Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Edgar Mulogo Mugema
ID: UNCST-2023-R008170
Leveraging Molecular Technologies to Improve Diagnosis and Management of Pediatric Acute Respiratory Illness in Resource-Constrained Settings.
REFNo: HS4539ES

Refine existing host immune response classifiers for the differentiation of bacterial and viral causes of febrile ARI among children in Uganda. Determine the etiology of febrile ARI episodes using a diagnostic assessment that includes physician adjudication and is augmented by pathogen metagenomics. Develop and internally validate a host immune response signature that differentiates between causes of pediatric ARI in Uganda using previously identified gene transcripts. Develop novel clinical algorithms for pediatric ARI to inform antibiotic treatment decisions ,The objective of this proposal is to develop novel clinical algorithms for pediatric febrile ARI in sub-Saharan Africa to identify children with bacterial illness. To augment samples collected during a previous cohort study (MUST REC 14/03-19) to achieve sufficient sample size to develop a host gene expression signature that differentiates between viral and bacterial ARI, we will enroll 160 children presenting to St. Pauls Health Center IV with ARI and 20 healthy controls.,
Uganda 2024-07-26 15:44:44 2027-07-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Stephen Okoboi
ID: UNCST-2019-R001356
UNDERSTANDING DRIVERS OF TB AND MALARIA PREVALENCE AND INCIDENCE, AND BARRIERS TO UPTAKE OF HEALTH SERVICES AND RETENTION IN CARE – COMMUNITY VOICE PERSPECTIVE IN NAMAYINGO DISTRICT
REFNo: SS2915ES

To collaboratively develop recommendations for driving sustainable impact and improving health outcomes in the context of TB and malaria.,To identify community-specific needs and gaps in current TB and malaria interventions and healthcare delivery systems.,To explore the socio-economic, cultural, and behavioral factors influencing the spread and persistence of TB and malaria within communities.,To engage directly with community members to understand their perspectives on the barriers and drivers of TB and malaria prevalence and incidence.,To understand the drivers of TB and malaria prevalence and incidence, as well as barriers to the uptake of health services and retention in care from a community voice perspective in Namayingo district,
Uganda 2024-07-26 15:43:11 2027-07-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
William  Veness Andrew
ID:
Assessing Causal Processes of Multi-Hazard Risk in the Rwenzori Region
REFNo: NS842ES

Generation of an evidence base for solutions through a multi-hazard risk assessment inthe Rwenzori Mountains
Hydrological characterisation of the highlands
Evidencing the mechanisms of landslides and potential for vegetative stabilisation
Evidencing geomorphological changes in river valleys
Assessment of whether water quality is being impacted by soil erosion
UK 2024-07-26 15:42:01 2027-07-26 Natural Sciences Non-Clinical Trial Degree Award
Ronald Angupale Jimmy
ID:
Design, Development and Characterization of Drug Delivery Systems for Ugandan Antimalarial Plants - Artemisia annua, Vernonia amygdalina and Microglossa pyrifolia
REFNo: HS1886ES

4. To optimize the developed drug delivery system(s) with respect to the critical product quality attributes and assess their antimalarial efficacy and safety,3. To design and develop suitable herbal drug delivery systems (conventional and novel) for the plant extracts,2. To carry out preformulation studies (physicochemical properties) for the plant extracts,1. To determine in vivo antimalarial efficacy of selected combinations of A. annua, V. amygdalina and M. pyrifolia ,To design, develop and characterize drug delivery systems for selected Ugandan antimalarial plants – Artemisia annua, Vernonia amygdalina and Microglossa pyrifolia,
Uganda 2024-07-26 13:50:14 2027-07-26 Medical and Health Sciences Non-Clinical Trial Degree Award
Jenny Löfgren
ID: UNCST-2024-R005428
Outcomes of paediatric inguinal hernia repair performed by surgeons versus medical officers
REFNo: HS4508ES

Calculate and compare costs and cost-effectiveness between the two groups. ,Compare patient related outcomes between the group that has been operated on by medical officers versus those who were operated by general surgeons. ,The general objective of the proposed study is to investigate the possibility of task sharing between general surgeons and medical officers in inguinal hernia repair in children in Uganda. ,
Sweden 2024-07-23 15:30:50 2027-07-23 Medical and Health Sciences Clinical Trial Degree Award
Immaculate  Atukunda
ID: UNCST-2021-R013573
EVALUATION OF A NEW LOW-COST APPLANATION TONOMETER (NEWTON) IN UGANDA
REFNo: HS3998ES

