Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Adelline Twimukye
ID: UNCST-2019-R000117
 FACTORS INFLUENCING PATIENT’S DECISION MAKING PROCESS ON SUBSTITUTING FROM EFAVIRENZ (EFV) TO DOLUTEGRAVIR (DTG) AT INFECTIOUS DISEASES INSTITUTE (IDI), KAMPALA- UGANDA.
REFNo: SS314ES

The overall objective of this study is to understand the factors influencing Patient’s decision-making Process on substituting from Efavirenz (EFV) to Dolutegravir (DTG) at Infectious Diseases (IDI), Kampala- Uganda.
Specific objectives
Qualitative
AIM 1. To evaluate the mechanism of the decision-making process and support required among HIV positive patients substituting from EFV to DTG at IDI in Uganda
AIM 2. To explore decision-making process of women in reproductive age (18-55 years) and explore how decisions about substitution from EFV to DTG substitution evolve over time.
AIM 5. Describe experiences around adherence among key populations taking DTG
AIM 9. To evaluate the DTG therapy implementation process among health care providers involved in the substitution from EFV to DTG.
Quantitative
AIM 3. To determine the proportion of stable Patient’s on their previous ART regimens switched to DTG.
AIM 4. To asses factors associated toxicities or adverse effects on patients switched from EFV or DTG.
AIM 6. To determine the proportion and characteristics of patients who have substituted from Efavirenz to DTG.
AIM 7. To determine factors associated with substituting from EFV to DTG
AIM 8. To describe quality of life of patients who have substituted from EFV to DTG.

 Uganda 2019-07-10 2022-07-10 Social Science and Humanities Non-degree Award
Sabine Haller
ID:
Amikacin Exposure and Toxicity - Pharmacokinetic-Pharmacodynamic Analysis in Patients with Multidrug-Resistant Tuberculosis in Uganda: A Pilot Study
REFNo: HS402ES

To describe the pharmacokinetics of amikacin in patients with multidrug-resistant tuberculosis.
To explore the relationship between exposure to amikacin and the toxicity of this drug using pharmacokinetic-pharmacodynamic modelling.

 Switzerland 2019-07-10 2022-07-10 Medical and Health Sciences Non-degree Award
STEPHEN LUTOTI
ID:
Anti-Proliferative Activity screening of bioactive compounds from medicinal plants traditionally used by Breast Cancer patients in Central Uganda
REFNo: HS405ES

The general objective of this study is to discover novel, potent anti-breast cancer compounds from plants used in traditional treatment of breast cancer by in Central Uganda.

Specific Objectives
This study is designed to address four specific objectives, namely:
i. To describe the beliefs and practices of breast cancer patients in Central Uganda towards use of herbal medicines.
ii. To document the medicinal plants used in traditional treatment of breast tumours in Central Uganda.
iii. To establish the anti-proliferative activity of extracts of selected medicinal plants identified from the ethnobotanical survey.

iv. To elucidate the bioactive compounds in the two most efficacious extracts against breast cancer.

Uganda 2019-07-10 2022-07-10 Medical and Health Sciences Degree Award
Elliot Howard-Spink Charles
ID:
Do cultural evolutionary processes shape the long-distance vocalisations of wild chimpanzees (Pan troglodytes)?
REFNo: NS97ES

Overall Objective: To determine the extent to which populations of chimpanzees show differences in their long-distance communication behaviours, and what factors may drive differences in these behaviours between populations. I will do this by completing the following four sub-objectives. Objective 1 – Create an ethnography for behavioural features of chimpanzee pant-hoot displays. I intend to collect video and audio footage of the pant-hoot displays of chimpanzees in the Bugoma rainforest, which I can then compare to pre-existing video and audio footage of pant-hoots by chimpanzees in other populations across Africa. I will use collected data, and pre-existing data, to create an ethnography of pant-hoot displays in different chimpanzee populations (Whiten et al., 1999). Once a working ethnography of the behavioural features of these displays has been established, I will investigate the biological forces that may be driving inter-population variation in pant-hoot displays. Objective 2 – Determine the extent to which genetics determines the behavioural features of pant-hoot displays. I will do this by following a method outlined by Lycett et al, 2007, who investigated the genetic influences of chimpanzee tool use behaviours. The ethnography generated in objective 1 will be used to create a maximum-likelihood phylogenetic tree based on the traits of pant-hoot displays. This will then be compared with well-established genetic phylogenies of chimpanzee populations. Increasing similarities between these evolutionary trees would suggest that genetics is increasingly more likely in explaining behavioural differences in pant-hoot calls between chimpanzee populations. Objective 3 - Determine the extent to which environmental variables determine the behavioural features of pant-hoot displays. This will be done by creating mathematical models which try to explain variation in pant-hoot displays using physical and social environmental variables of the caller’s environment. Physical variables include weather patterns and vegetation density. Social variables include the immediate social party, caller identity, and caller status at the time of vocalization. These models will assess the variation in pant-hooting which can be explained by the caller’s environment, as well as the variation which remains unexplained. Objective 4 – Assess the likelihood of cultural evolutionary forces driving pant-hoot variation between chimpanzee populations. This will be done by method of exclusion. This would involve taking variation in pant-hooting behaviour which cannot be explained by genetics or the environment and discussing the likelihood of its formation due to vocal learning behaviours in chimpanzees. The existence of these behaviours in chimpanzee populations remains inconclusive, and this project aims to begin to elucidate the extent to which chimpanzees show cultural differences in their communicative behaviours. Lycett, S. J., Collard, M. and McGrew, W. C. (2007) ‘Phylogenetic analyses of behavior support existence of culture among wild chimpanzees’, Proceedings of the National Academy of Sciences, 104(45), pp. 17588–17592. Whiten, A. et al. (1999) ‘Cultures in chimpanzees’, Nature, 399(6737), pp. 682–685. doi: 10.1038/21415.
UK 2019-07-10 2022-07-10 Natural Sciences Degree Award
Johnblack Kabukye Kabaalu
ID: UNCST-2019-R001109
 Requirements for an Interactive Voice Response system for provision of cancer information to patients and general public in Uganda
REFNo: HS418ES

To co-create a program theory for development, implementation and evaluation of IVR system for provision of cancer information to patients and general public in Uganda
 Uganda 2019-07-10 2022-07-10 Medical and Health Sciences Degree Award
Stephen Asiimwe
ID: UNCST-2019-R000059
 Quality of Life and Aging with HIV in Rural Uganda
REFNo: HS419ES

Aim 1: Use qualitative methods to develop a conceptual framework explaining how HIV influences quality of life among older-aged people in Uganda.

We will conduct semi-structured interviews among 60 study participants stratified by sex and HIV serostatus to explore conceptualizations of and domains that meaningfully impact quality of life. We will use an inductive analytic approach to identify locally relevant domains that determine health and quality of life for older people in our study population. The over-arching goal of Aim 1 is to develop a conceptual framework and optimize selection of measures related to quality of life to be used in study Aims 2 and 3.

Aim 2: Compare trajectories of social, cognitive, and physical functioning, and global quality of life by HIV serostatus in Uganda.

We will use the Aim 1 findings to inform appropriate selection of measures. We will observe 600 participants annually for four years to collect outcome measures of physical, cognitive, and social functioning, and quality of life. We hypothesize that PLWH will exhibit steeper declines in physical, cognitive, and social functioning, and quality of life compared to HIV-negative individuals.

Aim 3: Identify intervention targets, and assess the acceptability and feasibility of promising interventions, to improve functioning and quality of life among older PLWH in Uganda.

We will fit mixed effects regression models with data from the Aim 2 cohort to identify determinants of quality of life among PLWH, including social (e.g. stigma, depression, familial deaths), biomedical (e.g. comorbidities, opportunistic infections), and HIV-specific factors (e.g. viral load, nadir CD4, sCD14). We hypothesize that HIV-associated stigma and familial deaths due to HIV will predict faster decline in functional domains and quality of life among older PLWH. We will supplement these analyses with participant and stakeholder workshops to assess the preliminary acceptability and feasibility of potential interventions to improve quality of life in this population.

