Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
ROVINE NALUYIMBAZI
ID: UNCST-2024-R005302
 Expanding laparoscopic simulation in Uganda
REFNo: HS4783ES

Aim 3: Create, conduct, and review a hybrid laparoscopic surgery training course for practicing Ugandan surgeons.,Aim 2: Create a low-cost, high-fidelity laparoscopy training model. We will utilize the Duke-Muk educational partnership that forms the foundation for the Shipping Container MakerSpaces to develop and build a laparoscopic training model, demonstrating the effectiveness of the previously developed infrastructure for biomedical engineering.,Aim 1: Assess level of baseline laparoscopic training and experience for Ugandan surgeons. We will survey the members of the Ugandan Surgical Society regarding their needs, expectations, and willingness to participate in a laparoscopic training course,We will assess the needs of local surgeons and trainees about their needs and experiences in laparoscopy to develop a low-cost box-trainer that is manufactured locally. This box will enable LMIC surgeons to develop the fundamental skills necessary to perform laparoscopy and improve surgical patient outcomes. The developed box trainer will form the foundation of a hybrid laparoscopy training course to be facilitated by local surgical and medical educators.,
 Uganda 2024-10-31 16:41:56 2027-10-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ombeva  Malande Oliver
ID: UNCST-2024-R004335
 LIVED EXPERIENCES OF SURVIVORS OF VACCINE PREVENTABLE DISEASES IN UGANDA
REFNo: HS4189ES

3. To analyze the views of the caregivers to and survivors of vaccine preventable diseases in Uganda concerning the role of vaccines and vaccination in disease prevention?,2. To determine and document the lived experiences of caregivers to people suffered from or died from vaccine preventable diseases in Uganda?,1. To determine and document the lived experiences of survivors of vaccine preventable diseases in Uganda?,
 Kenya 2024-10-31 16:35:06 2027-10-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Susan  Nabadda
ID: UNCST-2020-R014331
 Validation of the liquid biopsy to diagnose endemic Burkitt lymphoma in children in Uganda.
REFNo: HS4525ES

To compare the performance of the liquid biopsy test with conventional pathology in diagnosing endemic Burkitt lymphoma in Uganda. ,To evaluate the turnaround times for liquid biopsy and conventional pathology for diagnosing EBVL in real life settings in Uganda,To compare the sensitivity and specificity of liquid biopsies versus locally enhanced available pathology in Uganda.,To validate the liquid biopsy to diagnose endemic Burkitt lymphoma in children and young adults in Uganda.,
 Uganda 2024-10-31 16:17:43 2027-10-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
PIUS MATOVU DDUMBA
ID: UNCST-2024-R004025
 Family Environment and Depressive Symptom among older adults in Central Uganda: The Mediating Role of Patient Factors
REFNo: SS2854ES

6. To test the causal model indicating whether patient factors have a mediating effect on family environment and depressive symptoms among older adults in Central Uganda using SEM modeling.,5. To assess the influence of patient factors on depressive symptoms among older adults in Central Uganda.,4. To examine the relationship between patient factors and family environment among older adults in Central Uganda.,3. To examine the influence of system maintenance on depressive symptoms among older adults in Central Uganda.,2. To assess the effect of personal growth on depressive symptoms among older adults in Central Uganda.,1. To analyze the influence of interpersonal relations on depressive symptoms among older adults in Central Uganda.,The purpose of this study is to analyze the effect of family environment on depressive symptoms among older adults in Central Uganda.,
 Uganda 2024-10-31 16:12:27 2027-10-31 Social Science and Humanities Non-Clinical Trial Degree Award
ANDREA KADDU KAGGWA
ID: UNCST-2024-R004958
 FREQUENCY, COURSE, OUTCOMES AND FACTORS ASSOCIATED WITH DELIRIUM AMONG ADULT PATIENTS ADMITTED TO THE UGANDA CANCER INSTITUTE RefNo: Mak-SOMREC-2024-900
REFNo: HS4862ES

1. To determine the frequency of delirium among adult patients admitted to the UCI. a). to determine the prevalence of delirium among adult patients on admission to the UCI. b). to determine the incidence of delirium among adult patients admitted to the UCI during a 1-week period of follow up 2. To determine the course and outcome of delirium during a 1-week period after diagnosis among adult patients admitted to the UCI. 3. To determine the factors associated with delirium among adult patients admitted to the UCI.
Uganda 2024-10-31 16:10:08 2027-10-31 Medical and Health Sciences Non-Clinical Trial Degree Award
Annet Nanvubya
ID: UNCST-2025-R015525
 Tuberculosis case finding at the completion of the Ubuntu clinical trial: a substudy to CoVPN 3008 (Ubuntu).
REFNo: HS4715ES

Primary Objective 1: Identify participants with previously undiagnosed tuberculosis (TB) disease, including subclinical TB.
Primary Objective 2: Identify demographic and other participant characteristics that are associated with the diagnosis of TB, including subclinical TB.
Primary Objective 3: Investigate peripheral blood biomarkers associated with diagnosis of TB, including subclinical TB.
Primary Objective 4: Follow participants with confirmed TB for six months and identify those that remain microbiologically positive for TB.

