Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Kirsten Ward
ID:
Evaluation of delivery practices for multiple vaccines at a single immunization visit in low- and middle-income countries Uganda
REFNo: HS170ES

Aim: This evaluation aims to describe current preparation, administration and communication practices in the delivery of more than one vaccine to a single child at a single immunization visit in Uganda. Objectives: 1. To document the processes and techniques used to prepare and administer more than one vaccine, primarily injectable vaccines, to children in Uganda; 2. To understand the timing, content, and extent of communication messages about co-administration of one or more vaccines and post-vaccination care delivered by providers to caregivers in Uganda; and 3. To use results from 1 & 2 to develop recommendations about best practices for: a) the preparation and delivery of multiple vaccines with a focus on injectable vaccines, and b) provider communication to the caregiver about delivery of multiple vaccines and post-vaccination care.
Australia 2018-05-15 2021-05-15 Medical and Health Sciences Non-degree Award
Damalie Nakanjako
ID:
Inflammation and immune aging among HIV-infected adults with at least 12 years of antiretroviral therapy in an African cohort.
REFNo: HS194ES

1. To describe innate system phenotype and function [Natural killer (NK) cells, monocytes and innate lymphoid cells (ILCs)], after long-term suppressive HAART for at least 12 years of HAART, within the Infectious Diseases Institute (IDI) HIV treatment cohort. 2. To determine levels of immune aging markers among HIV-infected adults with suppressive ART, relative to age-and gender-matched HIV negative counterparts, despite twelve years and more of suppressive ART. 3. To describe those biological pathways which remain deranged after at least 12 years of suppressive HAART, and identify markers/pathways that are known to increase the risk of non-AIDS complications of chronic HIV.
Uganda 2018-05-15 2021-05-15 Medical and Health Sciences Non-degree Award
Joy Gumikiriza- Onoria Louise
ID:
SELF - PERCEPTIONS OF AGING AND QUALITY OF LIFE AMONG THE ELDERLY IN UGANDA
REFNo: HS195ES

To 1) Examine the association between quality of life and perceptions of aging among older people in rural and urban Uganda, 2) Translate and culturally adapt the Brief Aging perceptions questionnaire (B-APQ), and 3) Translate and culturally adapt the Older People’s Quality of Life questionnaire (OPQOL) for use with Luganda speaking older people in Uganda.
Uganda 2018-05-15 2021-05-15 Medical and Health Sciences Non-degree Award
Caitlin Jenks Alexandra
ID:
EVALUATION OF ANEMIA PREVENTION EFFORTS AFFECTING YOUTH IN IGANGA, UGANDA; CASE OF MUSANA COMMUNITY DEVELOMENT ORGANIZATION
REFNo: HS198ES

General Objective To evaluate the quality of the current anemia prevention efforts at MCDO, as well as the behavior and beliefs around anemia from healthcare workers and other staff, so the findings can be used to enhance the organization’s strengths, and implement recommended changes. Specific Objectives Objective 1 To evaluate, through staff interviews and a research survey tool, the MCDO staff’s current knowledge and beliefs on anemia and how much emphasis they deem should be placed on prevention efforts. Objective 2 To find out, through staff interviews and observations, if there are any current prevention efforts surrounding anemia on MCDO’s campuses including nutrition education, supplementation, deworming policies, and malaria prevention strategies. Objective 3 To observe and evaluate qualitative data on the student’s consumption of food on a weekly basis, living quarters, classrooms, dining areas, and footwear of the nursery and primary school students at MCDO.
USA 2018-05-15 2021-05-15 Medical and Health Sciences Degree Award
Pakoyo Kamba Fadhiru
ID:
Burden and drivers of controlled prescription drug abuse among selected populations in Uganda
REFNo: HS203ES

The goal of this project is to determine the magnitude and factors associated with controlled prescription drug abuse among selected high risk populations in Uganda. There are five specific objectives: • To establish the prevalence of controlled prescription drug abuse among health care workers in Uganda. • To establish the prevalence of controlled prescription drug abuse among patients with mental disorders in Uganda. • To establish the drivers of controlled prescription drug abuse among health care workers and patients with mental disorders in Uganda. • To establish the compliance of Uganda’s medicine supply chain to regulations on controlled prescription drugs. • To establish the factors associated with compliance of Uganda’s medicine supply chain to regulations on controlled prescription drugs
Uganda 2018-05-15 2021-05-15 Medical and Health Sciences Non-degree Award
Sylvia Nabukenya
ID: UNCST-2019-R000906
ASSESSMENT OF THE INFORMED CONSENT PROCESS FOR STUDIES INVOLVING GENETIC RESEARCH AMONG PEOPLE LIVING WITH HIV AT THE INFECTIOUS DISEASES INSTITUTE (IDI)
REFNo: HS199ES

