Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Flavia Matovu Kiweewa
ID: UNCST-2021-R013337
Bone Health in Older Ugandan Women with and without HIV
REFNo: HS5455ES

To examine bone mineral density (BMD) and body composition in older (peri-menopausal and postmenopausal) African women who are living with HIV and taking antiretroviral therapy (ART) drugs compared to women representing similar age and background characteristics who are HIV-negative.
Uganda 2025-02-07 17:30:13 2028-02-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jennifer Serwanga
ID: UNCST-2024-R002056
Universal Protocol for Standardizing emerging Assays and Advancing vaccine Immunogenicity Assessments for Emerging and Re-emerging viral Threats through UVRI’S Partnership with the coalition for Epidemic Preparedness Innovations (CEPI)’s Centralized Clinical Laboratory Network (CLN).
REFNo: HS5330ES

To standardize and accelerate the evaluation of vaccine candidates against CEPI priority diseases, including Ebola, Marburg, Lassa, Nipah, Rift Valley Fever, SARS-CoV-2, MPOX and unidentified emerging threats, by leveraging UVRI's infrastructure and expertise.

To contribute to accelerated global vaccine development and licensure by ensuring rapid, accurate, and consistent data generation, while enhancing regional outbreak preparedness through technology transfer and capacity building.
Uganda 2025-02-04 8:15:09 2028-02-04 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ronald  Bahati
ID: UNCST-2023-R007024
NAVIGATING MENTAL HEALTH IN SCHOOLS PROJECT: EDUCATORS’ MENTAL HEALTH LITERACY CONCERNING ANXIETY, DEPRESSION AND NON-SUICIDAL SELF INJURY
REFNo: HS5381ES

To ascertain the educators’ confidence in providing help to affected school aged adolescents in selected schools in southwestern Uganda.,3. To assess educators’ level of mental health literacy about non-suicidal self-injury among school aged adolescents in selected schools in southwestern Uganda.,2. To assess educators’ level of mental health literacy about depression among school aged adolescents in selected schools in southwestern Uganda,1. To assess educators’ level of mental health literacy about anxiety among school aged adolescents in selected schools in southwestern Uganda,To assess educator’s mental health literacy about anxiety, depression and non-suicidal self-injury and their confidence in providing help to affected school aged adolescents in selected schools in southwestern Uganda.,
Uganda 2025-01-31 8:00:54 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Shevin  Jacob Thomas
ID: UNCST-2022-R010715
The Sub-Saharan Africa ConsorTium for the Advancement of Innovative Research and Care in Sepsis (STAIRS) Cohort Study: A prospective multi-country network cohort of hospitalized sepsis patients
REFNo: HS5205ES

1. Describe the cohort’s epidemiologic, sociodemographic, clinical and management characteristics and to identify risk factors for disease severity and outcomes. 2. Characterize etiologic (and antimicrobial resistance patterns when relevant) and host response profiles and to evaluate their potential associations with clinical presentation, disease severity and outcome. 3. Determine the performance characteristics of innovative sepsis diagnostic platforms for pathogen identification, host response profiling and risk stratification in comparison with diagnostic testing available for usual care (including blood culture and existing sepsis scores).
USA 2025-01-31 7:59:00 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sabiti Makara
ID: UNCST-2024-R003444
Crisis Emergencies, State Responses and ‘Windows’ of Corruption in Uganda
REFNo: SS3621ES

To implement bottom-up strategies for fighting corruption in emergency responses ,To examine the possibilities of grassroots actions and pressures that could have significant impacts on the fight against corruption,To establish the extent to which political considerations abate corruption with a focus on procurement and contracting during emergency crisis responses,To establish the gaps in regulatory frameworks that are opportunistically exploited by corrupt officials and their cronies to undermine anti-corruption efforts during emergency responses,Establish the actual costs of corruption and find out if the population is aware of its effects on public service delivery for the ordinary citizens,To examine the forms, practices, and patterns of corruption in emergency crisis responses in Uganda,Our main objective is to highlight and deepen our understanding of the extent which the risk of corruption intensifies during emergencies and to develop grassroots-based strategies to fight the vice.,
Uganda 2025-01-31 7:50:39 2028-01-31 Social Science and Humanities Non-Clinical Trial Non-degree Award
Vincent Ferrer Bukenya
ID: UNCST-2024-R004868
Examination of the relationships between refugee settlements and wood energy consumption: A case study of Bidibidi refugee settlement in northwest Uganda
REFNo: A527ES

