Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Andrew Mujugira
ID: UNCST-2019-R000871
 CHOICE-BASED PrEP DELIVERY FOR TRANSGENDER PEOPLE IN UGANDA
REFNo: HS2316ES

Aim 1: Identify PRECEDE factors that influence PrEP implementation for transgender people in Uganda.

Guided by the PRECEDE-PROCEED model, which is widely used for public health interventions, we will analyze previously collected qualitative data from four TGP studies and also conduct two new focus groups with TGP and providers to identify predisposing, reinforcing, and enabling factors that may impact implementation of choice-based PrEP. A stakeholder workshop anchored in good participatory practice will discuss results of the qualitative research and guide design of the optimal choice-based PrEP delivery model for Aim 2.

Aim 2: Offer PrEP choice to transgender people in a DSD model and evaluate implementation and effect on PrEP use (PROCEED).

We will offer choice of CAB-LA or oral PrEP, and choice of facility or community delivery (with option to switch), to 300 HIV-negative TGP with follow-up for 24 months. Adverse events, product switching, and trajectories of choice over time will be monitored and documented. Persistence on CAB LA and oral PrEP will be compared during the choice period, and with a historical cohort without PrEP choice (ClinicalTrials.gov, NCT04491422). Primary outcomes are choice of PrEP option & delivery model, adherence, and persistence.

Aim 3: Use mixed methods to evaluate how choice influences PrEP use among TGP (PROCEED).
Inductive and deductive analyses based on in-depth interviews with purposively sampled PrEP users (n=50) and providers (n=10) will be used to explain “how” and “why” choice did or did not work and interpret implementation data from Aim 2. Choice preferences will be assessed via structured questionnaires.

Aim 4: Estimate cost implications associated with integrating CAB LA into HIV programs.
We will conduct health system versus client cost analyses to inform budgeting. Costs incurred and averted will be estimated using activity-based micro-costing, study budget, and the literature. Costs and modeled outcomes will be combined to estimate budget impact with PrEP persistence at 6 and 12 months.


 Uganda 2022-06-28 16:44:09 2025-06-28 Medical and Health Sciences Clinical Trial Non-degree Award
Victor Musiime -
ID: UNCST-2021-R013794
 Building Resources to Assess Impaired Neurocognition in Children with HIV in Low and Middle Income Countries (BRAIN Child LMICs)
REFNo: HS2271ES

(1) Adapt NeuroScreen for Luganda-speaking children 5-12 years. (a) Through expert focus groups and multiple rounds of cognitive interviewing with children, determine necessary adaptations to make the NeuroScreen tests valid, acceptable and understandable to Luganda-speaking children, (b) implement
those adaptations in the app, (c) re-evaluate the adapted app with children, (d) examine its acceptability by clinical staff most likely to administer it, and (e) make further adaptations, as needed.

(2) Examine construct validity of the child version NeuroScreen tests. (a) Compare NeuroScreen test performance to gold standard neuropsychological test battery performance among Ugandan children 5-12 years with and without HIV, and (b) explore the relationship between performance on NeuroScreen and behavioral health.


 Uganda 2022-06-28 16:42:46 2025-06-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sophie Riddick
ID: UNCST-2022-R010576
 Decision-making and religious beliefs across cultures
REFNo: SS1336ES

study how children learn about religious beliefs and practices over development, gain an understanding of how children attend to normative information presented by a peer or by an adult
 UK 2022-06-28 14:39:43 2025-06-28 Social Science and Humanities Non-Clinical Trial Degree Award
ERICK SSEGUJJA
ID: UNCST-2021-R012964
 Donor transition and its effect on health coverage in Uganda
REFNo: HS2112ES

The aim of this study is to better understand how and why Uganda has (or not) been able to sustain effective coverage of health interventions after projects previously funded by donors ended and the enablers and barriers encountered in this,4. Identify health system adaptation strategies devised by (sub)national actors for sustaining coverage of the two selected interventions when donor projects ended from 2016-2017 to date.,3. Understand how the end of project funding affected the coverage of maternal health interventions and HIV services in case-study districts in 2016 and 2017 respectively.,2. Determine changes in (i) select maternal health indicators (ii) key HIV service indicators three years after the end of project funding between 2016 and 2017 in select donor- supported districts.,1. Explore the political, financing and health system factors that influenced whether coverage of maternal health interventions and HIV services were sustained once the projects funded by the donors ended between 2016 and 2017. ,
 Uganda 2022-06-27 8:45:40 2025-06-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Pontiano Kaleebu
ID: UNCST-2021-R013577
 Implementation of Point of Care HIV Viral Load Monitoring to improve Viral Load Suppression among Children and Adolescents Living with HIV in East Africa.
REFNo: HS2025ES

14. Objectives of the research project:
Purpose: The purpose of EAPOC-VL project is to examine the feasibility, acceptability, and effectiveness of using point of care viral load (PoC VL) monitoring to improve viral load suppression among children and adolescents (age ?19 years) living with HIV in Kenya, Rwanda, Tanzania and Uganda.

Main Study Aims:
i) To determine the effectiveness of PoC VL monitoring in improving viral suppression among children and youth living with HIV in East Africa. ii) To evaluate feasibility and acceptability of using PoC VL monitoring among children and adolescents living with HIV in East Africa.

Objectives of Aim 1:
Primary objective
i. To estimate the effect of PoC VL monitoring on viral load suppression among children and adolescents living with HIV in East Africa at 6 and 12 months of followup.

Secondary objectives
i. To describe the effect of PoC VL monitoring on the proportion of children and adolescents living with HIV that experiences virological rebound after initial suppression within 6 and 12 months of follow-up.
ii. To describe the effect of PoC VL monitoring on time to initiation of intensive adherence counselling following virological failure among children and adolescents living with HIV.
iii. To estimate the effect of PoC VL monitoring on the proportion of children and adolescents living with HIV that experiences change of ART regimen within 6 and 12 months of follow-up.
iv. To determine the effect of PoC VL monitoring on the proportion of children and adolescents living with HIV that is retained in care at 6 and 12 months.

Objectives of Aim 2
i. To assess the acceptability of the implementation and scale-up of PoC VL testing and monitoring from the perspective of children, adolescents and their care givers. ii. To assess the critical determinants that may affect the implementation of PoC VL testing and monitoring from the perspective of healthcare workers and policy makers.
iii. To assess potential barriers and facilitators to implementation and scale-up of PoC VL testing and monitoring among children and adolescents living with HIV.
iv. To assess the incremental cost-effectiveness of PoC VL from a modified societal perspective using established models, with data collected alongside the implementation of the intervention combined with data estimated based on existing studies.

Uganda 2022-06-27 16:03:08 2025-06-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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