Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Seju Kang
ID: UNCST-2024-R015536
 Developing Environmental Wastewater-Based Surveillance in Non-Sewered Areas in Low-Income Contexts
REFNo: HS5809ES

Research questions: To develop and validate a community-based environmental surveillance approach to detect infectious disease pathogens in urban areas with non-sewered sanitation. Objective 1: To design and implement a sampling plan that identifies high-risk locations for pathogens in non-sewered urban environments. Objective 2: To analyze pathogen levels and correlate findings with demographic and spatial data.
South Korea 2025-09-12 16:17:44 2028-09-12 Medical and Health Sciences Non-Clinical Trial Non-degree Award
alice namatovu
ID: UNCST-2025-R017415
 EVALUATION OF THE EFFECTIVENESS OF BACTERIOPHAGE COCKTAILS AGAINST MULTI-DRUG-RESISTANT BACTERIA ON PATIENTS WITH DIABETIC FOOT ULCERS ATTENDING SELECTED REFERRAL HOSPITALS IN UGANDA
REFNo: HS5652ES

Main objective:
To assess the efficacy of bacteriophages in the management of diabetic foot wounds/ulcers in animal models and among patients attending the selected referral hospitals in Uganda.

Specific Objectives
i) To determine the biological and genotypic characteristics of lytic bacteriophages against the MDR- bacteria isolated from diabetic wounds of patients.

ii) To determine the virulence genes of the bacteria isolated from DFU patients and those genes associated with antimicrobial resistance.
iii) Determine the phage receptor genes on the MDR bacteria isolated from DFU patients.

iv). To evaluate the effectiveness of the identified Bacteriophage preparation/cocktail in the healing of induced diabetic wounds in mice.
v). To evaluate the effectiveness of the identified bacteriophage preparation/cocktail in the healing of diabetic foot wounds on patients in selected referral hospitals in Uganda.

 Uganda 2025-09-12 16:14:57 2028-09-12 Medical and Health Sciences Clinical Trial Non-degree Award
Solomon Mbina Adomi
ID: UNCST-2024-R015658
 EFFECTS OF LYOPHILIZED LEAF EXTRACT OF KHAT (Catha edulis Forsk) ON HEPATORENAL SYSTEM AND LIPID METABOLISM IN HIGH FAT DIET INDUCED HYPERLIPIDEMIC MALE ALBINO WISTAR RATS
REFNo: HS5753ES

1. To characterize the bioactive compounds in lyophilized Catha edulis leaf extract using Gas chromatography-mass spectrometry (GC-MS) technique. 2. To determine the molecular interactions between bioactive compounds of Catha edulis leaf extract. and key proteins involved in lipid metabolism (leptin, adiponectin, and HMG-CoA reductase) using molecular docking analysis. 3. To determine the effect of lyophilized Catha edulis leaf extract on serum liver function parameters, (Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Alkaline Phosphatase (ALP), bilirubin, Albumin). in HFD-induced hyperlipidemic male albino Wistar rats. 4. To evaluate the effect of lyophilized Catha edulis leaf extract on kidney function indices (Urea, creatinine, serum electrolytes) in HFD-induced hyperlipidemic male albino Wistar rats. 5. To determine the effect of lyophilized Catha edulis leaf extract on serum leptin and adiponectin hormones levels in HFD-induced hyperlipidemic male albino Wistar rats. 6. To evaluate the effect of lyophilized Catha edulis leaf extract on serum lipid profile (Total cholesterol, High-density lipoprotein, low-density lipoproteins, and triglycerides) in HFD induced hyperlipidemic male albino Wistar rats. 7. To examine the effect of lyophilized Catha edulis leaf extract on the histology of the liver and kidney of HFD induced-hyperlipidemic male albino Wistar rats.
Nigeria 2025-09-12 16:13:25 2028-09-12 Medical and Health Sciences Non-Clinical Trial Degree Award
Magololo Mutesi Fiona
ID: UNCST-2024-R015533
 Changes in inpatient antibiotic use and antimicrobial resistance rates, through a collaborative quality improvement intervention: a study on adult surgical wards at Mulago National Referral Hospital.
REFNo: HS6321ES

4.1 Objectives. 4.1.1 General objective To reduce irrational inpatient antibiotic use by at least 10% in the adult surgical wards of Mulago National Referral Hospital using a collaborative quality improvement intervention approach. 4.1.2 Specific Objectives. 4.1.2.1 Specific Primary objectives. 1. To determine baseline and closeout rates of irrational inpatient antibiotic use in the adult surgical wards of Mulago National Referral Hospital at Month one and Month seven respectively. 2. To describe antimicrobial resistance rates and drug susceptibility patterns of commonly isolated bacterial pathogens obtained from patients admitted to the adult surgical wards of Mulago National Referral Hospital during the 24 months preceding this study (July 2023-June 2025). 3. To determine monthly rates of irrational antibiotic use on the adult surgical wards of Mulago National Referral Hospital from Month two to Month six, during the QI intervention implementation. 4. To explore health worker perceptions and lived experiences on antimicrobial resistance, antibiotic prescription and antimicrobial stewardship as well as the impact of AMR on the adult surgical wards of Mulago National Referral Hospital, at Month one and Month seven. 5. To reduce irrational antibiotic use by 10%, through developing and implementing a collaborative quality improvement intervention to on antimicrobial stewardship on the adult surgical wards of Mulago National Referral Hospital. 5.1.2.2 Specific Secondary objectives. 6. To describe the change in monthly rates of irrational inpatient antibiotic use following a quality improvement intervention in the adult surgical wards of Mulago National Referral Hospital. 7. To describe the relationship between irrational inpatient antibiotic use rates and antimicrobial resistance rates in adult gastrointestinal surgical wards of Mulago National Referral Hospital. 8. To describe the change in antimicrobial resistance rates and drug susceptibility profiles of isolates obtained from patients admitted to the adult surgical wards of Mulago National Referral Hospital during this study, compared to those of patients admitted in 24 months before this study (24 months preceding month 1).
Uganda 2025-09-12 12:24:29 2028-09-12 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jerry Okal Okoth
ID: UNCST-2025-R016719
 Evaluation of the Challenge Initiative (TCI)
REFNo: SS3773ES

