Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Gorrette Nalwadda Kayondo
ID:
Analysis of Reproductive Maternal Newborn Child Adolescent Health Referral Pathways in Rural and Urban Health Care Settings in Uganda
REFNo: HS646ES

1. Examine the referral pathways relevant to RMNCAH from community level to the various health system levels that is HC II – IV, district and regional referral hospitals.
2. Explore the key challenges, lessons learnt and opportunities that enable or hinder RMNCAH referrals
3. Propose practical ways of improving the referral pathways for better RMNCAH service delivery outcomes in Uganda.

 Uganda 2020-11-04 2023-11-04 Medical and Health Sciences Non-degree Award
David Ayebare Santson
ID:
Factors Influencing Cervical Cancer Screening In Sheema District
REFNo: HS661ES

To identify the socio-demographic, cultural, and economic factors influencing low uptake of Cervical Cancer Screening services among women aged 25-49 years in Sheema district.
 Uganda 2020-11-04 2023-11-04 Medical and Health Sciences Non-degree Award
Lydia Nakiyingi
ID:
Effect of the COVID-19 situation on vulnerable HIV-infected and -affected adolescent girls and young women: A case of Kampala district
REFNo: HS746ES


General objective
• To determine the effect of the Uganda COVID-19 response on underprivileged HIV-infected and affected adolescent girls and young women with the aim is to develop relevant interventions, informed by their experiences, to address their actual needs.
Specific objectives:
• Document experiences of underprivileged HIV-infected and -affected adolescent girls and young women in Kampala during the COVID-19 period.
• Determine unmet needs of underprivileged HIV-infected and -affected adolescent girls and young women during the COVID-19 period.
• Assess perceptions of HIV-infected and affected adolescents towards the COVID-19 prevention interventions.
• Determine effects of the COVID-19 situation on physical, mental and psychosocial wellbeing of underprivileged HIV-infected and -affected adolescent girls and young women.
• Develop COVID-19 context-specific implementable recommendations (guided by the study’s findings) to inform interventions for underprivileged HIV-infected and -affected adolescent girls and young women.

 Uganda 2020-11-04 2023-11-04 Medical and Health Sciences Non-degree Award
Timothy  Muwonge Ronald
ID: UNCST-2020-R014680
 DIAL-COVID: Remote mitigation through telephone symptom surveillance in refugee settlements in Uganda
REFNo: HS901ES

The primary objective is to assess uptake and validate a mobile telephone surveillance and mitigation tool (“Dial-COVID”) in refugee settlements in Uganda.
The secondary objectives are:
1. To implement a mobile telephone interactive voice response (IVR) symptom tracker and information dissemination tool (“Dial-COVID”) and assess its uptake in the refugee population.
2. To iteratively test and validate a screening algorithm for COVID-19 using symptoms and risk factors reported by Dial-COVID users to predict infection determined by positive COVID-19 tests.
3. To assess COVID-19 risk perceptions and knowledge among refugees.
4. To understand barriers and facilitators to adoption of COVID-19 prevention and control measures in refugee settlements.
 Uganda 2020-11-04 2023-11-04 Medical and Health Sciences Non-degree Award
Sarah  Skeen
ID:
The Sharing Stories Project: Promoting playful parenting through sharing digital books in the COVID-19 era
REFNo: SS517ES

Relying on in-person book-sharing models, we will adapt this project to be deliverable over WhatsApp, and engage parents through sending digital books, holding weekly webinars, and sending individualized messages to support parents’ mental health and wellbeing. We will partner with the Regional Psychosocial Support Initiative (REPSSI) and the Africa Early Childhood Network (AfECN) to deliver this digital intervention to parents with young children with the aim to promote parenting through play, parental sensitivity, responsiveness and mental health, and child social, emotional and cognitive development.

South Africa 2020-11-04 2023-11-04 Social Science and Humanities Non-degree Award
SHEBA  NAKACUBO GITTA
ID:
How can UK Health Worker Volunteers Effectively and Sustainably Support the Development of Ugandan Health Workforce?
REFNo: HS837ES

1. To provide an overview of current approaches and priorities to health worker volunteer placements in Uganda;
2. To identify the priority needs for health worker volunteer placements in partnership with the Ministry of Health;
3. To give insight into the volume of health worker placements available and make recommendations on how such schemes can be designed to achieve mutual benefit for the UK, Uganda and other host countries.

