Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Paineto Masengere
ID: UNCST-2021-R013195
 Perceptions, barriers, and facilitators of adoption of healthy lifestyles for cardiovascular disease prevention among slum communities in Kampala, Uganda
REFNo: HS1661ES

1. To explore how slum dwellers in Kampala district define a healthy lifestyle in the context of cardiovascular disease prevention.
2. To explore the barriers and facilitators to adopting recommended lifestyles for cardiovascular disease prevention among slum dwellers.
3. To explore the potential roles of community actors in slums in cardiovascular disease prevention.

Uganda 2021-09-10 2024-09-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Felix Oyania
ID: UNCST-2021-R013492
 Feasibility of Primary Repair for Anorectal Malformations in Uganda
REFNo: HS1632ES

To determine the feasibility of primary repair for anorectal malformations in Uganda.,
 Uganda 2021-09-10 2024-09-10 Medical and Health Sciences Non-Clinical Trial Degree Award
FRANK MULINDWA
ID:
Changes in insulin kinetics after withholding dolutegravir in Ugandan HIV patients who develop diabetes while on dolutegravir.
REFNo: HS1493ES

To determine changes in; insulin secretion, insulin sensitivity, insulin clearance and HBA1C at 24 weeks after DTG discontinuation in Ugandan HIV patients who develop diabetes while on DTG.
 Uganda 2021-09-09 2024-09-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Martha Musyoka Mbenia
ID:
PREDICTORS OF ADVERSE FETO-MATERNAL OUTCOMES AMONG MOTHERS ADMITTED WITH ANTEPARTUM HEMORRHAGE AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS1450ES

To describe adverse outcomes and determine predictors of adverse feto-maternal outcomes in mothers with antepartum hemorrhage at Mbarara Regional Referral Hospital
 Kenya 2021-09-09 2024-09-09 Medical and Health Sciences Clinical Trial Degree Award
Jimmyy Opee
ID:
PROPORTION AND FACTORS ASSOCIATED WITH INTRA-PROCEDURAL PAIN AMONG WOMEN UNDERGOING MANUAL VACUUM ASPIRATION FOR INCOMPLETE ABORTION AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS1462ES

General objective
To determine the proportion and factors associated with intra-procedural pain among women undergoing Manual Vacuum Aspiration for incomplete abortion at gynecology ward at Mbarara Regional Referral Hospital.

Specific objectives
1. To determine the proportion of women with intra-procedural pain undergoing Manual Vacuum Aspiration for incomplete abortion at gynecology ward at Mbarara Regional Referral Hospital.
2. To determine the factors associated with intra-procedural pain among women undergoing Manual Vacuum Aspiration for incomplete abortion at gynecology ward at Mbarara Regional Referral Hospital.

 Uganda 2021-09-09 2024-09-09 Medical and Health Sciences Non-Clinical Trial Degree Award
Ronald Mulebeke
ID:
A pilot study to assess the impact of Supportive Supervision and Behavior Change Communication at private health facilities in Uganda
REFNo: HS1588ES

This study will assess the impact of supportive supervision and behaviour change communication to improve the quality of malaria care and data management delivered by clinicians at private health facilities in Uganda.
Uganda 2021-09-09 2024-09-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
ANTHONY KAYIIRA
ID: UNCST-2020-R014108
 Understanding Reproductive Health among Survivors of Paediatric and Young adults (URHSPY) Cancers: a mixed method study
REFNo: HS1652ES

To explore the knowledge, perceptions, and attitude of; parents or caretakers of children with cancer, and health workers on cancer treatment-related reproductive morbidity, at the Uganda Cancer Institute,To describe self-reported reproductive morbidity associated with cancer treatment among childhood and young-adult cancer survivors.,To establish the extent of reproductive morbidity associated with cancer treatment among young cancer survivors in Uganda. In addition, we aim to explore the contextual enablers and barriers to addressing cancer treatment-related reproductive morbidity in Uganda.,
 Uganda 2021-09-09 2024-09-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Susan  Nabadda
ID: UNCST-2020-R014331
 Study Protocol for the Evaluation of Covid 19 Antibody and Antigen Rapid Diagnostic Test (RDT) In the EAC Partner States
REFNo: HS1591ES

Evaluation of ELISA cross-reactivity on stored archived negative samples between East African Partner States. ,Evaluation RDT performance differences between the East African Partner States,- Evaluate the clinical specificity of antibody RDT and ELISA using serum/plasma specimens from COVID-19 negative specimens from pre-COVID-19 (archived stored samples),- Evaluation of COVID19 antibody RDTs and ELISA’s in the East African region, using serum/plasma samples from COVID-19 confirmed based on RT-PCR results (RT-PCR positive test results). ,Evaluation of COVID19 antigen RDTs against gold standard PCR in the East African region,
 Uganda 2021-09-09 2024-09-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Susan  Nabadda
ID: UNCST-2020-R014331
 Evaluation of TUBEX Typhoid TF IgM Antibody test for Early Diagnosis of Typhoid fever Among patients in Uganda
REFNo: HS1548ES

1) To carry out blood culture testing on all samples from patients with signs and symptoms of typhoid fever in the selected facilities of Uganda.
2) To carry out serological testing for Salmonella antibodies using the TUBEX Typhoid TF IgM Antibody test on the serum samples of consented/assented patients whose samples grew Salmonella Typhi.