 Uganda 2024-10-31 16:05:35 2027-10-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jennifer Verdolin
ID:
Establishing a Long-Term Behavioral and Ecological Monitoring Research Program in Queen Elizabeth Conservation Area
REFNo: NS841ES

This research aims to explore several critical issues affecting savannah ecosystems:
1. Impact of Macro and Microplastics on Wildlife: Plastic pollution is an emerging threat to wildlife health in savannah ecosystems. Both macroplastics and microplastics can cause physical harm, ingestion issues, and toxicological effects in wildlife, disrupting health, reproduction, and survival rates.
2. Sources of Plastic Pollution: Identifying and understanding the critical sources of plastic pollution within and between communities is essential. This includes examining local waste management practices, the role of tourism, and community awareness and behaviors regarding plastic use and disposal.
3. Animal Movement Patterns and Ecological Impact: Changes in animal movement patterns, driven by factors such as habitat fragmentation, climate change, and human disturbances, can significantly affect feeding ecology and population dynamics of predators, prey, and other fauna. Understanding these changes is vital for predicting ecological outcomes and managing wildlife populations.
4. Bush Encroachment Patterns and Drivers: Bush encroachment, the process where woody plants invade grassland areas, alters the structure and function of savannah ecosystems. This study will characterize the patterns of bush encroachment and investigate the factors driving these changes in different zones of the park, such as fire regimes, grazing pressure, and climatic variables.
5. Disease Outbreaks and Pathogen Evolution: Disease outbreaks, including anthrax, pose a significant threat to wildlife populations. This research will focus on understanding the patterns of these outbreaks, how pathogens are evolving, and predicting future impacts on wildlife health and ecosystem stability.
 USA 2024-10-31 15:52:31 2027-10-31 Natural Sciences Non-Clinical Trial Non-degree Award
Valence Mfitumukiza
ID: UNCST-2024-R004532
 Enteric pathogens and intestinal injury in Ugandan children with malaria RefNO: KABREC-2024-155
REFNo: HS4732ES

To examine the association of invasive enteric pathogens with stool and circulating host markers of intestinal and systemic inflammation,To define the frequency of common enteric pathogens among children with malaria and diarrhea, comparing to controls without malaria and/or diarrhea.,To characterize enteric pathogens in children with falciparum malaria and diarrhea as potential drivers of intestinal leak and systemic inflammation,
 Uganda 2024-10-31 15:49:23 2027-10-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Antje  Daniel
ID: UNCST-2024-R003872
 "New kids on the block”? Youth environmental engagement and Fridays for Future. An intersectional and global perspective
REFNo: SS3040ES

This new environmental youth engagement as a young and quickly developing movement has not received in-depth academic attention, neither in the field of youth studies nor in social movement studies, especially not youth engagement in the Global South (see below). The motives of youth and their particular understandings of engagement remain insufficiently investigated. In addition, there is increasing criticism of youth environmental activism, namely that FFF is at least in Europe ‘white’ and supported by a well-educated middle-class elite leading to the accusation that it reproduces hierarchies (see below). However, there are hardly any academic studies that examine privileges, hierarchies and discrimination within FFF from an intersectional perspective. In order to respond to these research gaps an intersectional perspective is used to understand the motives and activism of youth in Austria, Bangladesh and Uganda and thereby their global interrelatedness. This scientifically necessary and timely research is also politically relevant since youth are acting at the forefront of environmental movements. In addition, youth engagement participants have become increasingly integrated into the international politics of the UN and are in dialogue with politicians. It can be argued further that youth engagement is not ‘just’ a certain stage of life but that it lays the foundation for transformation processes (Harré 2016; Riemer et al. 2016). Young advocates are frequently those taking up important political and social leadership in the future due to their interest and experience of advocacy (Giugni 1998; Leistner 2018): They are a “cohort of citizens who will be active participants in democracy” (Fischer 2019, 430).
Because a new youth activism emerged which is unique due to its global scope and the low average age new scientific perspectives are needed to analyse this phenomenon: A synthesis of youth and civil society studies combined with intersectionality and a comparative case study design offer an original analytical framework. This framework will provide in-depth knowledge on context-specific differences of youth engagement in Austria, Bangladesh and Uganda and commonalities of global youth activism and its activism towards ecological transformation. This research is needed scientifically because FFF is one of the major civil society players in global environmental politics and in manifold national contexts.