 Uganda 2020-11-02 2023-11-02 Medical and Health Sciences Non-degree Award
Rhoda Wanyenze
ID: UNCST-2021-R013352
 Development of a community-led intervention to prevent and control unintended immediate socio-economic and health consequences of COVID-19 among slum dwellers in Kampala, Uganda 2020
REFNo: SS638ES

1. To assess the immediate socio-economic and health vulnerabilities due to COVID-19 among slum dwellers of Bwaise I and Bwaise III, in Kampala Uganda.
2. To explore predisposing factors to the vulnerabilities.
3. To determine the level of adherence and barriers to compliance with COVID-19 prevention measures.
4. Use the Human centred design (HCD) to explore and design potential interventions to reduce vulnerabilities and determine their feasibility.
5. To explore lessons for future policy and designing inclusive outbreak interventions for slum dwellers.

 Uganda 2020-10-29 2023-10-29 Social Science and Humanities Non-degree Award
Namuguzi Namuguzi Mary
ID:
Exploring Individual Health-Promoting Lifestyle Behaviours for Prevention of Hypertension in Rural Communities of Uganda
REFNo: HS617ES

1. What knowledge do individuals have about prevention of hypertension in rural communities of Uganda?
2. What individual health lifestyle behaviours influence the prevalence of hypertension in rural communities of Uganda?
3. What is the prevalence of hypertension in two rural communities (Mende and Kasengejje) of Uganda?
4. How do individuals in rural communities of Uganda prevent hypertension?
5. What interventions are effective for the prevention of hypertension in Low and Middle-income countries?

 Uganda 2020-10-27 2023-10-27 Medical and Health Sciences Degree Award
Viola  Nyakato Nilah
ID: UNCST-2021-R013698
 Understanding the Marginalized Indigenous Batwa People of South-Western Uganda
REFNo: SS452ES

The general objective of the study is to generate data on the livelihood of Batwa indigenous community living in the districts of Kabale, Kisoro, Rubanda and Kanungu in Southwestern Uganda, in order to build evidence around the factors that compromise their livelihoods across policy, access to services and resources, culture and their history/heritage.

The specific objectives of the study will be:
1.To assess and understand the vulnerable issues and factors of marginalization of the Batwa from the districts of Kabale, Kisoro, Rubanda and Kanungu
2.To generate evidence on the social, structural and other barriers the Batwa Community face for their livelihood improvement interventions
3.To undertake participatory approaches to develop and evaluate development interventions improvement for the Batwa livelihoods
4.To propose recommendations on how to develop appropriate livelihood improvement programmes and policies for Batwa indigenous people communities living South Western Uganda.

 Uganda 2020-10-27 2023-10-27 Social Science and Humanities Non-degree Award
LYNDA NAKALAWA ESTHER
ID:
The dilemma of youth empowerment in Uganda:interrogating the mindset question
REFNo: SS454ES

Research Questions
Overall Research Question: How have the mindsets of youth from selected youth empowerment programs in Uganda been shaped by the social, cultural and historical processes at play in the society within which these programs operate.
Specific research questions
1. How are youth positioned in the social, cultural and historical discourse around youth empowerment in Uganda?
2. What is the impact of this discourse on the mentalities, including attitudes, unconscious biases or ingrained beliefs of youth in selected youth empowerment programs in Uganda?
3. How are the youth’s mindsets expressed in their behavior or actions?
 Uganda 2020-10-27 2023-10-27 Social Science and Humanities Degree Award
Rodgers Tugume
ID:
prevalence and factors associated with pelvic organ prolapse among women attending gynaecological outpatient clinic of Mbarara Regional Referral Hospital
REFNo: HS706ES

1.To determine the prevalence of pelvic organ prolapse among women attending gynaecological outpatient clinic at Mbarara regional referral hospital.
2.To determine the commonest stage of pelvic organ prolapse at presentation of women attending gynecological outpatient clinic at MRRH.
3.To identify the socio-demographic, obstetric, gynaecological, and medical factors associated with pelvic organ prolapse among women attending gynecological clinic at Mbarara Regional Referral Hospital.

