Yahaya Gavamukulya
ID: UNCST-2019-R001017
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Green Synthesis and Biochemical Evaluation of Anticancer Activities of Silver Nanoparticles Conjugated Ethanolic Extracts of Leaves of Annona muricata (Graviola)
REFNo: NS43ES
General Objective
To undertake green synthesis and biochemical evaluation of anticancer activities of AgNPs-conjugated ethanolic extracts of leaves of Annona muricata (Graviola).
Specific Objectives
1. To conduct LCMS analysis of the ethanolic extracts of leaves of Annona muricata and undertake green synthesis and characterization of the extracts’ mediated AgNPs.
2. To investigate the effects of the AgNPs-conjugated ethanolic extracts of leaves of Annona muricata on the biological properties (morphology, migration, growth, and death) of selected cancer cell lines using selected assays.
3. To evaluate the effects of the AgNPs-conjugated ethanolic extracts of leaves of Annona muricata on the transcriptome for expression of cancer associated genes in selected cancer cell lines using RNA-Seq analysis.
4. Evaluation of the in vivo anticancer activities of the AgNPs-conjugated ethanolic extracts of leaves of Annona muricata against chemically induced tumours in mice models.
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Uganda |
2018-02-13 |
2021-02-13 |
Natural Sciences |
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Degree Award |
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Helen Liebling Jane
ID:
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Sexual and Gender-Based Violence and Torture Experiences of South Sudanese Refugees in Northern Uganda: Health and Justice Responses
REFNo: SS126ES
Specific objectives are to:(1) examine the experiences of South Sudanese refugees and impact of Sexual and Gender-Based Violence (SGBV) and torture on their lives (2) analyse reproductive and psychological health,and justice needs of refugees from their own and service providers’ perspectives
and (3) evaluate responses to refugees by state justice, health services and key
stakeholders.
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UK |
2018-02-13 |
2021-02-13 |
Social Science and Humanities |
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Non-degree Award |
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Helen Byakwaga
ID: UNCST-2019-R001168
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Study of Newly Diagnosed Kaposi's Sarcoma
REFNo: HS157ES
1) Describe the clinical and laboratory characteristics of HIV-infected patients who develop KS.
2) Determine survival after KS occurrence in both ART-treated and ART-untreated HIV-infected patients.
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Uganda |
2018-02-13 |
2021-02-13 |
Medical and Health Sciences |
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Non-degree Award |
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Stephen Kyakulumbye
ID:
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A framework for developing citizen-centric e-government applications in developing contexts: The design-reality gap
REFNo: IS9ES
To document a feasible participatory design methodology for citizen e-government applications.
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Uganda |
2018-02-13 |
2021-02-13 |
Social Science and Humanities |
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Degree Award |
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Mohammed Lamorde
ID: UNCST-2019-R001293
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Steady-state pharmacokinetics of efavirenz (Sustiva/Stocrin) 400 mg once daily in the presence of rifampicin and isoniazid (Rifinah or the local generics)
REFNo: HS161ES
Primary Objective: To evaluate the steady-state pharmacokinetics of efavirenz (Sustiva/Stocrin) 400 mg once daily during co-administration with rifampicin and isoniazid (Rifinah or local generic)
Secondary Objectives:
1. To assess the safety and tolerability of efavirenz (Sustiva/Stocrin) 400 mg once daily during co-administration with rifampicin and isoniazid (Rifinah or local generic)
2. To investigate the association between genetic polymorphisms in drug disposition genes and drug exposure.
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Nigeria |
2018-02-06 |
2021-02-06 |
Medical and Health Sciences |
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Non-degree Award |
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Mohammed Lamorde
ID: UNCST-2019-R001293
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A PHARMACOKINETIC EVALUATION OF ETONOGESTREL IMPLANT IN HIV-INFECTED WOMEN ON DARUNAVIR VERSUS RIPILVIRINE-BASED ANTIRETROVIRAL THERAPY (DRIVE-I)
REFNo: HS145ES
Primary objective:
To compare the PK of ENG (68 mg) contraceptive implant over 6 months in Ugandan HIV-infected women receiving DRV-based ART or RPV-based ART versus historical controls
Secondary objectives:
(1) To predict the disposition of ENG over the subsequent 2.5 years of intended use through PK modeling of ENG concentrations beyond 12 months of use in HIV-infected women using DRV- or RPV-based ART
(2) To describe the PK exposure over 12 months of ENG contraceptive implant in Ugandan HIV-infected women receiving DRV-based ART or RPV-based ART
(3) To describe the pharmacokinetics of DRV 12 hours post-dose (C12) and RPV 24 hours post-dose (C24) prior to and during 12 months of combined use with ENG.