To evaluate the acceptability of the use of Newton to measure IOP in patients by different eye care workers.,To evaluate the acceptability of the use of Newton to measure IOP by patients,To evaluate agreement between IOPs from the Newton versus two other established tonometers (Goldmann applanation tonometer (GAT) and iCare).,To determine the specificity and sensitivity of Newton in measuring IOP versus Goldmann applanation tonometer (GAT) as the gold standard.,
Uganda 2024-07-23 14:44:42 2027-07-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
John ILUNGOLE Stephen
ID:
EVALUATION OF THE EFFECTIVENESS OF UMEME WUUYO CAMPAIGN AGAINST POWER THEFT IN UGANDA
REFNo: SIR339ES

ii. To find out whether the public received the messages used in the Wuuyo communications campaign against power theft. ,i. To assess the effectiveness of campaign messages used in the Wuuyo campaign against power theft. ,To assess whether the Umeme Wuuyo Communications Campaign against power theft in Uganda was successful.,
Uganda 2024-07-22 17:18:00 2027-07-22 Engineering and Technology Non-Clinical Trial Degree Award
LAKER SCOVIA
ID: UNCST-2023-R006650
Antioxidants and Nutritional Potential of Enriched Millet Based Composite Flour Using Spirulina (Arthrospira platensis)
REFNo: A432ES

The objectives will be to; 1. determine the proximate composition (moisture content, ash content, fiber content and protein content) in non-germinated and germinated millet flours of eight selected local millet varieties (Ekwangapel, Ekaama, Emoro moru, Ayuku manyige, Odyera, Min bel, Luk caa and Adyang adyang). 2. determine the concentration of minerals (zinc, calcium, magnesium and iron) in non-germinated and germinated millet flours of eight selected local millet varieties (Ekwangapel, Ekaama, Emoro moru, Ayuku manyige, Odyera, Min bel, Luk caa and Adyang adyang). 3. determine the concentration of anti-nutritional factors (oxalates, tannins and Phytates) in non-germinated and germinated millet flours of eight selected local millet varieties (Ekwangapel, Ekaama, Emoro moru, Ayuku manyige, Odyera, Min bel, Luk caa and Adyang adyang). 4. determine the antioxidant potential (Beta carotene) in spirulina powder and germinated millet composite flours of three selected local millet superiors. 5. determine the consumer acceptability of the spirulina millet-based product (porridge) of three selected local millet superiors.
Uganda 2024-07-22 17:15:54 2027-07-22 Agricultural Sciences Non-Clinical Trial Degree Award
Alex Ario Riolexus
ID:
Surveillance System Performance, Timeliness Metrics and Framework of Response to Anthrax Outbreaks in Uganda: Implications for Programming and Control of Zoonotic Diseases Epidemics
REFNo: HS4277ES

4- Develop a One Health Model response framework for zoonotic disease outbreaks,3- Examine timeliness of response to anthrax outbreaks in Uganda for the period 2014 to 2023 and compare with 7:1:7 as a metric for strengthening response and improving systems in real time,2- Assess the human and animal anthrax surveillance system functions and attributes in Uganda,1- Identify gaps in epidemiological investigations of anthrax outbreaks in Africa for the period 2014 to 2023,The general objective of this study is to assess performance of the surveillance system and timeliness of response to anthrax outbreaks in Uganda, 2014 - 2023.,
Uganda 2024-07-22 17:13:33 2027-07-22 Medical and Health Sciences Non-Clinical Trial Degree Award
Swaibu Zziwa
ID: UNCST-2022-R011017
MOBILITY RECOVERY AFTER A LOWER LIMB BONE FRACTURE; EFFECTS OF A MULTI- COMPONENT HOME BASED REHABILITATION PROGRAM ON MOBILITY RECOVERY IN GREATER KAMPALA, UGANDA
REFNo: HS4641ES

