Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Isaac Ssewanyana
ID: UNCST-2020-R014336
RightSign® HIV 1.2.O Rapid Test Cassette (Whole Blood/Serum/ Plasma) - Diagnostic sensitivity & diagnostic specificity, specimen equivalence, precision and qualification of usability.
REFNo: HS4998ES

4) To demonstrate the usability of this rapid diagnostic test (RDT) when performed by the intended users. It will be assessed whether the intended users comprehend all key messages from labelling and packaging (i.e. label comprehension study) and whether they can correctly interpret pre-determined test results (i.e. result interpretation study).,3) To estimate the precision (repeatability and reproducibility) of the RightSign® HIV 1.2.O Rapid Test Cassette (Whole Blood/Serum/Plasma) according to WHO TSS-1 Part 1: 1.3.1.,2) To demonstrate the equivalence of serum, plasma (EDTA-K2), venous whole blood (EDTA-K2) and fingerprick whole blood collected from HIV positive patients according to WHO TSS-1 Part 1: 1.1.1.,1) To establish the diagnostic sensitivity and diagnostic specificity of the RightSign® HIV 1.2.O Rapid Test Cassette (Whole Blood/Serum/Plasma) in plasma samples according to the WHO TSS-1 part 2.1.,
Uganda 2024-09-25 13:23:10 2027-09-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
TOM OGWANG
ID:
The lived experiences of severe Covid-19 Survivors treated in Covid-19 treatment unit at Lira Hospital.
REFNo: HS4906ES

To explore the coping strategies employed by Survivors of Severe COVID–19 disease treated in Lira Hospital-isolation unit,To describe the lived experiences of survivors of Severe COVID–19 disease treated in Lira Hospital-isolation unit.,To explore the lived experiences and coping strategies of Survivors of Severe COVID–19 disease treated in Lira Hospital. ,
Uganda 2024-09-25 13:07:57 2027-09-25 Medical and Health Sciences Non-Clinical Trial Degree Award
EVA NATUKUNDA
ID: UNCST-2020-R014330
An Open-label, Single-arm Study to Provide Continued Access to Study Drug to Participants Who Have Completed Pediatric Clinical Studies Involving Gilead HIV Treatments
REFNo: HS4706ES

To provide Continued Access to Study Drug to Participants Who Completed Pediatric Clinical Studies Involving Gilead HIV Treatments
Uganda 2024-09-25 12:50:13 2027-09-25 Medical and Health Sciences Clinical Trial Non-degree Award
Susan  Nakubulwa Kiwanuka
ID:
An investigation of Predictors of Brucellosis infection in Nakasongola District, central Uganda
REFNo: HS4967ES

i) To investigate the predictors of Brucellosis infection in Nakasongola District. ii) To investigate the barriers and facilitators of infection control measures for Brucellosis and give recommendations for disease control. iii)To examine the barriers and facilitators utilization of the One Health approach in Nakasongola District.
Uganda 2024-09-24 9:57:52 2027-09-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Diane Kabanyana
ID: UNCST-2024-R003450
Evaluating the impact of VSLA-led water funds on handpump functionality and safe WASH behaviors in Kabarole District. RefNO:UCUREC-2024-923:
REFNo: SS3109ES

To examine the influence of VSLAs with water funds on the adoption of safe WASH (Water, Sanitation, and Hygiene) behaviors within communities. This includes determining whether communities with a water-fund VSLA show increased receptiveness to sanitation and hygiene promotion and exhibit higher rates of chlorination, safe water storage, handwashing, and latrine use.,To assess the impact of VSLA-led water funds on communities’ expenses for handpump maintenance and the functionality of handpumps. Specifically, this involves evaluating whether communities with active VSLA-led water funds collect higher financial contributions from water users, allocate more funds to handpump upkeep and repairs, and achieve better handpump functionality, as indicated by fewer days of downtime and enhanced user convenience (e.g., improved pump capacity and reduced leakage),
Rwanda 2024-09-23 13:58:45 2027-09-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
Samuel Kiwanuka  Lubega
ID:
PREVALENCE OF WORK-RELATED MUSCULOSKELETAL DISORDERS AMONG KYAMBOGO UNIVERSITY STAFF
REFNo: HS4890ES

