Isaac Ssinabulya
ID: UNCST-2021-R004352
|
ImpleMEntation of a Digital-first care deLiverY model for heart failure in Uganda (MEDLY Uganda)
REFNo: HS4581ES
In this study, we will implement a digital-first, multi-component strategy for HF (Medly Uganda) and evaluate both implementation and clinical outcomes. The primary objective is to assess the implementation and clinical effectiveness of a digital-first implementation strategy to improve HF self-care in Uganda. We will conduct a stepped-wedge, cluster randomized trial in outpatient departments at 6 Ugandan RRH. The co-primary outcomes will be the Self-Care of HF Index (implementation) and the composite of mortality and HF hospitalization (clinical effectiveness). The secondary objectives will include the following.
Conduct a mixed method process evaluation to inform iterative adjustments to the implementation process. We will use a community-engaged approach to systematically collect qualitative and quantitative process data at pre-determined time points based on the Learn-As-You-Go design and make contextually appropriate implementation adaptations. Prior to recruitment, we will also explore patients’ journeys to heart failure diagnosis in Uganda through a qualitative component by conducting in-depth interviews. The aims of this work will be to explore factors associated with patient’s journeys to heart failure diagnosis, including descriptions of initial symptoms, progression, health care referral journey, barriers and facilitators to care, and role of health education and self-care awareness.
We will assess the implementation fidelity and sustainability of Medly Uganda with a focus on reach, adoption, and maintenance. Using Medly Uganda meta data from patients (app) and providers (dashboard), we will identify patterns and predictors of usage. We will interview patients and providers to explore these findings, and ensure implementation fidelity. We will also explore patient and provider perspectives on the sustainability of Medly Uganda, using semi-structured interviews to explore patient and provider barriers and facilitators of long-term use, to surface strategies that would optimize Medly Uganda implementation over time.
We shall explore cost, cost effectiveness, and sustainability factors for Medly Uganda. We will collect and examine cost data from patients and facilities examining the unit cost (cost per HF patient treated and per HF patient controlled) of control and Medly Uganda scenarios both from a financial and societal perspective. Primary outcomes for cost effectiveness analysis will be the Incremental Cost-Effectiveness Ratio per patient treated and per death averted.
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Uganda |
2024-11-18 22:56:37 |
2027-11-18 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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MUTEEBWA LABAN
ID: UNCST-2022-R010550
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Barriers and facilitators of the intention to use, and the preferred model for HIV Self-Testing among young women in the Kampala Metropolitan Area
REFNo: HS5167ES
4. To assess factors associated with the intention to use HIVST services among AGYW in KMA.,3. To determine the preferred model for delivering HIVST services among AGYW in KMA.,2. To explore the barriers and facilitators influencing the use of HIVST services among AGYW in KMA,1. To determine the level of intention to use HIVST services among AGYW in KMA ,To determine the level of intention to use HIVST services, the influencing barriers and facilitators, associated factors and the preferred model for delivering HIVST services among AGYW in the KMA, Uganda.,
|
Uganda |
2024-11-18 22:50:43 |
2027-11-18 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Hannah Kibuuka
ID: UNCST-2020-R014355
|
Secondary Analysis Protocol entitled “Biomarker-guided patient stratification for diagnosis, prognosis, and monitoring of severe infectious disease at the point of need"
REFNo: HS5187ES
Transition existing host-based biomarker classifiers to protein and nucleic acid based fieldable detection devices to validate and optimize performance
|
Uganda |
2024-11-18 22:47:28 |
2027-11-18 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Edgar Mulogo Mugema
ID: UNCST-2023-R008170
|
Getting Malaria “off the backs†of women and children in western Uganda
REFNo: HS4758ES
The scientific objective is to demonstrate the protective effect of permethrin-treated lesus against P. falciparum malaria in infants and young children.,
|
Uganda |
2024-11-18 13:40:11 |
2027-11-18 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Catherine Nabbumba
ID: UNCST-2024-R002912
|
Genome wide association studies and polygenic prediction of major depressive disorder in samples of African ancestry from Uganda
REFNo: HS5159ES
1) investigate the prevalence and sociodemographic and clinical correlates of MDD among general outpatients attending care at 5 hospitals in Uganda
2) undertake a systematic review on common genetic variants associated with MDD among respondents of non-European ancestry using different datasets from PGC
3) explore common genetic variants associated with MDD in 2 African samples (ED6 study (n=150 cases, 150 controls) (A) and NeuroGAP study (n=324 cases, 876 controls) (B))
4) optimise a PRS for MDD initially developed from MDD-PGC datasets for use in the African setting of Uganda
|
Uganda |
2024-11-18 13:36:01 |
2027-11-18 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
|
THOMSON LAKWO LURONI
ID: UNCST-2023-R007843
|
Evaluating the specificity and cross-reactivity of Mansonella perstans sera against biomarkers for Onchocerca volvulus and Wuchereria bancrofti
REFNo: HS4889ES
To evaluate the specificity and cross-reactivity of M. perstans sera against biomarkers of O. volvulus and W. bancrofti.
