Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Christopher  Aheebwa
ID: UNCST-2024-R003719
BUILDING A QUALITY CULTURE FOR ENHANCED QUALITY ASSURANCE PROCESSES OF HIGHER EDUCATION INSTITUTIONS IN A RESOURCE-CONSTRAINED CONTEXT.
REFNo: SS4538ES

1. How have agents been conditioned to understand quality and quality-related activities at MMU? 2. What enables and constrains the pursuit of a quality culture at MMU? 3. What actions can be taken to contribute to developing a quality culture at MMU?
Uganda 2026-05-15 17:00:27 2029-05-15 Social Science and Humanities Non-Clinical Trial Degree Award
Irene Najjingo
ID: UNCST-2021-R012634
Feasibility and Diagnostic yield of stool and tongue swabs in comparison with gastric aspirates for diagnosis of pulmonary tuberculosis among children less than 10 years in Uganda (FAST-TB Study)- A sub study on OPTIC-TB Study
REFNo: HS7173ES

1. To assess the diagnostic yield of stool and tongue swabs in comparison with gastric aspirates /sputum for diagnosis of pulmonary tuberculosis among children less than 10 years in Uganda

2. To assess the feasibility of stool, tongue swabs and gastric aspirates/sputum for diagnosis of pulmonary tuberculosis among children less than 10 years in a programmatic setting in Uganda.
3. To assess the effectiveness of concurrent testing in comparison with WHO-TDA for diagnosis of pulmonary tuberculosis among children less than 10 years in a programmatic setting in Uganda.
Uganda 2026-05-15 16:58:36 2029-05-15 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Cleisey Mwanga Emmanuel
ID: UNCST-2025-R021305
Factors Influencing Awareness and Acceptance of Genetically Modified Organisms in South Western Uganda: Perspectives from Farmers and Key Stakeholders
REFNo: A689ES

The main objective of the study is ‘To analyse the factors that affect awareness and acceptability of genetically modified organisms among farmers in South Western Uganda
Uganda 2026-05-15 16:56:37 2029-05-15 Agricultural Sciences Non-Clinical Trial Degree Award
Vincent Muwonge
ID:
Utilizing Play to Mitigate Aggression Among Children in Slum-based Early Childhood Development Centers of Kampala
REFNo: SS5141ES

1. To assess how children aged 5-6 years in slum-based ECD centres in Kampala recognize, label, and interpret emotional cues during play. 2. To analyze how children aged 5-6 years in slum-based ECD centres in Kampala select and apply emotion regulation strategies during play. 3. To assess how children aged 5-6 years in slum-based Early Childhood Development (ECD)centres in Kampala implement and sustain selected emotion strategies during play. 4. To determine the effect of an EPM informed guided play intervention on aggressive behavior among children aged 5-6 years in slum-based ECD centres
Uganda 2026-05-15 16:26:57 2029-05-15 Social Science and Humanities Non-Clinical Trial Degree Award
Habib Maliamungu Uthuman
ID: UNCST-2025-R021632
Peacebuilding Through Demobilisation: A Case Study of the Uganda National Rescue Front II Peace Agreement, West Nile, Uganda
REFNo: SS5067ES

Main Objective
To examine the UNRF II peacebuilding through demobilisation processes and their impacts on peace and stability in the West Nile.
Specific Objectives
1. To analyse the contextual evolution of the UNRF II armed conflict in West Nile.
2. To examine the negotiation practices adopted during the UNRF II peace agreement in the West Nile.
3. To examine the UNRF II peace agreement demobilisation components and their implementation efforts
4. To examine the impacts of the UNRF II demobilisation processes on peacebuilding and security in West Nile

Uganda 2026-05-14 14:14:10 2029-05-14 Social Science and Humanities Non-Clinical Trial Degree Award
Felix Aruho
ID: UNCST-2025-R019450
The efficacy of Learning management systems in Curriculum implementation process in higher learning institutions, a case study of Kyambogo University
REFNo: SS5148ES

1. To analyse how feedback mechanisms within the Learning Management Systems contribute to curriculum implementation in higher learning institutions.
2. To examine the relationship between collaborative learning through Learning Management Systems and curriculum implementation
3. To assess whether personalized learning through learning management system influences curriculum implementation in higher learning institutions

Uganda 2026-05-14 13:51:34 2029-05-14 Social Science and Humanities Non-Clinical Trial Degree Award
AIDAHKIBEDI NAMBUSI
ID: UNCST-2025-R021070
TUTOR-TEACHER SUPPORT AND PUPILS’ ACHIVEMENT IN LITERACY AND NUMERACY AMONG PUBLIC BOARDING PRIMARY SCHOOLS IN GREATER MUKONO, UGANDA
REFNo: SS5269ES