 Uganda 2020-10-27 2023-10-27 Medical and Health Sciences Degree Award
George  Semivule William
ID:
MANAGEMENT PRACTICES AND IMPLEMENTATION OF STRATEGIC PLANS, IN NDEJJE UNIVERSITY UGANDA
REFNo: SS480ES

1. To determine the effect of planning implementation of of strategic plans on Ndejje University.

2. To assess the effects of organizing on implementation of the strategic plans of Ndejje University.

3. To establish how leading affects the implementation of strategic plans of Ndejje University.

4. To determine the effect of controlling on implementation of the strategic plans of Ndejje University.
Uganda 2020-10-27 2023-10-27 Social Science and Humanities Degree Award
Felix Twinomucunguzi Rutaro Baineki
ID:
A Socio-Technical Decision Support Framework for Reducing Groundwater Contamination Risk in Peri-Urban Areas, Kampala
REFNo: SS482ES

Determine the recent extent of groundwater contamination in low income peri-urban areas, with focus on emerging organic contaminants.

Investigate the specific vulnerability to emerging groundwater contamination in low income peri-urban areas.

Assess the key socio-institutional factors influencing increased risk of groundwater contamination in low income peri-urban areas.

Develop qualitative decision support framework for reducing risk of groundwater contamination in low income peri-urban areas.

 Uganda 2020-10-27 2023-10-27 Social Science and Humanities Degree Award
Hakim Sendagire
ID:
Evaluation of the World Health Organization criteria and the Uganda National Policy; antiretroviral treatment regimen switch, from first line to second line HIV drug combinations, following ‘virological failure but without drug resistance testing’.
REFNo: HS743ES

1. To determine the prevalence of virologic failure among patients receiving first line failure in Uganda.
2. Establish the resistance patterns at the time of switching therapy.
3. Validate the correctness of the decision to switch therapy, thereby evaluate the WHO public health approach in management of ART.

Uganda 2020-10-27 2023-10-27 Medical and Health Sciences Non-degree Award
Jackson Orem
ID: UNCST-2021-R012016
 Effect of Patient Navigation Services on Patients’ Experience of Cancer Care and Adherence to Treatment at Uganda Cancer Institute 2020-2023
REFNo: HS950ES

Overall research Objective
To assess the effect of patient navigation program on patients’ experience of cancer care and adherence to treatment at Uganda Cancer Institute
Specific research Objectives
1.To assess changes in patient barriers to accessing care and adhering to treatment as a result of the implementation of patient navigation services at UCI
2.To assess the changes in patients’ experience of cancer care as a result of the implementation of patient navigation services at UCI
3.To assess the changes in adherence to treatment as a result of the implementation of patient navigation services at UCI.

 Uganda 2020-10-27 2023-10-27 Medical and Health Sciences Non-degree Award
Patrick  Ogwok
ID:
Effectiveness of a combined food literacy and physical activity intervention to optimize metabolic health among women of reproductive age in urban Uganda
REFNo: HS974ES

1. To assess the effect of the combined food literacy and physical activity intervention on metabolic health (waist circumference, blood glucose; blood lipid profile – total cholesterol, HDL cholesterol and triglycerides; body composition and blood pressure) of WRA in urban Uganda 2. To assess the effect of the combined food literacy and physical activity intervention on moderate physical activity behavior among WRA in urban Uganda 3. To assess the effect of the combined food literacy and physical activity intervention on consumption of fruits and vegetables among WRA in urban Uganda 4. To assess the effect of the combined food literacy and physical activity intervention on the use of food, nutrition and physical activity information among WRA in urban Uganda
Uganda 2020-10-27 2023-10-27 Medical and Health Sciences Degree Award
Gloria Seruwagi Seruwagi
ID:
Adherence, Lived Experiences and Resilient Transformation among “slumdwellers” (ALERTs) in COVID-19: A study of Ki-Mombasa and Kabalagala-Kataba slums in Kampala
REFNo: SS555ES

General objective
We seek to study slum dwellers’ lived experiences, assess behavioural shifts and determine public compliance and social behaviour in light of COVID-19.
Specific objectives
1. To assess knowledge or awareness of COVID-19 and local perception of risk in urban slums. This will also capture infodemic issues, myths, fears, etc
2. To identify local pre-post COVID attitudes and practices relating to health and social norms. This will include e.g. WASH, healthseeking behaviour, community cohesion practices
3. To explore implementers’ interpretation and enforcement of COVID-19 guidelines. Implementers will include healthworkers, police, LDUs, politicians, etc
4. To determine the feasibility of, and adherence to, COVID-19 preventive measures.
Will include local interpretations, experiences, innovations, improvisations and explanatory factors
5. To identify community resources, systems and assess their efficacy in the COVID-19 response. This will cover essential systems & services including health, social care and community leadership