|
Uganda |
2024-11-18 13:34:32 |
2027-11-18 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Rogers Kalyetsi
ID: UNCST-2024-R004177
|
GENETIC DIVERSITY OF PLASMODIUM FALCIPARUM AND VECTOR SPOROZOITE INFECTIVITY RATES IN SELECTED FLOOD PRONE VILLAGES IN KASESE DISTRICT, WESTERN UGANDA
REFNo: HS4978ES
d. Generate maps for the spatial distribution of infected Anopheles mosquitoes and identify the hot spots in the flood-prone selected villages in Kasese district.,C. To determine vector species composition and sporozoite effectivity rates in selected flood-prone villages in Kasese district,b. Describe the genetic diversity of P. falciparum species responsible for malaria epidemics in selected flood-prone villages in Kasese district.,a. To establish the positivity rates of P. falciparum among children ≤ 12 years in selected flood-prone villages in Kasese district ,To determine the genetic diversity of Human Plasmodium falciparum species and vector sporozoite effectivity in selected flood-prone villages in Kasese district, western Uganda,
|
Uganda |
2024-11-18 13:24:42 |
2027-11-18 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
|
Noah Nyende Robert
ID: UNCST-2024-R003575
|
Health-Seeking Behaviour and Utilization of Sexual and Reproductive Health Services by Adolescents in Uganda: An Analysis of Attitudes, Perceptions and Preferences in The Busoga Region.
REFNo: SS3374ES
4. To assess how personal factors moderate the effect of health-seeking behaviours and the utilization of SRH services by adolescents in the Busoga region of Uganda,3. To examine the relationship between health-seeking preferences and the utilization of sexual and reproductive health (SRH) services by adolescents in the Busoga region of Uganda.,2. To explore the influence of health-seeking perceptions on the utilization of sexual and reproductive health (SRH) services by adolescents in the Busoga region of Uganda.,1. To investigate the effect of health-seeking attitudes on the utilization of sexual and reproductive health (SRH) services by adolescents in the Busoga region of Uganda.,This study aims to investigate the influence of health-seeking behaviours on the utilization of sexual and reproductive health (SRH) services by adolescents in the Busoga region of Uganda. The ultimate objective is to contribute to the creation of an evidence-based model that improves the delivery and acceptance of SRH services among adolescents in Uganda.,
|
Uganda |
2024-11-18 13:22:16 |
2027-11-18 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
|
LADY MARY KABAPAGASA
ID: UNCST-2024-R002479
|
DIGITAL LITERACY COMPETENCIES AND SKILLS AMONG INFORMAL SMALL-SCALE WOMEN TRADERS IN THE RWENZORI REGION, UGANDA
REFNo: SS3371ES
5. To develop a policy brief to empower informal women traders with digital literacy skills and competencies in the country.,4. To examine the support systems available to informal small-scale women traders to optimally use digital devices and platforms to enhance their businesses in Rwenzori region,3. To examine the factors that influence the use of digital devices and platforms by informal small-scale women traders to boost trade in Rwenzori region,2. To establish digital literacy competencies and skills among informal small-scale women traders that enhance their use of digital devices and platforms for trade in Rwenzori region,1. To establish the types and application of digital devices and platforms that informal small-scale women traders use to enhance performance of their trade in Rwenzori region.,To examine the digital literacy competencies and skills among informal small-scale women traders in Rwenzori region, Uganda aiming to develop a national policy brief for empowering them with relevant digital literacy competencies and skills.,
|
Uganda |
2024-11-14 9:11:43 |
2027-11-14 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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Deo Wabwire Ogema
ID: UNCST-2021-R013932
|
A Phase 2 Randomized, Adaptive, Dose-Ranging, Open-Label Trial of Novel Regimens for the Treatment of Pulmonary Tuberculosis (RAD-TB) Version 2.0, Dated 21 Mar 2024
REFNo: HS5088ES
Primary objectives
(i)To compare Mycobacterial Growth in Tube (MGIT) liquid culture Time to Positivity (TTP) slope over the first 6 weeks of treatment for each experimental treatment arm to the standard of care (SOC) arm.
