to patients with cancer at Mbarara Regional Referral Hospital and Uganda Cancer Institute. (ii). To determine the prevalence of, and the factors associated with immune sensitization among patients with hematological malignancies at Mbarara Regional Referral Hospital and Uganda Cancer Institute. (iii). To identify the specificities of anti-RBC alloantibodies in patients with hematological malignancies at Mbarara Regional Referral Hospital and Uganda Cancer Institute (iv). To determine the incidence of acute and delayed serologic or delayed hemolytic transfusion reactions among patients with cancer at Mbarara Regional Referral Hospital and Uganda Cancer Institute (v). To describe the caregivers' perceptions of blood use and availability in southwestern Uganda. Main objective: To assess transfusion safety and efficacy among patients with cancer in Uganda and caregivers’ perceptions of blood use.
 Uganda 2024-08-26 18:26:57 2027-08-26 Medical and Health Sciences Non-Clinical Trial Degree Award
Edward  Tumwesige
ID: UNCST-2024-R003855
 Assessing Community Willingness and Acceptance to Utilize Locally Developed Vaccines
REFNo: SS2875ES

• Assess the community's level of knowledge and awareness regarding locally developed vaccines.
• Explore trust and willingness of the community to utilise locally developed vaccines.
• Identify factors contributing to positive or negative perceptions of locally developed vaccines.
• Explore the most effective communication channels for sharing information about locally developed vaccines.

 Uganda 2024-08-26 18:25:34 2027-08-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
ASUMAN KHAMIS SHAFI
ID:
Timing Of Neurosurgical Intervention And Short-term Outcome Of Patients With Traumatic Brain Injury Admitted To Mulago Hospital Emergency Department
REFNo: HS4610ES

1. To determine the average decision-to-intervention time among patients with TBI admitted at MNRH ED. 2. To determine factors associated with the neurosurgical intervention among patients with TBI admitted to the MNRH ED. 3. To determine the 72-hour outcome mong patients with TBI requiring neurosurgical intervention admitted to MNRH ED.
 Uganda 2024-08-26 18:24:09 2027-08-26 Medical and Health Sciences Non-Clinical Trial Degree Award
Patience Kinengyere Bemanya
ID: UNCST-2024-R004964
 PROJECT EVALUATION FOR THE INCREASING EQUITABLE ACCESS TO EFFECTIVE CATARACT SERVICES IN WEST, SOUTH, AND SOUTH-WESTERN UGANDA PROJECT
REFNo: SS2923ES

6. To evaluate the impact on the broader health system, including the referral system and the ability to handle increased demand for eye health services. ,5. To analyse the efficiency of operational processes within the project, including infrastructure development, capacity-building initiatives, and improvements in surgical procedures. ,4. To assess the extent of integrating health services for women with eye care services, its merits and demerits, challenges encountered, and the factors for scalability/sustainability. ,3. To evaluate the project’s success in promoting equity and inclusivity in health service delivery, mainly focusing on gender-specific barriers and access challenges marginalised populations face. ,2. To examine the effectiveness of community engagement strategies and awareness activities in increasing eye health awareness, improving access to services, increasing uptake of eye care services and reducing barriers to access to eye health services.,1. To evaluate overall project impact and effectiveness in terms of increasing equitable access to adequate services, improving service quality, achieving gender equity in eye health and reducing cataract-related blindness in the project area. ,To assess the extent to which the project\'s two components have met their objectives, key outputs, outcomes, and overall impact. It will also validate the monitoring data collected by in-country program teams during implementation. It will contribute to improvement by extracting valuable lessons from each part of the project. These insights will be instrumental in enhancing current and future programming within the region, guiding the development of future projects, and evaluating the potential scalability of the project to improve eye health.,
 Uganda 2024-08-26 18:22:11 2027-08-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Timothy  Muwonge Ronald
ID: UNCST-2020-R014680
 Tailoring community ART delivery to the needs and preferences of people living with HIV in refugee settlements in Uganda
REFNo: HS4193ES

The overarching objective of the proposed study is to evaluate how community ART delivery can be optimized for people living with HIV (PLHIV) in refugee settlements in Uganda.
Specific aims:
Aim 1A: To identify key barriers to community antiretroviral therapy (ART) delivery participation and implementation in refugee settlements experienced by PLHIV, health workers, and expert clients.
Aim 1B: To characterize perspectives of PLHIV, health workers, and expert clients on the optimal design of community ART delivery for refugee settlements.
Aim 2: To quantify community ART delivery preferences among PLHIV in refugee settlements and identify demographic groups with similar preference profiles.