This research will examine the relationships between refugee settlements and household access to sustainable wood energy. 1. To establish what forms the bulk of wood energy used by refugees and host communities in Bidibidi Refugee Settlement in North-Western Uganda. 2. To assess wood energy consumption patterns in refugee and host communities in relation to the right to energy in Bidibidi Refugee Settlement in North-Western Uganda. 3. To examine how the refugee response framework provides for household access to wood energy by refugees and host communities in Bidibidi Refugee Settlement in North-Western Uganda. 4. To determine the contribution of the refuge-host community relationships to households’ ability to sustainably access wood energy.
Uganda 2025-01-31 7:43:24 2028-01-31 Agricultural Sciences Non-Clinical Trial Degree Award
Ikuomola  Orire Emmanuel
ID: UNCST-2024-R003700
EFFECT OF DIFFERENT FRACTIONS OF BRASSICA OLERACEA (COLLARD GREENS) ETHANOL EXTRACT ON CIMETIDINE INDUCED REPRODUCTIVE TOXICITY IN MALE WISTAR RATS.
REFNo: HS5192ES

i. Identify and quantify the constituents of crude aqueous leaf extract and fractions of Uganda collard green plant using gas chromatography mass spectrometry (GCMS);
ii. Evaluate the impact of crude aqueous leaf extract and fractions of Uganda collard greens on the relative weights of the testes, epididymis and anterior pituitary gland compared to body weight in male Wistar rats with cimetidine-induced reproductive toxicity by [specific date] male Wistar rats;
iii. Assess the effects of crude aqueous leaf extract and fractions of Uganda collard greens on sperm parameters, including motility, morphology, viability, agglutination, and total sperm count in Wistar rats with cimetidine-induced reproductive toxicity;
iv. Analyze the effect of crude aqueous leaf extract and fractions of Uganda collard greens on serum levels of steroid androgens (LH, FSH, Testosterone and antioxidant enzyme activities (catalase, Malondialdehyde, superoxide dismutase) in male Wistar rats with cimetidine-induced reproductive toxicity in male Wistar rats;
v. Examine the histological changes in the testes, epididymis, and anterior pituitary gland in male Wistar rats with cimetidine-induced reproductive toxicity following treatment with crude aqueous leaf extract and fractions of Uganda collard greens in male Wistar rats.

Nigeria 2025-01-31 7:40:27 2028-01-31 Medical and Health Sciences Non-Clinical Trial Degree Award
Miriam  Amutuheire
ID: UNCST-2024-R001859
Home-based tourism businesses and destinaion sustainability in Kabale Municiplaity, Kabale District, Uganda.
REFNo: SS3399ES

i.To assess the effect of the home-based tourism business operations on destination sustainability in Kabale municipality, Kabale District, Uganda.    
ii. To determine the influence of home-based tourism businesses competitiveness on destination sustainability in Kabale municipality, Kabale District, Uganda.  
iii. To establish the influence of government policies, impart on home-based tourism businesses that affect destination sustainability in Kabale municipality, Kabale District, Uganda.  
Uganda 2025-01-31 7:38:46 2028-01-31 Social Science and Humanities Non-Clinical Trial Degree Award
Karugahe Wilber
ID: UNCST-2023-R005686
Effectiveness of Cognitive behaviour therapy for mental health problems among adult patients with type-II diabetes mellitus: a controlled study
REFNo: SS3413ES

a. To assess the effectiveness of CBT in treating mental health problems (psychological distress, depression, anxiety, quality of life, treatment adherence, hopelessness, pessimism) among adult patients with T2DM
b. To assess whether CBT affords a better control of glycaemia and the metabolic disturbances associated with T2DM.