(ii)To compare new Grade 3 or higher adverse events (AEs) (safety) over the first 8weeks of treatment for each experimental treatment arm to the SOC arm.
Secondary Objectives
i)To compare time to stable culture conversion by MGIT liquid culture by week 8
for each experimental treatment arm to the SOC arm.
ii)To compare MGIT liquid culture TTP slope over the first 8 weeks of treatment for
each experimental treatment arm to the SOC arm.
iii) To compare new Grade 3 or higher AEs (safety) over 26 weeks of treatment for
each experimental treatment arm to the SOC arm.
iv) To compare discontinuations of anti-TB drugs for any reason prior to 8 and 26
weeks of treatment for each experimental treatment arm to the SOC arm.
v) To determine the dose- and exposure-response relationships between experimental drug estimated pharmacokinetic (PK) parameters with safety and efficacy.
vi) To compare a composite of efficacy and safety outcomes using a risk-benefit
approach for each experimental treatment arm to the SOC arm.
vii) To compare MGIT liquid culture TTP slope over the first 6 weeks of treatment for Arms 3A-3B and Arms 4A-4B compared to Arm 2.
viii) To compare durable cure by 52 weeks after treatment initiation in each
experimental treatment arm to the SOC arm.
|
Uganda |
2024-11-13 18:02:04 |
2027-11-13 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
JOSAPHAT KAYOGOZA BYAMUGISHA
ID: UNCST-2019-R001680
|
Heat-stable carbetocin for the treatment of postpartum haemorrhage: a phase III, randomized, double-blind, active controlled, multicountry, multicentre, non-inferiority trial
REFNo: HS5151ES
To evaluate the cost-effectiveness of the PPH treatment with HSC compared to PPH treatment with oxytocin, if HSC is proven non-inferior. ,To evaluate the comparative effects of HSC versus oxytocin on haemodynamic outcomes when used for PPH treatment in women receiving HSC for prophylaxis; ,The primary objective of this trial is to evaluate whether HSC is non-inferior to oxytocin for treatment of PPH in women who receive HSC for PPH prophylaxis, in the prevention of additional blood loss of 500 ml or more at 90 min following randomization. ,
|
Uganda |
2024-11-13 17:36:53 |
2027-11-13 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Gertrude Namazzi
ID: UNCST-2024-R002568
|
Mapping the Bottlenecks and Challenges of the At-Risk Surveillance System for Child Developmental Disabilities in Uganda
REFNo: HS5106ES
To map the bottlenecks and challenges of the At Risk Surveillance system for child developmental conditions and disabilities in order to inform targeted strategies to improve the overall effectiveness of the ARSS system,
|
Uganda |
2024-11-13 17:34:14 |
2027-11-13 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
ANTHONY NUWA
ID: UNCST-2022-R011102
|
Across Sectional Survey to improve the capacity of the healthcare system to detect, report,
and respond to arboviral threats in Uganda.
REFNo: HS5063ES
1. To ascertain the availability and density of mosquito vector species involved in virus
transmission and their bionomics in Uganda.
2. To describe and document the current practices on diagnosis and management of
arboviral diseases in Uganda and provide recommendations for improvement and
strengthening.
3. To describe the current arboviruses data collection, reporting and data use system for
decision making in Uganda.
4. To evaluate current arboviral outbreak detection and response mechanisms in Uganda
To evaluate outbreak hotspots and human/animal cluster susceptibilities to identify
appropriate target sentinel sites.
6. To determine the Yellow Fever, Chikungunya, O’nyong nyong epidemic potential based
on findings from the entomological and historical data collected during the study.
7. To assess knowledge, attitudes and practice among target communities regarding
arbovirus awareness and risk behavior.