Uganda 2019-07-10 2022-07-10 Medical and Health Sciences Non-degree Award
Samuel Kyobe
ID: UNCST-2019-R000108
 Role of Class I HLA Alleles in HIV Disease Progression in Botswana and Uganda
REFNo: HS421ES

1) To describe the baseline characteristics of the pediatric HIV cohort in Uganda and Botswana.
2) To describe the distribution of class I HLA alleles in pediatric HIV in Botswana and Uganda.
3) To determine the HLA Class I alleles that are associated with HIV disease progression in Botswana and Ugandan African paediatric populations.
4) To determine the structural and functional (binding) characteristics of those class I HLA alleles associated with HIV disease progression.
 Uganda 2019-07-10 2022-07-10 Medical and Health Sciences Degree Award
Roy Carr-Hill Ngugi
ID:
Impact Evaluation of interventions to prevent Violence Against Children in Schools (VACiS) in Uganda
REFNo: SS322ES

1. Assess the extent to which the objectives of the teacher training and life skills education through school clubs are consistent with beneficiaries’ needs as far as creating a safe learning environment
2. Determine the impact (positive, negative, intended and unintended) of teacher training and learners’ life skills education through school clubs on reducing violence against children in schools.
3. Assess the likelihood of continuation of benefits from the VACiS interventions after UNICEF assistance to supported schools has ceased
4. Provide recommendations on how to strengthen teacher
UK 2019-07-04 2022-07-04 Social Science and Humanities Non-degree Award
Hailey Tiarks Jo
ID:
Testing the role of turbidity on the visual sensitivity of an African cichlid fish (Pseudocrenilabrus multicolor victoriae)
REFNo: NS90ES

The goal of the proposed research is to better understand the influence of turbidity and other environmental stressors on behavior and development of visual and behavioural traits in an African cichlid fish (Pseudocrenilabrus multicolor victoriae). Environmental degradation can introduce persistent environmental stressors that impair many behaviors in fishes that could influence their ability see their environment, which can obscure reproduction, predation, and other inter/intra species visual cues. It is important to understand how species continue to persist in degraded tropical aquatic habitats to help conserve essential biodiversity for the health of aquatic ecosystems. We will investigate how important stressors, such as turbidity, influence the behavior and development of visual traits in a widespread African cichlid in the lakes, rivers, and swamps near Lake Nabugabo, western Uganda.
 USA 2019-07-01 2022-07-01 Natural Sciences Degree Award
Caitlin Monroe Cooke
ID:
Defining History: Education, expertise, and women's knowledge in Western Uganda, 1800-1980
REFNo: SS269ES

This project has four objectives: 1.) Identify early systems of indigenous education in Western Uganda 2.) Explore the role of women and women's knowledge in those indigenous education initiatives 3.) Explore how education initiatives – from indigenous ones to colonial schools – separated the discipline of "history" from other kinds of knowledge about the past 4.) Ask how this neglected women's knowledge changes our contemporary understandings of intellectual history
 USA 2019-07-01 2022-07-01 Social Science and Humanities Degree Award
Eva  Wanyenze Wodeya wodeya
ID:
CONTINUOUS LABOR SUPPORT: EXPLORATION OF PRACTICES, EVALUATION OF THE EFFECT OF TRAINING A BIRTH COMPANION ON BIRTH OUTCOMES AND WOMEN’S EXPERENCES IN THE BUGISU SUB-REGION
REFNo: HS377ES

1. To explore support practices provided by birth companions in relation to women’s needs during labour and birth
2. To assess the effectiveness of continuous labour support by a trained companion of choice on anxiety and coping during active labour.
3. To determine the effect of continuous labour support provided by a trained companion of choice on labour outcomes and maternal satisfaction.
4. To describe birthing experiences of women continuously supported during labour by a trained companion.

Uganda 2019-07-01 2022-07-01 Medical and Health Sciences Degree Award
Herbert Muyinda
ID: UNCST-2019-R000373
 Cango Lyec Study: Developing and Testing Interventions to Reduce HIV risk, increase access to treatment and promote resilience in war affected populations in Northern Uganda – Baseline Study
REFNo: HS328ES

1) Estimate prevalence and incidence of HIV / syphilis/Hepatis B, and identify risk factors among conflict-affected populations in Northern Uganda

2) Investigate associations between posttraumatic stress, resilience, and depression, with HIV/Hep. B incidence among conflict-affected populations in Northern Uganda

 Uganda 2019-07-01 2022-07-01 Medical and Health Sciences Non-degree Award
HILLARY AHEISIBWE
ID:
PREVALENCE AND FACTORS ASSOCIATED WITH HEPATITIS B SURFACE ANTIGEN POSITIVITY AMONG WOMEN RECEIVING ANTENATAL CARE AT MBARARA REGIONAL REFERRAL HOSPITAL.
REFNo: HS342ES

General objective
To determine the prevalence and factors associated with hepatitis B surface antigen positivity among women attending Antenatal care at Mbarara Regional Referral Hospital
b) Specific Objectives
1. To determine the Prevalence of hepatitis B infection among mothers attending Antenatal Care at Mbarara Regional Referral Hospital.
2. To determine the socio-demographic characteristics of the pregnant women with a positive hepatitis B surface antigen attending ANC clinic at MRRH.
3. To describe the factors associated with Hepatitis B surface antigen positivity among pregnant women attending antenatal care.

 Uganda 2019-07-01 2022-07-01 Medical and Health Sciences Degree Award
Agathe Verhulst Julie
ID:
Prevalence of Oesophagostomum spp. in mountain gorillas (Gorilla beringei beringei) and livestock at Bwindi Impenetrable National Parc, Uganda.
REFNo: HS369ES

To gain a better understanding of the parasite’s prevalence in order to prevent future infection at the gorilla/livestock/human interface and following a one health approach: improve the health of the gorillas and the livelihood of
the human population neighbouring the BINP.
 France 2019-07-01 2022-07-01 Medical and Health Sciences Non-degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
 Current and prior viral zoonotic infections among adults admitted with acute febrile illness in North and Central Uganda
REFNo: HS371ES

Primary objective:
To determine the prevalence of 1) current and 2) prior viral zoonotic infections among hospitalized adults with acute febrile illness in Northern and Central Uganda

Secondary objectives:
1.To determine epidemiologic or historical risk factors associated with a) viral zoonotic infections and b) resistant bacterial infections.
2.To determine the prevalence of bacteremia and antibacterial resistance among hospitalized adults with acute febrile illness.To characterize clinical factors associated with antibiotic prescription and discontinuation among patients hospitalized with acute febrile illness.

 Nigeria 2019-07-01 2022-07-01 Medical and Health Sciences Non-degree Award
Irene Ayakaka
ID:
PATIENT AND HEALTH WORKER EXPERIENCES WITH COMMUNICATION ABOUT TUBERCULOSIS (TB) AND CHRONIC LUNG DISEASE (CLD) IN HOSPITALS AROUND KAMPALA, UGANDA.
REFNo: HS407ES

Overall objective

The overall aim of this project is to improve understanding of the practice context for patient-centred communication and to explore effective, feasible and sustainable ways to improve its frequency and effectiveness for CLD management in the routine public health system in Uganda.
Specific objectives

Specifically, the study will seek to elicit patient and health worker perspectives of communication during CLD diagnosis and treatment and to understand the impact of this on patient choices for disease management and for disease coping strategies.
Objective 1: To explore patients’ perceptions of their illness and how this affects their quality of life and coping strategies.
Objective 2: To characterize the practice context for communication about CLD at public health care facilities in Uganda.
Objective 3: To describe how health workers, perceive and prioritize communication.
Objective 4: To explore patient priorities and preferences for improved communication around CLD.

 Uganda 2019-07-01 2022-07-01 Medical and Health Sciences Degree Award
Fenella Hayes Marion
ID:
A qualitative research project to explore healthcare providers and program managers’ knowledge, attitudes and perceptions of the role of international medical volunteers
REFNo: HS389ES

Overall Study Aim: To assess the relationship between the non-government organisation (NGO) volunteers from VSO Uganda and their in-country partners (healthcare providers and program managers) to improve the development and sustainability of the programs in Uganda. Objectives: 1) To explore the attitudes and perceptions of International Medical Volunteers by healthcare providers and program managers in-country. 2) To identify the challenges and opportunities facing healthcare providers and programme managers when working with International Medical Volunteers. 3) To investigate what recommendations could be made to improve the Volunteer Partner Relationships between International Medical Volunteers and their in-country partners (healthcare providers and programme managers) to improve the development and sustainability of VSO Uganda and therefore other NGO projects
 UK 2019-07-01 2022-07-01 Medical and Health Sciences Degree Award
Silvia Awor
ID: UNCST-2019-R000591
 Using ultrasonography and maternal characteristics to predict preeclampsia and adverse pregnancy outcomes at St. Mary's Hospital Lacor
REFNo: HS258ES

General Objective To determine Doppler ultrasonography indices and maternal characteristics that predict preeclampsia and adverse pregnancy outcomes at St. Mary's Hospital Lacor Specific objectives 1. To determine the cut-off second trimester uterine artery Doppler Sonography PI and RI with potential to predict PE by the time of delivery at St. Mary's Hospital Lacor 2. To determine the maternal characteristics taken during the second trimester of pregnancy with potential to predict PE by the time of delivery at St. Mary's Hospital Lacor 3. To determine if selected Laboratory findings taken during the second trimester of pregnancy predict PE by the time of delivery at St. Mary's Hospital Lacor.
 Uganda 2019-06-24 2022-06-24 Medical and Health Sciences Degree Award
Mackenzie Carlson
ID:
Investigating the prevalence and practices of herbal medicine use in antenatal care in Mukono District, Uganda
REFNo: HS386ES