i) To investigate on the common work-related musculoskeletal disorders of Kyambogo
University staff.
ii) To determine the relationship between physical activity levels and work-related
musculoskeletal disorders among Kyambogo University staff.
iii) To establish the relationship between psychosocial factors and work-related
musculoskeletal disorders among Kyambogo University staff.
Uganda 2024-09-23 13:51:40 2027-09-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Edmund Okello
ID:
INCIDENCE, TIME TO TREATMENT INTERRUPTION AND ASSOCIATED FACTORS AMONG TB PATIENTS IN PAKWACH DISTRICT, WESTNILE REGION, UGANDA
REFNo: HS4834ES

To determine the health systems factors associated with treatment interruption among TB patients in Pakwach district,To determine the socio-demographic factors associated with treatment interruption among TB patients in Pakwach district.,To determine the patient factors associated with treatment interruption among TB patients in Pakwach district.,To determine the incidence and the median time to treatment interruption among TB patients in Pakwach district.,To determine the incidence, time to treatment interruption and associated factors among TB patients in Pakwach district.,
Uganda 2024-09-23 13:49:57 2027-09-23 Medical and Health Sciences Non-Clinical Trial Degree Award
Julian Hopwood
ID: UNCST-2022-R010178
Sustainable tree use in Acholi, northern Uganda: A post-colonial approach to protecting an African community and environment
REFNo: SS3036ES

To use, develop and analyse the collaborative autoethnography method as a post colonial approach to research.,To evaluate strategies for influencing commuities on sustainable use fo natural resources.,To explore the influences of public authorities on communities in respect of natural resource use.,To understand the relationship between different public authorities and natural resources.,To understand the customary ownership of natural resources in Acholi.,To design a communications strategy around how domestic use of natural resources, especially trees, can be sustainable.,
UK 2024-09-23 13:46:41 2027-09-23 Social Science and Humanities Non-Clinical Trial Degree Award
Fred Nsubuga
ID: UNCST-2021-R012063
Hospital Based Sentinel Surveillance of Adverse Events of Special Interest (AESI) after Vaccination with COVID-19 Vaccines in Uganda
REFNo: HS4771ES

1. Identify and describe successes and challenges experienced by Uganda during vaccine safety HBSSS planning, development, and implementation phases,3. Document implementation process and lessons learned to inform global vaccine safety partners on the use of HBSSS in low- and middle-income settings,2. Assess feasibility of using HBSSS to generate improved data on adverse events of special interest (AESI) conditions in Uganda (including background rates),1. Assess benefits and consequences of HBSSS implementation on existing vaccine safety surveillance practices in Uganda (i.e., reporting, investigations, causality assessments),
Uganda 2024-09-23 13:44:46 2027-09-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sheila Balinda Nina
ID: UNCST-2021-R013804
Assessment of suitability of biomedical prevention products against the contemporary strains of HIV-1 in India and Uganda.
REFNo: HS4843ES

a. Describe the genetic diversity of contemporary HIV-1 Viruses from India and Uganda and compare them with historical viruses using single genomes and next-generation sequencing technologies (Dr. Nanaocha Sharma, Dr. Jyoti Sutar, Dr Sheila Balinda)
b. Assessment of sequence diversity and phylodynamics of contemporary and historical genomic sequences towards elucidating epidemic divergence over time (Dr Nanaocha Sharma, Dr Jyoti Sutar)
c. Determination of features associated with virus replication and their correlation with altered pathogenicity through full genome infectious molecular clones with unique signatures representing recombinants (Dr. Sheila Balinda)
d. Identification of contemporary broadly neutralizing antibody (bnAbs) epitopes from recombinant HIV-1 specifically distinct from historical viruses and in vitro assessment of neutralization sensitivity against clinically important bnAbs towards suitability assessment of bnAb-based preventive vaccines in India and Uganda (Dr Jyoti Sutar, Dr Sheila Balinda)