1. To assess the adequacy of informed consent documents used for pharmacogenetic research and the collection, storage and future use of human samples. 2. To determine the methods used by researchers to ensure research participants’ understanding during the informed consent process in pharmacogenetic research. 3. To assess the factors that influence participants’ understanding during the consent process in pharmacogenetic research
Uganda 2018-05-04 2021-05-04 Medical and Health Sciences Degree Award
Jenna  Wozniak Marie
ID:
Community Knowledge, Attitudes, and Practices Around Individual Blackfly Control and the Diseases They Transmit in Northern Uganda
REFNo: HS200ES

The objective of this research project is to determine what individual level control efforts are being used to protect against blackfly biting within communities. Although large-scale control efforts have been implemented in onchocerciasis endemic regions, individual level control efforts are not well recorded or understood. Through the use of a KAP (knowledge, attitudes, and practices) survey it is hoped that this will be understood. Demographic data will also be collected to find correlations between knowledge and education level. Future application of this information can be used to either modify existing methods or to suggest personal control methods for communities where onchocerciasis and nodding syndrome are endemic. This project will take place in the district of Kitgum and Lamwo in northern Uganda were both onchocerciasis and nodding syndrome have been observed. Over a five-week period, I will travel to several communities within each district to conduct my survey. The research question of this project is what do individuals in communities where onchocerciasis and nodding syndrome are observed know as well as perceive about blackflies and what practices do they use to prevent blackfly biting?
USA 2018-05-04 2021-05-04 Medical and Health Sciences Degree Award
Pakoyo Kamba Fadhiru
ID:
Elucidating the mechanism of interaction of mycobacteria rhomboid proteases with their specific substrates
REFNo: NS49ES

The goal is to elucidate the mechanism(s) of interaction of mycobacteria rhomboid proteases with their specific native substrates. There are three specific objectives: • To identify the native peptide substrates for mycobacteria rhomboid proteases. • To elucidate the substrate residues essential in interaction with mycobacteria rhomboid proteases. • To elucidate the mycobacteria rhomboid protease residues essential in interaction with their substrates.
Uganda 2018-04-30 2021-04-30 Natural Sciences Non-degree Award
Andrea  Calcagno
ID:
Using Calcaneal Quantitative Ultrasound (cQUS) and urine Retinol Binding Protein to screen HIV-infected cART-treated patients for reduced bone mineral density: a pilot study
REFNo: HS204ES

Primary objective: To compare DEXA and cQUS in predicting reduced BMD in a population of Ugandan HIV-infected individuals on long-term cART. Secondary objective: To assess the prevalence of abnormal RBP/Cr and the correlation between abnormal RBP/Cr and reduced BMD.
Italy 2018-04-30 2021-04-30 Medical and Health Sciences Non-degree Award
Michael Juma
ID:
EXAMINING THE EFFECT OF SERVICE DELIVERY FACTORS ON TIMELY INITIATION OF TUBERCULOSIS TREATMENT WITHIN PRIMARY CARE SETTINGS IN UGANDA
REFNo: HS205ES

The study goal is to examine the association between service delivery factors and timeliness of Tuberculosis treatment initiation within accredited primary care facilities in Uganda. Here service delivery factors are characteristics relating to HF structure and care delivery. The specific aims are: Aim 1: To explore the association between service-delivery factors (structural and care delivery characteristics) and process timeliness (diagnosis time, laboratory turnaround time and treatment initiation time) Aim 2: To measure the association between process timeliness and Tuberculosis treatment initiation Aim 3: Describe perspectives of healthcare workers (in-charges of outpatient departments, heads of clinical teams and heads of laboratories) within each accredited health facility on preventing delays in diagnosis and initiation of Tuberculosis treatment.
Uganda 2018-04-30 2021-04-30 Medical and Health Sciences Degree Award
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