Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Timothy Makumbi Kabanda
ID: UNCST-2021-R011760
MICRO RNAS PROFILING: BIOPATHOLOGIC CHARACTERIZATION AND SURVIVAL OF EARLY ONSET BREAST CANCER AMONG UGANDAN Ref No. Mak-SOMREC-2021-272
REFNo: HS3699ES

iii) To correlate aberrantly expressed miRNAs profiles with associated survival among women with EOBC.,ii) To determine the association between MicroRNAs dysregulation and the clinical pathological characteristics among women with EOBC. ,i) To determine the prevalence of dysregulated MicroRNAs expression profiles among women with EOBC.,To determine the prevalent profiles of aberrantly expressed(dysregulated) miRNAs and how they influence the specific pathological characteristics, and survival after mastectomy breast surgery for early onset breast cancer (EOBC),
Uganda 2025-09-17 12:32:26 2028-09-17 Medical and Health Sciences Non-Clinical Trial Degree Award
Andrew Mujugira
ID: UNCST-2019-R000871
Integrating HIV prevention with TB household contact evaluation in Uganda (TB PrEP)
REFNo: HS6341ES

Aim 1: Assess the implementation and effectiveness of home- based HIV self-testing and PrEP initiation versus clinic referral on PrEP initiation and continuation during household TB contact investigation.

Aim 2: Examine processes of implementing HIV self-testing and PrEP initiation during household TB contact evaluation using qualitative methods.

Aim 3: Estimate the cost-effectiveness of implementing home- based HIV testing and PrEP initiation for household members of people with TB in Uganda compared to clinic referral.

Uganda 2025-09-17 12:30:43 2028-09-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
NUWAGIRA KENETH
ID: UNCST-2025-R016664
FINANCIAL INCLUSION AND GROWTH OF MICRO, SMALL AND MEDIUM-SIZED ENTERPRISES (MSMES) IN KAMPALA CITY, UGANDA.
REFNo: SS3991ES

Main Objectives
The purpose of the study is to investigate the effect of financial inclusion on growth of micro, small and medium-sized enterprises (MSMEs) in Kampala City, Uganda.

1.4 Specific objectives
i) To determine the effect of credit accessibility on the growth of MSMEs in Kampala City, Uganda.
ii) To establish the effect of mobile money services on the growth of MSMEs in Kampala City, Uganda.
iii) To explore the effect of financial literacy on the growth of MSMEs in Kampala City, Uganda.

Uganda 2025-09-17 12:28:56 2028-09-17 Social Science and Humanities Non-Clinical Trial Degree Award
Twinamasiko Specioza
ID: UNCST-2022-R008954
Empowering Ugandan Refugee–Host Communities in Becoming Climate Resilient: The Case Studies of Nakivale and Rhino Camp Refugee Settlements
REFNo: NS983ES

1. To assess the resilience of refugees and their host communities to water access and land tenure in Nakivale and Rhino Camp
2. To monitor water quality within the refugee settlements and host communities of Nakivale and Rhino Camp.
3. To analyze hazards and farming practices within the refugee settlements and host-communities of Nakivale and Rhino Camp refugee-host communities
4. To document the different traditional practices and indigenous knowledge on agriculture, water source preservation and forest conservation prevalent among the refugee and host communities of Nakivale and Rhino Camp Refugee settlements.
5. To identify ways in which traditional environmental practices and indigenous knowledge can complement the contemporary modern scientific policies of environmental conservation and protection in refugee-host communities

Uganda 2025-09-17 12:27:48 2028-09-17 Natural Sciences Non-Clinical Trial Degree Award
Sadia Mohamed Mahad
ID: UNCST-2024-R004826
Prevalence and Factors Associated with Substance Use Among Refugees In Nakivale Settlement South-Western Uganda
REFNo: HS6217ES

i. To determine the prevalence of substance, use among refugees in Nakivale Refugee Settlement. ii. To identify and describe the modifiable and non-modifiable factors associated with substance use among refugees in Nakivale Refugee Settlement.,
Somalia 2025-09-17 12:08:46 2028-09-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jazira Tumusiime
ID: UNCST-2024-R003664
EXPLORING CAREGIVERS AND HEALTH WORKERS’ PERCEPTIONS TOWARDS HPV VACCINATION AT MBARARA REGIONAL REFERRAL HOSPITAL ADOLESCENT CLININC AND BWIZIBWERA HEALTH CENTRE IV, UGANDA
REFNo: HS6193ES