 Uganda 2021-09-09 2024-09-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Fred Nalugoda
ID: UNCST-2021-R013343
 Exploring the impact of out-migration on remaining partners’ HIV and sexual behavior perceptions and practices in Rakai, Uganda: a qualitative study.
REFNo: SS981ES

The overall aim of this study is to qualitatively explore the impact of out-migration amongst heterosexual couples on non-migrating partners’ HIV and sexual behavior perceptions and practices in Rakai, Uganda.
Uganda 2021-09-09 2024-09-09 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jafesi Pulle
ID: UNCST-2020-R014213
 TRUST IN MEDICAL RESEARCH AMONG PATIENTS AT A REGIONAL REFERRAL HOSPITAL AND COMMUNITY MEMBERS IN LIRA DISTRICT, NORTHERN UGANDA
REFNo: HS1685ES

Explore community perceptions of trust in medical research,2. Determine the other factors associated with trust of medical research,1. Compare level of trust for medical research among community members and persons that are hospitalized.,To compare the level of trust in medical research among people hospitalized at a hospital and the community members, identify associated factors and explore prevailing community perceptions of trust in medical research.,
 Uganda 2021-09-09 2024-09-09 Medical and Health Sciences Non-Clinical Trial Degree Award
Daniel Mongovin David Thomas
ID:
Dry Rifting in the Albertine-Rhino Graben (DRIAR)
REFNo: NS160ES

To conduct a geological investigation of faulting associated with continental rifting in the magma-poor rift environment in the northernmost Western Branch of the East African Rift System.
 USA 2021-09-08 2024-09-08 Natural Sciences Non-Clinical Trial Degree Award
Julian Bagyendera Kobutungi
ID:
Gender, Youth and Social Inclusion Baseline Assessment for the USAID Local Partner Health Services – Ankole (USAID LPS – Ankole)
REFNo: SS1002ES

The main objective is to conduct a mixed method gender and youth social inclusion assessment which includes a literature review; collection of primary quantitative and qualitative data.,
 Uganda 2021-09-08 2024-09-08 Social Science and Humanities Non-Clinical Trial Non-degree Award
Nixon Niyonzima
ID: UNCST-2020-R014577
 UNDERSTANDING PATHOGENESIS OF BURKITT LYMPHOMA TO DEVELOP BETTER TREATMENTS FOR AFRICAN ENDEMIC BURKITT LYMPHOMA
REFNo: HS1546ES

4. To establish a BL tumor biorepository at the Uganda Cancer Institute ,3. To generate PDX mouse models of BL to understand the molecular factors that govern response to COM therapy in children with endemic BL at the Uganda Cancer Institute. ,2. To describe the molecular differences between endemic BL and sporadic BL. ,1. To determine the molecular profile of endemic BL tumors at the Uganda Cancer Institute,
 Uganda 2021-09-08 2024-09-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
 PERFORMANCE EVALUATION OF COVID-19 ANTIGEN RAPID DIAGNOSTIC TESTS
REFNo: HS1690ES

To determine the association of positive index test results with disease stage (days since symptom onset, e.g. acute, early, late), symptom severity and symptom severity.,To determine the diagnostic accuracy of SARS-CoV-2 Ag RDTs on a respiratory specimen (NP swab, OP swab, nasal swab, saliva), vs Cobas SARS-CoV-2 assay as performed in patients presenting with influenza-like illness.,
 Uganda 2021-09-08 2024-09-08 Medical and Health Sciences Clinical Trial Non-degree Award
Pontiano Kaleebu
ID: UNCST-2021-R013577
 A clinical trial to assess the safety and immunogenicity of LNP-nCOV saRNA-02, a self-amplifying ribonucleic acid (saRNA) vaccine encoding the S glycoprotein of SARS-CoV-2, the causative agent of COVID-19, in SARS-CoV-2 seronegative and seropositive Uganda population
REFNo: HS1641ES

Primary Objective:

• To compare the safety and immune responses for SARS-CoV-2 seronegative and seropositive individuals from two immunisations with LNP-nCOV saRNA-02 administered IM 4 weeks apart at one dose level in 42 participants age 18-45 years.

Exploratory Objectives:
• To characterise the humoral and cellular immune responses to LNP-nCOV saRNA-02 administered at one dose given at 0 weeks and 4 weeks for individuals seronegative and seropositive for SARS-CoV-2 antibodies
• To characterise the profile of class and sub-class of antibody responses
• To characterize infection induced immune responses in participants with naturally acquired infection who are also exposed to the vaccine

 Uganda 2021-09-08 2024-09-08 Medical and Health Sciences Clinical Trial Non-degree Award
David Musoke
ID:
Collaboration between Biomedical and Traditional Mental Health Service Providers in Wakiso District, Uganda
REFNo: HS1581ES

To explore how biomedical service providers and traditional healers can work together to improve access to mental health care in Wakiso district, Uganda.
 Uganda 2021-09-08 2024-09-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Janet SEELEY
ID:
Examining ethical issues, stakeholder engagement and acceptability of biobanking in Sub-Sahara Africa
REFNo: HS1645ES

General Objectives:
To explore perceptions, informed opinion and experiences of key stakeholders on approaches and value of community engagement in biobanking in LMIC; and if and how community approval should be obtained.