|
Uganda |
2024-11-13 17:30:13 |
2027-11-13 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Moses Joloba Lutaakome
ID: UNCST-2022-R011558
|
Clinical Performance Evaluation of POC BVBLUE Test for Diagnosis of Bacterial Vaginosis in Uganda
REFNo: HS5231ES
To evaluate the performance of the BVBlue test, a point-of-care test, compared to Amsel, Nugent and Allplex Bacterial Vaginosis plus Assay. ,
|
Uganda |
2024-11-13 17:27:22 |
2027-11-13 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
RUKUNDO LYDIA LYDIA
ID: UNCST-2023-R005547
|
PSYCHOSOCIAL CHALLENGES AND COPING STRATEGIES OF CARE - GIVERS OF CHILDREN WITH SICKLE CELL DISEASE AGED 0-9, ATTENDING MULAGO SICKLE CELL CLINIC
REFNo: HS4975ES
To document the coping strategies adopted by care-givers of children with sickle cell disease, attending MSCC. ,To explore the psychosocial challenges experienced by care-givers of children with sickle cell disease, attending MSCC. ,To explore the psychosocial challenges and coping strategies of care-givers of children with sickle cell disease, attending MSCC. ,
|
Uganda |
2024-11-13 17:19:00 |
2027-11-13 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
JOSELYN RWEBEMBERA
ID: UNCST-2021-R013915
|
Rapid AI-assisted Echocardiography Detection and Analysis of Rheumatic Heart Disease
(RADAR) Tool – Evaluation of Acceptability and Feasibility for Field Deployment
REFNo: HS4948ES
Specific Objective 1: To assess the acceptability of this AI tool by the team members (echo nurses) in the echo screening environment.
Specific Objective 2: To evaluate the feasibility of this tool in the echo screening setting. These measures include evaluating time from screening to results, reliability of real-time image transfer from
the echo device to the RADAR tool, and functionality of the device in this environment (i.e. battery life, heat tolerance).
|
Uganda |
2024-11-13 17:17:03 |
2027-11-13 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
STELLA KIZANYE
ID: UNCST-2024-R003321
|
Design and Fabrication of a Plastic Processing Machine for Recycling High-Density Polyethylene and Polypropylene Plastic Waste- A Means of Environment Reclamation.
REFNo: SIR399ES
1. To collect data about plastic waste collected daily by Kampala waste management centres so as to inform the extent of plastic waste accumulation and show the need for collection of this problem.
2. To determine the design parameters of the components of the plastic processing/recycling machine in relation to the industry standards and need requirements.
3. To fabricate the plastic processing machine so that the recycling process can be initiated.
4. To test the machine by processing a sample of HDPE and PP plastic waste into plastic products.
|
Uganda |
2024-11-13 17:08:35 |
2027-11-13 |
Engineering and Technology |
Non-Clinical Trial |
Non-degree Award |
|
Priscilla Namaganda
ID: UNCST-2019-R001653
|
Oncogenic viral proteins associated with lymphomas at the Uganda Cancer Institute, Uganda, a comparison between HIV-associated and non-HIV-associated lymphomas.
REFNo: HS4342ES
To describe the oncogenic viral protein patterns among lymphomas at the Uganda Cancer Institute (UCI), comparing HIV-associated and non-HIV-associated lymphomas.,To determine the effect of oncogenic viral proteins on treatment outcomes of lymphoma among patients, HIV infected and uninfected at the UCI. ,
|
Uganda |
2024-11-13 17:04:50 |
2027-11-13 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Rosalind Parkes-Ratanshi Parkes
ID: UNCST-2019-R000717
|
CROWDSOURCING A TRAINING DATASET OF QUESTION-AND-ANSWER PAIRS FOR ARTIFICIAL INTELLIGENCE-ENABLED HEALTH INFORMATION TOOLS ON SEXUALLY TRANSMITTED INFECTIONS
REFNo: HS5173ES
To provide to the public, an open-access, contextualized training dataset of question-and-answer pairs (Q&A pairs) on sexual health and Sexually Transmitted Infections (STIs) in English. ,To process and curate and the question-and-answer pairs into a training dataset for AI-enabled sexual health information tools.,To provide accurate, evidence-based answers, based on the World Health Organization Guidelines, to questions collected on sexual health and Sexually Transmitted Infections (STIs) from the general public in English in Sub-Saharan Africa.,To collect contextualized English questions on sexual health and Sexually Transmitted Infections (STIs) from the general public using the internet and public events in Sub-Saharan Africa over a period of six months.,The study’s main objective is to engage communities so as to develop an open-access, contextualized question-and-answer-pair training dataset on sexual health in English for AI-enabled health information tools.,
|
UK |
2024-11-13 16:57:49 |
2027-11-13 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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David Onyango
ID: UNCST-2024-R004067
|
Stress Coping Mechanism and Trauma of Poverty among Adolescent in Information Settlements Tororo Municipality Tororo District Uganda
REFNo: SS2799ES
To investigate stress coping mechanisms and trauma of poverty among adolescents living in informal settlements in Tororo Municipality, Tororo District, Ugandan,
|
Uganda |
2024-11-13 16:54:19 |
2027-11-13 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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