Uganda 2024-09-23 13:41:04 2027-09-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Success Kamuhanda
ID: UNCST-2024-R004280
Assessing the knowledge, attitude, practices about and barriers to deworming of school aged children among care givers in Kampala slums
REFNo: SS2921ES

To identify the barriers to effective deworming programs for school-aged children in these communities.,To determin the deworming practices among care givers of school-aged children in communities in different slums of Kampala.,To determine the attitude towards deworming among care givers of school-aged children in these communities.,To assess the knowledge about deworming among care givers of school-aged children in communities in different slums of Kampala.,To assess the knowledge, attitudes, and practices (KAP) regarding deworming among caregivers of school-aged children in Kampala slums, and to identify the barriers influencing the uptake of deworming medication.,
Uganda 2024-09-23 13:35:08 2027-09-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
Andrew Kennedy Boyd
ID:
An Exploration Early Life Stress Exposure and Enamel Defect Occurrences in the Kibale Chimpanzee Project’s Primate Skeletal Collection
REFNo: NS864ES

Image the teeth of the primates within the Kibale Chimpanzee Faunal Collection. I plan to image enamel bands on the incisors, canines and premolars of each specimen in the collection in an effort to compare markers of ealry life stress (ELS) between primate species using enamel defects as a proxy.
USA 2024-09-23 13:32:49 2027-09-23 Natural Sciences Non-Clinical Trial Degree Award
Aisha Nanyiti
ID: UNCST-2021-R013489
Climate-related risks and sustainable cage fish farming in Vietnam and Uganda
REFNo: SS3009ES

The project aims to investigate cage fish farmers’ adaptation to climate-related risks to inform policy makers regarding sustainable cage fish production.,To identify the determinants of cage fish farmers’ choice of adaptive measures to climate related risk.,To analyze factors affecting cage fish farmers’ perceptions of risks.,To explore cage fish farmers’ perceptions of risks and risk preferences.,
Uganda 2024-09-23 13:26:11 2027-09-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
Queenie Nyati Annette
ID: UNCST-2023-R008468
Youth-hood Khat related injuries and their social determinants in North Western Uganda.
REFNo: HS3958ES

To prevent the initiation and use of khat among secondary school youth in North-western Uganda.,4. To develop and test a Psycho-Education (PE) model for prevention of first user of khat among youth in north western Uganda. ,3. To document stakeholder perceptions on the association between youth-hood Khat abuse and injuries and injury deaths. ,2. To establish the social determinants of khat abuse and khat related youth-hood injuries.,1. To estimate the magnitude of khat use, injuries and deaths attributable to Khat abuse among the youth in North Western Uganda. ,
Uganda 2024-09-23 13:22:32 2027-09-23 Medical and Health Sciences Non-Clinical Trial Degree Award
Eddy Walakira Joshua
ID: UNCST-2022-R009077
Social Cohesion in Refugee and Host Communities of Kyaka II and Kyangwali Settlements in Kyegegwa and Kikuube Districts
REFNo: SS2593ES

Main objective

To examine the status of social cohesion in refugee and host communities of Kyaka II and Kyangwali Settlement within Kyegegwa and Kikuube Districts, prior to the implementation of the SMILES project

Specific objectives

i.To establish the current status of relationships between refugee and host communities in Kyaka II and Kyagwali Settlements.

ii.To examine the status of relationships within refugee communities in Kyaka II and Kyagwali Settlements.

iii.To study the status of relationships within host communities of Kyaka II and Kyangwali Settlements.