(4) To describe the safety and tolerability of combined use of DRV/RTV or RPV and ENG during 12 months of combined use.
(5) To describe the relationship between ENG concentrations and participant specific covariates including body weight, albumin, sex-hormone binding globulin and pharmacogenetic factors.
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Nigeria |
2018-01-29 |
2021-01-29 |
Medical and Health Sciences |
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Non-degree Award |
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Mohammed Lamorde
ID: UNCST-2019-R001293
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A PHARMACOKINETIC EVALUATION OF LEVONORGESTREL IMPLANT IN HIV-INFECTED WOMEN ON DARUNAVIR VERSUS RIPILVIRINE-BASED ANTIRETROVIRAL THERAPY (DRIVE-II)
REFNo: HS146ES
Primary objective: To compare the PK of LNG (150 mg) contraceptive implant over 6 months in Ugandan HIV-infected women receiving DRV-based ART or RPV-based ART versus historical controls.
Secondary objectives:
(1) To compare the PK of LNG over 12 months among women receiving DRV-based ART or RPV-based ART versus historical controls
(2) To predict the disposition of LNG over the subsequent 4 years of intended use through PK modeling of LNG concentrations beyond 12 months of use in HIV-infected women using DRV- or RPV-based ART
(3) To describe the pharmacokinetics of DRV 12 hours post-dose (C12) and RPV 24 hours post-dose (C24) prior to and during 12 months of combined use with LNG.
(4) To describe the safety and tolerability of combined use of DRV/r or RPV and LNG during 12 months of combined use.
(5) To describe the relationship between LNG concentrations and participant specific covariates including body weight, albumin, sex-hormone binding globulin and pharmacogenetic factors.
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Nigeria |
2018-01-29 |
2021-01-29 |
Medical and Health Sciences |
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Non-degree Award |
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Charlotte Hawkins
ID:
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The Anthropology of Smartphones and Smart Ageing
REFNo: SS141ES
This project will investigate fundamental changes in people’s relationship to age and health associated with the global rise of the smartphone. The aim is to combine an intellectual challenge in understanding the contemporary nature of age and the impact of new media, with an applied challenge to use this knowledge to help make mHealth (mobile health) interventions more effective. mHealth has potential both for helping those with limited access to professional care but also threatens to bypass and undermine professional medical services. Our aim is to complement technology-led mHealth interventions with ethnography-led participatory design, consisting of a three-way collaboration between mHealth professionals, our ethnographically informed team and our informants in the field. We aim to demonstrate how such collaborations can lead to more culturally appropriate mHealth interventions and more effective improvements in people’s lives.
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UK |
2018-01-29 |
2021-01-29 |
Social Science and Humanities |
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Degree Award |
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Rose Gawaya
ID:
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Challenges faced by women’s organisations in the AID space: Case studies in South Africa and Uganda
REFNo: SS90ES
The purpose of the research is to explore how women’s organisations access and utilise development aid. Access and utilisation of development aid impact on how women’s organisations achieve their organisational goals to address problems faced by women.
The specific study objectives are to:
1.Determine how women’s organisations define and respond to the development aid space.
2.Identify what functions determine the participation of women in the development aid space.
3.Examine how access and utilisation of development aid contributes to feminist agendas.
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Uganda |
2018-01-16 |
2021-01-16 |
Social Science and Humanities |
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Degree Award |
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Charles Okuonzi
ID:
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Follower Voice Behavior and Leadership Competencies of Owner-managers in SMEs in Uganda
REFNo: SS142ES
The objective of thestudy is to establish the relationship between follower voice behaviour and leadership competencies of Ugandan SME owner-managers. The study is purely academic and shall involve owner-managers from 65 SMEs and 500 of their followers as respondents
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Uganda |
2018-01-11 |
2021-01-11 |
Social Science and Humanities |
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Degree Award |
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