Specific Aim 1: Collect qualitative data using a standardized questionnaire to evaluate the prevalence of herbal medicine use in pregnancy, including which herbs are taken for what purposes.
Specific Aim 2: Identify ways in which herbal medicines are obtained and prepared for use in pregnancy.
Specific Aim 3: Identify the concordance between what recommendations and medications are given to pregnant women to prepare for labor and delivery by traditional birth attendants versus government midwives.
Hypotheses: We hypothesize that most pregnant women in the Mukono District use herbal medicine during pregnancy and that the exact preparations of herbal medications vary by traditional birth attendant preparing them and by village.
 USA 2019-06-24 2022-06-24 Medical and Health Sciences Non-degree Award
Jennifer Davis
ID: UNCST-2019-R000218
 Reliable handpumps at scale? Evaluating costs and benefits of, and demand for, professionalized preventative maintenance services in rural Uganda
REFNo: SS309ES

(1) Characterize common models of infrastructure maintenance for rural boreholes with handpumps in Uganda.
(2) Assess rural communities’ willingness and ability to pay for professionalized preventative maintenance service designed to enhance handpump reliability.
(3) Estimate the costs and benefits of providing handpump maintenance services to communities in Apac and Kwania districts
 USA 2019-06-24 2022-06-24 Social Science and Humanities Degree Award
Norbert  Kaggwa
ID:
Factors influencing the utilization of postabortion contraception at the Gynecology ward Mbarara Regional Referral Hospital
REFNo: HS379ES

1. To determine the proportion of women seeking PAC services at the Gynecology ward MRRH, that accept a postabortion family planning method.
2. To establish the factors influencing post abortion family planning uptake at Gynecology ward MRRH


 Uganda 2019-06-11 2022-06-11 Medical and Health Sciences Degree Award
Moses Tetui
ID:
Prevalence of modern contraceptive use among the urban poor, and stakeholder perceptions on family planning services in slums. The case of Kira municipality, Wakiso district, Uganda
REFNo: HS382ES

1. To conduct a landscape analysis of the existing family planning services in Kira municipality, Wakiso district, Uganda
2. To determine the prevalence of modern contraceptive use and the unmet need among the urban poor in Kira municipality, Wakiso district
3. To explore the provider and urban poor perceptions towards existing family planning services in Kira municipality, Wakiso district
4. To make recommendations of strategies for improving the uptake of family planning services among the urban poor in Kira municipality

 Uganda 2019-06-11 2022-06-11 Medical and Health Sciences Non-degree Award
Samson Okello
ID: UNCST-2019-R001580
 Experiences and Perspectives of Patients with Hypertension in Mbarara, Uganda
REFNo: HS343ES

To understand the patient experience of hypertension, including diagnosis, understanding of disease, medical adherence, and treatment regimens.

 Uganda 2019-06-06 2022-06-06 Medical and Health Sciences Non-degree Award
Moses Ssebuliba Kiwanuka
ID:
NECK CIRCUMFERENCE AS A SCREENING TEST FOR RISK OF CARDIOVASCULAR DISEASE IN HIV INFECTED PATIENTS UNDER INFECTIOUS DISEASE INSTITUTE CARE, UGANDA
REFNo: HS353ES

General objective.
1.To determine the accuracy of neck circumference as a screening tool for cardiovascular disease among HIV patients.
Specific objectives.
1.To determine the accuracy of using neck circumferences compared to Framingham cardiovascular risk scores as a screening tool for increased risk of cardiovascular disease among HIV patients presenting at urban clinic.
2.To determine the cutoff point of neck circumference diameter that indicates increased risk of cardiovascular disease.
3.To determine the factors (socio-demographic, clinical, laboratory) associated with a large neck circumference or a high Framingham CVD risk score in HIV patients attending care in an urban clinic.

 Uganda 2019-06-06 2022-06-06 Medical and Health Sciences Degree Award
Robert Kairania
ID:
Reassessing the HIV and STI syndemic in Rakai, Uganda after scale-up of combination HIV prevention interventions: a population-based study
REFNo: HS364ES

Aim 1: To measure population-level prevalence of syphilis, Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Trichomonas vaginalis (TV), and herpes simplex virus 2 (HSV-2) among ~2000 RCCS participants aged 18-49.

Aim 2: To assess the prevalence of antimicrobial resistant mutations among individuals with PCR-confirmed gonococcal infection

Aim 3: To assess the association between individual-level and partner use of CHIs and STI prevalence.

 Uganda 2019-06-06 2022-06-06 Medical and Health Sciences Non-degree Award
Joseph Baluku B
ID: UNCST-2019-R000612
 Evaluating Narrative As An Intervention For Upscalling Screening Of Cancer Of The Cervix Among Countryside Residents In Kenya And Uganda
REFNo: HS378ES

1. To find out the level of awareness and knowledge on cervical cancer screening among women aged 30 years and above
2. To determine the use of cervical cancer screening services among women aged 30 years and above
3. To examine the effect of narration on use of cervical cancer screening services among women aged 30 years and above

 Uganda 2019-06-06 2022-06-06 Medical and Health Sciences Non-degree Award
Marie Vollbrecht Luise
ID:
The effect of hypoxia on brain cell proliferation, neurogenesis and cognitive performance of weakly electric fish
REFNo: NS91ES

To understand how weakly electric fish from a low oxygen habitat vary in their cognitive performance.

To show how low oxygen influences sensory performance, behavior and anatomy in the wild.
 Germany 2019-06-06 2022-06-06 Natural Sciences Degree Award
James Ditai
ID:
The BabySaver Kit: development and evaluation of a novel device for affordable neonatal resuscitation in a low-income region in Africa
REFNo: HS349ES

• To evaluate the usability of the BabySaver kit for providing neonatal resuscitation by describing the range of resuscitation procedures performed on a group of babies,
• To assess whether the Kit allows resuscitation with intact umbilical cord based on the proportion of babies successfully resuscitated on the kit with an intact cord.
• To assess the safety of the BabySaver kit from post-resuscitation temperature measurements and serious adverse event reports
• To assess its acceptability to health workers compared with the routine resuscitation equipment, based on a questionnaire,
Uganda 2019-05-30 2022-05-30 Medical and Health Sciences Degree Award
Sam Ononge
ID: UNCST-2020-R000328
 Tranexamic acid for the prevention of postpartum bleeding in women with anaemia: an international, randomised, double-blind, placebo controlled trial.
REFNo: HS346ES

To determine the effects of Tranexamic acid on postpartum bleeding and other health outcomes in women with moderate or severe anaemia.


 Uganda 2019-05-28 2022-05-28 Medical and Health Sciences Non-degree Award
Ahmed Ddungu
ID: UNCST-2019-R000944
 THE ROLE OF TRANSFORMING GROWTH FACTOR BETA1 AS A PREDICTOR OF COPD IN A COHORT OF POST-TB HIV INFECTED PATIENTS IN UGANDA
REFNo: HS350ES

Primary objective:
• To assess for long term respiratory outcomes of TB in HIV infected adults by determining the burden of COPD and associated factors among members in the Study on Outcomes related to Tuberculosis and HIV drug concentrations’ (SOUTH) TB-HIV cohort at IDI at 0 and 24 months after enrolment in the TGFbeta study.
Secondary objectives
• To assess the association between serum TGFβ1 levels and burden of COPD amongst post-TB patients in the IDI ‘(SOUTH) TB-HIV cohort.
• To assess for an association between chest X-ray abnormalities at the end of TB treatment and COPD in post-TB HIV infected adults in the SOUTH study TB-HIV cohort at IDI.

 Uganda 2019-05-28 2022-05-28 Medical and Health Sciences Non-degree Award
Jackline Kampire
ID:
PHENOTYPIC AND GENETIC CHARACTERIZATION OF LOCAL PIG POPULATIONS IN SOUTH WESTERN AGRO-ECOLOGICAL ZONE (SWAEZ): THEIR DISTRIBUTION AND PORK QUALITY
REFNo: A44ES

1.To map the abundance and distribution of the local pig populations in SWAEZ.
2.To determine the phenotypic features of local pig breeds in SWAEZ.
3.To determine the genetic relationship between local pig populations and exotic breeds in SWAEZ.
4.To determine the pork quality of the local pig populations in SWAEZ.

