Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Amanyire Jordan Mutambi
ID:
Depression, associated factors and psychosocial interventions among elderly individuals living with HIV/AIDS in SW Uganda accessing services in Mbarara City
REFNo: HS2331ES

1. To document evidence on psychosocial interventions those have been effective in treatment of depression among elderly people in low and middle income countries.
2. To determine the prevalence of depression among the elderly living with HIV/AIDS in SW Uganda accessing HIV/AIDS care within selected health facilities in Mbarara city.
3. To explore the factors associated with depression among elderly people living with HIV/AIDS in SW Uganda accessing services in selected health facilities in Mbarara city
4. To assess the effectiveness of Behavioral Family Therapy (BFT) in reducing depressive symptoms among elderly HIV patients accessing HIV care in selected health facilities Mbarara city, southwestern Uganda.

 Uganda 2022-07-18 14:34:09 2025-07-18 Medical and Health Sciences Non-Clinical Trial Degree Award
Joseph Baluku B
ID: UNCST-2019-R000612
 Mycobacterium tuberculosis infection and DNA damage in HIV-associated lung cancer in Uganda
REFNo: HS2328ES

STUDY AIM 1: To determine the association between Mycobacterium tuberculosis
infection and HIV-associated lung cancer in Uganda.

STUDY AIM 2: To compare the degree of DNA damage and methylation among people
with HIV-associated cancer with and without Mycobacterium tuberculosis infection.


SECONDARY AIM: To determine the effect of tuberculosis preventive therapy (TPT) on
the six-month survival of people with HIV-associated lung Cancer and LTBI in
Uganda
 Uganda 2022-07-18 14:31:31 2025-07-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Nelson Sewankambo K
ID: UNCST-2020-R014578
 Development and Evaluation of an Information Management and Communication System for Population-wide Point-of-Care Infant Sickle Cell Disease Screening (SIMCS)
REFNo: HS2333ES

1. To develop and evaluate a four module 3G or more cell phone app for a novel SCD screening information management and communication system (SIMCS) 2.To evaluate the impact of the SCD SIMCS on access to screening and care and outcomes of children with SCD.
Uganda 2022-07-18 14:29:19 2025-07-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Andrew Obuku Ekii
ID: UNCST-2024-R002288
 IMMUNOLOGICAL AND VIROLOGICAL FACTORS ASSOCIATED WITH VIROLOGICAL CONTROL IN ACUTE AND EARLY HIV-I INFECTION.
REFNo: HS2264ES

• To characterize the earliest host factors associated with plasma viral load decline from peak viremia to viral setpoint.
a) To determine the functional and molecular profile of innate immune cells at each stage of acute and early HIV infection.
b) To determine the functional and molecular profile of adaptive immune cells at each stage of acute and early HIV-I infection.
c) To determine the impact of early cART treatment on:
l) Size of translational competent viral reservoirs
Il) Development of HIV specific immune responses
d) To determine HIV evolution in acute and early HIV1 infection

Specific objectives are:
1 . To determine the association of CD8 T cell subsets with plasma viral load and CD4 trajectories following acute and early HIV-I infection.
2. To determine the association of cell death mechanism with T cells following acute and early HIV-I infection.
3. To determine the viral replicative inhibitory properties of CD8 T cell subsets following acute and early HIV-I infection.
4. To determine the TCR and BCR of the cells with the highest viral inhibition potency.
5. Predict antigen that induced the TCR and BCR specificity in the cellular subsets with the highest viral inhibition potency.
6. To associate HIV specific B cell phenotypes with viremia in acute and early HIV infection.
7. To associate complement proteins with viremia and development of broadly neutralizing antibody in acute and early HIV-I infection.


 Uganda 2022-07-18 14:27:23 2025-07-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Macdonald Isabel
ID:
Do anonymous ratings build trust in mobile money agents? Evidence from Uganda
REFNo: SS1344ES

The goal of the research is to determine if mobile money users in Uganda trust anonymous customer ratings, and if these ratings would make users more willing to trust unknown agents. Furthermore, the research will explore the extent to which social stigmas restrict information sharing about agent trustworthiness.
Specific Objectives
Establish whether anonymous reviews increase trust, both in behavioral games and in unknown mobile money agents
Investigate if social stigmas restrict info sharing about agent trustworthiness

 USA 2022-07-15 15:59:49 2025-07-15 Social Science and Humanities Non-Clinical Trial Non-degree Award
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