Specific Objectives:
1. To explore key stakeholders’ perceptions, informed opinions and underlying values around potential benefits of biobanks in SSA and important aspects of operationalising a biobank in LMICs.
2. To describe approaches that could be used to engage communities and stakeholders about biobanking.
3. To examine governance systems and structures that should be in place for a biobank to become operational, and ways in which community voices might be included in those systems
4. To determine initial key elements required to assume a community social license based on outputs of 1-3

UK 2021-09-08 2024-09-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Edward  Mukiibi
ID:
RESEARCH DATA MANAGEMENT PRACTICES IN SELECTED HEALTH INSTITUTES IN UGANDA
REFNo: HS1714ES

i) To describe the characteristics of research data created and held in selected Health Institutes in Uganda.

ii) To examine the research data management practices in selected Health Institutes in Uganda.

iii) To evaluate research data management readiness of selected Health Institutes in Uganda.

iv) To explain the challenges affecting adoption and uptake of RDM practices in selected Health Institutes in Uganda.

v) To propose interventions to improve RDM practices in selected Health Institutes in Uganda.

 Uganda 2021-09-08 2024-09-08 Medical and Health Sciences Non-Clinical Trial Degree Award
Zarin Machanda Machanda
ID:
The form and functions of leadership in wild chimpanzees
REFNo: NS288ES

This project will establish chimpanzees (Pan troglodytes) as a new comparative model of human-like leadership by testing how individual variation across a leader’s temperament, behaviour, and physiology shapes collective action in natural social groups. The first aim of the project is to support continuing long-term data collection by the Kibale Chimpanzee Project. We have three additional research aims that are specific to this project: (1) to identify and describe different domains of leadership in wild chimpanzees; (2) identify and describe the characteristics of chimpanzee leaders; and (3) evaluate the success of different pathways to leadership for chimpanzees. This project aims to collect both observational and experimental data that will provide detailed empirical insight into leadership among wild chimpanzees
 USA 2021-09-08 2024-09-08 Natural Sciences Non-Clinical Trial Non-degree Award
Robert Opika Opoka
ID: UNCST-2021-R014036
 An implementation toolkit for the use of hydroxyurea in the treatment of sickle cell anemia in Ugandan children
REFNo: HS1646ES

1) Assess the uptake and proper use of hydroxyurea among SCA patients at Jinja and Atutur Hospitals as a result of the implementation toolkit pilot,
 Uganda 2021-09-03 2024-09-03 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Walter Ojok
ID: UNCST-2021-R004415
 SYNTHESIS OF NOVEL MESOPOROUS ADSORBENTS FOR FLUORIDE REMOVAL FROM WATER
REFNo: NS158ES

(i) To study the hydrochemical characteristics of Ndali-Kasenda crater lakes used as water sources with focus on the occurrence and spatial distribution of fluoride.
(ii) To explore the possibility of synthesizing biosorbents for fluoride removal using local base materials (Phoenix reclinata seeds, cassava starch and banana extract as soft templates.
(iii) To conduct batch and column experiments on removal of fluoride using synthesized biosorbents to assess their fluoride removal performance.
(iv) To design laboratory scale pilot column filter studies for fluoride removal with high performance synthesized biosorbent for Ndali-Kasenda lake water.

Uganda 2021-09-03 2024-09-03 Natural Sciences Degree Award
Suzan van der Lee
ID:
Dry Rifting In the Albertine- Rhino Graben, Uganda (DRIAR)
REFNo: NS255ES

A geophysical, geochemical, geological, and geodynamic investigation of the Albertine-Rhino Graben in western and northwestern Uganda to improve our understanding of continental rifting in areas where volcanic activity is minimal.
Netherlands 2021-09-03 2024-09-03 Natural Sciences Non-Clinical Trial Non-degree Award
Joweria Nambooze
ID: UNCST-2019-R001118
 FOOD CHOICES AND THE FOOD ENVIRONMENT OF SMALL-HOLDER FARMERS IN MPIGI
REFNo: A146ES

Examine factors influencing maternal food choices and nutrition outcomes and understand how they interact.,Explore the internal and external food environments and how they impact food choice among rural female smallholder farmers,Determine the relationship between agricultural activities on maternal time use and food choices among rural female smallholder farmers,Determine the daily time use patterns of rural female smallholder farmers,Assess the nutritional status of rural female smallholder farmers,To examine the dynamic interactions between women’s time use and food environments and their influence on food choices and nutrition outcomes of rural smallholder female farmers living in Mpigi district,
 Uganda 2021-09-03 2024-09-03 Agricultural Sciences Non-Clinical Trial Non-degree Award
Tu Hoang Phuong
ID:
Forest succession analyses in Kitigo as a basis for close-to-nature reforestation planning
REFNo: NS279ES

To understand the details of termite-fungi relationships in the context of soil nitrogen allocation in Central African derived savanna; to clarify and classify the Nitrogen absorption strategies of various woody species/tree families, in order to develop crucial criteria for tree species selection for Nitrogen limited target sites; to work out if Nitrogen-15 of tree’s living sapwood could be an indicator for soil nitrogen availability.