 Uganda 2019-05-28 2022-05-28 Agricultural Sciences Degree Award
joseph  mwizerwa
ID:
Strengthening academic advancement for enrolled nurses: Developing a new program framework for enrolled nurses in Uganda.
REFNo: HS375ES

1.Explore experiences, aspirations and needs of ENs in Uganda with respect to advancing their nursing careers.
2.Identify the barriers and facilitators for academic advancement of ENs within Uganda.
3.Examine the suitability of Ugandan EN advancement programs in meeting EN education needs.
4.Critically examine international educational programs developed for ENs (or similar level nurses) career progression, to assess their applicability to the Ugandan context.
5.Develop a new academic advancement framework for ENs in Uganda and generate consensus for it.

 Uganda 2019-05-28 2022-05-28 Medical and Health Sciences Degree Award
Annabel  Morales-Smith
ID:
Assessing local attitudes towards tourism and conservation at Bwindi Impenetrable national park, Uganda
REFNo: SS302ES

This master’s research aims to investigate if park tourism can improve attitudes of residents involved in small-scale tourism enterprises towards protected area conservation, by delivering economic development; using Bwindi Impenetrable National Park (BINP) in Uganda as a case study.
The research objectives are:
• Measure expectations of residents involved in small-scale tourism enterprises based on their experiences of park tourism.
• Evaluating if recent interventions to enhance small-scale tourism enterprises have increased economic benefits from park tourism and if this has improved attitudes towards PA conservation.
• Assess the sustainability of these interventions.
The research hypothesis is: ‘Local attitudes towards protected area conservation improve when residents involved in small-scale tourism enterprises receive benefits from park tourism’.
And the research questions I will ask to test this hypothesis & achieve the aim of this project are:
• What expectations do residents involved in small-scale tourism enterprises have of park tourism?
• Do local attitudes towards protected area conservation improve when residents involved in small-scale tourism enterprises receive benefits from tourism?
• Do people feel they are sufficiently trained to continue without further interventions?

 UK 2019-05-21 2022-05-21 Social Science and Humanities Degree Award
Henry Kajumbula Mawerere
ID: UNCST-2019-R001531
 IDENTIFICATION OF VIRULENCE FACTORS, TRANSMISSION PATTERNS AND ANTIBIOTIC RESISTANCE MECHANISMS OF EAST AFRICAN Vibrio cholerae ISOLATES BY WHOLE GENOME SEQUENCING
REFNo: HS338ES

Aim: To obtain whole genome sequences (WGS) of Vibrio cholera O1 isolated in various parts of Uganda from 2014 to 2018 and use the data to determine the evolution, spread, antimicrobial resistance mechanisms and pathogenesis of the isolates

Specific objectives:
1. Determine patterns of spread of V.cholerae O1 in Uganda and within the East African region using WGS
2.Infer relatedness and evolution of strains of V.cholerae O1 isolated in Uganda and the East African region from WGS data
3.Identify any uniqueness in virulence genes or their expression among strains of V.cholerae isolated in Uganda and the East African region from WGS data
4.Identify genes of antimicrobial resistance and infer prevailing mechanisms of antimicrobial resistance among V. cholerae O1 isolated in Uganda

 Uganda 2019-05-14 2022-05-14 Medical and Health Sciences Non-degree Award
Catriona  Waitt John
ID: UNCST-2019-R001068
 INVESTIGATION OF THE PHARMACOKINETICS OF ATAZANAVIR IN PREGNANT WOMEN, INDIVIDUALS AT EXTREMES OF BMI, CHILDREN AND ADOLESCENTS. AN OBSERVATIONAL STUDY NESTED WITHIN THE VIRTUAL CONSORTIUM
REFNo: HS351ES

Primary Objectives
1. To describe the pharmacokinetic parameters of ATV currently used in the clinical care of HIV-infected pregnant and postpartum women, children and adolescents, and individuals with obesity or malnutrition.
2. To compare these parameters to those observed in non-pregnant HIV-infected adults on second-line ART who enter a dose escalation study of ATV/r + RIF as WP2 of the VirTUAL programme
Secondary Objectives
1. To use nonlinear mixed-effects modelling to describe sources of variability on the pharmacokinetics of ATV

 UK 2019-05-14 2022-05-14 Medical and Health Sciences Non-degree Award
PALLAVI PRABHAKAR
ID:
Reproductive and maternal health care provision for refugees and host populations in Northern Uganda
REFNo: SS296ES

This study aims to undertake: 1.A policy analysis to examine access and health financing arrangements for Sexual , Reproductive and Maternal Healthcare (SRMH) and the delivery of these services for refugees and host populations in Uganda, in the context of transition from an acute emergency to a development response model. 2.An impact , process and economic evaluation of the BRAC ELA programme which aims to train the adolescent girls on issues related to health, nutrition, financial literacy, and life skills.
India 2019-05-14 2022-05-14 Social Science and Humanities Non-degree Award
Daniel  Atwine Warren
ID:
Community Intervention for Tuberculosis Active Contact Tracing and Preventive Therapy - A Cluster Randomized Study (CONTACT)
REFNo: HS329ES

To compare the proportion of household child TB contacts eligible for PT (<5 years and HIV-infected children 5-14 years without active TB) who initiate and complete PT using facility-based and decentralized community-based models of care for contact screening and management.
 Uganda 2019-05-07 2022-05-07 Medical and Health Sciences Non-degree Award
Shallon  Atuhaire
ID:
Self-fulfilling Prophecies and Self-efficacy: Association with Community Reintegration and Rehabilitation of Obstetric Fistula Patients in Kitovu Hospital, Uganda
REFNo: HS361ES


i. To identify self-fulfilling prophecies among repaired and unrepaired obstetric fistula patients in Kitovu Mission Hospital.
ii. To assess the highest level of self-efficacy among repaired and unrepaired obstetric fistula patients in Kitovu Mission Hospital.
iii. To determine the role played by self-fulfilling prophecies in community reintegration and rehabilitation of obstetric fistula in Kitovu Mission Hospital.
iv. To measure the association between obstetric fistula patients’ levels of self-efficacy and their rehabilitation in Kitovu Mission Hospital.
v. To explore the extent to which obstetric fistula patients of different fistula repair statuses are involved in rehabilitation in Kitovu Mission Hospital.

 Uganda 2019-05-07 2022-05-07 Medical and Health Sciences Degree Award
Musa Kayondo
ID:
PELVIC ORGAN PROLAPSE IN SOUTHWESTERN UGANDA: PATTERNS, IMPACT ON QUALITY OF LIFE, SURGICAL OUTCOMES AND THE PREDICTING FACTORS, OF PATIENTS ATTENDING MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS368ES

1. To determine the patterns of POP in the Gynecology department of MRRH.
2. To establish the quality of life (physical, social, emotional and sexual function) before and after surgery among women with POP at MRRH.
3. To determine the outcomes of surgical treatment and related prognostic factors of POP at MRRH.

 Uganda 2019-05-07 2022-05-07 Medical and Health Sciences Degree Award
Katia  Peterson
ID:
A quasi-experimental study of Interpersonal Group Therapy (IPT) treatment attribution on decreasing depression severity among depressed women in Iganga District, Makuutu Sub County and Mukono District, Kimenyedde Sub Counties
REFNo: SS297ES

General objective

To establish a baseline prevalence of depression and determine the period and treatment effects of depression severity between depressed women in Iganga (Makuutu Sub County) and Mukono District (Kimenyedde Sub Counties).

Specific objectives
1. Determine the prevalence of depression in Makuutu Sub County (Iganga) and Kimenyedde Sub Counties (Mukono).
2. Determine the change in depression severity, as measured by the PHQ-9, within control subjects at six months and one year follow up.
3. Determine the change in depression severity, as measured by the PHQ-9, between control and treatment subjects at six months and one-year follow up.
4. Determine the change in well-being as measured by the “Well-being Indicator Survey” within control subjects and between control and treatment subjects at six months and one year follow up.

 USA 2019-05-07 2022-05-07 Social Science and Humanities Non-degree Award
NICHOLAS BARI NDAHURA BARI
ID:
EFFECTIVENESS OF NUTRITION EDUCATION ON GLYCAEMIC CONTROL IN PEDIATRIC TYPE 1 DIABETES MELLITUS PATIENTS IN UGANDA
REFNo: HS186ES

1. To assess the level of knowledge of nutrition management of T1DM among caregivers of T1D children (3-12 years) at selected T1DM clinics in Uganda. 2. To determine the dietary intake and adequacy of T1D children (3-12 years) at selected T1DM clinics in Uganda. 3. To develop a nutrition education training module for caregivers and T1D children (3-12 years) at selected T1DM clinics in Uganda. 4. To determine the effectiveness of nutrition education on HbAlc levels, knowledge of nutrition management of T1DM and dietary practices among caregivers and T1D children (3-12 years) at selected T1DM clinics in Uganda.
Uganda 2019-04-30 2022-04-30 Medical and Health Sciences Degree Award
Isaac  Kimbowa
ID:
ANTIMICROBIAL STEWARDSHIP PRACTICES AND QUALITY OF ANTIBACTERIAL USE IN CHILDREN UNDER-FIVE IN SELECTED HEALTH FACILITIES IN UGANDA
REFNo: HS339ES

1. To determine the structure and functional roles of MTCs in optimizing antibacterial use in management of childhood infections in under-five children in selected RRHs and PNFP health facilities in Uganda (sub-study I).
2. To determine stewardship practices guiding optimizing antibacterial use in management of infections in under five children in selected Health facilities in Uganda (sub-study II)
3. To determine extent of off-label and unlicensed use of antibacterial among children -five in paediatrics wards of selected RRHs and PNFPs in Uganda (Study III)
4. To determine the extent of antibacterial exposure to neonates during perinatal period among women delivering in selected regional referral hospitals in Uganda (Study IV).