Uganda 2025-01-31 7:37:29 2028-01-31 Social Science and Humanities Non-Clinical Trial Non-degree Award
ANNETTEE NAKIMULI OLIVIA
ID: UNCST-2022-R011194
Maternal immunization readiness network for the introduction of potential new maternal vaccines to prevent early childhood infectious diseases in Uganda
REFNo: HS5271ES

General objective:

To identify, characterize and support the platform, policy, and preparedness requirements for the introduction of potential new maternal vaccines to prevent infectious diseases in Uganda


Specific objectives:

1. To identify and implement approaches to assess health systems, facilities, and community readiness to introduce new maternal vaccines in Uganda
a. Identify and implement approaches to assess MI readiness for respiratory syncytial virus / Group B streptococcus vaccinations across the health system, including mapping key regulatory and financing requirements.
b. Map professional societies within the country and initiate country-based communities of practice for MI.
2. Generate and synthesize health economic evidence, in the Ugandan context, to support decision-making of respiratory syncytial virus / Group B streptococcus vaccination program adoption in low- and middle-income countries (LMICs).
3. Prospectively develop nationally tailored maternal vaccine demand strategies to support the uptake and sustained demand for existing and new maternal vaccines in Uganda.
4. Identify and effectively engage with diverse stakeholders, in a harmonized manner, to incorporate their views and expertise in the study’s outputs, to advance the maternal immunization readiness agenda in Uganda.

Uganda 2025-01-31 7:35:56 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Emmanuel Rukundo NSHAKIRA
ID: UNCST-2021-R012277
Improving School Management in a Low-Income Country: Experimental Evidence from Uganda
REFNo: SS3462ES

To evaluate the impact of the Inspect and Improve (I&I) program on student outcomes (learning, safeguarding, and inclusion) and school quality, focusing on both short-term and long-term effects.
Uganda 2025-01-31 7:32:19 2028-01-31 Social Science and Humanities Non-Clinical Trial Non-degree Award
Moses Ochora
ID: UNCST-2021-R012659
RUNYA-PHIV: Rural Uganda Neurocognitive Youth Assessment with Perinatally acquired HIV
REFNo: HS5534ES

To explore the differences in NeuroScreen performance among adolescents aged 12-19 years with Perinatally acquired HIV in urban (Kampala) vs rural areas (Mbarara).,To adapt NeuroScreen to assess neurocognition among Runyankole-speaking adolescents aged 12-19 years with Perinatally Acquired HIV ,
Uganda 2025-01-31 7:31:16 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Samuel Kyobe
ID: UNCST-2019-R000108
DSpace – Ethical Implications of Pediatric EHR Use in Medical Research in Uganda and Botswana
REFNo: HS5301ES

1. Analyze the ELP issues raised by the use of pediatric EHR in medical research in Uganda and Botswana
2. Determine/analyze the implications of data linkage on participant consent and privacy
Uganda 2025-01-31 7:27:19 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Emmanuel Maleka
ID: UNCST-2024-R015301
Sex differences in alcohol consumption and its impact on vulnerability and susceptibility to develop dementia in rural Uganda.
REFNo: SS3477ES

1. To determine the patterns of alcohol consumption among men and women aged 60 years and above in Ibanda and Lira districts.
2. To assess the association between alcohol consumption and cognitive impairment among men and women in rural Uganda
3. To determine the socio-cultural factors that contribute to gender differences in the vulnerability to alcohol-related cognitive impairment in Ibanda and Lira districts.

Uganda 2025-01-31 7:24:38 2028-01-31 Social Science and Humanities Non-Clinical Trial Non-degree Award
john semuwemba
ID: UNCST-2022-R015225
Association between prenatal alcohol exposure and Cognitive and Behavioral impairments among primary school children aged 6 to 10 years in rural Rwampara and Lira districts.
REFNo: HS5331ES

General Objective.
To determine the prevalence of prenatal alcohol exposure and the association between prenatal alcohol exposure and cognitive and behavioral impairments among primary school children aged 6 to 10 years in rural Rwampara and Lira districts.
Specific Objectives.
1 To determine the prevalence of prenatal alcohol exposure in rural Rwampara and Lira districts.
2 To determine the prevalence of cognitive and behavioral impairments among primary school children aged 6 to 10 years in rural Rwampara and Lira districts.
3 To determine the association between prenatal alcohol exposure and cognitive and behavioral impairments among primary school children aged 6 to 10 years in rural Rwampara and Lira districts.