The objective of the deep dive is to assess whether and to what extent TCI inputs and activities have led to or contributed to intended IOs in Uganda, and the process for how those IOs were achieved. ,
 Kenya 2025-09-10 12:20:33 2028-09-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Othman Kakaire
ID: UNCST-2019-R000359
 Monitoring, Learning and Evaluation for the Commercial Introduction and Scale-up of DMPA-SC in East Africa (DMPA SC MLE STUDY)
REFNo: HS6422ES

General objective: To support the monitoring, learning and evaluation of the commercial introduction of DMPA-SC in the private sector in Uganda, including identifying scalable strategies for increasing uptake of DMPA-SC. Specific objectives: To determine the value proposition of commercially available DMPA-SC To explore the effective strategies to increase awareness, acceptability, and uptake of DMPA-SC and SI at pharmacies and drug shops To understand how DMPA-SC and related services are being managed and delivered by pharmacy and drug shop providers/outlets (staffing and training, counselling, supportive supervision, etc.) To understand the strategies and approaches that are effective in driving quality of service delivery and counselling
Uganda 2025-09-09 8:31:27 2028-09-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Nazarius Tumwesigye Mbona
ID: UNCST-2019-R000664
 WEB-BASED INTERVENTION FOR ALCOHOL AND SUBSTANCE ABUSE AMONG YOUNG UNIVERSITY STUDENTS
REFNo: SS1785ES

To assess feasibility and effectiveness of the web-based intervention for prevention and treatment of ASUD problems among youth 18-24 years attending Universities in Uganda,To develop a web-based intervention for prevention and treatment of ASUD problems among youth 18-24years attending Universities in Uganda,To establish the prevalence of ASUD problems among youth 18-24years in selected Universities,To contribute to the improvement of the quality of ASUD treatment services in Uganda among the youth through the development of a web-based intervention and assess its feasibility and effectiveness for the prevention and treatment of ASUD among University students in Uganda,
 Uganda 2025-09-09 8:17:25 2028-09-09 Social Science and Humanities Clinical Trial Non-degree Award
SHARON NAMIIRO MIRIAM
ID: UNCST-2023-R006661
 Prevalence of Human Papilloma Virus in lung cancer tumors of adult people with and without HIV, and its association with lung cancer stage at diagnosis.
REFNo: HS6375ES

1. To determine the prevalence of Human Papilloma Virus (HPV) in primary lung cancer tumors of adult patients living with and without HIV 2. To compare the most prevalent HPV subtypes in the primary lung cancer samples of adult people living with and without HIV in Uganda. 3. To determine the association of HPV with lung cancer stage among adults with and without HIV.
Uganda 2025-09-09 16:45:06 2028-09-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Blasio BWAMBALE Bisereko
ID: UNCST-2020-R014574
 Influence of Terrestrial and Wetland Ecosystems on Species occurrences of Aedes and Culex Mosquitoes as vectors of Arboviruses in Northern Uganda
REFNo: NS1003ES

(i) To determine the occurrence and abundance of the species of Aedes and Culex mosquitoes in selected terrestrial ecosystems of districts in West Nile and the Acholi Sub-region in Northern Uganda
(ii) To determine the composition and abundance of the species of Aedes and Culex mosquitoes in selected wetland ecosystems of districts in West Nile and the Acholi Sub-region in Northern Uganda
(iii) To determine the prevalence of occurrence of arboviruses in the species of Aedes and Culex mosquitoes from the mentioned selected ecosystems of districts of West Nile and the Acholi Sub-region in Northern Uganda

 Uganda 2025-09-09 16:43:05 2028-09-09 Natural Sciences Non-Clinical Trial Degree Award
Adoke Yeka
ID: UNCST-2021-R004300
 Randomised controlled trial to assess the efficacy of artemisinin combination therapies in a setting of emerging artemisinin resistance in Uganda.
REFNo: HS6327ES

To assess the 42-day clinical and parasitological efficacy of artemether-lumefantrine (AL) and pyronaridine-artesunate (PA) for the treatment of uncomplicated P. falciparum malaria in Uganda.
 Uganda 2025-09-09 16:41:47 2028-09-09 Medical and Health Sciences Clinical Trial Non-degree Award
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