 Uganda 2020-10-26 2023-10-26 Social Science and Humanities Non-degree Award
Michael Olanya West
ID:
Head Teachers’ Views of their Instructional Leadership Practices; A Case Study of Four Primary School Head Teachers in Kitgum Municipal Council, Uganda
REFNo: SS568ES

a) To investigate how primary school head teachers in Kitgum Municipal Council perceive their instructional leadership practices
b) To find out head teachers’ understanding about instructional leadership practices
c) To find out factors which facilitate or hinder head teachers’ practice of instructional leadership
 Uganda 2020-10-26 2023-10-26 Social Science and Humanities Degree Award
JOAN KEMPANGO
ID:
“Assessment of Factors Associated with Acquisition of Clinical Competences Among Undergraduate Nursing Students in Ugandan Universities”
REFNo: HS639ES

1) To determine the involvement of clinical mentors in the undergraduate acquisition of clinical skills;
2) To investigate clinical mentors preparedness in facilitating undergraduate student’s clinical skills
3) To assess student perception of the learning environment in a clinical set-up among undergraduate nursing students in Uganda;
4) To identify the available learning resources for the acquisition of clinical skills among undergraduate nursing students in Uganda;
5) To establish the influence of institutional factors on competence acquisition by the undergraduate nurses in Uganda.
6) To establish the effect of student factors on clinical competence acquisition by the undergraduate nurses in Uganda.

 Uganda 2020-10-22 2023-10-22 Medical and Health Sciences Degree Award
Mary  Nanteza Bridget
ID:
Does recombination of polio viruses with locally circulating enteroviruses play a role in acute flaccid paralysis and vaccine-derived polioviruses?
REFNo: HS770ES

1. General Objective
To identify polio mutations that are common to AFP, and cVDPV cases.

2. Specific Objective
i) To determine if polio/non-polio recombination has occurred in AFP cases
ii) To characterize primary recombination events in the polio virus genome that are associated with AFP, and
iii) To compare the recombination events common in AFP with published cVDPVs and characterize the events that could be common in VDPVs.

 Uganda 2020-10-22 2023-10-22 Medical and Health Sciences Non-degree Award
Munshi Sulaiman
ID:
Evaluation of the Disability-Inclusive Ultra-Poor Graduation Programme (DIG) in Uganda
REFNo: SS529ES

1. To estimate the impact of the Ultra-Poor Graduation programme on poverty, livelihood and social participation of people with disabilities and their families, compared to controls who do not receive the intervention.
2. To estimate the impact of the Ultra-Poor Graduation programme on poverty, livelihood and social participation of people with disabilities and their families, compared to people without disabilities who received the intervention
Bangladesh 2020-10-22 2023-10-22 Social Science and Humanities Non-degree Award
Cristina Clerici
ID:
The Parallel Pandemic of Domestic Violence Against Women in Uganda: is the Lockdown to Blame?
REFNo: SS553ES

Our project seeks to study the relationship between IPV and the relative economic conditions of spouses in Uganda, by exploiting the implementation of COVID-19 containment measures as a source of exogenous variation in the woman's relative income.
Italy 2020-10-22 2023-10-22 Social Science and Humanities Degree Award
Pontiano  Kaleebu
ID: UNCST-2020-R019901
 PERCEPTIONS OF HEALTHCARE WORKERS REGARDING LOCAL INFECTION PREVENTION AND CONTROL PROCEDURES FOR COVID-19
REFNo: HS867ES

Primary aim: To better understand health care worker perceptions of infection prevention and control procedures to prevent Covid-19 transmission.

Objectives:
1. To evaluate healthcare worker perceptions of their preparedness to ensure effective infection prevention and control of Covid-19 in healthcare settings, and to evaluate healthcare worker’s level of trust in their healthcare organization/facility.

2. To consider how these factors vary
a. Across age, staff role, and length of clinical experience;
b. Between respondents whose hospital is receiving suspected/ confirmed patients and those whose hospitals are not;
c. Between those who have direct experience of treating Covid-19 patients and those who have not.
d. Across different regions in the country that have dealt with other epidemics other than COVID19.
e. Between countries in different global regions where this survey is conducted.

