Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Violet Nkwanzi
ID: UNCST-2024-R002493
 Examining the Impact of Adverse Childhood Experiences on Human Trafficking Vulnerability and the Long-term Mental Health Outcomes of Women Survivors of Trafficking (18-35 years) in Uganda.
REFNo: SS3451ES

Aim 1: To quantitatively examine the association between ACEs, human trafficking vulnerability, and long-term mental health outcomes (anxiety, depression, PTSD). Aim 2: To determine the factors that moderate the effects of ACEs on human trafficking vulnerability and the long-term mental health outcomes of women survivors of trafficking. Aim 3: To qualitatively explore sources of resilience and gaps in existing policies and services for women affected by human trafficking in Uganda To inform comprehensive survivor centered interventions, this study will collect additional data on quality of life, gender-based violence, substance use and financial capability of survivors of trafficking.
Uganda 2024-12-10 16:01:57 2027-12-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Akusa Patrice Mawa
ID: UNCST-2024-R015660
 Service availability and readiness assessment for establishing biobanks of patient left-over samples from routine healthcare provision in Uganda and Kenya
REFNo: HS5328ES

1. To assess the current practices with left-over samples in hospitals and the attitude, willingness, and acceptability of stakeholders towards biobanking.
2. To audit human resources, laboratory infrastructure, governance, and data systems to understand available resources to support the establishment of left-over sample biobanks in health facilities
3. Undertake a detailed analysis of costs that will be needed to sustain operational activities on a yearly basis for either a federated or centralised approach of biobanking left-over samples in Uganda and Kenya
4. Assess the regulatory environment and engage relevant national regulatory bodies to adapt guidelines for left-over sample biobanking in Uganda and Kenya.


 Uganda 2024-12-10 16:00:04 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Stephen Tukwasibwe
ID: UNCST-2022-R011535
 Surveillance of P. falciparum Drug and Diagnostic Resistance in Refugee Populations
REFNo: HS5230ES

To conduct comprehensive malaria molecular surveillance in refugee populations to generate high quality molecular, epidemiological and entomologic data for monitoring geographic and temporal trends and thereby inform interventions to best protect refugee and local host populations.
Uganda 2024-12-10 15:59:04 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jude  Nicholars Iyke
ID: UNCST-2023-R007962
 THE EFFECTS OF PERSONALITY TRAITS ON THE ACCEPTANCE OF BIOMETRIC CONTROLLED HEALTH INFORMATICS IN PUBLIC HOSPITALS IN UGANDA
REFNo: SIR430ES

The purpose of this sequential mixed-method design study is to assess the relationship between the personality traits and acceptance of Biometric Controlled Health Informatics in Gulu and Soroti Regional Referal public Hospitals in Uganda that will help health strategists and policy makers evaluate how the personality traits of health workers affect their acceptance of biometric controlled health informatics (BCHI) for secure access for clinical and non-clinical health workers to patient records in public hospitals in Uganda . ,To examine how personality traits affect the acceptance of Biometric Controlled Health Informatics in these public hospitals using the acceptance model that was developed for that purpose,To determine the connection between acceptances of Biometric Controlled Health Informatics and personality traits in these public hospitals.,To establish health workers’ awareness of Biometric Controlled Health Informatics in these public hospitals,
 Nigeria 2024-12-10 15:54:44 2027-12-10 Engineering and Technology Non-Clinical Trial Degree Award
Susan Nayiga
ID: UNCST-2020-R014642
 Managing AMR: Everyday experience with antibacterial drug resistant infections in central Uganda
REFNo: SS3469ES

1. To track the trajectories of illness, care, recovery or decline of patients diagnosed with antibacterial drug resistant infections.
2. To link the social, economic and illness histories and opportunities of patients with their onward trajectories with antibacterial drug resistant infections
3. To identify equity dimensions of the how systems manage antibacterial drug resistant infections and points for intervention to support recovery

 Uganda 2024-12-10 15:53:27 2027-12-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Francis Kakooza
ID: UNCST-2024-R002803
 Evaluation of capture enrichment for viral sequencing in a remote setting in Uganda.
REFNo: HS5270ES