Uganda 2025-01-31 7:22:50 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
David Mukunya
ID: UNCST-2022-R010707
A phase III, randomized, open-label, clinical trial to evaluate the safety and efficacy of emollient therapy for very low birthweight infants (<1500g) in Uganda in promoting survival, health, growth and development compared to no emollient treatment
REFNo: HS5338ES

To evaluate the efficacy of emollient therapy with SSO – compared to standard care without use of emollients – among hospitalised very low birth weight (VLBW, <1500g) infants in Uganda on: the rate of in-hospital mortality, serious infections, hypothermia, growth, intraventricular haemorrhage, and skin condition; maternal depression and anxiety; maternal and neonatal interaction; infant growth and neurodevelopment at 12 month corrected age (chronological age reduced by the number of weeks born before 40 weeks of gestation); and infant mortality.
Uganda 2025-01-31 7:21:53 2028-01-31 Medical and Health Sciences Clinical Trial Non-degree Award
Adam Hewitt Smith
ID: UNCST-2019-R001658
Evidence based QUality Improvement for Prescribing Stewardship in ICU (EQUIPS-ICU): protocol for type III hybrid implementation-effectiveness study.
REFNo: HS5389ES

To evaluate the impact of a structured antimicrobial review on rates of antimicrobial density, redundancy and associated indicators of antimicrobial utilisation.,To determine whether a structured antimicrobial review can be implemented in LMIC ICUs,
UK 2025-01-31 7:20:18 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
WAYENGERA Misaki
ID: UNCST-2024-R002503
DECIPHERING HOST GENETICS AND VIRAL DETERMINANTS OF MPOX PATHOGENESIS IN THE DEMOCRATIC REPUBLIC OF CONGO AND THE NEIGHBORING COUNTRIES (DECIPHER-MPOX)
REFNo: HS5409ES

The goal of the DECIPHER-MPOX project is to determine the host genetic and viral determinants of mpox in Uganda and in the Democratic Republic of Congo (DRC) among survivors of mpox and their house hold contacts ,
Uganda 2025-01-31 7:18:46 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jackson Tumwine Bwagiro
ID: UNCST-2024-R004504
Promotion of integrated and sustainable community interventions to prevent GBV and strengthen Adolescent Sexual Reproductive health and rights. A realistic evaluation protocal from Uganda
REFNo: SS3540ES

The overall objective is to promote integrated and sustainable community interventions to prevent GBV and Strengthen SRHR,
Uganda 2025-01-31 7:17:15 2028-01-31 Social Science and Humanities Non-Clinical Trial Non-degree Award
Andrew Kanyike Marvin
ID: UNCST-2020-R014554
Optimizing Hypertension and Type 2 Diabetes Mellitus Management among People Living with HIV using a HEARTS-Based Strategy in Eastern Uganda: A Feasibility and Preliminary Effectiveness Study.
REFNo: HS5399ES

To identify the barriers and facilitators to the optimal management of HTN and T2DM among PLHIV at Mbale Regional Referral Hospital in Eastern Uganda.

To develop and implement a HEARTS-based strategy for optimized management of HTN and T2DM among PLHIV at Mbale Regional Referral Hospital in Eastern Uganda.

To determine the feasibility, acceptability, and preliminary effectiveness of the HEARTS-based strategy in optimizing the management of HTN and DM among PLHIV at the Mbale Regional Referral Hospital in Eastern Uganda.

To evaluate the reach, adoption, implementation, and maintenance of the HEARTS-based strategy for optimizing hypertension and diabetes mellitus management among PLHIV at Mbale Regional Referral Hospital.

Uganda 2025-01-31 7:16:22 2028-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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