 Vietnam 2021-09-03 2024-09-03 Natural Sciences Non-Clinical Trial Degree Award
Cristina Clerici
ID:
Yes, women can. The role of information and norms in encouraging women to enter male-dominated sectors in Uganda
REFNo: SS968ES

Gain insights on information available to aspiring female entrepreneurs and the constraints they face when choosing their sector of business.
 Italy 2021-09-03 2024-09-03 Social Science and Humanities Non-Clinical Trial Degree Award
Ziidah Namwaya
ID:
Exploring the use of Active Birthing Techniques for Normal Labour and Birth among Midwives working in the Metropolitan Region, Kampala-Uganda
REFNo: SS976ES

1. To evaluate the status of the environment in the three health facilities Kitebi, Komamboga and Kisugu as regards the use of active birthing techniques
2. To identify the available active birthing techniques at the health facilities
3. To assess current practice as regards the use of active birthing techniques for normal labour and birth among midwives working at the health facilities
4. To determine the level of knowledge as regards the use of active birthing techniques
5. To explore the potential factors that might influence the use of active birthing techniques for normal labour and birth among midwives working at the facilities
6. To describe the acceptability and experience of using upright positions such as hands- and-knees position, squatting, leaning forward, kneeling among pregnant women and midwives in the selected health facilities.

 Uganda 2021-09-03 2024-09-03 Social Science and Humanities Non-Clinical Trial Degree Award
Solomon Wafula Tsebeni
ID: UNCST-2021-R013883
 Assessment of indoor air quality, risk factors and potential health effects among residents in an urban informal settlement in Kampala, Uganda
REFNo: SS996ES

To describe the potential health effects associated with indoor air pollution. ,To assess the factors associated with indoor air pollution among households. ,To determine the levels of indoor PM2.5, and Carbon monoxide (CO) in households., To determine levels of indoor air pollution, its associated risk factors and potential health effects among residents in an informal settlement in Kampala so as to generate information that can be used in design appropriate strategies, policies and practices that promote good air quality in households, hence mitigate health problems associated with indoor air pollution. ,
 Uganda 2021-09-03 2024-09-03 Social Science and Humanities Non-Clinical Trial Non-degree Award
Amy  Ritterbusch Elizabeth
ID:
Child Protection Mapping and Honour
REFNo: SS970ES

1.To examine the effect of global narratives of child wellbeing on child protection and rights practices in Uganda
2.To explore prospects for local child protection practices in informing and enriching global child protection policy
3.To explore the concept of honour and examine how it promotes children’s wellbeing and or sustains violence against children in the Ugandan context.

USA 2021-09-03 2024-09-03 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jesca Nantume
ID: UNCST-2021-R013984
 Knowledge, attitudes and practices towards the tobacco use control measures among teenagers aged (13-19) years; A cross sectional study in the slum areas of Kampala Uganda
REFNo: SS988ES

To evaluate knowledge, attitudes and practices towards tobacco control among teenagers
aged (13-19) years
1. To evaluate existing control measures among teenagers
2. To assess the knowledge, attitudes, and practices of the current tobacco control
measures among teenagers.
3. To evaluate the cause of initiation of tobacco use in slums among teenagers
 Uganda 2021-09-03 2024-09-03 Social Science and Humanities Non-Clinical Trial Degree Award
Danette Cagnet Lee
ID:
Community-led Total Sanitation Programming and the Maintenance of Sanitation Behaviors
REFNo: SS737ES

The purpose of this qualitative, exploratory, case study research is to better understand stakeholder's, including village community members, village leadership, and CLTS practitioner, perceptions of the facilitators and hindrances to the maintenance of sanitation in the maintenance stage of Community-led Total Sanitation programming in Uganda, East Africa. This study seeks the perspective of and participation of village community stakeholders receiving the Community-led Total Sanitation intervention implemented by the non-governmental organization, Kibo Group International.
 USA 2021-09-02 2024-09-02 Social Science and Humanities Non-Clinical Trial Degree Award
Joyce Kambugu Balagadde
ID: UNCST-2020-R014996
 Acute Leukemia Banking and Biology Study for Patients at the Uganda Cancer Institute.
REFNo: HS1590ES

1. To determine the genomic profile of patients with acute leukemia and identify the prevalence of various fusions and mutations in these patients.
2. To collect and store corresponding subjects’ medical information including diagnosis and disease characterization, laboratory and imaging studies, treatment, and outcome.

 Uganda 2021-09-02 2024-09-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
John Baptist Asiimwe
ID: UNCST-2021-R013716
 The Traditional Medicine Practitioner’s Concept of Cancer, its Care, Herbal medicine use and the Patients Perceived benefits (Clinical outcomes) in Selected Districts of Central Uganda.
REFNo: HS1602ES

1. To establish the prevalence and predictors of the use of herbal medicines’ in cancer
2. To explore the concept of cancer and its care in traditional medicine as perceived by traditional medicine practitioners (TMPs) in selected districts of central Uganda
3. To document the herbs used by traditional medicine practitioners (TMPs) to manage cancer in selected districts of central Uganda.
4. To determine the clinical outcomes in patients with cancer treated by traditional medicine practitioners (TMPs).

