Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Stevens Bechange
ID: UNCST-2022-R009190
 Understanding Access to Business Financing for Young Entrepreneurs with and without Disabilities in Urban Uganda
REFNo: SS3471ES

The specific objectives will be:
1. To identify the different types of business financing options accessible by and preferred by young enterpreneurs with and without disabilities including what drives them to use these options.
2. To understand existing barriers for young enterpreneurs with and without disabilities in accessing and using the different business financing products, what can be done to address these and recommendations for more widespread access.
3. To describe how financial products from the RISE/E Programme affect young enterpreneurs with and without disabilities and their businesses and how they can be further improved.
4. Develop a database that includes demographic, socio-economic; and business financing information to facilitate the evaluation of success or failure with access to finance.

Uganda 2024-12-10 15:17:09 2027-12-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
DORAH NAMPIJJA
ID: UNCST-2022-R009694
 Improving heart failure self-care with short, structured telephone calls in Uganda (HEART-CALLS)
REFNo: HS5307ES

To improve heart failure self-care through feasible and acceptable short, structured telephone calls in Uganda
Uganda 2024-12-10 15:16:13 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kamya Moses
ID: UNCST-2020-R014203
 Transformative approaches to rapidly and efficiently test demand creation interventions to promote HIV retesting in adults at increased risk of HIV The Innovative Behavioral Intervention Strategies Megatrial (IBIS-Megatrial) Study
REFNo: HS5319ES

Aim 1. Adapt behavioral economics interventions to promote HIV retesting using a participatory prototyping approach in rural Kenya and Uganda.
Aim 2. Determine the effectiveness of many behavioral economics interventions to promote HIV retesting among high-risk adults in a multi-arm randomized trial.
Aim 3. Estimate heterogeneous treatment effects and identify optimal demand creation interventions.

 Uganda 2024-12-10 15:15:04 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Hannah Kibuuka
ID: UNCST-2020-R014355
 Sub-Study C – “Evaluation of Host-Response and/or Pathogens from Biospecimens Collected with a Capillary Blood Collection TASSO that Minimizes Pain Among a Subset of Patients Enrolled in an Observational Study of Sepsis in Uganda
REFNo: HS5332ES

1) Identify pathogens collected via the minimal pain Tasso collection device and those
collected via venipuncture (0 Hour and Day 28 of the main study)
2) Identify host-response biomarkers collected via the minimal pain Tasso collection device
and those collected via venipuncture (0 Hour and Day 28 of the main study)
3) Evaluate the correlation between host biomarkers and pathogens collected via the
minimal pain Tasso collection device to those collected via venipuncture at two study
visits (0 Hour and Day 28 of the main study)
4) Evaluate collection failure rates with the Tasso device

Uganda 2024-12-10 15:13:26 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Naheem Tijani Adekilekun
ID: UNCST-2022-R010325
 Biogenic synthesis of silver nanoparticles from Termitomyces sp. and their antimicrobial activity against clinical samples of resistant pathogenic Candida species
REFNo: HS5244ES

i. To synthesize silver nanoparticles (AgNPs) by employing the metabolites of Termitomyces species;

ii. To characterize the AgNPs biosynthesized and establish the phylogeny of Candida species using molecular techniques;

iii. To determine the antimicrobial activity of the fabricated AgNPs in contrast to common antifungal agents against resistant pathogenic Candida species.

 Nigeria 2024-12-10 15:11:28 2027-12-10 Medical and Health Sciences Non-Clinical Trial Degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
 STANDARD Q Syphilis Ab Test – Validation of Specimens
REFNo: HS5333ES

The objective of this study is to demonstrate the equivalence of serum, venous whole blood (EDTA-K2, EDTA-K3, sodium citrate, sodium heparin), plasma (EDTA-K2, EDTA-K3, sodium citrate, sodium heparin) and fingerprick whole blood on the STANDARD Q Syphilis Ab Test according to WHO TSS-6 Part 1: 1.2.1.
 Uganda 2024-12-10 15:09:47 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Rose Nakasi
ID: UNCST-2022-R010805
 Automated Mobile Microscopy for Tuberculosis Diagnosis in Uganda
REFNo: SIR450ES

1. Create an open, labelled, inclusive dataset for digital sputum microscopy images collected from the Ugandan population,
2. Develop a machine learning aided point-of-care learning platform for digital sputum microscopy image acquisition and interpretation.
3. Develop machine learning models for automatic recognition of TB bacilli features in digital sputum microscopy images,
4. Integrate the developed models in a decision support web application,
5. Validate the developed system in a clinical study.