 Uganda 2020-10-22 2023-10-22 Medical and Health Sciences Non-degree Award
Imran Rasul
ID:
Firm Dynamics and Worker Resilience to the COVID-19 Shock in Uganda
REFNo: SS565ES

The overall objective of this prpject is to study the effects of the Covid-19 shock on SMEs and workers in Uganda. The study will aim at answering the following research questions:
1. What firm-level characteristics predict firm survival and growth in an expansionary business cycle? Do the same characteristics predict firm resilience to the shock of COVID-19?
2. How do markets evolve during periods of economic growth, in terms of the number of firms, firm size distribution, and level of competition? How does the COVID shock affect the structure and level of competition within markets?
3. How do different types of skills training affect workers’ resilience to the economic shock caused by COVID-19?

 UK 2020-10-22 2023-10-22 Social Science and Humanities Non-degree Award
Fred Wabwire-Mangen
ID: UNCST-2021-R013549
 Assessing the Burden of Asymptomatic SARS-COV-2 Infection among Patients Seeking Health Care at Health care facilities in Uganda
REFNo: HS889ES

To determine the prevalence of SARS-CoV-2 among a sample of patients seeking health care and HCWs at participating surveillance sites who do not meet the case definition for COVID-19.
 Uganda 2020-10-22 2023-10-22 Medical and Health Sciences Non-degree Award
ANNETTEE NAKIMULI OLIVIA
ID: UNCST-2022-R011194
 In-depth case study of large referral maternity wards in four countries in sub-Saharan Africa: a case study of Kawempe National Referral Hospital and Mulago Specialized Women and Neonatal Hospital in Uganda
REFNo: HS907ES

1) To document the preparedness and response to COVID-19 among large maternity/newborn wards in four countries in sub-Saharan Africa over time
2) To serve as a platform for exchange of information and experiences across the contexts studied.

 Uganda 2020-10-22 2023-10-22 Medical and Health Sciences Non-degree Award
Joyce Kambugu Balagadde
ID: UNCST-2020-R014996
 A regional approach to improved childhood cancer drug access in East Africa: Understanding access and coordinating procurement
REFNo: HS681ES

1. Undertake detailed institutional and health system data collection to obtain key metrics of drug availability and price in participating jurisdictions 2. Describe policies and practices related to childhood cancer drug procurement and provision in partner jurisdictions 3. Analyse the key determinants of childhood cancer drug access in the health system context 4. In partnership with national governments, establish agreements and mechanisms for coordinated procurement of essential childhood cancer medicines, based on evidence-based estimates of need.
Uganda 2020-10-21 2023-10-21 Medical and Health Sciences Non-degree Award
Brian Kanaahe Mwebaze
ID:
“Understanding And Addressing The Sexual Reproductive Health And Rights Needs Of Young Women And Girls In Humanitarian Settings In Nigeria And Uganda"
REFNo: SS611ES

1.Synthesize existing literature on the Sexual Reproductive Health and Rights challenges of young refugee women and girls, highlighting promising solutions and best practice service delivery models.
2.Conduct participatory, mixed methods formative research to generate evidence on the Sexual Reproductive Health and Rights knowledge and challenges of young women and girls in the target refugee settings.
3.Assess existing service provision models against global standards and best practice guidelines for adolescent/youth friendly Sexual Reproductive Health and Rights services in humanitarian settings with a comparison between refugees and Internally Displaced Persons (IDPs).
4.Support existing Sexual Reproductive Health and Rights initiatives in refugee camps in the target countries to use emerging evidence to improve advocacy for, demand for, and provision of Sexual Reproductive Health and Rights services for adolescent girls.
 Uganda 2020-10-21 2023-10-21 Social Science and Humanities Non-degree Award
Harriet Mpairwe
ID: UNCST-2025-R017439
 Psychosocial well-being and urbanisation among adults in Uganda: A pilot study
REFNo: HS831ES

1. To assess the feasibility of collecting data on psychosocial factors among adults in urban (Kampala) and rural (Mpigi and Wakiso) Uganda
2. To establish the hair cortisol concentration assay in our immunology laboratory
3. To assess the acceptability of scalp hair sample collection for research purposes

 Uganda 2020-10-19 2023-10-19 Medical and Health Sciences Non-degree Award
Fred Ssewamala
ID: UNCST-2020-R014060
 Suubi4STEM: A signature program to advance STEM education in Africa
REFNo: SS475ES

Objective 1. Test the feasibility, acceptability, and preliminary impact of innovative Suubi4STEM intervention in promoting educational STEM opportunities and life options for young people in Uganda.