Uganda 2019-04-24 2022-04-24 Medical and Health Sciences Degree Award
Julia Downing
ID:
Children’s, Adults and Health Professionals Understanding Illness, Death and Dying in Uganda
REFNo: HS276ES

The study aims to gain an understanding of children, adults and health professionals understanding of illness, death and dying in order to inform the provision of palliative care services in Uganda. The objectives of the study are to understand the following questions: I. What are Ugandan adults understanding of illness, death and dying? II. What are Ugandan children’s understanding of illness, death and dying? III. What is the understanding of Ugandan health professionals with regards to illness, death and dying?
UK 2019-04-16 2022-04-16 Medical and Health Sciences Non-degree Award
Adam Hewitt Smith
ID: UNCST-2019-R001658
 A cluster randomised trial to determine whether increased postoperative surveillance of adult African surgical patients reduces postoperative mortality
REFNo: HS298ES

Primary objective - To determine whether increased postoperative surveillance reduces in-hospital mortality in high-risk adult surgical patients aged 18 years and over in Africa. Primary outcome measure - In-hospital mortality, censored at 30 days if the patient is still alive and in-hospital. Secondary objective - To determine whether increased postoperative surveillance reduces the incidence of the composite of severe in-hospital complications and mortality in high-risk adult surgical patients aged 18 years and over in Africa. Secondary outcome measure - Composite of severe in-hospital complications and mortality, censored at 30 days if the patient is still alive and in-hospital.
 UK 2019-04-16 2022-04-16 Medical and Health Sciences Non-degree Award
miriam nantamu
ID:
Biosciences in nursing education: assessment of the level of explicit knowledge on antibiotic resistance (ABR) among preregistration nursing students in Uganda.
REFNo: HS313ES

Specific objectives
1. To assess the current level of knowledge on ABR among 3rd and 4th year nursing pre-registration nursing students in Uganda.
2. To identify the factors associated with the current level of bioscience knowledge among 3rd and 4th year pre-registration nursing students in Uganda.

 Uganda 2019-04-16 2022-04-16 Medical and Health Sciences Degree Award
Sabine Haller
ID:
Species Identification of Non-Tuberculous Mycobacteria in the Ugandan Population
REFNo: HS330ES

Primary Objective:
To describe the non-tuberculous mycobacteria (NTM) species isolated in the Ugandan population.
Secondary Objective:
To describe patient characteristics and outcomes.

 Switzerland 2019-04-16 2022-04-16 Medical and Health Sciences Non-degree Award
Anna Agnes Ojok Arach
ID:
Perinatal death: risk factors, postpartum depression, lived experiences and cultural perspective in lira, Uganda
REFNo: HS356ES

The study has the following objectives:

1. To determine the incidence and risk factors of perinatal deaths in Lira,

2. To examine the association between perinatal death and postpartum depression among women in Lira,

3. To describe the lived experience of women and partners who experienced perinatal death in Lira

4. To explore the cultural perspective of the Lango community on perinatal death.

 Uganda 2019-04-16 2022-04-16 Medical and Health Sciences Degree Award
Prof. Dr. med. Hans Konrad Biesalski
ID:
Dietary Intake and Nutritional Situation of Women of Reproductive Age (20-50 Years Old) in Lango Sub-Region of Northern Uganda: Implementation of Calculator for Inadequate Micronutrient Intake (CIMI) Program
REFNo: HS319ES

The main objective of this study is to assess the dietary intake and nutritional status of women of reproductive age in the predominantly rural North of Uganda. Therefore, the innovative
nutrition software called Calculator for Inadequate Micronutrient Intake (CIMI) will be used and validated with the obtained data.

Research objectives:
(1) To evaluate the dietary intake and nutritional status of women of reproductive age (20-50 years old) from Lango Sub-Region in Northern Uganda.
(2) To adapt CIMI program to the country Uganda and to compare CIMI with the software NutriSurvey for its ability to analyze dietary nutrients intake (Fe, Zn and Vitamin A and protein) and energy content in the study region. For the validation of CIMI, a new localization (appropriate to Ugandan Food) will be implemented in the nutrition software before.
(3) To identify the main causes of poor food consumption patterns of Ugandan women of reproductive age.
 Germany 2019-04-03 2022-04-03 Medical and Health Sciences Degree Award
Nasur Buyinza
ID:
NURSE - LED INTEGRATED PALLIATIVE CARE FOR MULTI DRUG RESISTANT TUBERCULOSIS PATIENTS TAKING ANTI MULTI DRUG RESISTANT TB THERAPY IN UGANDA – A RANDOMIZED CONTROLLED TRIAL
REFNo: HS275ES

I.To determine health professionals’ views on an appropriate model of integrated palliative care for MDR TB patients and their families alongside TB treatment II.To model a feasible integrated palliative care intervention for MDR TB using staff views and existing literature III.To test the effectiveness of the new model as compared to existing care in an RCT design IV.To determine patients’ post intervention perceived mechanism of action V.To identify a minimum palliative care package for MDR TB patients
Uganda 2019-04-03 2022-04-03 Medical and Health Sciences Non-degree Award
David Meya Bisagaya
ID: UNCST-2019-R000837
 Single dose liposomal amphotericin for asymptomatic cryptococcal antigenemia (ACACIA)
REFNo: HS284ES

Study Objectives Primary Objectives: 1. To assess 24-week efficacy of single dose liposomal amphotericin in the treatment of asymptomatic cryptococcal antigenemia for meningitis-free survival. Secondary Objectives: 1 . To determine safety and tolerability of single-dose liposomal amphotericin for the treatment of asymptomatic cryptococcal infection. 2- To determine 24-week survival in those who receive the intervention compared to those who receive standard of care. 3. To evaluate cost and cost-effectiveness of single dose liposomat amphotericin for the treatment of asymptomatic cryptococcal antigenemia
Uganda 2019-04-03 2022-04-03 Medical and Health Sciences Non-degree Award
Daniel Stein
ID:
Unconditional Cash Transfers in Kiryandongo Refugee Settlement, Uganda
REFNo: SS281ES

Due to limited evidence on the effect of large, one-off unconditional cash transfers in refugee contexts, the commissioning organization GiveDirectly has requested IDinsight to conduct a rigorous impact evaluation. The research study aims to answer the following core research questions:
1. What is the impact of large, unconditional cash transfers on refugee households for outcomes such as income, assets, consumption, enterprise, food security and psychological wellbeing?
2. What do any changes caused by the cash transfers mean for the lives of refugee households and how did those changes come about?
3. What is the effect of cash transfers on host communities, and their relationship with the refugee communities?
 USA 2019-03-26 2022-03-26 Social Science and Humanities Non-degree Award
Sulaiman Wasukira Bugosera
ID:
Use of Invitation Cards and Peer-to-Peer Cancer Awareness As Tools to Increase Women's Uptake of Cervical Cancer Screening at Two Hospitals in Kenya and Uganda.
REFNo: HS335ES

1. To study the demographic characteristics of women attending cervical cancer screening services at the Department of Obstetrics and Gynaecology, Mulago Hospital, Kampala and Thika level 5 hospital. 2. To determine the knowledge of women aged 19 years and above attending cervical cancer screening services at the Department of Obstetrics and Gynaecology, Mulago Hospital plus Thika Level 5 hospital about cervical cancer screening. 3. To describe the uptake of cervical cancer screening services among women aged 19 years and above in Kenya and Uganda after being invited for cervical cancer screening.
Uganda 2019-03-26 2022-03-26 Medical and Health Sciences Non-degree Award
Dorothy Balaba
ID:
The Kampala Slum Maternal Newborn Project: Innovating for Better Systems Outcomes (The Kampala MaNe Project): Protocol for the Formative phase studies
REFNo: HS327ES