Uganda 2024-09-23 13:20:13 2027-09-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
JOHN ISIIKO
ID: UNCST-2022-R011328
Identifying provider-perceived barriers and facilitators of cancer treatment services in Uganda: a qualitative study
REFNo: SS2741ES

Explore potential solutions to improving cancer treatment processes for patients, providers, and health systems.,Determine key challenges and facilitators for patients, providers, and health systems in receiving and providing cancer treatment. ,
Uganda 2024-09-23 13:16:59 2027-09-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
WABUSA DAVID FRANCIS
ID:
IMPLICATIONS OF LAND TENURE SYSTEMS ON FOOD SECURITY IN MBALE DISTRICT-EASTERN UGANDA
REFNo: SS2720ES

iv. Recommend policy interventions and strategies to improve land tenure systems in Mbale district.,iii. Identify the key challenges and barriers that affect food security for households in Mbale, Uganda.,ii. Determine the implications of the land tenure systems for household food security in Mbale, Uganda. ,i. Assess the existing land tenure systems in Mbale, Uganda ,To understand the implications of land tenure systems on food security of households in Mbale district. ,
Uganda 2024-09-23 13:15:34 2027-09-23 Social Science and Humanities Non-Clinical Trial Degree Award
Henry Kajumbula Mawerere
ID: UNCST-2019-R001531
Comparison of community and hospital Antibiotic use practices, Susceptibility and resisTance and determinants of care seeking among patients with Urinary Tract Infections (CAST-UTI)
REFNo: HS4458ES

6. Determine the outcome of infections.,5. Assess the treatment practices of healthcare workers for acute UTIs in CDROs and hospitals.,4. Examine the resistance profiles for differences between neighbourhoods (Namuwongo and Muyenga),3. Determine the appropriateness of treatment based on standard treatment guidelines for acute UTIs in the community (based on organism and resistance profile,2. Explore the social context of antibiotic prescribing and use in the community. ,1. Determine and compare the resistance profiles of the disease-causing organisms in community drug retail outlets (CDRO’s)/clinics, and in hospitals/ WHO-GLASS ,
Uganda 2024-09-23 13:14:32 2027-09-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Richard Nyeko
ID: UNCST-2021-R012815
Acute myeloid leukaemia in children in a resource-limited setting: epidemiology, management, and outcomes in Uganda
REFNo: HS4479ES

Aim of the study
This doctoral study aims to investigate paediatric AML in Uganda and other African countries, namely the incidence and prevalence of paediatric AML, the AML biological characteristics, the supportive care needs, and overall survival after the introduction of an adapted AML treatment protocol with a reduced-intensity induction regimen.

Specific objectives
1. To describe the incidence and prevalence of paediatric AML in Uganda.
2. To evaluate paediatric AML management and outcomes in Uganda and other African countries based on different treatment protocols.
3. To determine the risk factors for induction failure and treatment-related morbidity and mortality in children with AML.
4. To conduct a “proof-of-concept” study to test the recommendations of the SIOP-PODC (renamed SIOP Global) adapted guidelines for paediatric AML in resource-limited settings.
5. To identify the limitations in supportive care (anti-bacterial, blood products, and intensive care) needs in the treatment of paediatric AML in Uganda.

Uganda 2024-09-23 13:05:19 2027-09-23 Medical and Health Sciences Non-Clinical Trial Degree Award
Muniru Sewanyina
ID: UNCST-2021-R013988
CORPORATE GOVERNANCE PRACTICES AND NON-PERFORMING LOANS OF COMMERCIAL BANKS IN GREATER BUSHENYI DISTRICTS; WESTERN UGANDA
REFNo: SS3114ES

To ascertain the moderating influence of interest rates on non-performing loans of commercial banks in Greater Bushenyi Districts, western Uganda, To examine the extent to which board compensation influences non-performing loans of commercial banks in Greater Bushenyi Districts western Uganda ,To determine the extent to which relationship between shareholders\' rights and non-performing loans of commercial banks in Greater Bushenyi Districts, western Uganda,To examine the extent to which financial transparency influences non-performing loans of commercial banks in Greater Bushenyi Districts, western Uganda ,To assess the extent to which board accountability influences non-performing loans of commercial banks in Greater Bushenyi Districts, western Uganda, The purpose of this study will be to assess the effect of corporate governance practices on non-performing loans of commercial banks in Greater Bushenyi Districts; Western Uganda,
Uganda 2024-09-23 12:16:25 2027-09-23 Social Science and Humanities Non-Clinical Trial Degree Award
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