Germany 2024-10-31 15:48:00 2027-10-31 Social Science and Humanities Non-Clinical Trial Non-degree Award
Julius Okuni Boniface
ID: UNCST-2019-R000963
 Molecular evolution of Mycobacterium avium subspecies paratuberculosis (MAP) in Africa (Phase II)
REFNo: NS860ES

i) To determine the occurrence of Mycobacterium avium subspecies paratuberculosis in water and animal products
ii) To determine the persistence of MAP in the farm environment in Uganda
iii) To determine gut microbiome profile of animals infected with MAP
v) To identify virulence factors of African MAP strains
vi) To investigate the biology of susceptibility and resistance of cattle to MAP
 Uganda 2024-10-30 12:12:45 2027-10-30 Natural Sciences Non-Clinical Trial Non-degree Award
Stephen  Ojiambo Wandera
ID: UNCST-2021-R012147
 Substance and Alcohol Use, Dating Violence, and Sexually Transmitted Infections among Makerere University Students in Kampala Uganda
REFNo: SS3276ES

1.3 Study Aims
Therefore, this study aims to investigate the prevalence and correlates of alcohol use, drug use, dating violence (DV), depression, and sexually transmitted infections risk among University Students in Uganda.
Specific aims of the study include:
Aim 1: To determine the prevalence and correlates of alcohol use, drug use, and dating violence among students at Makerere University, Kampala, Uganda.
Hypothesis 1: Alcohol and DV risk profiles will be significantly different among male and female students and socio-demographics (age and sex, socio-economic status, and environmental factors).
Aim 2: To estimate the association between dating violence and sexually transmitted infections risk among students at Makerere University, Kampala, Uganda.
Hypothesis 2: The prevalence of HIV risk and sexually transmitted infections will be greater among science students compared to those from the arts and humanities.
Analysis: We will determine the risk factors for dating violence, Intimate Partner Violence, HIV risk, STIs
Aim 3: To determine the association between dating violence and depression among students at Makerere University.

Uganda 2024-10-23 18:02:34 2027-10-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
BYONA STELLA MARY
ID: UNCST-2024-R002159
 ICT and E-Passport management in Uganda Immigration Service: A case of Directorate of Citizenship and Immigration Control (2008-2023)
REFNo: SS3210ES

General Objective
The study analyses the effect of ICT and E-Passport Management as a shift from the Machine Readable Passport to the E-Passport in relation to the citizens’ accessibility and the use of a National ID as a new requirement for the Passport in Uganda.
Specific Objectives
1. To understand the Preparedness of Immigration Service Office in the use of ICT and E-Passport as a shift from the Machine Readable Passport to the E-Passport in Uganda.
2. To analyze the citizens’ accessibility to the use of ICT and E-Passport as a new technology innovation in Uganda.
3. To assess the effect of the use of the National ID as a new requirement for the E-Passport in Uganda.


 Uganda 2024-10-23 18:01:16 2027-10-23 Social Science and Humanities Non-Clinical Trial Degree Award
Edgar Mulogo Mugema
ID: UNCST-2023-R008170
 After the flood: Optimal Strategies to Prevent Malaria Epidemics Caused by Severe Flooding
REFNo: HS5041ES

1. Determine the effectiveness of chemoprevention with or without peri-domestic larvicide application to reduce the incidence of P. falciparum malaria after severe flooding. 2. Elucidate the dynamics of vector populations, feeding behaviors, and sporozoite rate in affected villages up to one year after flooding. 3.Evaluate the relative cost-effectiveness of chemoprevention (Aim 3A) and assess social and economic impacts on households.,The objective of this proposal is to evaluate the effectiveness of a targeted, time-limited malaria chemoprevention intervention with and without complementary larval source management (LSM) to reduce excess disease burden in a perennial, high-transmission setting where severe flooding is frequent and relatively predictable. ,
 Uganda 2024-10-23 18:00:25 2027-10-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ruth Kigozi Nassali
ID: UNCST-2021-R013025
 Optimizing malaria programming through quality routine surveillance: evaluating a package of data quality and use interventions in Uganda
REFNo: HS5054ES

2. To understand the main challenges and enablers to data quality and use improvements and their sustainability,1. To assess the quality and use of routine health facility malaria data in target districts before, during and after implementation of a package of interventions ,The study aims to improve the quality and use of routine malaria data in two districts of Uganda,
 Uganda 2024-10-23 17:59:08 2027-10-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Rachel Byarugaba
ID: UNCST-2024-R003083
 CONSUMER PREFERENCES OF PROCESSED LEAF AMARANTH (AMARANTHUS SPP.) PRODUCTS
REFNo: A470ES