Objective 2: Evaluate Analytical Performance in Uganda. NGS testing of blood samples from confirmed clinical cases and suspected clinical samples will be conducted. This includes de-identified archived blood samples collected from a sepsis cohort among participants who consented for their samples to be used for future research related to sepsis in Fort Portal, Uganda, at Fort Portal Regional Referral Hospital, which has enhanced biosafety capabilities. ,Objective 1: Develop and Optimize NGS Platform To pilot the use of a field-deployed portable next-generation sequencing for testing of archived sepsis blood samples in Uganda to search for hantavirus or bunyavirus infections. The project plans to field test the Oxford Nanopore Technologies (ONT) platform with archived blood samples. Phylogenetic trees will be developed, and virus clades and variants or new viruses will be described. The performance of enriched-NGS to detect the virus will be compared to index testing with RT-PCR when there are 5 or more positive results.,
 Uganda 2024-12-10 15:52:01 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Anke Weisheit
ID: UNCST-2024-R004890
 ETHNO BOTANICAL SURVEY OF MEDICINAL PLANTS USED IN THE TREATMENT OF WOUNDS IN GULU DISTRICT
REFNo: SS2928ES

To investigate the preparation and application methods of these medicinal plants for wound healing purposes.,To identify and document medicinal plants used by the local communities in Gulu district for treating various types of wounds.,The aim of this study is to conduct an ethnobotanical survey to document the traditional knowledge and use of medicinal plants for treating wounds among the communities in Gulu district, Uganda.,
 Germany 2024-12-10 15:50:43 2027-12-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Irene Nakayenga Mutesi
ID: UNCST-2024-R004951
 Global Corridor, Urbanisation, Everydaylife and Techno-social Differentiation
REFNo: SS2860ES

2. To explore the everyday assembling of Corridor Urbanization to assess how investment in infrastructure is generating intra-urban and inter-urban relations/material connections between urban regions., To explain the global, urban geography of infrastructural corridors in reshaping the urbanization process in order to set a new agenda for global research,3. To investigate the everyday experiences of Corridor Urbanization within urban regions in order to understand the differentiated ways in which infrastructure is operated and accessed,1. To assess the global, urban geography and selected history of new corridors and the ways these projects are assembled in order to understand the role of urban regions,The aim of GlobalCORRIDOR is to address the challenge of how we understand Corridor Urbanization and to assess how these infrastructure led transformations are shaping urban inequality, as an everyday experience of techno-social differentiation,
 Uganda 2024-12-10 15:50:00 2027-12-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Joseph Ngonzi
ID: UNCST-2019-R001579
 OPTIMIZATION, VALIDATION AND ASSESSMENT OF FEASIBILITY AND ACCEPTABILITY OF HPV TESTING USING CODA
REFNo: HS4734ES

To develop and establish a novel rapid multi-modal algorithm (CANOPY) for screening and treatment of cervical cancer integrating multiple (CODA, VIA, ML) screening modalities to improve diagnostic yield. ,To gather design feedback to improve CODA workflow and device design, and refine CODA device, assay, and workflow using this critical feedback provided by Ugandan stakeholders,To evaluate the feasibility and acceptability of CODA in a clinical setting in Uganda based on feedback from clinical, public health, and patient stakeholders,To evaluate HPV testing using CODA in comparison to other (VIA, ML, ATILA System) devices for clinicians and patients engaged in community-based cervical cancer screening. ,To determine the diagnostic accuracy of CODA a clinical setting, using FP rate and comparison with gold-standard HPV tests and cytology,We will optimize, validate and assess the feasibility and acceptability of HPV testing using CODA and develop and validate a multimodal cervical cancer screening algorithm to optimize diagnostic yield (CANOPY).,
 Uganda 2024-12-10 15:49:00 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Anxious   Niwaha Jackson.
ID: UNCST-2023-R008010
 Investigating the pancreas pathology underlying Lean Sub Saharan African Diabetes in Uganda
REFNo: HS5340ES

a. To compare the beta cell mass in pancreata obtained at autopsy in lean diabetes cases
versus lean controls
b. To evaluate the degree of pancreatic immune infiltration (Insulitis) in lean diabetes cases
and lean controls
c. To quantify the degree of misfolded protein stress in pancreata obtained at autopsy in lean
diabetes cases and lean controls
d. To evaluate beta cell dedifferentiation in lean SSA diabetes
e. To examine the exocrine pancreas for chronic pancreatitis and pancreatic duct calcification
in pancreata obtained at autopsy in lean diabetes cases versus lean controls
f. To determine the concentration of POPs in pancreata obtained at autopsy in lean diabetes
cases and lean controls.
g. To establish a pancreata and related tissue (blood and mesenteric fat) platform to enable
further studies related to diabetes and other metabolic diseases.