1.To describe the type of care received by patients with lower limb fractures after hospital discharge in Greater Kampala, Uganda. 2.To determine mobility recovery and predictors of mobility recovery among patients with lower limb bone fractures in Greater Kampala, Uganda. 3.To develop and validate a multi component home based rehabilitation program to improve mobility recovery among patients with lower limb bone fractures in Greater Kampala, Uganda. 4.To evaluate the effect of a multi component home based rehabilitation program on mobility recovery among patients with lower limb bone fractures in Greater Kampala, Uganda.
Uganda 2024-07-22 17:09:51 2027-07-22 Medical and Health Sciences Non-Clinical Trial Degree Award
AKANKWASA JOHNSON
ID: UNCST-2023-R006429
Factors Associated with Home Based Care Services in the Control of Covid - 19 Infection in Sheema Municipality, Sheema District
REFNo: SS2402ES

3.To establish the existing, new policies and practices about home based care agencies that addressed challenges resulting from the COVID-19 pandemic in the 3 years of the peak pandemic.,2. To establish the social demographic, social economic and environmental factors that affected home based care services (HBC) in all the COVID-19 suspects during 2019 pandemic.,1. To investigate the level of utilization of Home Based Care services (HBC) in percentages among the isolated COVID-19 suspects in the control of COVID-19 infection in Sheema Municipality from 2020 to 2023.,To establish factors associated with Home Based Care Services (HBC) during COVID -19 infection in Sheema Municipality, Sheema District.,
Uganda 2024-07-22 17:06:47 2027-07-22 Social Science and Humanities Non-Clinical Trial Degree Award
Mathias Seviiri
ID:
Genetics of Glaucoma in High-risk Diverse Populations (GoGLAD) Study
REFNo: HS3427ES

General objective
To apply and critically evaluate the efficacy of genetic-based risk prediction models for glaucoma in an understudied, high-risk, genetically diverse continental African population in Uganda.

Specific objectives
1. To test the feasibility of collecting quality pilot clinical data on glaucoma related phenotypes, genetic data from a unique high-risk diverse population in Uganda.
2. To assess cross-ancestry genetic-based prediction of glaucoma risk in major diverse ancestry populations.
2A- To apply our current European-based genetic prediction model of glaucoma to a high-risk population of African ancestry from Uganda.
2B - To develop, and calibrate an African ancestry genetic prediction model of glaucoma and implement it in populations of European and African ancestries.
2C- To develop, model and calibrate a cross-ancestry genetic prediction model and apply it in populations of European and African ancestries.
3. To apply artificial intelligence to eye images to characterise ancestral differences in glaucoma risk and evaluate estimation of disease risk and progression.
4. To assess participants’ attitude towards genetic testing for glaucoma.

Uganda 2024-07-22 17:03:10 2027-07-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Nura Izath
ID: UNCST-2022-R009201
Autothermo-a wearable continuous temperature measuring bracelet with a central display screen.
REFNo: HS3034ES

To assess the performance of Autothermo- a wearable continuous temperature measuring bracelet and a central display screen in comparison to the standard thermometer.,To assess the feasibility and acceptability of Autothermo among health workers and parents/caregivers of admitted neonates at Mbarara Regional Referral Hospital(MRRH).,
Uganda 2024-07-22 16:57:35 2027-07-22 Medical and Health Sciences Clinical Trial Non-degree Award
David Aderu
ID: UNCST-2023-R008280
Mainz II Pouch: A viable option for the incurable fistula in Uganda
REFNo: HS3247ES

3. To assess the quality of life of recipients of the Mainz II pouch in clients with fistula deemed incurable at SRRH from 2009 to 2018.,2. To describe sonographic characteristics of the upper urinary tract in recipients of the Mainz II pouch procedure at SRRH from 2009 to 2018.,1. To determine the biochemical profile of patients with fistula deemed incurable who have undergone Mainz II pouch procedure at SRRH from 2009 to 2018.,To evaluate the viability of the Mainz II urinary diversion for women with Fistula deemed incurable in Uganda. ,
Uganda 2024-07-22 16:53:11 2027-07-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Aisha Nanyiti
ID: UNCST-2021-R013489
Electric cooking in the energy transition: how much subsidization is needed?
REFNo: SS2896ES

To assess the willingness to pay for modern electronic cooking technology within the grid connected urban and peri-urban areas. To assess the effect of benchmark goods on the willingness to pay for modern electronic cooking technology. To assess the impact of information provision towards the demand for modern electronic cooking technology within the grid connected urban and peri-urban areas.
Uganda 2024-07-22 16:52:07 2027-07-22 Social Science and Humanities Non-Clinical Trial Non-degree Award
JOSELYN RWEBEMBERA
ID: UNCST-2021-R013915
Identifying the Essential Elements of Case Managers and Peer Support Groups for Prophylaxis Adherence in Rheumatic Heart Disease” (CAMPS Plus)
REFNo: HS4346ES

Objective 1: Determine the difference in 1-year SAP adherence rates of children newly diagnosed with RHD in Uganda receiving one of two support strategies: case manager only (CM) and case manager plus peer support group (CM + PG).