 Uganda 2024-08-26 18:17:13 2027-08-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
FREDDIE SSENGOOBA Peter
ID: UNCST-2021-R011834
 Estimating the cost of introduction, delivery and budget impact of malaria vaccine introduction in Uganda (A prospective projection)
REFNo: HS4096ES

4. To determine the budget impact of introducing and delivering Malaria vaccine among children under five years in Uganda. ,3. To estimate and compare the cost of delivering the malaria vaccine under different vaccination modalities/approaches,2. To estimate the additional resource requirements for the introduction and rollout of the malaria vaccine into Uganda’s routine immunizations programme.,1. To explore perspectives of key stakeholders on Uganda’s plan to introduce the malaria vaccine among children under five years.,To estimate the incremental resources (cost) and budget impact of introducing the new malaria vaccine in Uganda to inform the country decision-making regarding the introduction, delivery, national scale-up, as well as impact of the malaria vaccine on other vaccines in the routine immunization system.,
 Uganda 2024-08-26 18:14:03 2027-08-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kisembo Vincent
ID: UNCST-2024-R003679
 NATURAL RESOURCE GOVERNANCE AND HUMAN-ECOLOGICAL WELLBEING IN THE OIL AND GAS SUB SECTOR IN BUNYORO SUB-REGION
REFNo: SS2971ES

the study's main objective is to assess natural resource governance and human-ecological wellbeing in the oil and gas sub sector in Bunyoro sub-region, specifically in the districts of Hoima, Kikuube and Buliisa.
Specifically, the study aims to;
1. To analyse the established legal and institutional framework for oil natural resource governance in ensuring the well-being of human -ecological wellbeing in Buliisa, Hoima and Kikuube districts
2. To examine the policies on human wellbeing to the communities in the Oil and Gas sub sector in Buliisa, Hoima and Kikuube districts
3. To analyze the implications of oil and gas sub sector activities on ecological wellbeing in Buliisa, Hoima and Kikuube districts.
4. To examine social and environmental challenges emanating from Oil and gas activities in Buliisa, Hoima and Kikuube districts

Uganda 2024-08-26 15:11:29 2027-08-26 Social Science and Humanities Non-Clinical Trial Degree Award
Teopista Akoyi Kevin
ID: UNCST-2024-R004534
 AfriFoodLinks Project - Mbale City Research
REFNo: SS2990ES

d. Actively engage government actors, creating a project feedback mechanism. ,c. Engage other project work packages towards constructing positions on multi-level governance, agri-food system entrepreneurship and innovation and urban food environments,b. Actively contribute to development of urban food system researcher network in partner African cities,a. Support the generation of new and path-leading urban food systems knowledge,to generate scientific evidence to inform actions geared towards transforming urban food systems in such a manner that tackles the systemic foundations of food insecurity and environmental impact.,
 Uganda 2024-08-26 15:00:52 2027-08-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Herbert Ainamani Elvis
ID: UNCST-2020-R014674
 The Impact of Self Help Plus and Climate Smart Agriculture on Mental Health and Food Security in the Rhino and Nakivale Refugee Settlements of Uganda
REFNo: HS4691ES

To compare the uptake of HGI between the mothers in the combined intervention group (HGI & SH+) with those in the HGI group living in Nakivale refugee settlement,To assess the effect of SH+ on the development of children aged 3-6 years belonging to participating mothers living in Rhino and Nakivale refugee settlements,To assess the effect of SH+ on the mental health of mothers with children aged 3-6 years living in Rhino and Nakivale refugee settlements ,To assess the perceptions and attitudes towards a home gardening intervention (HGI) among participating mothers living in Nakivale refugee settlement,To assess the effectiveness of Self Help Plus (SH+) and home gardening on maternal mental health, food security and child development in the Rhino and Nakivale refugee settlements of Uganda,
 Uganda 2024-08-26 14:58:27 2027-08-26 Medical and Health Sciences Clinical Trial Non-degree Award
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