1.3 Purpose of the Study The purpose of this study is to establish the relationship between tutor- teacher support and pupils’ learning achievements in literacy and numeracy among public boarding primary 14 schools in Greater Mukono region Uganda and whether teachers’ performance moderates this relationship. The specific objectives for this study include; 1. Establish the relationship between lesson observation by tutors and pupils’ learning achievement in literacy and numeracy among public boarding primary schools in Greater Mukono region 2. Find out the extent to which feedback provision by tutors relate to pupils’ learning achievement in literacy and numeracy among public boarding primary schools in Greater Mukono region. 3. Explore the relationship between mentorship by tutors and pupils’ learning achievements in literacy and numeracy among public boarding primary schools in Greater Mukono region. 4. To determine if the teachers’ performance moderates the relationship between tutorteacher support and pupils’ learning achievement in literacy and numeracy among public boarding primary schools in Greater Mukono region.
Uganda 2026-05-14 13:46:23 2029-05-14 Social Science and Humanities Non-Clinical Trial Degree Award
Grace Ahumuza
ID: UNCST-2025-R020204
Association between early onset preeclampsia and adverse maternal outcomes among women with preecclampsia at Mbarara Regional Referral Hospital
REFNo: HS7376ES

1 To compare the prevalence of adverse maternal outcomes among women with early-onset preeclampsia and late-onset preeclampsia at Mbarara Regional Referral Hospital
2 To determine the association between early-onset preeclampsia and adverse maternal outcomes among women with preeclampsia at Mbarara Regional Referral Hospital

Uganda 2026-05-14 13:44:42 2029-05-14 Medical and Health Sciences Non-Clinical Trial Degree Award
Anatoli Mawanda
ID: UNCST-2024-R015927
Cytological Follow-Up & Molecular Exploration of HPV In HIV+ And HIV- Individuals Post-LEEP
REFNo: HS7427ES

To investigate cytological changes and molecular profiles of HPV variants in individuals post-LEEP,
distinguishing between those with and without HIV.
To compare post-LEEP cytological alterations in HIV+ and HIV- cohorts,
To identify the genotypes associated with HPV persistence or recurrence in two cohorts.
To explore the correlation between HIV status and HPV recurrence post-LEEP.
Uganda 2026-05-14 13:41:48 2029-05-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Tomos Proffitt
ID: UNCST-2025-R020181
Western Rift Archaeology and Palaeoenvironment Project (WRAP)
REFNo: SS5248ES


The overarching research question driving the WRAP project is: How and when did Homo adapt to the diverse ecotone environments of the Albertine Rift compared to the more open mosaic environments of the East African Rift?

The WRAP Project consists of five interlinked work packages (WP1-WP5; Table 2), each aimed at a specific objective:
• WP1- Conducting new field survey and excavations to identify and record new Plio-Pleistocene archaeological sites across the length of the Albertine Rift in Uganda.
• WP2- Reconstructing hominin behaviour in the Albertine Rift during the Pleistocene.
• WP3- Refining the chronology of the hominin cultural and fossil record of the Albertine Rift in Uganda by applying new dating techniques.
• WP4- Reconstructing the Pleistocene environments both synchronically and diachronically in the Albertine Rift of Uganda.
• WP5- Synthesising and comparing the Pleistocene archaeological record of the Albertine Rift into the broader understanding of hominin evolution, environmental and behavioural adaptations in the wider African continent.

UK 2026-05-14 13:35:14 2029-05-14 Social Science and Humanities Non-Clinical Trial Non-degree Award
Nixon Niyonzima
ID: UNCST-2020-R014577
Clinical Effectiveness of Point-of-Care Breast Cancer Diagnostics in Ugandan Community Health Centers
REFNo: HS7522ES

To evaluate effectiveness of POC diagnostic evaluation administered by trained sonographers and cytopathologists, vs. standard care,To compare the sensitivity and specificity of the diagnostic kit to standard of care at the UCI,Development of an Automated FNA targeting System,
Uganda 2026-05-14 13:33:40 2029-05-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Joseph Ngonzi
ID: UNCST-2019-R001579
AI-driven placental imaging tool to reduce adverse pregnancy outcomes through prediction of neonatal sepsis risk: Feasibility of clinical use
REFNo: HS7432ES