 Uganda 2024-12-10 15:02:13 2027-12-10 Engineering and Technology Non-Clinical Trial Non-degree Award
Yasushi Miyauchi
ID: UNCST-2023-R005483
 Analysis of excitatory amino acids in Ustilago maydis of maize and sorghum in northern Uganda.
REFNo: A475ES

To measure the amount of each excitatory amino acid contained in Ustilago maydis of maize and sorghum by using Gas Chromatography,
 Japan 2024-12-10 15:01:21 2027-12-10 Agricultural Sciences Non-Clinical Trial Degree Award
Saidah  Menya
ID: UNCST-2024-R003540
 Improving quality maternal and new-born care: An investigation into the relevance and effectiveness of quality care processes in three health facilities with in Nakaseke and Luwero districts in Uganda
REFNo: HS5038ES

4. To evaluate whether the quality improvement process improves maternal and newborn outcomes. ,3. To establish a baseline data and evaluate whether the quality improvement process increases quality of care scores in three health facilities and compare with the baseline,2. To implement and monitor the quality improvement tool and relevant processes and gather feedback on their relevance and utility in the AdaraNewborn facilities.,1. To develop a quality improvement process within all AdaraNewborn facilities, including a quality improvement tool that prioritise the WHO maternal and newborn health standards,To monitor and assess the implementation of quality improvement processes to evaluate whether they contribute to improved quality of care within a health facility and overall maternal and newborn outcomes.,
 Uganda 2024-12-10 14:58:15 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Muriel Mac-Seing
ID: UNCST-2024-R005208
 Invisibility of disability in Global South and North: Equitable access to health services in the context of climate change
REFNo: SS3507ES

To strengthen research collaboration and solidarity through co-creation, trust-building, and inclusive co-learning between partners and researchers from Uganda and Canada.,Considering the results of the above objective, to further explore the perspectives of relevant intersectoral actors on the relationships between access to health services for women and men with disabilities, including access to veterinary services for their animals, and climate change in Québec, Canada, and Gulu District, Northern Uganda.,To identify key priority research areas through a scoping review that will synthesise the existing literature and identify research gaps in the relationships between access to health services for PWD, including access to veterinary services for their animals, and climate change.,To explore the perspectives on the relationships between access to health services among women and men with disabilities and climate change in the Global South and North.,
 Canada 2024-12-10 14:56:23 2027-12-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Deo Nsamba
ID: UNCST-2024-R004495
 INNOVATIVE ALTERNATIVE INTERIOR DECORATES AND EXECUTION OF SEMI ABSTRACT LANDSCAPE MONUMENTS AT KABALE UNIVERSITY
REFNo: SIR319ES

i. To assess areas with quality clay around Kabale using a pilot study in developing innovative interior decorates and semi abstract landscape monuments
ii. To identify and analyze the characteristics and properties of selected clays in the laboratory of civil engineering Kabale University. for use in developing innovative interior decorates and semi-abstract landscape monuments.
iii. To explore and develop creative techniques for transforming the selected local clays into innovative interior decorates and semi abstract landscape monuments.
iv. To execute and evaluate the effectiveness of the developed interior decorates and semi abstract landscape monuments in enhancing aesthetic appeal, functionality and sustainability.
Research questions


i. How will quality clay around Kabale be assessed in developing an innovative interior decorates and semi abstract landscape monuments.
ii. What type of selected local clays will be identified and analyzed through their characteristics and properties in Kabale for use in developing innovative interior decorates and semi abstract landscape monuments?
iii. What suitable techniques will be explored and developed to have creative techniques that will transform the selected local clays into innovative interior decorates and semi abstract landscape monuments?
iv. How will creative innovative approaches of innovative interior decorates and semi abstract landscape monuments be executed and evaluated?

Uganda 2024-12-10 14:54:46 2027-12-10 Engineering and Technology Non-Clinical Trial Non-degree Award
Sarah Lewinger Julianne
ID: UNCST-2024-R004045
 Prayer, Poetry, and Protest: Pentecostalism and Political imagination among Ugandan Youth
REFNo: SS2594ES

