Fahad Muwanda
ID:
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Childhood responses to Hepatitis B vaccine in Uganda: the role of Human Leukocyte Antigen (HLA) and T-Cell Receptor (TCR) diversity
REFNo: HS2604ES
To determine the long-term persistence of protective hepatitis B vaccine antibody titers among 15-17 years old childhood recipients who were enrolled on the UNEPI. ,Characterize the T-cell immunophenotypes and function, and compare hepatitis B vaccine responders with non-responders. ,Characterize host TCR and HLA genotypes and their association with hepatitis B vaccine responses among under 5 year-old childhood recipients in the UNEPI.,To determine the prevalence of immunological non-responsiveness to hepatitis B vaccine among under 5 year-old childhood recipients in the UNEPI recruited in Kawempe Division, Kampala.,To determine the immunogenetic factors associated with non-responsiveness in hepatitis B vaccine childhood recipients, and persistence of immuno-protection accorded by the vaccine in Uganda.,
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Uganda |
2022-12-23 18:04:07 |
2025-12-23 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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Jonathan Kayondo
ID: UNCST-2021-R008325
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Contained laboratory studies of the genetically-modified, non-gene drive, self-limiting male bias Anopheles gambiae strain Ag(PMB)1.
REFNo: HS2601ES
• Establishing and maintaining wild-type Anopheles strains Ag(WT) for use in the study.
• Importing and maintaining of the Ag(PMB)1 strain from Target Malaria partner laboratories into the insectary in accordance with ACL2 standard operating procedures for this strain.
• Further Introgression and maintaining the Ag(PMB)1 strain in a local genetic background.
• Confirmation of the genotype of the Ag(PMB)1 strain by molecular methods, including storage of samples.
• Conducting experiments on specific insect life history parameters under containment including:
o Effect of the transgenes on lifecycle parameters
o Female feeding avidity
o Fecundity
o Egg hatch
o Confirming the male bias phenotype by observing the distortion of sex ratio and proportions of transgenic vs. non transgenic individuals
o Accuracy of mosquito sorting methods
o Larval development rate and adult hatching (eclosion)
o Adult eclosion (emergence of an adult insect from a pupa) and adult longevity
• Conducting a colony augmentation exercise, to temporarily increase colony numbers.
• Assessment of mating competitiveness between Ag(WT) and strain Ag(PMB)1 males.
• Assessment of insecticide susceptibility status of the Ag(PMB)1 strain compared with the non-transgenic wild-type An. gambiae, using standard World Health Organization protocols.
• Conducting experiments to optimize mosquito rearing methods.
All studies will be performed using the imported Ag(PMB)1 strain and local wild-type Ag(WT), no genetic transformation of either of these two strains will be done in country.
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Uganda |
2022-12-23 18:02:42 |
2025-12-23 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Robert Downing George
ID: UNCST-2020-R014615
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Sample collection for the development of a new Abbott Rapid Diagnostics COVID- 19/ Flu A&B Rapid Panel
REFNo: HS2592ES
Influenza (Flu) and COVID-19 are both contagious respiratory illnesses - they share some similar symptoms but are caused by different viruses. Because some of the symptoms of flu and COVID-19 are similar, distinguishing infection between these viruses cannot be made based on symptoms alone. Diagnostic testing is needed to determine which of the two viruses is the cause of the illness.
Abbott Rapid Diagnostics is developing a new COVID-19 / Flu A&B rapid test device that can detect both flu and COVID-19 viruses in a patient sample and distinguish between them. The test is being developed on an improved lateral flow platform, to be conducted at the point-of-care. This study is intended to collect samples to aid in the research and development process for this new test. The study will provide standard-of-care PCR testing and potentially molecular sequencing for patient management at clinical sites in Uganda.
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UK |
2022-12-23 18:01:38 |
2025-12-23 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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DARIUS OWACHI
ID: UNCST-2022-R009373
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KNOWLEDGE, ATTITUDE AND PRACTICES OF HEALTH WORKERS TOWARDS ANTIMICROBIAL RESISTANCE AND ANTIMICROBIAL STEWARDSHIP – A CROSS-SECTIONAL SURVEY IN KAMPALA, UGANDA
REFNo: HS2598ES
To determine the knowledge, attitude and practices of antimicrobial prescribers at Kiruddu Hospital towards antimicrobial resistance ,
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Uganda |
2022-12-23 18:00:14 |
2025-12-23 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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EUNICE Ndyareeba
ID:
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Achievement Goal Orientation, Self-efficacy and Academic Engagement among Compassion and Non-compassion supported Adolescent students in Secondary Schools in Southwestern Uganda
REFNo: SS1562ES
1.Assess the relationship between achievement goal orientation and academic engagement
2.Determine the relationship between self-efficacy and academic engagement
3.Examine the mediation role of self-efficacy on the relationship between achievement goal orientations and academic engagement
4. Examine whether there is a significant difference between achievement goal orientation and academic engagement among compassion-supported and non-compassion supported adolescents
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Uganda |
2022-12-23 17:58:52 |
2025-12-23 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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