The aim of the formative phase is to understand the implementation setting and contextual factors influencing MNH and care for people living in slums of Kampala, taking a demand and supply side perspective. We will seek to understand how the MNH market might be failing the urban poor woman (from both the (supply side) and socio-ecological spheres (demand side) leading to the high morbidity and mortality that has been observed in slums.
 Uganda 2019-03-21 2022-03-21 Medical and Health Sciences Non-degree Award
Cristina de la Torre
ID:
Assessing How Changes in District HIV Program Management Capacity Affect HIV Epidemic Control in Uganda
REFNo: HS268ES

• To explore the relationship between management capacity (as measured through the DPMS) and HIV service delivery performance at the district level • To determine the management capacity domains in the DPMS that were most strongly correlated to improvements in HIV service delivery MER indicators or Outcome indicators • To understand the pathways that led to changes (increase or decrease) in HIV program management and the service delivery outcomes
USA 2019-03-20 2022-03-20 Medical and Health Sciences Non-degree Award
Emmanuel Akampurira
ID:
Human Wildlife Conflict Mitigation The role of social capital in effective management of human-wildlife conflicts in Bwindi Impenetrable and Queen Elizabeth National Parks, Southwestern Uganda
REFNo: SS194ES

-Determine the effectiveness of HWC interventions and the demographic variables of the frontline communities -Measure and compare the social capital of selected frontline Communities -Compare the effectiveness of interventions with level of social capital of Communities served by the intervention -Identify the perceived community benefits associated with Human-Wildlife Conflict management intervention
Uganda 2019-03-19 2022-03-19 Social Science and Humanities Degree Award
Mikko Virtanen
ID:
Bidi Bidi Refugee Settlement: A study of how organisations effect social fields in a Uganda refugee settlement
REFNo: SS278ES

To observe how organizational forms of the help organizations effect the organizational forms of the refugees them selves. How the organizations effect the organization of home structure, education, religion, work and other aspects of every day life.
Norway 2019-03-19 2022-03-19 Social Science and Humanities Degree Award
Andrew Kambugu
ID: UNCST-2019-R000823
 A randomised controlled trial of darunavir versus dolutegravir and tenofovir versus zidovudine in second-line antiretroviral therapy regimens for the public health approach in sub-Saharan Africa, THE NADIA Trial
REFNo: HS333ES

The aims of this trial are: To determine whether a regimen of DTG with two NRTIs is non-inferior to a regimen of DRV/r with two NRTIs as second-line therapy in patients failing on an NNRTI-based first-line regimen in the setting of the public health approach in sub-Saharan Africa, with substantial NRTI cross-resistance.

To determine whether continuing tenofovir and lamivudine is non-inferior to switching to zidovudine and lamivudine in a second-line therapy regimen in patients failing on an NNRTI-based first-line regimen in the setting of the public health approach.


Uganda 2019-03-19 2022-03-19 Medical and Health Sciences Non-degree Award
PAUL KATO KALYEBARA KALYEBARA
ID:
FACTORS HINDERING ACCESS TO ELECTIVE REPEAT CAESAREAN SECTION AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS259ES

General objective To determine factors hindering access to elective repeat Caesarean section and compare the immediate maternal and neonatal outcomes among elective repeat Caesarean section and mismatch emergency Caesarean deliveries at MRRH. Specific objectives 1.To determine the proportion of women with indications for elective repeat Caesarean section that deliver by a scheduled Caesarean section at Mbarara Regional Referral Hospital. 2.To determine the factors hindering access to elective repeat Caesarean section at Mbarara Regional Referral Hospital. 3.To compare the immediate maternal and neonatal outcomes among elective repeat Caesarean section and mismatch emergency Caesarean deliveries at Mbarara Regional Referral Hospital.
Uganda 2019-03-14 2022-03-14 Medical and Health Sciences Degree Award
Joseph Ochieng
ID:
Genetics and genomics research in Uganda: Towards context-specific ethics guidelines
REFNo: SS268ES

1. Assess stakeholder awareness of GGR, and the nature of ethical and social concerns associated with GGR in Uganda, to better understand local needs and issues and provide robust data for later guideline development 2. Evaluate existing guidance and guidelines on the ethics and oversight of GGR for applicability to the Ugandan setting, with a particular emphasis on guidance and guidelines developed by and for Africa. 3. Develop and disseminate a model guideline for the ethics of GGR in Uganda.
Uganda 2019-03-14 2022-03-14 Social Science and Humanities Non-degree Award
Hellen Opolot
ID: UNCST-2019-R001724
 A BASELINE ASSESSMENT OF THE ETHICS AND REGULATORY REVIEW PROCESSES FOR CLINICAL TRIALS REGISTERED IN UGANDA BETWEEN JANUARY 2016 AND JULY 2017
REFNo: SS276ES

1. To establish the turnaround times for clinical trial applications reviewed by the Research Ethics Committees and the NRAs in Uganda between January 2016 and July 2017.
2. To document the challenges faced by each stakeholder group along the regulatory review pathway during the study period.
3. To document possible solutions to identified challenges and make some best-practice recommendations that could potentially improve efficiency in the ethics and regulatory review process for clinical trials in Uganda.

 Uganda 2019-03-14 2022-03-14 Social Science and Humanities Non-degree Award
Elizabeth Namukwaya
ID:
“Understanding data and information needs for palliative care to target mobile –phone based intervention development in Uganda and Zimbabwe”
REFNo: HS325ES

1. Establish a consortium of academic researchers (from Uganda, the UK and Zimbabwe) including our research team, non-governmental organisations, palliative care providers, policymakers and mHealth development and implementation expertise, to catalyse mHealth research and generate evidence that can guide palliative cancer care development across sub-Saharan Africa
2. Understand the acceptability and optimal implementation of patient-level data collection (e.g. patient-reported outcome measures and patient-reported experience measures) using mHealth approaches in Uganda and Zimbabwe through patient and caregiver engagement
3. Determine information needs and pathways for leveraging evidence generated from mHealth approaches in service development in Uganda and Zimbabwe through health professional and service manager engagement
4. Determine information needs and pathways for leveraging evidence generated from mHealth approaches in policymaking in Uganda and Zimbabwe through policymaker engagement
5. Define the mechanisms for implementation of mHealth approaches to support development of palliative cancer care in sub-Saharan Africa

 Uganda 2019-03-14 2022-03-14 Medical and Health Sciences Non-degree Award
ERIC WOBUDEYA
ID: UNCST-2019-R001047
 IMPACT OF SYSTEMATIC EARLY TUBERCULOSIS DETECTION USING XPERT MTB/RIF ULTRA IN CHILDREN WITH SEVERE PNEUMONIA IN HIGH TUBERCULOSIS BURDEN COUNTRIES
REFNo: HS331ES

To evaluate the impact on all-cause mortality at 12 weeks of adding systematic early detection of TB with Xpert MTB/RIF Ultra performed on one NPA and one stool sample to the WHO standard of care (SOC) in young children with severe pneumonia, followed by immediate anti-TB treatment initiation in children with a positive Ultra result, in high TB incidence countries, as compared to the SOC alone.
 Uganda 2019-03-14 2022-03-14 Medical and Health Sciences Non-degree Award
Satoru Mikami
ID: UNCST-2019-R000358
 The Effect of Participation and Alignment on the Sustainability of Development Aid: Evidence from a Field Experiment of a Household Water Treatment and Safe Storage Project in Uganda
REFNo: SS285ES

The purpose of this study is to explore the ways in which development aid can become more sustainable and effective. Among others, this study focuses on the impact of participation and alignment on the stainability of aid projects. However, it would be futile to directly ask stakeholders about their opinions on the contested impact of participation and alignment on sustainability because their opinions are driven more by ideology than by analysis. Therefore, this study uses a specific, concrete field situation where abstract relationships between participation, alignment and sustainability can be translated into actual behaviours.