Objective 2: Explore implementation determinants among case managers, participants, and participant families to inform deployment of program at scale.
Uganda 2024-07-22 16:49:34 2027-07-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ronald Kiguba
ID: UNCST-2019-R000844
Understanding adverse drug reactions to dolutegravir and isoniazid in people living with HIV in Uganda: incidence, risk factors, management and patient reporting
REFNo: HS3364ES

To determine the incidence, characteristics and risk factors of ADRs to DTG/ IPT in PLHIV in Uganda,To identify barriers and facilitators of using the app to report ADRs by PLHIV in Uganda,To determine the rate of ADR-reporting by PLHIV at selected ART-sites in Uganda,To implement the Med Safety app to promote ADR-reporting by PLHIV in Uganda,To identify genetic polymorphisms associated with DTG-induced weight gain and hyperglycaemia, and isoniazid-related hepatotoxicity, using the GWAS approach among PLHIV in Uganda,To investigate the prevention, monitoring, management of ADRs to DTG/ IPT in PLHIV in Uganda,
Uganda 2024-07-22 16:37:17 2027-07-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Elisa  Macchi
ID: UNCST-2023-R004097
Pressure to Hire, Technology Adoption, and Productivity: Experimental Evidence from Uganda
REFNo: SS2013ES

1. The project aims at contributing to several strands of the literature. First, an emerging literature
hasshown how social- and self-image concerns affect the labor market through changesin the labor
supply

2. Our evidence suggests that the reputational concerns associated to hiring and technology
adoption decisions are induced by resource-sharing practices with kin and neighbors.

3. Finally, our work links to the literature on cross-country differences in productivity. Lewis et al.
(1954) observed that developing economies have a large “traditional sector” where marginal
productivity is low and where workers may be compensated above their marginal product through
informal arrangements (see Gollin (2014) for a recent discussion). When wages do not equal
marginal product, workers may be employed in relatively less-productive tasks, resulting in
misallocations. Gollinetal
Italy 2024-07-22 16:32:03 2027-07-22 Social Science and Humanities Non-Clinical Trial Degree Award
Patience Atuhaire
ID: UNCST-2023-R007423
TORCHES (TOXOPLASMOSIS, RUBELLA, CYTOMEGALOVIRUS, HERPES AND OTHER AGENTS LIKE SYPHILIS) and relation to Preterm Delivery and Low birth weight among pregnant women living with HIV and their babies in the IMPAACT 1077BF trial
REFNo: HS4352ES

Assess/evaluate the associations between select peripartum infections with risk of PTD and LBW, across the ART groups reported in PROMISE,assess the prevalence of select peripartum co-infections (TORCH infections) among PROMISE 1077BF women living with HIV and their HEU babies at the MU-JHU CRS in Kampala Uganda using stored plasma specimens obtained at delivery,
Uganda 2024-07-22 15:03:09 2027-07-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Douglas Bulafu
ID: UNCST-2021-R011774
From COVID-19 to Ebola: How did lessons on Maintaining Essential Health Services during the COVID-19 Pandemic inform the Ebola response in Uganda?
REFNo: HS4422ES

5. To compare disruption to essential health services due to COVID-19 and Ebola in Mubende and Kassanda districts of Uganda.,4. To estimate the effect (disruption) of COVID-19 and Ebola in Mubende and Kassanda districts of Uganda.,3. To explore the challenges faced during implementation of public health and social measures during the Ebola epidemic in Uganda.,2. To document how lessons from previous pandemics informed the application of public health and social measures during the Ebola epidemic in Uganda.,1. To document how lessons from previous epidemics informed the health system adaptations to ensure the continuity of essential health services during the Ebola epidemic in Uganda.,To compare disruption to essential health services during COVID-19 and the 2022 Ebola outbreak and document how lessons from the COVID-19 pandemic informed the Ebola response in Uganda to inform how to prevent and respond to future epidemics.,
Uganda 2024-07-22 15:02:01 2027-07-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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