GRACE MARY KENYONGA
ID:
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Attitudes towards the use of pre-exposure prophylaxis for HIV among women in Uganda
REFNo: SS1473ES
General aim
Examine the attitudes towards the use of pre-exposure prophylaxis for HIV among women in Uganda.
Specific Objectives
1. Explore the attitudes women have towards PrEP
2. Identify the factors that influence the present attitudes towards PrEP
4. Identify other community variables that may encourage or constrain the uptake of PrEP.
6. Identify and recommend necessary interventions and measures to counteract any prevailing negative attitudes towards PrEP that may be prevailing in the community.
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Uganda |
2023-03-28 1:00:59 |
2026-03-28 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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Alison Elliott
ID: UNCST-2023-R006524
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Risk factors for severe schistosomal morbidity: an adult case-control study
by the Uganda Schistosomiasis Multidisciplinary Research Centre (U-SMRC)
REFNo: HS2570ES
We hypothesise that factors at each step of the parasite life cycle interact to determine
morbidity in schistosomiasis.
The objective of this work is to investigate risk factors associated with advanced schistosomiasis morbidity among adults, using a case-control study.
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UK |
2023-03-24 2:35:04 |
2026-03-24 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Birungi Edwin Mutahunga Rwamatware
ID: UNCST-2021-R004880
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Prevalence and predictors of antimicrobial resistance in clinical- and community-acquired upper respiratory bacterial samples in children under 5 in south-western Uganda
REFNo: HS2625ES
Upper respiratory infections are the second leading cause of death in children under 5 in Uganda, and account for 40% of all under-5 outpatient attendance at clinics and hospitals nationwide in Uganda.
As bacterial cultures of lung aspirates are often not practical, the WHO recommends using a rapid breathing and chest wall in-drawing to diagnose pneumonia in children under 5, and recommends treatment with oral amoxicillin or co-trimoxazole, or intramuscular penicillin. The only study of anti-microbial resistance (AMR) in nasopharyngeal bacteria in Uganda comes from healthy children in the Iganga/Mayuge region (Eastern Uganda), where the authors found that one-third of children were given a self-prescribed antibiotic within the past two weeks for fever, running nose, or cough, that 60% carried Streptococcus pneumoniae, and that a high proportion (80% to 99%) of cultures were resistant to co-trimoxazole, penicillin, and oxacillin.
At Bwindi Community Hospital, suspected acute respiratory infections accounted for 75% of all under-5 outpatient diagnoses in 2015/2016, and are the most common reason for under-5 admissions to the Pediatrics Ward (e.g., 34% of 830 admissions in 2015/2016). In addition, the majority of antibiotics prescribed for both children and adults were for suspected acute respiratory illness (5,273 of 17,910 prescriptions). Our proposed study seeks to build on previous work concerning Antimicrobial Resistance in the developing world with a specific focus, on clinical- and community-acquired upper respiratory bacterial infections in children under 5 in southwestern Uganda, and it will be the first to analyse spatio-temporal patterns of resistance and explicitly link those patterns to cultural and social characteristics and behaviours on the ground as well as healthcare infrastructure.
We propose a multi-layered study to;
1) Analyze the prevalence and spatial associations of antibiotic resistance in nasopharyngeal bacterial isolates from children under 5 in the Bwindi Community Hospital (BCH) catchment area for a year in Kanungu District, Southwestern Uganda.
2) Assess the use of antibacterial drugs at home to treat acute respiratory illness in these children from children under 5 in the Bwindi Community Hospital (BCH) catchment area in Kanungu District
3) Assess practices of antibiotic distribution at drug shops in the BCH catchment region.
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Uganda |
2023-03-24 2:31:31 |
2026-03-24 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Alison Elliott
ID: UNCST-2023-R006524
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Investigating determinants of varying schistosomal morbidity among
preschool-age children in the Lake Albert and Lake Victoria regions: a cohort study by the
Uganda Schistosomiasis Multidisciplinary Research Center
REFNo: HS2568ES
Our main objective is to understand the biological determinants of severe Schistosoma
mansoni-associated morbidity and to identify better strategies for its prevention and
control.
Our specific objectives are to:
1. Compare, in pre-school age children, early-life Sm infection and Sm-specific
immune responses between Lake Albert and Lake Victoria regions and identify
co-exposures that modulate Schistosoma mansoni-specific immune responses
and morbidity risk
2. Determine if there is a parasite genetic basis for differential Schistosoma
mansoni morbidity
3. Determine how the population biological determinants of fresh-water snail
Biomphalaria spp. act as local epidemiological drivers of Schistosoma mansoni
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UK |
2023-03-24 2:29:21 |
2026-03-24 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Olive Kobusingye Chifefe
ID:
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Building the evidence-base for the integration of rehabilitative services into health systems – a case study of clubfoot treatment in Uganda
REFNo: HS2614ES
The study has two aims, each with subsequent research questions:
Aim 1: To explore how policy makers, health providers, and caregivers define, understand and experience service integration and the potential implications for clubfoot treatment. (Qualitative)
• How do health care providers define and experience service integration, and what are the impacts of integration on their day-to-day clinical operations, workflow, and roles?
• How do district- and national-level bureaucrats and donors understand integration, and how does that shape integration of clubfoot treatment?
• How do caregivers understand and experience integration, and how does it impact their child’s treatment?
• How is the NCPU financed and what relationship does financial contribution have with integration?
Aim 2: To improve understanding of how the CAST mobile health application (CAST) impacts health providers’ behavior, and what potential impacts the CAST could have on service quality. (Mixed)
• What is the reach and adoption rate of CAST and its components among eligible Ugandan providers?
• How might CAST modify provider behavior at the facility level, both for clubfoot treatment and other services?
• How might the CAST facilitate quality of care and patient treatment?
o How do supportive services from MiracleFeet/CoRSU contribute to this? (e.g. training, supportive supervision, help desk)
o How does data from and usage of the Cast Community contribute to this?
• What is the potential future of the CAST if external support is withdrawn from clubfoot treatment and all services are fully managed by the public sector?
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Uganda |
2023-03-24 2:25:26 |
2026-03-24 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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