The primary objective of this research project is to investigate how young people in Kampala, Uganda, aged eighteen to thirty-five, mobilize charismatic Christian discourses, practices, and communities to imagine their futures, engage with politics, and navigate conditions of political repression, economic precarity, and social disintegration. Specifically, the project aims to:
1. Explore the diverse ways in which young people draw upon charismatic Christianity as a resource for making sense of their lives, asserting their dignity, and envisioning alternative social and political possibilities.
2. Examine how young people's "god-talk" – a critical and creative method of biblical reinterpretation and intimate conversation with the divine – challenges conventional understandings of the political and expands notions of political agency and engagement.
3. Investigate the role of social memory in shaping contemporary youth political imaginations, by considering how young people's religious-political expressions both draw upon and depart from earlier movements, such as the Holy Spirit Movement.
4. Identify and analyze the spaces, practices, and cultural forms through which young people develop and express their political subjectivities, with a focus on artistic and creative practices, such as spoken word poetry and music.
5. Contribute to anthropological debates on the complex and often contradictory role of religion in social movements, as well as the ways in which marginalized youth navigate and challenge the constraints of their political contexts.
This project aims to generate new insights into the religious and political imaginations of urban Ugandan youth, and to shed light on the diverse and unexpected ways in which young people are actively engaging with politics outside of the formal political sphere. By taking seriously the political significance of religious and artistic imaginaries, this research has the potential to expand our understanding of what constitutes the political and to contribute to broader debates about youth agency, social movements, and the role of religion in public life.
USA 2024-12-10 14:52:31 2027-12-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
PREETI KUMARI
ID: UNCST-2024-R001852
 Science Laboratory Operationalization, Secondary School Students’ Academic Attitude, Motivation, and Performance in Mbarara City, Uganda
REFNo: SS3434ES

1. To assess the conditions of science laboratories in secondary schools in Mbarara City, Uganda, to get a ground-level reality check.
2. To examine the relation between science laboratory operationalization and student’s attitude towards science.
3. To investigate the effect of science laboratory operationalization on motivation in choosing science as a career.
4. To relate the science laboratory operational conditions to students' performance in science education.
5. To study the mediation effect of student’s attitude and motivation in science subjects on performance.

 India 2024-12-10 14:47:47 2027-12-10 Social Science and Humanities Non-Clinical Trial Degree Award
sandra etumah omon
ID: UNCST-2024-R003992
 Assessment of the Nutritional Profile and Biochemical Adaptation of Zea mays L. Grown around Kilembe Mining Area, Kasese, Uganda
REFNo: NS809ES

1. To assess the Physicochemical characteristics of the soil and heavy metal content such as copper, lead, cobalt, Nickel, Cadmium, Mercury, chromium, and arsenic at the research site.
2. To analyze the heavy metals content (copper, lead, cobalt, Nickel, Cadmium, Mercury, chromium, and arsenic) of the maize plant grown at the mining site and their translocation.
3. To analyze the nutritional profile: proximate analysis (carbohydrates, protein, fats/oil, crude fiber, moisture, and ash), mineral element (iron, magnesium, manganese, calcium, sodium, phosphorus, sulfur, and potassium), and Vitamins (thiamine, niacin, riboflavin, retinol, cobalamin, pyridoxine, tocopherol, ascorbic acid, and cholecalciferol) of the maize grown around the mining site.
4. To assess the oxidative stress markers (malondialdehyde, tocopherol, and proline) and the enzymatic antioxidant capacity (glutathione peroxidase, superoxide dismutase, and catalase) in the leaves during the vegetative stage of the maize plant.
5. To quantitatively determine the hormonal levels (ABA, auxins, and brassinosteroids) in the leaves during the vegetative stage of the maize
6. To determine bioremediation options from the culturable rhizospheric soil bacteria isolated from around the mining site.

 Nigeria 2024-12-10 14:44:20 2027-12-10 Natural Sciences Non-Clinical Trial Degree Award
Maria Magdalene Namaganda
ID: UNCST-2021-R004319
 Development of a machine learning model for prediction of virological failure in a resource-limited setting
REFNo: HS3982ES

Sub-study 1 To identify the risk factors associated with virological failure among PLWH in east Africa from 2014 to 2024. Sub-study 2 To analyse the trends of ART use and incidence of virological failure rates among PLWH in TASO-Uganda health centres from 2014 to 2024. Sub-study 3 To develop and validate machine learning models for prediction of virological failure. Sub-study 4 To evaluate the practical utility of the HIV virological failure predictive models developed in a clinical setting.
Uganda 2024-12-10 14:40:45 2027-12-10 Medical and Health Sciences Non-Clinical Trial Degree Award
Jackson Orem
ID: UNCST-2021-R012016
 A Phase III, Randomized, Open-Label, Non-Inferiority Study of Paclitaxel and Pegylated Liposomal Doxorubicin for Treatment of HIV-related Kaposi Sarcoma in Resource-Limited Settings
REFNo: HS4073ES