This main objective of the study is to determine the factors influencing the consumer preferences of processed leaf amaranth products by considering both emotional and sensory profiling. The objectives are to: 1) measure the consumers’ sensory perceptions and emotional responses to the products 2) investigate the relationship between the sensory and emotional attributes of the products and liking 3) examine the influence of food neophobia on the acceptability and emotional responses of the products.
 Uganda 2024-10-23 17:57:44 2027-10-23 Agricultural Sciences Non-Clinical Trial Degree Award
Rhona Mijumbi M
ID: UNCST-2023-R006843
 Digital Gender-Inclusive Tools for Evidence Use
REFNo: SIR425ES

To pilot and test the digital gender tools in (3) to improve the timeliness, efficiency, and effectiveness of evidence-informed decision-making processes,To apply newer technologies, such as Artificial intelligence and machine learning in the design and/ or modification of new and/ or existing digital tools to enhance the efficiency and effectiveness within EIPM processes,To identify existing digital tools and new digital technologies, such as Artificial intelligence and machine learning, that facilitate the timeliness, efficiency, and effectiveness of evidence-informed decision-making processes,To map the demand and opportunities for digital gender tools in evidence-informed decision-making processes with an aim of improving the timeliness, efficiency, and effectiveness of evidence-to-policy,To explore the role of- and develop digital gender-inclusive tools to enhance the timeliness, efficiency, and effectiveness of evidence-informed decision-making processes.,
 Uganda 2024-10-23 17:48:16 2027-10-23 Engineering and Technology Non-Clinical Trial Non-degree Award
Rapheal Wangalwa
ID: UNCST-2022-R008718
 UNDEREXPLORED MYCORRHIZAL FUNGAL COMMUNITIES OF BWINDI IMPENETRABLE NATIONAL PARK (BINP), UGANDA (FUNGI-BIP)
REFNo: NS869ES

i. To determine the diversity of mycorrhizal fungi in the three altitudinal zones of Bwindi Impenetrable National Park using soil DNA metabarcoding. ii. To determine the influence of vegetation characteristics on the diversity and occurrence of Mycorrhizal fungi in the three altitudinal zones of Bwindi Impenetrable National Park. iii. To establish the variation in physical and chemical parameters of rhizosphere soil collected from three altitudinal zones of Bwindi Impenetrable National Park.
Uganda 2024-10-23 17:44:42 2027-10-23 Natural Sciences Non-Clinical Trial Non-degree Award
Adam Drolet
ID: UNCST-2024-R002915
 Improving infection prevention and control practices in primary healthcare facilities: an evaluation of Aqua Research STREAM Disinfectant Generator in Uganda
REFNo: SS3183ES

Evaluate changes in microbiological cleanliness of high-touch surfaces within patient zones including surgical theatre, labor, and postnatal patient zones resulting using STREAM chlorine and commercial chlorine for disinfection,1. 1. Assess the STREAM total cost of ownership and cost-effectiveness of the STREAM for reducing the risk of hospital acquired infections and treatment costs for hospital acquired infections compared to use of existing commercial chlorine supplies in 5 health facilities across five districts,Assess the effect of the STREAM on chlorine availability and quality in health facilities,
 USA 2024-10-23 17:44:00 2027-10-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
Douglas Serwada
ID: UNCST-2024-R003939
 Examining The Barriers and Facilitators to Accessing Comprehensive Sexual and Reproductive Health Services Among Young People with Disabilities in Mayuge District.-MAKSHSREC-2024-723
REFNo: SS3153ES

To examine the barriers and facilitators to accessing comprehensive sexual and reproductive health (SRH) services among young people with disabilities in Mayuge district.To examine the societal attitudes and cultural norms contributing to the stigma and discrimination faced by young people with disabilities in accessing sexual and reproductive health services in Mayuge district.To evaluate the extent and forms of stigma and discrimination encountered by young people with disabilities in Mayuge district and their impact on access to sexual and reproductive health services.To determine the effectiveness of existing policies and programs aimed at reducing stigma and discrimination against young people with disabilities in accessing sexual and reproductive health services.
 Uganda 2024-10-23 17:42:17 2027-10-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
FRANCIS KAMUGANGA
ID: UNCST-2022-R010959
 Resource Efficient Concurrent Data Structures Design and Performance Analysis
REFNo: SIR145ES

To evaluate throughput and energy efficiency of the designed data structure and compare with other concurrent data structure designs.,To design and develop an efficient concurrent data structure that outperforms existing data structure designs in specific use cases.,To analyze different concurrent data structure designs in order to discover performance strengths and bottlenecks.,To improve throughput and energy efficiency of concurrent data structures by designing and developing an efficient concurrent data structure.,
 Uganda 2024-10-23 17:41:08 2027-10-23 Engineering and Technology Non-Clinical Trial Degree Award
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