Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
DICKSON TAYEBWA
ID: UNCST-2021-R012253
 ECOLOGY OF FREE-ROAMING DOGS AND THE CONTROL MEASURES TO ALLEVIATE THE ASSOCIATED PUBLIC HEALTH RISKS IN SELECTED DISTRICTS IN UGANDA
REFNo: HS5222ES

1. To determine the demographics and ecology of free-roaming dogs in Kampala metropolitan area
2. To assess the risk of dog bites and transmission of rabies that free-roaming dogs pose to the community in Kampala metropolitan area
3. To identify viruses of importance to human and animal health circulating in free-roaming dogs in Uganda across a gradient of contact with wildlife
4. To document the dog ownership practices that perpetuate free-roaming dogs in urban and rural settings in Uganda.
5. To assess the dog community sentiments towards free-roaming dogs in urban and rural settings in Uganda.
6. To assess the effectiveness of a sterilization community clinic in managing the population and the public health risks associated with free-roaming dogs

Uganda 2025-07-18 14:35:31 2028-07-18 Medical and Health Sciences Non-Clinical Trial Degree Award
SHAKILLAH  NAMATOVU
ID: UNCST-2022-R009404
 ASSESSMENT OF HUMAN PAPILLOMAVIRUS VACCINATION UPTAKE AND ITS PREDICTORS AMONG FEMALE ADOLESCENTS (10-14 YEARS) IN MBARARA DISTRICT
REFNo: HS6133ES

General Objective
This study aims to assess the level of uptake of the HPV vaccine and its predictors among female
adolescents (10-14 years) in mbarara district
4
1.3.2. Specific Objectives
(i). To assess the level of awareness of and uptake of HPV vaccination among females aged 10-14
years in mbarara district
(ii). To determine factors associated with the uptake of HPV vaccination among females aged 10-
14 years in mbarara distric
 Uganda 2025-07-18 14:30:06 2028-07-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Paineto Masengere
ID: UNCST-2021-R013195
 Sustainability of Evidence-Based Interventions for Cardiovascular Disease Prevention in Mukono and Buikwe Districts, Uganda: A Post-Intervention Study
REFNo: HS6237ES

1. Examine the trends of CVD profiles and their determinants in Mukono and Buikwe districts over 10 years (2015-2024).
2. Evaluate the effectiveness of the interventions of the SPICES project for the prevention of CVDs in Mukono and Buikwe districts, Uganda.
3. Assess the sustainability of evidence-based interventions for the prevention of CVDs in Mukono and Buikwe districts, Uganda, three years post SPICES project implementation.
4. Explore the factors influencing the sustainability of evidence-based interventions for the prevention of CVDs in Mukono and Buikwe districts, Uganda.

 Uganda 2025-07-18 14:22:43 2028-07-18 Medical and Health Sciences Non-Clinical Trial Degree Award
Emmanuel Rukundo NSHAKIRA
ID: UNCST-2021-R012277
 Uncertainty and Frictions in Gig Work: Evidence via Conditional Income Guarantee Interventions
REFNo: SS3790ES

This study will identify how interventions designed to reduce uncertainty in earnings may affect labor supply and productivity in the informal gig economy in developing cities.
 Uganda 2025-07-18 14:17:44 2028-07-18 Social Science and Humanities Non-Clinical Trial Non-degree Award
Dorothy Okello Kabagaju
ID: UNCST-2021-R011847
 Digitally Enabled Resilience Policy Innovations (DERPIn)
REFNo: SIR467ES

Main Objective
1. The objective of the proposed data collection is to enhance food system resilience in Uganda by increasing the availability of agricultural data and evidence which will be deployed in a customized AI platform for biophysical data analysis and crop modeling, enabling informed, gender-sensitive, and inclusive policymaking.

Specific Objectives
1. Build Capacity and Promote Knowledge Sharing: Conduct training sessions and outreach activities to empower stakeholders in utilizing the digital tools, data, and insights generated by the project for informed decision-making and policy formulation.
2. Launch a Customized AAgWa Platform: Deploy a user-friendly, interactive AAgWa platform tailored to the Ugandan context, providing data visualization, crop production forecasts, and decision-support tools for various stakeholders.
3. Create Crop Type Classification Maps: Utilize machine learning techniques and spectral signatures to generate high-resolution crop type maps for improved agricultural planning and resource management.
4. Develop and Calibrate Crop Models: Collect primary data on crop types and locations to train and calibrate the Africa Crop Production (AfCP) model for accurate yield forecast

 Uganda 2025-07-18 14:14:27 2028-07-18 Engineering and Technology Non-Clinical Trial Non-degree Award
WINFRED ARINAITWE
ID: UNCST-2024-R015869
 DEVELOPMENT OF A SECURITY FRAMEWORK FOR INFORMATION SHARING-ENABLED INTERNET OF MEDICAL THINGS IN SELECTED HEALTH INSTITUTIONS IN UGANDA
REFNo: SIR480ES

(i) To study existing security frameworks used in Information Sharing IoMT-compatible devices and applications.
(ii) To establish requirements for designing a security framework specific to the needs of Information Sharing-Enabled IoMT systems in selected Ugandan health institutions.
(iii) To develop a tailored security framework for Information Sharing-Enabled Internet of Medical Things.
(iv) To validate the developed Security Framework for Information Sharing-Enabled Internet of Medical Things.