Objective 2. Qualitatively examine participants’ and facilitators’ intervention experiences and identify individual, family and institutional-level facilitators and barriers to Suubi4STEM intervention implementation and participation. Objective 3. Evaluate the cost of implementing Suubi4STEM. Objective4. Disseminate program findings to promote the Suubi4STEM intervention on a larger scale

 Uganda 2020-10-16 2023-10-16 Social Science and Humanities Non-degree Award
Mandela Wangoola Robert
ID:
FACTORS INFLUENCING TRYPANOSOMA BRUCEI RHODESIENSE STABILITY IN CATTLE RESERVOIR IN LANGO SUB REGION
REFNo: NS135ES

General Objective
• Evaluate the factors influencing Trypanosoma brucei rhodesiense infections persistence and stability in the cattle reservoir in Lango sub region
Specific objectives
(i) To determine the prevalence of bovine trypanosomiasis in Lango sub region.
(ii) Assess the stability of T. b rhodesiense in naturally infected cattle in Lango sub region
(iii) Evaluate risk factors leading to continued cattle trypanosomiasis infection in Lango sub region

 Uganda 2020-10-16 2023-10-16 Natural Sciences Degree Award
Sara Nsibirwa
ID: UNCST-2021-R012889
 Antimicrobial resistance in trauma and burn patients with blood stream or wound infections – an observational cohort study from Kampala, Uganda
REFNo: HS815ES

The primary aims:
• To determine the prevalence of blood stream due to specific bacterial and fungal pathogens resistant to first choice empirical treatment in trauma and burn patients.
• To determine the prevalence of wound infections due to bacterial and fungal pathogens resistant to first choice empirical treatment in trauma and burn patients
The secondary aims:
• To describe the proportion of burns and trauma patients requiring a switch of antibiotic or antifungal treatment following wound swab and blood culture results.
• To describe the clinical outcomes of trauma and burn patients with blood stream and wound infections due to bacterial and fungal pathogens resistant to first choice empirical treatment
• To identify risk factors for the development of wound and blood stream infections due to resistant bacterial and fungal pathogens among trauma and burn patients.


Uganda 2020-10-15 2023-10-15 Medical and Health Sciences Non-degree Award
Emmanuel Gusango Humphrey
ID:
Constructivist informed teaching and preparation of students in Primary Teachers Colleges of South Eastern Region in Uganda
REFNo: SS498ES

i. Explore the constructivist principles used in the instruction of students in Primary Teachers Colleges.
ii. Examine the constructivist practices applied to the school practice supervisory process in Primary Teachers Colleges.
iii. Examine the implementation of coaching in the preparation of students’ professional growth.

Uganda 2020-10-14 2023-10-14 Social Science and Humanities Degree Award
Robert Tweyongyere
ID:
Optimizing SMART Dairy Technologies for Efficient Sustainable Productivity of Dairy Farmers in Uganda
REFNo: A80ES

Specific objectives
1. Determine the dairying problems and constraints, current solution options and priority list of solutions which are gender sensitive across age and space.
2. Determine the dairy farmers’ cattle feeding and breeding practices in the milk sheds of Uganda
3. Determine local feed ingredients nutrient profile for optimal dairy feed ration formulation
4. Develop a farmers’ community based breeding program
5. Increase Farmers’ access to elite genetics by artificial breeding technologies (artificial insemination(AI) and Embryo transfer(ET))
6. Determine the nutritional-metabolic profiles among the dairy cattle in selected DaFaN clusters to Optimize cost-effective forage production, preservation and utilization
7. Determine animal health and breeding profile parameters generated by ruminal or collar sensor technology for effective monitoring of individual animals on farms in Uganda

 Uganda 2020-10-14 2023-10-14 Agricultural Sciences Non-degree Award
Robert Newton Edward
ID: UNCST-2023-R006537
 Community surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and of coronavirus disease-2019 (COVID-19) in high risk and general populations.
REFNo: HS823ES