 Uganda 2021-09-02 2024-09-02 Medical and Health Sciences Non-Clinical Trial Degree Award
Moses Adriko
ID: UNCST-2019-R001787
 Gaining community insights into societal causes of and solutions for schistosomiasis transmission hotspots (InSight-ScHot)
REFNo: HS1616ES

To identify non-mass administration preventative chemotherapeutic control measures for schistosomiasis that members of the community see as implementable
 Uganda 2021-09-02 2024-09-02 Medical and Health Sciences Non-Clinical Trial Degree Award
Enock Matovu
ID:
Identification of the Genetic Markers of Trypanotolerance in Indigenous Cattle of Apach District, Northern Uganda
REFNo: NS247ES

Main Objective
To identify genetic markers of Animal African Trypanosomiasis (AAT) tolerance in indigenous cattle

Specific Objectives

i. To set up a panel of phenotypically characterized indigenous cattle with respect to AAT susceptibility

ii. To develop a data base of reference genomes and transcriptomes of indigenous cattle from an AAT endemic region of mid-northern Uganda
iii. To determine the genotypes associated with trypanotolerance in indigenous cattle

 Uganda 2021-08-31 2024-08-31 Natural Sciences Non-Clinical Trial Non-degree Award
Rhoda Wanyenze
ID: UNCST-2021-R013352
 Assessment of the Implementation Processes and Outcomes of the HIV Assisted Partner Notification Program, Ministry of Health, Uganda
REFNo: HS1671ES

3.2 General Objective
To assess the Implementation processes and outcomes of the HIV Assisted Partner Notification Program in Uganda
3.3 Study Objectives
1. To determine the current level of uptake of APN services and the factors associated with uptake of these services among HIV index clients.
2. To assess the acceptability and uptake of APN services among a sub-sample of partners of APN clients.
3. To assess the extent to which the existing service delivery environment influences the delivery of APN services.
4. To document the perceptions and experiences of users of APN services, challenges faced in utilizing APN services and concerns those users have regarding the way APN services are provided.
5. To determine the positive and negative outcomes of APN services in Uganda, and the support mechanisms available for those who experience negative outcomes.
6. To document the barriers to and facilitators of successful APN implementation and the challenges implementers face during APN implementation.
7. To document the existing opportunities that can inform the future scale-up of the APN program.

 Uganda 2021-08-31 2024-08-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Pontiano Kaleebu
ID: UNCST-2021-R013577
 A behavioural Science Research to Determine Factors that Facilitate Future Uptake of HIV Prevention Products and Multi-Purpose Prevention Technologies to Prevent HIV and Unwanted Pregnancy in Sub-Saharan Africa Universally Accessible HIV Prevention Technologies for African Girls and Young Women through Knowledge Applied from Behavioural Economics (UPTAKE)
REFNo: HS1540ES

Multi-purpose Prevention Technologies (MPTs) to prevent HIV and unwanted pregnancy in Sub-Saharan Africa

i. To understand facilitators of and barriers to uptake and retention of injectable and implantable long acting pre-exposure prophylaxis (LA-PrEP) and MPT to inform product development, using formative behavioural research methods
ii. To design interventions to impact the uptake of new biomedical HIV prevention products, as part of a suite of self-care and self-screening products for sexual and reproductive health, using quantitative behavioural research methods
iii. To test the effectiveness of the alternate design/interventions and strategies, using marketed LA contraceptive products as proxies for LA HIV prevention products in development
iv. To estimate the cost of retention interventions and the cost effectiveness of products and delivery methods among adolescent girls and young women (AGYW) and female sex workers (FSWs) for prevention of pregnancy and/or HIV, using modelling

 Uganda 2021-08-31 2024-08-31 Medical and Health Sciences Clinical Trial Non-degree Award
Emmy Okello
ID: UNCST-2020-R009792
 “Active Case Detection and Decentralized Dynamic Registry to Improve the Uptake of Rheumatic Heart Disease Secondary Prevention” (ADD-RHD)
REFNo: HS1561ES

Secondary objectives include technical proficiency, acquisition times, global image quality, and user satisfaction and confidence. Each of these parameters will be reported for the entire training group and a sub-group analysis will look for differences between curriculum groups. Acquisition times and image quality will be compared between trainees and expert sonographers.,To determine the impact of a pragmatic RHD primary prevention program in Uganda,
 Uganda 2021-08-30 2024-08-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Comfort Mukasa Hajra
ID:
Real-time access to sanitation information for improved management of sanitation services: A case Study in Kawempe division.
REFNo: HS1458ES

Main Objective:
To test if timely access to sanitation information leads to improved sanitation planning, increased access to safely managed sanitation services and improved multi-sectoral collaboration.

Specific Objectives:
1. To design and test the effectiveness of timely access to sanitation information for planning, coordination and access to improved sanitation services.
2. To validate user needs for sanitation service provision in Uganda.
3. To document scalable best practice mechanisms for improved multi-sectoral planning and coordination on sanitation.
 Uganda 2021-08-30 2024-08-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eric Awich Ochen
ID: UNCST-2021-R013266
 Preventing Gender-based Violence: Video Game Intervention Designed as an Educational Tool to Address Child Marriage in Uganda
REFNo: SS880ES

To assess the effectiveness of the game (Peace) in promoting pro-social attitude/behavior change and empathic capacity among young people to prevent violence.
• Help young people understand what sexual exploitation is and how it is linked to gender inequalities.
• Increase young people’s understanding about how adult power is misused to abuse and silence them.
• Show young people that perpetrators will seek out and exploit young women’s vulnerabilities.
• Help young people understand the impact that sexual coercion has on everyone involved.
• Empower young people in reporting incidents of child sexual abuse and sexual coercion.
• Increase awareness of the role of various agencies/individuals that can help.
• Help young people understand ways in which adults may groom them using various tactics.
• Help young people understand the relationship between sexual coercion and child marriage.
• Give young people the opportunity to develop skills, knowledge, and competencies that can help them make sound decisions for themselves or others in real life situations.
• To support and empower young people in avoiding child marriage