To describe the incremental cost-effectiveness ratio per QALY gained (as assessed by PROPr) between PLD and PTX,To assess quality of life across PROMIS domains (i.e., cognitive function, physical function, fatigue, pain interference, depressive symptoms, anxiety, ability to participate in social roles and activities, and sleep disturbance) with the PROPr tool at start of therapy, mid-treatment, and after treatment with PLD and PTX ,To describe the cost of therapy across AMC sites in sub-Saharan Africa to deliver both PLD and PTX by micro-costing analysis for goods and time-in-motion analysis for services. ,To estimate the objective response rate (defined as the sum of complete and partial responses) for AIDS-KS, response duration and overall survival in each treatment arm. ,To evaluate whether there is sufficient evidence to conclude that PLD is non-inferior to PTX in people with severe AIDS-associated KS receiving concomitant ART in resource-limited settings. ,
 Uganda 2024-12-10 14:39:24 2027-12-10 Medical and Health Sciences Clinical Trial Non-degree Award
Adelline Twimukye
ID: UNCST-2019-R000117
 HIV CARE AND ANTENATAL HEALTH SEEKING BEHAVIOUR PATTERNS OF PREGNANT AND BREAST-FEEDING WOMEN DURING PREVIOUS COVID-19 PANDEMIC IN UGANDA
REFNo: SS3219ES

To document the challenges faced by pregnant and breastfeeding women with HIV in accessing healthcare services in the COVID-19 period.,To interrogate the effects of COVID-19 pandemic to adherence to routine clinic appointments and antiretroviral therapy (ART) among pregnant and breast-feeding women living with HIV.,To examine the social or cultural norms that influence access to care among pregnant or breast-feeding women HIV during the COVID-19 pandemic.,To investigate health care worker’s knowledge, attitude, and practices about COVID-19 among pregnant and breast-feeding women living with HIV in Uganda.,The purpose of the study is to explore HIV care and antenatal seeking behavior patterns of pregnant and breast-feeding women during response and control of COVID-19 pandemic in Uganda.,
 Uganda 2024-12-10 14:37:39 2027-12-10 Social Science and Humanities Non-Clinical Trial Degree Award
VICENT MWESIGYE
ID: UNCST-2024-R002866
 LYMPHEDEMA: CAUSATIVE AGENTS, PATIENT AND CARETAKER KNOWLEDGE, SELF-REPORTED HEALTHCARE NEEDS AND PREVENTIVE STRATEGIES IN KAMWENGE DISTRICT.
REFNo: HS5335ES

3. To explore the lymphedema-related knowledge, lived experiences and healthcare needs of patients and their caretakers and preventive strategies in Kamwenge district, South Western Uganda.,2. To determine the causative agents of lymphedema among patients with lymphedema in Kamwenge district, South Western Uganda.,1. To describe the Preventive strategies, their effectiveness in patients with Lymphedema based on Scoping review globally.,To determine the causative agents, patient and caretaker knowledge, self-reported healthcare needs and preventive strategies amongst Lymphedema patients in Kamwenge District South Western Uganda.,
 Uganda 2024-12-10 14:35:45 2027-12-10 Medical and Health Sciences Non-Clinical Trial Degree Award
Tess Lallemant
ID: UNCST-2023-R007159
 How do Firms Hire? A Demand-Side Experiment to Reduce Matching Frictions in Uganda Labor Markets
REFNo: SS3487ES

1. Answer the research question: How do firms navigate the hiring process for graduate workers?
2. Answer the research question: How are firms identifying their employment needs?
3. Answer the research question: How are firms communicating their employment needs?
4. Answer the research question: To what extent are these hiring frictions affecting match quality?
5. Answer the research question: Do firms learn about hiring and adapt their search strategies to achieve higher match quality?
 USA 2024-12-10 14:24:53 2027-12-10 Social Science and Humanities Non-Clinical Trial Degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
 Optimizing the Implementation and Scale-Up of the WHO Treatment-Decision Algorithms for Children with Pulmonary Tuberculosis in Sub-Saharan Africa (OPTIC-TB)
REFNo: HS5246ES

1) To compare the effectiveness of TDA versus the Standard of Care strategies in routine non-research programmatic conditions.
2) To identify processes and contextual factors that influence the effectiveness and fidelity in the implementation of TDA.
3) To compare the costs, cost-effectiveness, and population-level impact of the TDA strategies on the burden of TB.
4. To estimate/validate the diagnostic performance (sensitivity, specificity, negative and positive predictive values) of the TDAs for TB in children under 10 years old in various healthcare system settings and in various clinical contexts (i.e, such as HIV, malnourished children, facility level, gender, rural, urban etc.

Uganda 2024-12-10 14:06:31 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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