1. To measure the changing incidence and prevalence of SARS-CoV-2 over time and, associated mortality. 2. To assess the impact of co-morbidities on acquisition and survival of SARS-CoV-2. 3. To examine in greater depth the public understanding of COVID-19 and the experience of the surveillance exercise.
UK 2020-10-14 2023-10-14 Medical and Health Sciences Non-degree Award
Robert Tweyongyere
ID:
EFFECTIVENESS OF ANTHELMINTICS IN CATTLE AND GOATS IN MIXED FARMING COMMUNITIES IN MBARARA, KIRUHURA SEMBABULE AND NAKASONGOLA DISTRICTS
REFNo: A83ES

General Objective:
To assess effectiveness of dewormers and generate information that would support decision on improving management of anthelmintics in Uganda

Specific objectives:
1. To document the knowledge, attitude and deworming practices of selected livestock farmers in Mbarara, Kiruhura, Sembabule and Nakasongola districts
2. Determine the worm burden among cattle and goats on the selected farms
3. To determine the ‘clinical efficacy’ of five identified dewormers commonly available to the farmers

Uganda 2020-10-14 2023-10-14 Agricultural Sciences Non-degree Award
Simon Peter Kibira Peter Sebina
ID: UNCST-2019-R000492
 Improving quarantine in Uganda as a key measure to combat COVID-19: Compliance, experiences, gaps and opportunities
REFNo: HS832ES

1. To determine compliance with COVID-19 quarantine measures among self and institutional quarantined persons in Uganda.

2. To determine factors associated with compliance with COVID-19 quarantine measures among self and institutional quarantined persons in Uganda.

3. To explore experiences and coping mechanisms among self and institutional quarantined persons in Uganda.

4. To identify gaps in the management and opportunities for improvement of the quarantine process in Uganda.
 

 Uganda 2020-10-14 2023-10-14 Medical and Health Sciences Non-degree Award
Victoria Nankabirwa
ID: UNCST-2021-R011871
 A multicenter, phase III, double-blind, randomised, active-controlled study to evaluate the efficacy and safety of VPM1002 in comparison to BCG in prevention of Mycobacterium tuberculosis infection in newborn infants
REFNo: HS838ES

Primary objectives
1. To demonstrate that VPM1002 is non-inferior to BCG SII in providing protection against incident Mtb infection
2. To demonstrate that vaccination with VPM1002 is superior to BCG SII in providing protection against incident Mtb infection

Secondary objectives
1. To compare the safety and tolerability profile of VPM1002 and BCG SII administered as a single dose to newborn infants
2. To compare the protective efficacy of VPM1002 versus BCG SII against TB disease
3. To compare the protective efficacy of VPM1002 versus BCG SII against sustained Mtb infection

Exploratory objectives
1. To evaluate the immunological response to vaccination with a single dose of VPM1002 compared to BCG SII in a subset (immunogenicity cohort) of HIV-exposed and HIV-unexposed newborn infants in terms of the following parameters:
o Concentration of Interferon (IFN)-γ in the supernatant after antigen re-stimulation as determined by ELISA
o CD4+ and CD8+ T-cells after antigen stimulation as determined by Fluorescence-activated cell staining/Intracellular cytokine staining (FACS/ICS)
o Transcriptomics
o Antibody production
2. To evaluate occurrence of QuantiFERON® Gold Plus In-tube test (QFT) conversion, where conversion is defined using alternative QFT thresholds (e.g. > 4 IU/ml); and sustained QFT conversion, where sustained conversion is defined as QFT ≥ 4IU /ml maintained for approximately 6 months following initial QFT conversion, compared across trial arms in all participants.
3. To determine the mortality rate in children receiving VPM1002 compared to BCG SII

Uganda 2020-10-14 2023-10-14 Medical and Health Sciences Non-degree Award
Victoria Nankabirwa
ID: UNCST-2021-R011871
 SARS-CoV-2 infection and COVID-19 in women and their infants in Kampala, Uganda
REFNo: HS915ES

Overall aim
To describe how the COVID-19 epidemic and Uganda's countermeasures affect women and their newborns, especially newborns of HIV-1 positive mothers, and to test whether BCG vaccination offers protection against SARS-CoV-2 infection and COVID-19.