Uganda 2021-08-30 2024-08-30 Social Science and Humanities Non-Clinical Trial Non-degree Award
NAMANDE MUGERWA SARAH
ID:
“EKISAAKAATE” (ROYAL ENCLOSURE) PEDAGOGY AND EARLY CHILDHOOD MORAL LEARNING OUTCOMES IN BUGANDA KINGDOM IN UGANDA
REFNo: SS975ES

To establish the mediating relationship between multiculturalism and early childhood moral learning outcomes.,To examine the relationship between “ekisaakaate” role play instruction pedagogy and early childhood moral learning outcomes.,To determine the relationship between “ekisaakaate” traditional story telling instruction pedagogy and early childhood moral learning outcomes.,To establish the relationship between “ekisaakaate” living values-based contextual instruction pedagogy and early childhood moral learning outcomes.,To find out the relationship between “ekisaakaate” native language instruction pedagogy and early childhood moral learning outcomes. ,
 Uganda 2021-08-30 2024-08-30 Social Science and Humanities Non-Clinical Trial Degree Award
Lazaaro Mujumbusi
ID: UNCST-2023-R007470
 Exploring understandings of and attitudes towards Covid-19 in Mayuge district Uganda
REFNo: SS977ES

1. To explore community members' perceptions of COVID-19 and its transmission, with a focus on ideas about responsibility.
2. To investigate how ideas about responsibility intersect with existing inequalities around occupation, tribe, and gender.
3. To examine whether, and how, understandings of COVID-19 transmission have impacted everyday WaSH practices.
4. To develop insight that may be of value to developing interventions aimed at reducing transmission and/or stigma.

Uganda 2021-08-30 2024-08-30 Social Science and Humanities Non-Clinical Trial Degree Award
Patrick  Vudriko
ID:
Survey to identify priority livestock diseases and diagnostic needs of animal health professionals and farmers in Central and Southwestern Uganda
REFNo: A84ES

Specific objectives
1. To identify the priority livestock and poultry diseases for which diagnostic services and diagnostic kits/aids are needed by various stakeholders (farmers, vets).
2. To assess the perception and attitudes of key stakeholders in the animal industry on the value and quality of existing animal diagnostic services in Uganda

 Uganda 2021-08-27 2024-08-27 Agricultural Sciences Non-degree Award
Suzanne  Kiwanuka N
ID: UNCST-2020-R014671
 Using High Impact Communication Strategies to increase blood donation awareness among secondary school students in Uganda
REFNo: SS802ES

1. To increase knowledge and awareness about blood donation among secondary school students in Uganda using targeted communication strategies.
2. To increase willingness to donate blood among secondary school students in Uganda using targeted communication strategies
3. To increase intention to donate blood among secondary school students in Uganda using targeted communication strategies

 Uganda 2021-08-27 2024-08-27 Social Science and Humanities Non-degree Award
Christine Akello Kalumera Kalumera
ID: UNCST-2021-R013514
 OPTIMISING USER INVOLVEMENT IN USER STORIES COLLECTION, ANALYSIS AND DESIGN TASKS FOR EHIS DEVELOPMENT: APPLYING COLLABORATION ENGINEERING PRINCIPLES TO HUMAN CENTRED DESIGN
REFNo: SIR62ES

The main of objective of this research is to develop a collaborative engineering process to improve user involvement in requirements gathering, analysis and design and stages of the user centred design approach, when developing electronic health information systems
 Uganda 2021-08-27 2024-08-27 Engineering and Technology Non-Clinical Trial Degree Award
Olive Kobusingye Chifefe
ID:
Assessing the impact of COVID-19 on the mobility patterns in Kampala Metropolitan Area
REFNo: HS1636ES

To explore the socio-economic impact of implementing the regulations on transportation.,To describe ways in which transporters coped with the COVID-19 related restrictions on transport. ,To identify ways in which commuters coped with the threat of COVID-19., The overall objective of this study is to examine the impact of the COVID-19 pandemic on mobility patterns in the Kampala Metropolitan area so as to inform planning transportation during the pandemic and in the post-COVID-19 period. ,
 Uganda 2021-08-27 2024-08-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
BRENDA GATI MIREMBE
ID: UNCST-2021-R013390
 A Phase 3, Randomized, Active Controlled, Double-blind Clinical Study to Evaluate the Efficacy and Safety of Oral Islatravir Once Monthly as Pre-Exposure Prophylaxis in Cisgender Women at High Risk for HIV 1 Infection.
REFNo: HS1631ES

Primary Objectives:
1. To evaluate the efficacy of oral ISL QM compared to FTC/TDF QD for the
prevention of HIV-1 infection as assessed by the incidence rate per year of confirmed
HIV-1 infection.

2. To evaluate the safety and tolerability of oral ISL QM compared to oral FTC/TDF QD as assessed by review of the accumulated safety data

Secondary Objective
1. To evaluate the efficacy of oral ISL QM in reducing the incidence per year of HIV-1
infection relative to the background rate.