 Japan 2019-03-14 2022-03-14 Social Science and Humanities Non-degree Award
Hella Peter Eszter
ID:
Variation in the leaf-tools of wild chimpanzees: Budongo Forest Reserve
REFNo: NS77ES

This research examines leaf-tool use and repertoire in the Budongo Forest Reserve, Uganda. In the forest, there are two habituated chimpanzee communities: Waibira, where habituation started in 2011, and Sonso, where habituation started in 1990. Both groups have a unique tool repertoire, without any stick or stone based tools, as opposed to those described at other long-term chimpanzee field sites. Additionally, the Waibira group faces an unusual ecological pressure during the dry season, when, despite being a forest living group, all permanent sources of water dry up. Describing their tool repertoire and investigating how it differs from the neighbouring Sonso community, who have permanent water sources all year around, will shed light on the ecological and social pressures driving the development of tool use. The project aims to provide a detailed description of the leaf-tool use of the Waibira chimpanzees of the Budongo forest, during the dry season lasting from December to end of February. Other aims are to determine variables that influence the use of leaf-tools, accurately measure leaf tools, and draw a developmental timeline for the most common type of leaf-tool, leaf-sponging. This will allow for detailed description of the leaf-tools of the community.
 Hungary 2019-03-11 2022-03-11 Natural Sciences Degree Award
Stephen Ssematimba Kato
ID:
PREGNANCY OUTCOME AMONG WOMEN OF ADVANCED MATERNAL AGE WHO DELIVER IN MULAGO HOSPITAL.
REFNo: HS260ES

General objective 1) To determine the association between advanced maternal age and adverse pregnancy outcomes among women who deliver in Mulago hospital. Specific objectives 1. To determine whether advanced maternal age is associated with adverse maternal outcomes in mothers who deliver from Mulago hospital. 2. To determine whether advanced maternal age is associated with adverse perinatal outcomes among mothers who deliver from Mulago hospital
Uganda 2019-02-26 2022-02-26 Medical and Health Sciences Degree Award
Ravinder Bhavnani D
ID:
MERIAM: Modelling Early Risk Indicators to Anticipate Malnutrition
REFNo: HS245ES

The central aim of the MERIAM project is to identify, test and scale up cost-effective means to improve the prediction and monitoring of undernutrition in difficult contexts, in such a way that it enables an effective response to manage and mitigate nutritional risk. The objectives of the overall, multi-year multi-country MERIAM research project include: (a) the creation of high-quality, relevant research that fills gaps in the evidence base on the prediction of undernutrition in response to shocks (e.g., conflict, drought, spikes in food prices); (b) the accessibility of results and evidence to both technical and non-technical audiences, including facilitation of audience engagement with data and the predictive model via a user-friendly online platform; and, (c) the successful uptake of MERIAM research by key stakeholders in policy and practice, with a focus on national-level actors and their utilization of the data and analysis to inform humanitarian response. The objectives of the Uganda-specific field visit for the computational modelling component include: (1) Visit locations where nutrition crises have occurred to get an understanding of the context, terrain, conditions, and populations (2) Administer questionnaires to identify and gauge key attributes, assets, choice sets, behavioral rules and practices (including adaptation and learning), drivers, constraints, and interventions. (3) Conduct simple vignette-based experiments where interviewees are presented with scenarios to which they answer with how they would respond to or judge various situations (4) Conduct open-ended discussions to make “explicit” the mental models practitioners use for assessment and decision-making
USA 2019-02-26 2022-02-26 Medical and Health Sciences Non-degree Award
Gavin Ackers Johnson
ID:
Assessing the Resistance Patterns of Bacteria Isolated from Cases of Maternal Sepsis at Fort Portal Regional Referral Hospital, Uganda; and Further Investigating the Potential Mechanisms of Antibiotic Resistance in the Staphylococcus aureus isolates obtai
REFNo: HS249ES

1. To determine the most common bacterial species that are associated with maternal sepsis at Fort Portal Regional Referral Hospital and their resistance profiles. 2. To use molecular typing to assess Staphylococcus aureus isolates and determine whether patients are being infected by the same strains, which may provide clues as to sources of infection 3. To identify the mechanisms of any antibiotic resistance observed.
 UK 2019-02-26 2022-02-26 Medical and Health Sciences Degree Award
Agnes Kiragga
ID:
A Pilot Test of a Technology-delivered HIV Self-Testing Intervention in Kampala, Uganda
REFNo: HS307ES

1) An established 24-hour call-in center staffed by medical providers who will deliver accurate HIV/STI information, perform pre- and post-test counselling, assist with conducting HIVST and interpreting the HIVST results, and referral and linkage to appropriate post-test prevention and treatment care; and 2) The use of SMS and social media streams – specifically private Facebook and Twitter messages - to “push” theoretically-grounded messages that promote HIVST and provide additional private communication routes between participants and medical provider research staff. The study aims are: Aim 1: Develop HIVST messages and finalize study procedures and materials with input from a Community Advisory Board (CAB), and beta test the intervention with 6 sexually active Ugandan adults (18-49 years old; 50% female). Aim 2: Using a pre-post design, assess the feasibility, acceptability and preliminary impact of the HIVST intervention developed in Aim 1 for Ugandan adults (n=100; 70% 18-24 years old, 30% 25-49 years old; 50% female). Feasibility will be assessed by whether enrollment targets are reached and the proportion of completed 1- and 3-month follow-ups calls. Acceptability items will be gathered at 1- and 3-month assessments. Preliminary impact will be determined by the percentage of participants who perform HIVST in the 3 months after enrollment. Aim 3: Analyze process indicators of the overall use of the HIVST intervention, including the number of HIVST kits requested, the volume of callers requesting HIVST during the study period, the number of persons calling for assistance with self-testing procedures, the number of post-test counseling calls received, and the number of persons linked to follow-up prevention and care services.
Uganda 2019-02-26 2022-02-26 Medical and Health Sciences Non-degree Award
Julie Hennegan Maree
ID:
Assessing girls’ menstrual practices and experience: development of a menstrual practices questionnaire and the menstrual perceptions scale.
REFNo: SS279ES

Background
After a history of neglect and taboo, the role of the menstruation in women and girls’ dignity, health, education, employment, and wellbeing has begun to receive attention. Stakeholders from governments to local charities have started to recognize the barriers that poor menstrual management and menstrual stigma present to gender equality. This has resulted in a rapid increase in the dissemination of interventions; from small-scale sanitary pad or puberty education provision to national policies such as large-scale sanitary pad distribution for schoolgirls in Ghana and Kenya. Despite this increased action, there is limited research available to inform intervention development or evaluation.
There is a lack of comprehensive, validated survey tools with which to measure women and girls’ menstrual practices and experiences. This limits the quality of cross-sectional and intervention research as well as monitoring and evaluation by NGOs and governments.

General Objective
This project aims to improve the measurement of menstrual practices and experiences in low resource settings through field testing and assessment of the psychometric properties of new measures of practices and perceptions.

Specific Objectives
1. To field-test acceptability and responses to a newly developed Menstrual Practices Questionnaire (MPQ), and Menstrual Perceptions Scale (MPS).
2. To assess the test-retest reliability of the MPQ and MPS.
3. To assess the factor structure of the MPS through exploratory and confirmatory factor analysis.
4. To assess convergent and divergent validity of the MPS, that is, association of the scale scores with hypothesized correlates.

 Australia 2019-02-26 2022-02-26 Social Science and Humanities Non-degree Award
Eve Smeltzer Ann
ID:
Conflict and Consensus: The Impacts of Socio-Ecological Contexts on Vervet Collaborative Movements
REFNo: NS83ES

This research will examine how vervet monkeys (Chlorocebus pygerythrus) use social strategies and democratic processes to mitigate conflicts of interests during collaborative movements and how their decisions are impacted by varying social and ecological contexts.
 USA 2019-02-19 2022-02-19 Natural Sciences Degree Award
Denis Muhangi
ID:
ROLE OF ASFV LATENTLY INFECTED PIGS AND SOFT TICKS IN AFRICAN SWINE FEVER EPIDEMIOLOGY IN ACHOLI SUB REGION, NORTHERN UGANDA
REFNo: A40ES

(i) Establish the prevalence of ASFV latently infected pigs in a post-outbreak situation. (ii) Investigate the existence of the soft tick O. moubata and their ASFV status.
Uganda 2019-02-19 2022-02-19 Agricultural Sciences Non-degree Award
Esther Uwimaana
ID:
Heme oxygenase-1 and neopterin plasma levels and their role in distinguishing active from latent TB in HIV/TB co-infected patients
REFNo: HS301ES

1. To determine and compare the median plasma levels of HO-1 1(in pg/ml) and neopterin (in ng/ml) among HIV patients co-infected with active TB, latent TB infection and individuals without TB infection alone attending Rubaga hospital. 2. To determine the diagnostic performance (sensitivity, specificity, positive predictive values and negative predictive values) of HO-1 and neopterin in diagnosis of latent tuberculosis infection using QuantiFERON2-TB test for latent TB infection as the gold standard. 3. To determine the diagnostic performance (sensitivity, specificity, positive predictive values and negative predictive values) of HO-1 and neopterin in diagnosis of active tuberculosis using sputum culture as the gold standard. 4. To determine the correlation between neopterin and HO-1 plasma levels with QuantiFERON2-TB Gold test in diagnosing latent TB infection.
Uganda 2019-02-19 2022-02-19 Medical and Health Sciences Degree Award
Kathryn LaRusso E
ID:
Access to Essential Surgical Care and Bellwether Procedures for Children in Uganda: A Public-Sector Evaluation
REFNo: HS231ES

