Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Luiza CardosodeAndrade
ID: UNCST-2025-R018410
 Measuring chlorination in areas with active Evidence Action chlorine delivery interventions
REFNo: SS3948ES

This study aims to assess the take-up of drinking water chlorination under DSW and ILC in Uganda and to compare different measurement methodologies to help improve monitoring protocols. The primary outcome of interest is the total number of people who use water pointers with DSW or ILC for which we can detect chlorine residual in the drinking water. Secondary outcomes explore differences in the methods used to estimate chlorination. In particular, we are interested in comparing chlorination rates measured using two different sampling frames (self-reported water point users and water point users listed) and two different chlorine residual measurement instruments (color discs and colorimeters). The tertiary outcome is the functionality of chlorination devices, which may be connected to low adoption. Finally, additional data will be collected to perform an exploratory analysis on other factors that may influence the adoption of chlorine for water treatment, such as the distance to the nearest water point where chlorine is available and the occurrence of symptoms related to the consumption of contaminated water.
 Brazil 2025-07-04 14:02:44 2028-07-04 Social Science and Humanities Non-Clinical Trial Non-degree Award
ANNETTEE NAKIMULI OLIVIA
ID: UNCST-2022-R011194
 Maternal Ultrasound Prospective Observational Study for Machine Leaning Model Training
REFNo: HS6020ES

1. Collect ultrasound data from pregnant and non-pregnant individuals presenting at Kawempe national referral hospital. 2. Use the collected data and ultrasound images to train and validate MOBUS algorithms.,
 Uganda 2025-07-04 14:00:42 2028-07-04 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bernard Kikaire
ID: UNCST-2021-R011663
 SEROPREVALENCE OF MARBURG VIRUS INFECTION AND OTHER WHO-PRIORITY PATHOGEN IN THREE (3) COUNTRIES IN AFRICA
REFNo: HS6241ES

Primary objectives 1.To assess previous exposure to Marburg Virus (MARV) Infection in the general population in three (3) African countries, determined by measuring circulating IgG antibodies.
2.To estimate MARV force of infection (FOI) in the three (3) African countries. 3.To develop a platform for the implementation of seroprevalence of WHO priority pathogens in Africa Secondary objectives 1.
To characterize age-specific and gender-specific seroprevalence trends. 2.To determine risk factors associated with prior infection with MARV in the three (3) African countries. 3. To assess host genetic factors including single nucleotide polymorphism (SNP) of candidate genes that could be associated with susceptibility/protection from infection with MARV and other outbreak-worthy pathogens. 4.To estimate the seroprevalence of other WHO priority filovirus pathogens, including EBOV, SUDV, BDBV, TAFV, RAVN, etc. Exploratory objectives 1.To evaluate potential cross-reactivity of MARV IgG with other filoviruses. 2.To investigate neutralizing capacity of human monoclonal antibodies against MARV
Uganda 2025-07-04 13:58:59 2028-07-04 Medical and Health Sciences Non-Clinical Trial Non-degree Award
ERIC WOBUDEYA
ID: UNCST-2019-R001047
 Paediatric Post-TB home-based Pulmonary Rehabilitation Feasibility Study
REFNo: HS6222ES

Primary objective:
• To explore the feasibility of implementing a 6-week at home pulmonary rehabilitation program in children with diagnosed with PTLD, including measures of participant retention and adherence.

Secondary objectives:
• To evaluate the change in health-related quality of life following the pulmonary rehabilitation intervention.
• To assess the change in exercise capacity following the 6-week pulmonary rehabilitation intervention.
• To explore the experiences and perceptions of children, caregivers, and healthcare providers related to the acceptability and feasibility of the pulmonary rehabilitation program

 Uganda 2025-07-04 13:57:06 2028-07-04 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Tarekegn Abeku Abose
ID: UNCST-2023-R005864
 improving early warning and control of mosquito-borne disease outbreaks caused by extreme weather in Uganda
REFNo: HS5162ES

Main Objective
1. The project’s main objective is to strengthen the health system capacity in Uganda for improved early warning and rapid control of mosquito-borne disease outbreaks caused by extreme weather events, focussing on malaria RVF and YF.
Specific Objectives
1. 1. To document past mosquito-borne disease outbreaks in Uganda and analyse their association with extreme weather
2. 2. To develop and validate a risk index and early warning models to forecast the outbreaks
3. 3. To develop a platform that maps risks and generates predictions continuously, where real-time surveillance data feed into, for routine use by disease control programmes
4. 4. To develop an outbreak preparedness and response plan for various risk scenarios
5. 5. To facilitate adoption and use of the system
6. 6. To engage communities in the research activities
 UK 2025-07-04 13:55:42 2028-07-04 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Francis Kiweewa
ID: UNCST-2020-R014929
 Longitudinal observation of cardiovascular diseases among people living with HIV in Lango Sub-region, Northern-Uganda.
REFNo: HS5900ES

Primary Objective
Assess the burden, risks and correlates of cardiovascular diseases (CVD) among people living with HIV (PLWH) in Northern Uganda to inform strategies for prevention, care and treatment in Sub-Saharan Africa.
The primary objective will be achieved through several secondary an explorative objective themed around forming a comprehensive understanding of the epidemiological, clinical, socio-behavioural, immunological, genetic, and microbiome-related factors influencing CVD among PLWH. The secondary and exploratory objectives are detailed in the attached protocol
 Uganda 2025-07-04 13:54:27 2028-07-04 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sam Ononge
ID: UNCST-2020-R000328
 A CLINICAL TRIAL TO EVALUATE THE PERFORMANCE AND SAFETY OFTHE WEKEBERE SYSTEM FOR MONITORING FETAL WELLBEING DURING LABOUR
REFNo: HS3407ES

The overall objective of this study is to demonstrate safety and performance of wekebere fetal monitoring system.