 Uganda 2021-08-27 2024-08-27 Medical and Health Sciences Clinical Trial Non-degree Award
ROSCO KASUJJA
ID: UNCST-2019-R000504
 Treating Depressive Symptomatology in Congolese Refugees in Uganda and Rwanda: Adapting and Evaluating Community-based Socio-therapy
REFNo: SS263ES

1. Develop implementation guidance for adapting, delivering, supervising and monitoring aCBS for refugees across diverse settings. 2. Build research capacity for evaluating complex interventions in Rwanda and Uganda. 3. Enhancing knowledge about a scalable and inclusive form of intervention aimed at supporting the mental and wellbeing of refugees – a group at high risk of experiencing mental disorders who are markedly underserved in terms of services and support at both the local and global level.
Uganda 2021-08-25 2024-08-25 Social Science and Humanities Non-degree Award
James Bugeza Katamba
ID: UNCST-2021-R013970
 EPIDEMIOLOGY OF BRUCELLOSIS AT THE HUMAN LIVESTOCK INTERFACE IN UGANDA
REFNo: HS1377ES

The general objective is To characterize Brucella infections in ruminants, swine and slaughterhouse workers in Uganda. The specific objectives are 1.To determine the seroprevalence of Brucella antibodies in cattle, shoats, and pigs at selected slaughterhouses in Uganda. 2.To determine the seroprevalence of Brucella antibodies and associated risk factors among slaughterhouse workers in Uganda 3.To determine the Brucella species, biovars circulating in cattle, shoats, swine and slaughterhouse workers and their epidemiological interrelatedness 4.To determine resistance of Brucella to first line antimicrobial agents (Rifampicin and streptomycin)
Uganda 2021-08-25 2024-08-25 Medical and Health Sciences Non-Clinical Trial Degree Award
Hakim Sendagire
ID:
Clinical chemistry, hematology and other laboratory profiles of COVID 19 patients, as surrogate markers in management of severe disease
REFNo: HS1339ES

1. To describe the characteristics of peripheral blood cells in patients with varying severity of COVID-19 as compared to those who are negative
2. To describe the characteristics of the clinical chemistry and inflammatory markers in patients with varying severity of COVID-19 as compared to those who are negative
3. To establish the relationship between peripheral blood cells, clinical chemistry and cytokines and the clinical manifestation of COVID 19 and describe the potential markers for disease monitoring.

 Uganda 2021-08-25 2024-08-25 Medical and Health Sciences Non-degree Award
Stella Muyanja Zawedde
ID: UNCST-2021-R014037
 Prevalence and Outcomes of Mycobacterium bovis infection in Karamoja sub-region, North Eastern Uganda
REFNo: HS1405ES

The primary objective of this study is to determine the prevalence of M. bovis strains among patients diagnosed with TB disease in Karamoja region.,To compare six-month treatment outcomes between patients diagnosed with mycobacterium tuberculosis (M. tb) and those diagnosed with other mycobacterial species including M. bovis. ,To describe the susceptibility patterns of all mycobacterial isolates to first line medicines used in the management of drug susceptible TB. ,To describe the factors associated with having M. bovis among patients diagnosed with TB in the Karamoja region. ,
 Uganda 2021-08-25 2024-08-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Janestic Twikirize
ID:
Social Traditional Norms and child Marriage research in Zombo, Nebbi, Packwachi and Adjuman Districts, West Nile
REFNo: SS852ES

What are the roles of (Parents, Clans and relatives, Religious leaders
Cultural leaders, Boys and men in the communities and women and girls in the communities) in a) Promoting Child Marriage b) Preventing child marriage? Elaborate the roles, the specific practices and norms as well as how effective their efforts for and against CEFM are

What is the involvement of the bride-to-be in the decision-making process about her marriage?

What has been and being done to address social norms and practices that promote child early and forced marriages by boys, girls, parents, clan leaders, religious leaders, cultural leaders and community leaders?

Assess the effectiveness of what has been and being done women and girls, men and boys, parents, clan leaders, community and religious leaders to mitigate socio-cultural practices that promote child early and forced marriages

Assess the functionality and effectiveness of Community Child Protection systems from the community, district and national level. Identify strength, weakness and make recommendations to inform project intervention
 Uganda 2021-08-25 2024-08-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
Catherine Abaasa N
ID:
Quality, Safety, community perceptions and Practices on Drinking water from selected water sources in Mbarara City , South Western Uganda
REFNo: HS1469ES

i. To assess the physical chemical and microbiological quality of drinking water from selected water sources and establish the water quality index for Mbarara city.
ii. To establish the occurrence of virulence genes associated with Esherichia coli pathotypes isolated from drinking water samples from selected water sources in Mbarara city.
iii. To establish the seasonal variation in safety, quality and water quality index of water from selected water sources in Mbarara city.
iv. To explore the communities’ and water service providers’ perceptions and practices about the quality and safety of drinking water and establish possible mitigation strategies at community level.

 Uganda 2021-08-25 2024-08-25 Medical and Health Sciences Non-Clinical Trial Degree Award
Lordrick Alinaitwe
ID:
Transmission and Occurrence of Leptospira infection among humans and livestock in Uganda
REFNo: HS1563ES

To determine the extent, risk factors and potential pathways for Leptospira transmission and infection among potential reservoir animals and human populations in Uganda.,To describe potential pathways and drivers for Leptospira transmission at the animal-human-environmental interface in Uganda, based on statistical modelling,To identify Leptospira species and serogroups that circulate in humans, livestock, and environmental sources in Uganda.,To determine Leptospira seroprevalence and infection among slaughter ruminants and swine in Uganda,To determine Leptospira seroprevalence and associated risk factors among slaughter workers in Uganda,
 Uganda 2021-08-25 2024-08-25 Medical and Health Sciences Non-Clinical Trial Degree Award
Mary Goretti Nakabugo Goretti
ID: UNCST-2021-R013051
 Are our Children Learning? Uwezo Basic Assessment of Literacy and Numeracy.
REFNo: SS959ES

Uwezo Uganda intends to undertake the 2021 assessment of basic learning outcomes in literacy and numeracy in order that:
i) Independent evidence on learning levels in literacy and numeracy of children aged 4-16 in Uganda is generated.
ii) The data generated from conducting the learning assessments increases knowledge, awareness and understanding of policy actors, practitioners and the public of children’s learning outcomes and their distribution and that the evidence is used to improve resource allocation and the delivery of education.