 Uganda 2024-12-10 15:47:20 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Nixon Niyonzima
ID: UNCST-2020-R014577
 Implementation and evaluation of peer support and navigation supported by Project ECHO for patients with cancer in Uganda
REFNo: HS5297ES

6. To evaluated perceived program feasibility, acceptability, and appropriateness through surveys and exit in-depth interviews with peer navigators, patients, and UCI oncologists,5. To adapt the Cancer Behavior Inventory (CBI-B) self-efficacy scale, Edmondton Symptom Assessment Scale (ESAS), and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ C30) quality of life for cancer patients questionnaire to the Uganda context by soliciting feedback from UWOCASO members and UCI oncology and palliative care specialists,4. To evaluate program impact by measuring patient self-efficacy, symptom burden, and quality of life using the above adapted scales at enrollment, 1, 3, 4 and 6 months after the program start ,3. To evaluate program impact by comparing the proportion of patients who completed treatment for early stage disease and or had treatment adherence of > 6 months in case of metastatic disease among patients matched with peer support and navigation right away versus six months later. ,2. To pair 100 cancer survivors with 200 matched patients with cancer in the Kampala, Wakiso, and Gulu districts of Uganda for peer support and navigation. Half of the selected patients will be randomized to be matched to peer support immediately, and half six months later . ,1. To provide refresher training in peer support and navigation to 100 cancer survivors. We will focus on the five most common cancers in Uganda (breast, cervical, prostate, Kaposi sarcoma, Non-Hodgkin lymphoma).,
 Uganda 2024-12-10 15:46:22 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
ELIZABETH KYAZIKE
ID: UNCST-2023-R005557
 The Lasting Scars of War: Understanding the Socio-environmental Impact of Changing Global Commodity Chains in East Africa During the Second World War, 1937-1962
REFNo: SS3146ES

General Objective
The project's general objective is to document the impact of World War II on the Lake Victoria-area environment in the immediate (wartime) and midterm (into the post-war period) periods.
Specific Objective
Specifically, the project seeks to:
1) Evaluate the changes in environmental patterns of use (agricultural use, resource extraction, etc.) during the Second World War and its socio-environmental impacts.
2) Examine how the linkages between Africa (affected population), Great Britain (colonial power and prosecutor of war) and Switzerland (experts and trading companies) drove environmental change.
3) Analyze how global patterns were evident in the Lake Victoria region, in particular in relation to sustainable practices and cultures.

 Uganda 2024-12-10 15:43:59 2027-12-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
DANIEL KIIZA
ID: UNCST-2024-R004044
 Development and Validation of a Machine Learning Prediction Model for Early Mortality among patients with HIV-Associated Cryptococcal Meningitis in Uganda
REFNo: HS5103ES

Primary Objectives: 1. To develop a machine learning model for the prediction of early mortality among patients with HIV-CM co-infection. 2. To validate a machine learning model for the prediction of early mortality among patients with HIV-CM co-infection. Exploratory Objective: 3. To develop and validate a machine learning model for the prediction of mortality (as a continuous outcome) among patients with HIV-CM co-infection.
 Uganda 2024-12-10 15:42:48 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Silvia Awor
ID: UNCST-2019-R000591
 PREDICTORS OF USE, PHYTOCHEMICAL PROFILES AND ANTISICKLING ACTIVITIES OF HERBAL MEDICINES FOR TREATING SICKLE CELL DISEASE IN ACHOLI SUB-REGION
REFNo: HS5030ES