To evaluate the feasibility, usability, and acceptability of the RAISE tool for use at delivery. ,
Uganda 2026-05-11 17:48:50 2029-05-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Crispus Natwijuka
ID: UNCST-2024-R016280
TESTING NRIMS VERSION 2
REFNo: SIR662ES

testing testing testing
Uganda 2026-05-06 10:30:12 2029-05-06 Engineering and Technology Clinical Trial Non-degree Award
Joseph Babigumira
ID: UNCST-2026-R023369
Behavioral Research for Informed Government Decision-Making Using Evidence (BRIDGE Trial)
REFNo: SS5072ES

Primary Objectives 1. To determine the relative effect of narrative framing (with citizen voice) versus technical framing of research evidence on senior policymakers' use of evidence, measured through citations in policy documents, requests for new analyses, and evidence-informed budget allocations. 2. To determine the relative effect of peer civil servant messengers versus external academic expert messengers on senior policymakers' use of research evidence, measured through the same behavioural outcomes. 3. To assess whether framing and messenger mechanisms interact, and which combination produces the greatest improvement across the four evidence-informed policymaking (EIPM) outcome domains: conceptual, attitudinal, procedural, and content. Secondary Objectives 4. To identify through which cognitive, social, and procedural pathways framing and messenger interventions influence evidence use (e.g., comprehension, trust, integration into decision routines). 5. To assess how treatment effects vary by ministry (Finance, Trade, Energy, NPA), seniority (U1–U2 vs. U3–U4), gender, and baseline orientation to evidence. 6. To estimate the cost-effectiveness of each intervention variant per unit increase in evidence uptake, expressed as cost per 0.1 standard deviation increase in the Evidence Use Index (EUI). 7. To examine how electoral cycles, bureaucratic turnover, and patronage networks moderate the effectiveness of behavioural interventions during Uganda's 2025–2027 reform window. Exploratory Objective 8. To assess what early signals suggest that increased evidence use contributes to improved economic policy outcomes (e.g., trade facilitation, domestic revenue mobilisation), recognising that attribution is limited within the 24-month trial horizon.
Uganda 2026-04-30 18:43:15 2029-04-30 Social Science and Humanities Non-Clinical Trial Non-degree Award
PROSSY SENYANGE
ID: UNCST-2025-R020541
PREVALENCE AND FACTORS ASSOCIATED WITH HIGH-RISK HPV POSITIVITY FOLLOWING TREATMENT FOR PRECANCEROUS CERVICAL LESIONS AMONG WOMEN LIVING WITH HIV AT MBARARA REGIONAL REFERRAL HOSPITAL.
REFNo: HS7368ES

General objective
To determine the prevalence and factors associated with high risk HPV positivity after treatment for precancerous lesions among women living with HIV at Mbarara Regional Referral Hospital
Specific Objectives
1. To determine the prevalence of high-risk HPV positivity after treatment for precancerous lesions among women living with HIV at Mbarara Regional Referral Hospital.
2. To determine the factors associated with high risk HPV positivity after treatment for precancerous lesions among women living with HIV at MRRH

Uganda 2026-04-30 18:41:23 2029-04-30 Medical and Health Sciences Non-Clinical Trial Degree Award
Mercy chelangat
ID: UNCST-2025-R017873
PREVALENCE OF HIGH ACUTE GLYCEMIC VARIABILITY, ITS ASSOCIATED FACTORS, AND 14 DAY MORTALITY AMONG PATIENTS ADMITTED WITH SEPSIS AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS7303ES

General Objective
To determine the prevalence of high acute glycemic variability, its associated factors and 14-day mortality among patients admitted with sepsis at MRRH.
Specific Objectives
1. Determine the prevalence of high acute glycemic variability among patients admitted with sepsis at MRRH
2. To determine the factors associated with high acute glycemic variability among patients admitted with sepsis
3. To compare the 14-day mortality rates between sepsis patients with high versus normal acute glycemic variability

Uganda 2026-04-30 18:40:37 2029-04-30 Medical and Health Sciences Non-Clinical Trial Degree Award
Henry Ochola
ID:
MATERNAL EARLY WARNING SCORES AT MBARARA REGIONAL REFERRAL HOSPITAL: SCREENING PERFORMANCE VERSUS SHOCK INDEX, RISK FACTORS, AND EARLY OUTCOME INDICATORS
REFNo: HS7372ES