 Uganda 2021-08-25 2024-08-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
Patrick  Vudriko
ID:
Innovations to Address Rampant Vaccine Failures, Shortages and Low Uptake for Sustainable Livestock Disease Control and Productivity in Uganda
REFNo: A136ES

The Proposal is designed to address selected immunizable diseases that affect health and productivity of poultry, small ruminant and cattle in Uganda. The study objectives include;
1. To assess the current animal vaccine supply chain and identify actors, distribution channels, use and constraints that affects animal vaccine utilization in Uganda.
2. To evaluate the level of protective Gumboro & IB virus disease antibodies among vaccinated chicken flocks in commercial farms.
3. To assess the sero-conversion of FMD vaccine and strengthen vaccination efficacy monitoring lab service at Research Center for Tropical Diseases and Vector Control (RTC) Laboratory at COVAB.
4. To assess the current PPR vaccination regimen and the clinical performance of combined PPR- SGP virus vaccine under field situations in small ruminants and develop a vaccination technical framework for effective control of the two diseases in Uganda.

Uganda 2021-08-25 2024-08-25 Agricultural Sciences Non-Clinical Trial Non-degree Award
Mike Kyewalyanga
ID: UNCST-2021-R013531
 Factors associated with virological non-suppression among HIV- Positive children under 5 years on antiretroviral therapy in Mbarara Regional Referral Hospital
REFNo: HS1584ES

1.To determine the proportion of virological non-suppression among HIV positive children under 5 years who have been on ART for at least 6 months, in the ISS clinic of Mbarara Regional Referral Hospital.

2.To determine the factors associated with virological non-suppression among HIV positive children under 5 years who are receiving ART from ISS clinic of Mbarara Regional Referral Hospital.
3.To determine the perceptions of health-care providers and parents/guardians on factors associated with virological non-suppression among HIV positive children under 5 years who are receiving ART from ISS clinic of Mbarara Regional Referral Hospital.

 Uganda 2021-08-25 2024-08-25 Medical and Health Sciences Non-Clinical Trial Degree Award
Luz Azlor del Valle
ID:
GAFSP Private Sector Window Uganda Impact Evaluation - Baseline
REFNo: SS943ES

The primary research question is – what is the impacts of an expansion in the fertiliser business on smallholder farmers. The purpose of the evaluation is to account for the interventions and support provided and to derive lessons and recommendations to improve future impact. To meet these objectives the eventual impact evaluation will attempt to answer the following evaluation questions:
1. How does the project affect yields?
2. How does the project affect household income and poverty status of farmers?
3. What is the project’s impact on food security and nutrition?
4. What is the project’s impact on women’s status and empowerment?
 Spain 2021-08-25 2024-08-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jayne Ellis
ID: UNCST-2021-R013987
 “Integrated management of cryptococcal and opportunistic infections to improve outcomes in advanced HIV disease (IMPROVE study)”
REFNo: HS1607ES

1) To generate evidence on the safety (adverse events) and feasibility (adherence and tolerability) of 1HP (one month of isoniazid and rifapentine) for TB preventative therapy (TPT) amongst adults with HIV-associated cryptococcal meningitis.
2) To generate preliminary data on potential secondary benefits (reduced loss to follow-up, reduced active TB disease, reduced mortality due to TB) of early (inpatient initiation) 1HP TPT as compared to standard (outpatient initiation) 1HP TPT amongst adults with HIV-associated cryptococcal meningitis.

UK 2021-08-25 2024-08-25 Medical and Health Sciences Clinical Trial Degree Award
Moses Joloba Lutaakome
ID: UNCST-2022-R011558
 Bacterial and Host Determinants in TB Transmission: Immune Phenotypes Associated with Exposure to High and Low Transmission Strains of MTB - Uganda
REFNo: HS1498ES

The goal of this study is to identify the bacterial and host factors that promote transmission of tuberculosis (TB), a necessary first step towards developing drugs and vaccines that prevent the inter-person spread of Mycobacterium tuberculosis (Mtb). This study has five specific aims:

Aim 1: Determine the extent to which household transmission is responsible for co-prevalent and incident TB cases caused by Mtb strains that are genetically distinct from those isolated from the index cases within the same household.

Aim 2: Investigate the in vitro immune phenotype of transmitted versus not-transmitted Mtb strains in households stratifying for HIV status.

Aim 3: Characterize the innate macrophage response to high and low transmission strains and the T-cell response in persons with known household exposure to high and low transmission isolates and the impact of HIV infection.
Aim 4: Identify the component of Mtb genes that aid in bacterial survival in aerosols.
Aim 5: Investigate the bacterial factors underlying divergence in the host response to high and low transmission isolates.


Uganda 2021-08-24 2024-08-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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