2. To document the herbal medicines used for treating sickle cell disease in AchTo determine the anti-sickling activity of aqueous crude extracts of herbal medicines for sickle cell treatment in the Acholi sub-region. ,To assess the phytochemical profiles of selected herbal medicines used for the treatment of sickle cell disease in Acholi sub-region,To document the herbal medicines used for treating sickle cell disease in Acholi sub-region,To determine the predictors of the use of herbal medicines for the treatment of sickle cell disease in Acholi sub-region,To assess the predictors of use and antisickling activities of herbal medicines used for treating sickle cell disease in the Acholi sub-region of northern Uganda,
 Uganda 2024-12-10 15:41:38 2027-12-10 Medical and Health Sciences Non-Clinical Trial Degree Award
Abbas Mugisha
ID: UNCST-2023-R007013
 Internally displaced persons and psychosocial challenges of females at Muhokya IDP, Kasese district, Ugands
REFNo: SS3392ES

i)To identify the psychosocial challenges experienced by internally displaced females at Muhokya IDP camp
ii)To explore the coping mechanisms employed by internally displaced females to manage the psychosocial challenges at Muhokya IDP camp
iii)To explore the redress mechanisms available for the psychosocial challenges faced by internally displaced females at Muhokya IDP camp
iv)To propose recommendations on how to best assist internally displaced females overcome their challenges at Muhokya IDP camp
 Uganda 2024-12-10 15:26:35 2027-12-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
ARTHUR EMORU
ID: UNCST-2024-R003421
 PREVALENCE AND FACTORS ASSOCIATED WITH CHRONIC POST-SURGICAL PAIN AMONG PATIENTS THAT RECEIVED AMBULATORY INGUINAL HERNIA SURGERY AT KYABIRWA SURGICAL CENTER
REFNo: HS5068ES

To determine factors associated with chronic pain after inguinal hernia repair among adult patients at Kyabirwa Surgical Center,To assess the prevalence of chronic pain after inguinal hernia repair among adult patients at Kyabirwa Surgical Center,To determine the prevalence of and factors associated with chronic pain after inguinal hernia repair in Kyabirwa Surgical Center’s adult patient population,
 Uganda 2024-12-10 15:25:15 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Orace David Tom
ID: UNCST-2024-R003113
 Students’ Loan Financing Scheme and Completion of STEM based Programmes in Public Universities in Uganda
REFNo: SS3353ES

i). To explore the nature of students’ loan financing scheme in public universities in Uganda
ii). To assess the completion of STEM based programmes by students on loans scheme in public universities in Uganda
iii). To evaluate the perceptions and experiences of STEM students regarding the impact of students’ loan scheme on their completion in public universities in Uganda
iv). To establish the relationship between students’ loan financing scheme and completion of STEM based programmes in public universities in Uganda

Uganda 2024-12-10 15:23:45 2027-12-10 Social Science and Humanities Non-Clinical Trial Degree Award
Stevens Bechange
ID: UNCST-2022-R009190
 Understanding Access to Business Financing for Young Entrepreneurs with and without Disabilities in Urban Uganda
REFNo: SS3471ES

The specific objectives will be:
1. To identify the different types of business financing options accessible by and preferred by young enterpreneurs with and without disabilities including what drives them to use these options.
2. To understand existing barriers for young enterpreneurs with and without disabilities in accessing and using the different business financing products, what can be done to address these and recommendations for more widespread access.
3. To describe how financial products from the RISE/E Programme affect young enterpreneurs with and without disabilities and their businesses and how they can be further improved.
4. Develop a database that includes demographic, socio-economic; and business financing information to facilitate the evaluation of success or failure with access to finance.

Uganda 2024-12-10 15:17:09 2027-12-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
DORAH NAMPIJJA
ID: UNCST-2022-R009694
 Improving heart failure self-care with short, structured telephone calls in Uganda (HEART-CALLS)
REFNo: HS5307ES

To improve heart failure self-care through feasible and acceptable short, structured telephone calls in Uganda
Uganda 2024-12-10 15:16:13 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kamya Moses
ID: UNCST-2020-R014203
 Transformative approaches to rapidly and efficiently test demand creation interventions to promote HIV retesting in adults at increased risk of HIV The Innovative Behavioral Intervention Strategies Megatrial (IBIS-Megatrial) Study
REFNo: HS5319ES

Aim 1. Adapt behavioral economics interventions to promote HIV retesting using a participatory prototyping approach in rural Kenya and Uganda.
Aim 2. Determine the effectiveness of many behavioral economics interventions to promote HIV retesting among high-risk adults in a multi-arm randomized trial.
Aim 3. Estimate heterogeneous treatment effects and identify optimal demand creation interventions.

 Uganda 2024-12-10 15:15:04 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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