Main Objective
To evaluate the screening performance of Maternal Early Warning Scores compared with the Shock Index, and to identify associated risk factors and early maternal outcome indicators among women receiving obstetric care at Mbarara Regional Referral Hospital
Specific Objectives
1. To compare the proportion of women flagged high-risk by Maternal Early Warning Signs versus the Shock Index among women admitted at the maternity and gynaecology units at Mbarara Regional Referral Hospital.
2. To determine factors associated with being flagged high-risk at the index observation among women admitted at the maternity and gynaecology units at Mbarara Regional Referral Hospital, monitored with the Maternal Early Warning Signs chart.
3. To describe key process indicators (documentation completeness; guideline-timely escalation) and early outcomes (ICU admission; maternal near-miss; in-hospital mortality) among women admitted at the maternity and gynaecology units at Mbarara Regional Referral Hospital, monitored with the Maternal Early Warning Signs chart.
Uganda 2026-04-30 18:39:12 2029-04-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Winnie  Muyindike R
ID: UNCST-2021-R013558
Exploring low-level HIV viremia among individuals on dolutegravir in sub-Saharan Africa (Low-V Africa Study).
REFNo: HS7580ES

Aim 2: To elucidate pharmacologic, viral, and host factor determinants of the progression to VF among participants in the Low-V Africa Cohort. In doing so, we will also characterize the prevalence of these factors in the setting of pLLV in the Low-V Africa cohort. We will evaluate viral suppression and long-term persistence of LLV as secondary outcomes. Analyses will employ longitudinal modeling with repeated measures, as well as machine learning techniques. Aim 2a will assess adherence, as measured by TFV-DP levels from DBS, as a predictor of VF after pLLV. Aim 2b will assess HIV drug resistance, defined by GSS, as a predictor of VF after pLLV. Aim 2c will evaluate the impact of a hyperactive HIV-1 viral reservoir, identified with long-range plasma SGS and MIP-Seq, on the risk of VF after pLLV. Aim 2d will estimate the relative contributions of adherence, resistance, and the reservoir to VF after pLLV. ,Aim 1: To determine longitudinal outcomes of individuals with pLLV while on tenofovir/lamivudine/dolutegravir (TLD). We will enroll a cohort of 200 adults in Uganda with pLLV (Low-V Africa Cohort), defined as at least two consecutive VLs ranging 50-1,000 copies/mL while on TLD for at least 12 months. We will follow participants for 96 weeks and will collect plasma, dried blood spots (DBS), and peripheral blood mononuclear cells (PBMCs) at enrollment, as well as 24-, 48-, and 96-week study visits. Aim 1a will estimate the 96-week cumulative incidence of VF and poor clinical outcomes after pLLV. We will perform VL quantification at each study visit to determine whether participants progress to virologic failure (>1,000 copies/mL), achieve viral suppression (<50 copies/mL), or have persistence of LLV. As secondary outcomes, we will also estimate the cumulative incidence of opportunistic infections, hospitalization, and death. Aim 1b will determine the 96-week cumulative incidence of emergent HIV drug resistance and a hyperactive reservoir in PWH with pLLV. We will perform Sager sequencing of plasma specimens with VLs >500 copies/mL and long-range plasma single-genome HIV RNA sequencing (SGS) of plasma specimens with VLs ≤500 copies/mL at each time point, with genotyping of the protease/reverse transcriptase and integrase. We will perform matched integration site and proviral sequencing (MIP-Seq) on follow-up specimens with ongoing viremia, evidence of high-level ART adherence (by tenofovir diphosphate [TFV-DP] levels), and an active ART regimen (genotypic susceptibility score [GSS]≥2). Results will identify individuals with resistance versus a hyperactive reservoir in the setting of pLLV. ,
Uganda 2026-04-30 18:38:20 2029-04-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
CHARLES TIONDI
ID: UNCST-2025-R022907
This research investigates the impact of the outreach programs on TVET training in Uganda
REFNo: SIR655ES

The study looks at the effect of outreach programme strategies and how they influence practical and soft skills development, industry partnerships, and equity-based interventions.
2026-04-30 18:35:17 2029-04-30 Engineering and Technology Non-Clinical Trial Degree Award
steven kavuma
ID: UNCST-2025-R020895
Prevalence, severity of, and factors associated with stress urinary incontinence among postpartum women at Mbarara Regional Referral Hospital
REFNo: HS7415ES

to determine the prevalence of stress urinary incontinence among postpartum women at mbarara regional referral hospital
to describe the severity of stress urinary incontinence among postpartum women at mbarara regional referral hospital
to determine the factors associated with stress urinary incontinence among postpartum women at mbarara regional referral hospital
Uganda 2026-04-30 18:33:20 2029-04-30 Medical and Health Sciences Non-Clinical Trial Degree Award
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