Specific Objectives
To determine accuracy of wekebere fetal monitoring in comparison with gold standard. To determine the safety of wekebere system
To determine’ uterine contractions

 Uganda 2025-06-30 9:35:11 2028-06-30 Medical and Health Sciences Clinical Trial Non-degree Award
Felix Bongomin
ID: UNCST-2020-R014224
 LIAISON® QuantiFERON®-TB Gold Plus II for the Diagnosis of Active and Latent Tuberculosis in Uganda
REFNo: HS6213ES

To evaluate the automated LIAISON® QuantiFERON® -TB Gold plus II immunoassay for the detection of IFN-γ in human lithium heparin plasma from subjects at low risk for M. tuberculosis infection, mixed risk for M. tuberculosis infection and with active TB disease.,
 Uganda 2025-06-30 9:16:34 2028-06-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Haruna Muwonge
ID: UNCST-2019-R000128
 Retrospective Analysis of RSV RTI Prevalence, Coinfections, and Risk Factors among Older Adults in Uganda: A Study Based on Sentinel Surveillance Data
REFNo: HS5423ES

Objectives
General Objective
To determine the prevalence, associated factors, and coinfection patterns of Respiratory Syncytial Virus (RSV) respiratory tract infections (RTI) among adults aged 60 and above in Uganda using sentinel surveillance data.
Specific Objectives
1. To determine the prevalence and seasonal trends of RSV RTI among older adults in Uganda using data collected from sentinel surveillance sites
2. To examine the relationship between comorbid conditions such as cardiovascular disease, diabetes, and chronic kidney disease, and the severity of RSV RTI among older adults in Uganda.
3. To determine the prevalence of coinfections with other respiratory viruses—SARS-CoV-2, Influenza A/B, and Pandemic A(H1N1) 2009—among older adults with RSV RTIs in Uganda.
4. To assess the association between coinfections with other respiratory viruses —SARS-CoV-2, Influenza A/B, and Pandemic A(H1N1) 2009— and clinical outcomes, including disease severity, hospitalization rates, and mortality, among older adults with RSV RTIs in Uganda.

 Uganda 2025-06-30 9:14:46 2028-06-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Peter Elyanu James
ID: UNCST-2021-R013210
 OPTIMAH Study: OPTImizing Malaria And HIV treatment in a shifting landscape in Africa
REFNo: HS6165ES

PRIMARY OBJECTIVES
1. Assess the impact of HIV/DTG on weight gain (BMI) in Ugandan children ages 5 to 17 years of age over two years of follow-up.
2. Assess for PK drug-drug interactions between the two most widely used ACTs
(AL or AS-AQ) and DTG in longitudinal cohorts of HIV-uninfected children and CLHIV living in a high endemic malaria region (Busia).
3. To assess the 28- and 42-day efficacy of AL and AS-AQ for the treatment of uncomplicated malaria in children with and without HIV in a setting where artemisinin resistance has emerged.

SECONDARY OBJECTIVES
1. To assess the impacts of DTG on changes in body composition, waist circumference, and metabolic derangements over 2-years of longitudinal follow-up.
2. To assess the impact of repeated malaria infection on changes in weight gain in CLHIV on DTG (comparing HIV-infected cohorts in Busia and Kampala).
3. To determine if changes in DTG PK exposure in the presence of repeated courses of ACTs are associated with impacts on virologic control (pharmacodynamics).
4. To assess for the development of dolutegravir-associated resistance mutations over two years of follow-up.
5. To determine if changes in ACT exposure in the presence of daily DTG for HIV treatment are associated with impacts on malaria treatment outcomes.
6. To critically compare the PK exposure of artemether, artesunate, and DHA in the context of the two leading ACTs in Africa and assess for associations between the PK exposure of artemisinin derivatives as drivers of parasitologic outcomes such as parasite clearance rates for artemisinin-sensitive and resistant infections.
7. To assess levels of gametocytemia in children with and without HIV infection and with artemisinin-sensitive and -resistant infections
8. To determine if repeated course of AL and AS-AQ are associated with selection of resistance-associated mutations to the partner drugs and/or the artemisinin component.
9. To identify novel mutations in known and/or putative loci associated with resistance to artemisinins, lumefantrine, and amodiaquine using amplicon-based sequencing and/or other genotyping methods.
10. To assess the exposure of unbound DTG, lumefantrine, and DEAQ and association with clinical outcomes (viral load or parasitemia)



 Uganda 2025-06-26 23:59:42 2028-06-26 Medical and Health Sciences Clinical Trial Non-degree Award
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