Primary objectives: 1. To conduct a nationwide survey using a convenience sample of two regional and two general referral hospitals in each region (Northern, Eastern, Western, and Central) of Uganda, and the national referral hospital (17 total facilities), using surgical capacity assessments to assess the availability of essential and emergency surgical care (EESC) for children. i. To pilot the new WHO-PGSSC-GICS Children’s Surgical Assessment Tool (CSAT) and compare the results with PediPIPES to assess the validity, usability and reliability of the new CSAT tool. 2. To identify candidate bellwether procedures for children’s surgery that can be used as a benchmark for essential surgical care for children based on national, regional and general hospital logbook data, surgical capacity assessments, and perioperative mortality if available. Secondary objectives: 3. To identify if the ratio of emergent surgery to elective surgery (Ee ratio) using logbook data from national, regional and general hospitals can be a simple and valid indicator of access to pediatric surgical care. 4. To verify if a convenience sample of 1-month of logbook data collection can reliability predict perioperative mortality rate vs 3- or 6-months of logbook data collection at MRRH.
USA 2019-02-18 2022-02-18 Medical and Health Sciences Non-degree Award
Sarah Baird
ID:
INCORPORATING MENTAL HEALTH PROGRAMMING INTO ADOLESCENT EMPOWERMENT PROGRAMMING.
REFNo: HS318ES

Despite adolescent girls being at high risk of anxiety, depression, and other forms of psychological distress, there is little extant evidence on how to treat mood disorders among adolescents in developing countries in a cost-effective manner. The aim of our research projects is to evaluate the use of group based interpersonal therapy (IPT-G) in reducing the prevalence of anxiety and depression among adolescents in developing countries. The specific objectives of the research project are the following: 1. To estimate the causal effect of IPT-G on the psychological wellbeing of adolescent females who are identified as at risk of anxiety and depression at baseline 2. To estimate the marginal effects of adding income support following the intervention, on the sustainability of IPT-G results on anxiety and depression. 3. To investigate the relationship between improved psychological wellbeing among adolescents (as a result of the intervention) and school attainment, teenage pregnancy, child marriage and risky behavior. 4. To find if ELA clubs can serve as a pathway to reach and engage adolescent females who are most affected by mental health disorders.
New Zealand 2019-02-12 2022-02-12 Medical and Health Sciences Non-degree Award
GODFREY OSINDE
ID:
The association between ABCB1 gene C3435T polymorphism and Doxorubicin pharmacokinetics in Breast Cancer patients at Uganda Cancer Institute
REFNo: HS239ES

1. To determine the pharmacokinetics of doxorubicin in breast cancer patients in Uganda. 2. To determine the frequencies of the ABCB1 gene: C3435T SNP in breast cancer patients in Uganda. 3. To determine the association between the ABCB1 gene: C3435T SNP and PK of doxorubicin in breast cancer patients.
 Uganda 2019-02-12 2022-02-12 Medical and Health Sciences Non-degree Award
EMMANUEL NAMBALE BUKUWA NAMBALE
ID:
THE ROLE OF SAVINGS GROUPS ON SMALLHOLDER AGRO-INPUT USE IN SIRONKO DISTRICT, UGANDA
REFNo: A38ES

The main objective of this study is to investigate the impact of membership in a savings group on Agro-input use by smallholder farmers. Specific objectives 1. To determine the proportion of group savings spent on agro-inputs by group members 2. To determine the difference in use of agro-inputs between members and non-members of savings groups 3. To identify factors determining the level of spending on agro-inputs
Uganda 2019-02-12 2022-02-12 Agricultural Sciences Degree Award
Provia Ainembabazi
ID:
BREAST CANCER RISK PERCEPTION AND RISK REDUCTION BEHAVIOURS OF FIRST DEGREE FEMALE RELATIVES OF BREAST CANCER PATIENTS AT UGANDA CANCER INSTITUTE, KAMPALA, UGANDA
REFNo: HS277ES

General Objective The general objective of this study is to explore self-perceived risk of breast cancer and intentions for screening and adoption of risk reduction behaviors among first degree female relatives of breast cancer patients attending Uganda Cancer Institute so as to inform design of interventions to enhance uptake of early detection and prevention services. Specific Objectives 1. To explore self-perceived risk of breast cancer and intended risk reduction behaviors among first degree female relatives of breast cancer patients at UCI. 2. To determine factors associated with self-perceived risk of breast cancer among the first degree female relatives of breast cancer patients at the UCI. 3. To determine the factors associated with risk-reduction behaviors among the first degree female relatives of breast cancer patients at UCI 4. To describe perceived barriers for adoption of risk reduction behaviors among first degree female relatives of breast cancer patients at the UCI.
Uganda 2019-02-12 2022-02-12 Medical and Health Sciences Non-degree Award
Stephen KIIRYA Kisembe
ID:
Psychosocial predictors of sexual risk behaviour among HIV infected and affected adolescents in HIV affected homes of Uganda
REFNo: SS270ES

Despite the long-lasting psychosocial impacts of HIV and the rising number of children progressing to adolescence and reproductive stages with HIV infection and or exposure in Uganda, the extent and factors of psychosocial and sexual risks among adolescents in HIV-exposed homes is unknown. Existing studies have ignored this population yet they are many and prone to psychosocial risks of HIV and focused on either older HIV-infected adolescents attending HIV care or young orphans. Additionally, these studies mainly examined levels and demographic factors of psychological distresses and risky sexual practices and do not therefore offer ample knowledge about the psychosocial situation and sexual risk behaviour among varied adolescents in HIV-affected homes to facilitate inclusive programming. This knowledge deficit begets three research questions, namely 1) What is the psychosocial and sexual risk behaviour situation of HIV infected and affected adolescents living in HIV-affected homes of Uganda? 2) How do HIV infected and affected adolescents compare concerning the psychosocial and sexual risk behaviour situations? 3) Does the psychosocial situation predict sexual risk behaviour in these groups? The proposed research therefore aims to: 1) determine the psychosocial and sexual risk behaviour situation of HIV infected and affected adolescents in HIV-affected homes across three HIV-burdened districts in Uganda; 2) compare the socio-demographic contexts and levels of community stressors, psychosocial distresses, coping ways and sexual risk behaviours of the two groups; 3) examine the coping mediated psychosocial predictors of sexual risk behaviour in these groups; and 4) evaluate if socio-demographic factors (age, sex, etc.) moderate the coping mediated associations between community stressors, psychosocial distresses and sexual risk behaviour in this population.
 Uganda 2019-02-12 2022-02-12 Social Science and Humanities Degree Award
Alfredo Guarino
ID:
Acute gastroenteritis as a presenting symptom for malaria
REFNo: HS225ES

The aim of the study is to investigate the prevalence of Acute Diarrhea in Children with Malaria in Northern Uganda, a high-transmission malaria setting where there is paucity of data on the etiological agents of childhood diarrhea. There is a solid scientific basis that could explain the pathogenesis of diarrhea in severe malaria. The starting point for our working hypotheses is the positive feedback of Ugandan and Italian Doctors who have been working in Lacor Hospital’s Children Ward, whose practical and clinical experience seems to confirm an increased rate of GI symptoms in children with malaria. There are previous clinical controlled Studies on the subject, however, despite the scientific premises and the clinical observations, these Studies have produced inconsistent and inconclusive results, and eventually failed to demonstrate a statistically significant prevalence of diarrhea in children with malaria. Moreover, setting, study groups and secondary endpoints differ from our Study. In conclusion and to the best of our knowledge, our Study would be the first to show a statistically significant association between acute diarrhea and malaria. The Study would also be the first to be performed since the introduction of artemisinin-based therapies for the treatment of malaria. Investigating the time of response, and the factors affecting an early (< 24 h) or late resolution (>24h) of diarrhea could provide new extra information on the clinical outcomes of children with GI symptoms during severe malaria treated with IV artesunate and ACTs and provide new prognostic factors on admission.
Italy 2019-02-05 2022-02-05 Medical and Health Sciences Non-degree Award
Irene  Lubega
ID: UNCST-2019-R000658
 Immunogenicity of Fractional One-fifth and One-half Doses of Yellow Fever Vaccine Compared to Full Dose in Children 9-23 months old in Uganda
REFNo: HS244ES

Primary • Assess whether seroconversion following one-fifth (0.1 ml) and one-half (0.25 ml) doses of YF 17DD vaccine is non-inferior to seroconversion following a full dose (0.5 ml) at 4 weeks post-vaccination in children aged 9 – 23 months Secondary • Assess whether the proportion of baseline seronegative children that are seropositive following one-fifth (0.1 ml) and one-half (0.25 ml) doses of YF 17DD vaccine is non-inferior to the proportion seropositive following a full dose (0.5 ml) of vaccine at 12 months post-vaccination • Compare the geometric mean antibody titers following the fractional doses to the geometric mean titer following the full dose at 4 weeks and 12 months post vaccination • Describe the safety profile of fractional and full-dose YF 17DD vaccine in children 9-23 months
Uganda 2019-02-05 2022-02-05 Medical and Health Sciences Non-degree Award
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