Moses Ocan
ID: UNCST-2020-R014731
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COVID-19 Vaccine Effectiveness, Vaccine Uptake Determinants, and Impact of Pandemic on Health Programs in Uganda
REFNo: HS2664ES
Objective 1: To evaluate the real-world COVID-19 vaccine effectiveness in Uganda using a retrospective study design
Objective 2: To identify the barriers and enhancers to COVID-19 vaccination among healthcare workers in Uganda
Objective 3: To assess the impact of COVID-19 on healthcare programs in Uganda
Objective 4: To evaluate the real-world COVID-19 vaccine effectiveness and safety in Uganda using a prospective study design
Objective 5: To develop a national biorepository for COVID-19 samples at H3Africa Biorepository at Makerere University Biomedical Research Center (MaKBRC), College of Health Sciences, Uganda
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Uganda |
2023-02-23 8:26:55 |
2026-02-23 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Robert Ssekitoleko
ID: UNCST-2019-R001716
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Promoting Universal Health Coverage for Amputees in Uganda through Social Enterprise and Engineering Innovation
REFNo: SIR192ES
The principles of patient autonomy, non-maleficence, beneficence, and justice will be employed. Institutional safeguards, such as human subjects review committees and policies governing organisational ethics, will be followed. To this end, we shall seek ethical approval from the Makerere University School of Biomedical Sciences Research Ethics Committee and the Uganda National Council for Science and Technology. We shall also seek permission from the Ministry of Health as well as the management of the health units from which the data will be collected. We will provide verbal and written explanations of the study, including the aim, the level of participation required, potential risks of involvement, and the approximate duration of participation. The consent will include full verbal (in case of illiteracy) and written/signed informed consent from all individuals and groups before accepting to be interviewed. We will seek written permission to record interviews, and access meeting minutes, reports, and other relevant documents from relevant persons prior to including them in the research. Participants will be asked to give verbal consent and confirm this by reading and signing the consent form (included in the appendix). The key informants, including service users, will be free to withdraw consent at any time without giving an explanation and without this negatively affecting the care they receive. Data collectors will translate information into the relevant local language where required. We will seek verbal consent from participants who struggle to read and write, and the next of kin will sign the consent form on behalf of the user. We will only include participants 18 years of age and older who can provide consent on their own. The participant information sheet will explicitly state that participation in this study is purely voluntary. Participants can withdraw at any time, up to 14 days after data collection, without giving the reason for their withdrawal from the study. Their decision to withdraw from the study will not affect the services they receive. Participants will have up to 48 hours after receiving full details about the study, to consider participating in the research and ask questions.
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Uganda |
2023-02-22 8:38:27 |
2026-02-22 |
Engineering and Technology |
Non-Clinical Trial |
Non-degree Award |
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Josephine Ayebare
ID:
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An E-participation Model and Mobile Application Prototype for Inclusive Governance and Policy Development in Rural Uganda: Participatory Approach
REFNo: SS1621ES
To evaluate the usefulness of the model designed in objective 2 in achieving participation objectives through assessing the mobile application prototype designed in objective 3.,To co-design a mobile application prototype with the rural population stakeholders of Isingiro district in Uganda for based on the model developed in objective 2. ,To co-design a multi-dimensional model with the rural population e-participation stakeholders of Isingiro district in Uganda using the social-technical contextual factors and their SWOT analysis identified in objective 1. ,To identify and analyse the socio-technical contextual factors that influence political e-participation in rural Uganda. ,Aims to design and develop a multidimensional e-participation model and a mobile application prototype suitable for promoting e-participation among the rural population in Isingiro district in Uganda.,
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Uganda |
2023-02-21 13:17:02 |
2026-02-21 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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Harriet Mayanja-Kizza
ID: UNCST-2021-R013074
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PHASE 2C CLINICAL TRIAL OF NOVEL, SHORT-COURSE REGIMENS FOR THE TREATMENT OF PULMONARY TUBERCULOSIS:
CRUSH-TB (Combination Regimens for Shortening TB Treatment)
REFNo: HS2650ES
Primary objective
(1) To compare the efficacy of each experimental regimen to the efficacy of standard treatment, using the intermediate endpoint of time to culture negative in liquid media.
Secondary objectives
(1) To compare the proportion of participants with a grade 3 or higher adverse event in each experimental arm with the control arm
(2) To describe the proportion of participants experiencing lack of sustained cure during treatment or follow-up to 52 weeks in each experimental arm as compared to control and make predictions as to how these regimens would perform in future phase III trials.
(3) To compare the efficacy of each experimental regimen to the efficacy of standard treatment, using the intermediate endpoint of time to culture negative in solid media
(4) To compare the proportion of participants in each arm who convert liquid and solid sputum cultures to negative by (a) 8 weeks of treatment and (b) 12 weeks of treatment
(5) To describe the rate of all-cause study drug discontinuation in each arm
(6) To compare time to sputum culture positivity curves through 17 weeks in the Mycobacterial Growth Indicator Tube (Bactec MGIT960) across arms
(7) To describe the proportion of participants experiencing lack of sustained cure during treatment or follow-up up to 78 weeks in each experimental arm as compared to control and make predictions as to how these regimens would perform in future phase III trials.
(8) To describe the population PK of bedaquiline and its M2 metabolite, with or without rifabutin co-administration (PK#1)
(9) To conduct pharmacokinetic/pharmacodynamics study of the test drugs to determine relationships between pharmacokinetic parameters (AUC, Cmax) and outcome measures (time to culture negativity or rate of change in TTP) using non-linear mixed effects models, adjusting for key covariates that may affect outcomes (e.g. companion drugs, HIV status, cavitary disease) (PK#2)
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Uganda |
2023-02-21 13:13:53 |
2026-02-21 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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KIRABO NAKASIITA NKAMBWE
ID:
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Mindset, Teaching and Learning Strategies in Sciences among Secondary School Students in Wakiso District: The mediating effect of Interest
REFNo: SS1591ES
6. To assess the moderating effect of teaching strategies on the relationship between mindset and learning strategies in sciences among O level students in Wakiso district,5. To assess the mediating effect of interest on the relationship between mindset and learning strategies in sciences among O level students in Wakiso district ,4. To determine the relationship between mindset and learning strategies in sciences among O level students in Wakiso district ,3. To assess the relationship between interest and learning strategies in sciences among O level students in Wakiso district ,2. To examine the relationship between mindset and interest in sciences among O level students in Wakiso district ,1. To establish the science interest levels among O level students in Wakiso district,To assess the effects of mindset, interest and teaching strategies on students’ use of learning strategies in sciences among O level students in Wakiso District,
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Uganda |
2023-02-21 13:08:23 |
2026-02-21 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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