To identify the barriers and facilitators influencing the uptake of HPV vaccination among adolescents at Mbarara Regional Referral Hospital and Bwizibwera Health Centre IV in southwestern Uganda.,To assess caregivers\' and healthcare workers\' knowledge and perceptions about HPV vaccination at Mbarara Regional Referral Hospital and Bwizibwera Health Centre IV in southwestern Uganda.,To explore caregivers’ and healthcare workers’ perceptions of HPV vaccination and identify the barriers and facilitators affecting the uptake of the HPV vaccine among adolescents at Mbarara Regional Referral Hospital and Bwizibwera Health Centre IV in southwestern Uganda.,
Uganda 2025-09-17 11:22:16 2028-09-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Miria Nandera
ID: UNCST-2021-R012140
SCHOOL CLIMATE AND WORK ENGAGEMENT MEDIATED AND MODERATED BY WORK-LIFE BALANCE AND JOB EMBEDDEDNESS OF PRE-PRIMARY TEACHERS IN CENTRAL UGANDA
REFNo: SS4033ES

1. To examine the influence of school climate on teacher work engagement of pre-primary teachers in Central Uganda.
2. To assess the influence of school climate on work-life balance of pre-primary teachers in Central Uganda.
3. To analyse the influence of work-life balance on teacher work engagement of pre-primary teachers in Central Uganda.
4. To test the mediating role of work-life balance on the influence of school climate on teacher work engagement of pre-primary teachers in Central Uganda.
5. To find out the moderating effect of job embeddedness on the influence school climate on teacher work engagement of pre-primary teachers in Central Uganda.
Uganda 2025-09-17 11:19:34 2028-09-17 Social Science and Humanities Non-Clinical Trial Degree Award
Ibrahim Adabara
ID: UNCST-2025-R019039
AGENTIC AI FOR CYBERSECURITY: A FRAMEWORK FOR THE DESIGN AND GOVERNANCE OF RESILIENT AUTONOMOUS DEFENSE SYSTEMS
REFNo: SIR547ES

1.3 Main Objective

The primary objective of this research is to construct a theoretically grounded and ethically aligned framework for conceptualizing, simulating, evaluating, and governing AAI systems in cybersecurity. The framework will serve as a strategic model for autonomous defensive agents, focusing on secure, transparent, and accountable operation in adversarial environments, in alignment with legal and normative expectations.

1.4 Specific Objectives

i. To develop a reference model for agentic AI systems integrating autonomy, ethical responsiveness, and adaptive reasoning by synthesizing existing literature and formalizing the framework within the first phase of the study.

ii. To design and implement a simulation-based methodology that models adversarial threat scenarios and tests agentic AI responses within a defined experimental period, using performance and ethical indicators as measurable outputs.

iii. To construct a multi-criteria evaluation framework that defines and measures agentic system performance in terms of transparency, latency, proportionality, and normative alignment, validated through simulated test cases in the second phase.

iv. To propose and validate a governance and ethical oversight model for agentic AI deployment, incorporating regulatory review, stakeholder auditability, and normative safeguards by the final phase of the project, following empirical evaluation.
Nigeria 2025-09-17 11:18:20 2028-09-17 Engineering and Technology Non-Clinical Trial Degree Award
Ronald Bisegerwa
ID: UNCST-2022-R011022
Accuracy of Pulse Oximeters with Profound Hypoxia
REFNo: HS6506ES

To generate two to three evidence-based recommendations to regulatory and procurement bodies within six months of study completion to guide pulse oximeter selection for diverse populations.,To collect and contribute data on pulse oximeter accuracy across diverse skin tones to an open-access device performance database by the study’s end, enabling manufacturers to refine pulse oximeter technology and ensure equitable performance across all skin tones, especially in low-resource settings.,To replicate the UCSF Hypoxia Lab in Uganda by establishing a fully equipped and operational facility within a year to evaluate pulse oximeter accuracy across diverse skin tones and hypoxia levels.,To evaluate the accuracy of pulse oximeters under controlled hypoxic conditions in a diverse population in Uganda, with a focus on understanding and addressing disparities in device performance related to skin pigmentation.,
Uganda 2025-09-12 17:03:12 2028-09-12 Medical and Health Sciences Clinical Trial Non-degree Award
Pauline Amuge Mary
ID: UNCST-2023-R005532
LC-REVITALIZE – A Long Covid Repurposed Drug Study
REFNo: HS6370ES

-To assess the efficacy of repurposed drugs compared to their
respective placebos in reducing standardized symptom severity scores
in participants with Long Covid.
-To compare the symptom burden (e.g., anxiety, depression, overall
well-being) in participants with Long Covid treated with repurposed
drugs versus their respective placebos.
- To assess whether symptom burden worsens in participants with Long
Covid treated with study drugs versus placebo, specifically when
symptoms are reported across multiple scales.
- To assess changes in exercise capacity over time of participants with
Long Covid treated with study drugs versus their respective placebos.
- To measure specific Long Covid pathophysiological biomarkers of study
drugs versus their respective placebos.

Uganda 2025-09-12 17:00:13 2028-09-12 Medical and Health Sciences Clinical Trial Non-degree Award
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