 Uganda 2025-07-18 14:10:11 2028-07-18 Engineering and Technology Non-Clinical Trial Degree Award
David Meya Bisagaya
ID: UNCST-2019-R000837
 A Phase 2 Novel Antimicrobial Combination Therapy to Treat Tuberculous Meningitis
REFNo: HS5711ES

1. Assess the safety and efficacy of a novel anti-TB combination regimen with greater bactericidal activity than current standard of care (SOC) therapy
 Uganda 2025-07-18 14:05:06 2028-07-18 Medical and Health Sciences Clinical Trial Non-degree Award
Kiconco KerenHappuchBita
ID: UNCST-2024-R016072
 “TRAINER-TRAINEE MANAGEMENT PROCESSES IN INFORMAL VOCATION EDUCATION TRAINING ARRANGEMENTS IN UGANDA”
REFNo: SS3744ES

1.4 Objectives of the study
i) To find out the management processes engaged in the practice of IVET.
ii) To discover how the informal nature shapes the management processes.
iii) To establish potential factors influencing the trainer –trainee management process of IVET.
iv) To find out coping approaches and strategies utilized in IVET management.


Uganda 2025-07-18 13:58:51 2028-07-18 Social Science and Humanities Non-Clinical Trial Degree Award
Elias Kumbakumba
ID: UNCST-2022-R011183
 Consortium to Reduce Infant Mortality in Uganda (CONRIM-U)
REFNo: HS6270ES

OBJECTIVES
The overall CONRIM objective is to contribute to the elimination of preventable Neural tube defects (NTDs), Neonatal Sepsis (NS) and the resultant Infectious Hydrocephalus in Uganda.

SURVEILLANCE OBJECTIVES
The study aims to investigate the burden of NS and NTDs within the Busoga subregion, their associated risk factors, the role of genomics in their causation, and the extent to which effective public health interventions and prevention policies can contribute to their reduction.
Specific objectives for the SURVEILLANCE ARM of the CONRIM Unified Protocol include:

1. To estimate the true burden of NTD and NS in Busoga region

In order to achieve this, we will
1.1 Establish comprehensive village level surveillance and build the community network and capacity for accurate routine surveillance on NS and NTDs.

1.2 Employ advanced methods of adaptive surveillance to optimize cost effective observation for NS and NTD at the community level. These can then be extrapolated to other important infant conditions like Malnutrition, and scaled up nationally

2. To determine genetic and environmental contribution to NTD and NS risk and prevention

In order to achieve this, we hope to

2.1 Identify populations or geographical areas that are at increased risk of NS and NTDs in Uganda, for targeted follow-on prevention measures, and policy formation

2.2 Determine whether ancestral genomics might separate different risk groups with similar folate levels. This will lead to optimization of folate for diverse African ancestries.

SAMPLING OBJECTIVES
The general objective of the Sampling Arm is to prospectively diagnose, treat and prevent infant paenibacillus infections.

Specific objectives for the SAMPLING ARM of the CONRIM Unified Protocol include:

3. To evaluate the ability to diagnose Paenibacillus infections at the hospitals.
In order to achieve this objective, we will

3.1 Set up real time qPCR sampling on site at specific sites treating these infants. This will enable the treating clinicians be able to diagnose this infection and plan treatment
3.2 Plan for Nanopore Same Day Sequencing for both Microbe Detection and Antibiotic Resistance determination

4. To determine the optimal treatment for infant paenibacillus infections and evaluate for outcomes.
In order to achieve this objective, we hope to

4.1 Start a prospective registry of infants diagnosed with this infection, focusing on observing treatments and outcomes.
4.2 Lay the foundational work for optimization of brain growth following treatment for infant infections and malnutrition.

5. To identify Sources and Routes of infection leading to infant Paenibacilliosis so as to Prevent these infections
In order to achieve this objective, we will

5.2 Identify potential environmental reservoirs of infant paenibacilliosis.

5.3 Assess for potential transmission routes of infection related to infant care and feeding practices. The consenting mothers whose infants underwent testing for Paenibacillus will be requested to complete a detailed structured interview designed to elucidate the possible pathways of infection stemming from infant care practices.

 Uganda 2025-07-18 13:55:00 2028-07-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Caroline Birungi
ID: UNCST-2021-R012954
 EVALUATING THE EFFECTIVENESS OF INSTRUCTION IN RESPONSIBLE CONDUCT OF RESEARCH ON TRAINEES’ KNOWLEDGE, SKILLS, AND ATTITUDES FOR DECISION-MAKING IN RESEARCH AND PRACTICE IN SOUTHWESTERN UGANDA
REFNo: HS5771ES

1.3.1 General Objective
To evaluate the effectiveness of instruction in responsible conduct of research on trainees’ knowledge, skills, attitudes and behaviors towards decision making in research and practice among those who attended RCR training under the Mbarara University Research Ethics Education Program (MUREEP) from March 2019 to December 2023.
1.3.2 Specific objectives
1. To assess the effectiveness of instruction in RCR offered by MUREEP from March 2019 to December 2023 on trainees' knowledge of the core norms, principles, regulations, and rules governing the practice of research.
2. To evaluate the effectiveness of instruction in RCR offered by MUREEP from March 2019 to December 2023 on trainees’ problem-solving skills for ethical conduct of research.
3. To examine the effectiveness of instruction in RCR offered by MUREEP from March 2019 to December 2023 on trainees’ attitudes and behaviors towards ethical decision-making in research

 Uganda 2025-07-18 13:52:09 2028-07-18 Medical and Health Sciences Non-Clinical Trial Degree Award
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