Specific objectives
1. To investigate if BCG vaccination of HIV-1 exposed infants at birth or at 14 weeks of age protects them against SARS-CoV-2 infection and COVID-19 until 14 weeks of age or against COVID-19 between 15 and 52 weeks of age, respectively.
2. To estimate the evolving prevalence of SARS-CoV-2 infection and of COVID-19 among HIV-1 positive as well as among HIV-1 negative women who have recently given birth, and describe their association with hospitalization on the day of birth, complications during delivery, low birth weight, and other adverse outcomes
3. To estimate the evolving 14-week cumulative incidence of SARS-CoV-2 infection and of COVID-19 among mothers and babies, and evaluate whether maternal HIV-1 infection affects maternal and infant risk of developing COVID-19 of varying severity
4. To evaluate the impact of wide-ranging preventive measures to control COVID-19 on women giving birth during the epidemic, their children, and their families

 Uganda 2020-10-14 2023-10-14 Medical and Health Sciences Non-degree Award
Emanuel  Peter L
ID:
Development of Standardized Herbal Formulation: Synergy between Momordica charantia, Aloe vera and Abelmoschus esculentus for Glycemic Control
REFNo: NS119ES

Objectives
1. To establish ethnomedical use of M. charantia and A. esculentus among indigenous community in Tanzania.
2.To establish physicochemical and stability parameters of freeze dried aqueous extracts of the three plant species separately in pre-formulation studies.
3. To evaluate efficacy of combined freeze dried extracts in different ratios of doses of M. charantia, A. esculentus and A. vera in vivo.
4. To establish safety profile of best optimal dose combination of M. charantia, A. esculentus and A. vera on healthy Wistar female rats.
5. To design a solid pharmaceutical dosage form of the optimal dose combination and evaluate its stability, safety and efficacy in vivo.

Tanzania 2020-10-12 2023-10-12 Natural Sciences Degree Award
Christine Aanyu
ID:
EQUITABLE MATERNAL CARE FOR WOMEN WITH DISABILITY (EMeralD) STUDY
REFNo: HS722ES

1) Specific Aim 1. Conduct an analysis of disability, pregnancy and birth outcomes, and maternal health care utilization data for pregnant women with disabilities in Uganda.
2) Specific Aim 2. Understand the needs and perceptions of pregnant women with disabilities and identify availability of, and barriers to accessing, maternal health care services.
3) Specific Aim 3. Formulate and develop a model for disability-friendly services for pregnant women.

Uganda 2020-10-07 2023-10-07 Medical and Health Sciences Non-degree Award
David Serwadda -
ID:
Characterizing community exposure to SARS-CoV-2 in Uganda, and assessing biological determinants of virus spread
REFNo: HS878ES

1.Assess the diagnostic sensitivity and specificity of the CoronaChekTM rapid COVID-19 IgM/IgG lateral flow test (CoronaChekTM by Hangzhou Biotest Biotech Co Ltd) for anti- SARS-CoV-2 antibodies detection in Uganda.
2.Conduct enhanced surveillance of COVID19-like symptoms in the context of an existing population cohort and assess the predictive value of prevailing symptoms for COVID-19 exposure based on rapid serological testing in this region.
3.Determine rates of sero-reactivity/positivity among key health care workers at high-volume health centers III and IV and also among PCR-negative contacts of confirmed COVID-19 cases in the region.
4.Explore ‘prior importation of COVID-19 infection in Uganda”/ pre-existing sero-reactivity (may due to ‘related’ coronavirus strains/shared epitopes) in purposively selected archived sera, prioritizing from truck drivers and commercial sex workers that was collected before the lockdown in Uganda / Rakai region.

Uganda 2020-10-06 2023-10-06 Medical and Health Sciences Non-degree Award
Richard Idro
ID: UNCST-2021-R013599
 Dihydroartemisinin-Piperaquine or Sulphadoxine-Pyrimethamine for the Chemoprevention of Malaria in Children with Sickle Cell Anaemia in eastern and southern Africa: a double blind randomised trial (the CHEMCHA trial)
REFNo: HS709ES

Primary objective
The general objective is to determine the efficacy and safety of malaria chemoprevention with weekly single day courses of DP compared to monthly single courses of SP in children with SCA in eastern and southern Africa.

Secondary objectives
1. Assess the feasibility and stakeholder perceptions on the uptake (acceptability) and the potential for future roll-out of weekly DP vs monthly SP.
2. Determine the safety of cumulative dosing of DP, especially on cardiac function.
3. Monitor the development of malaria parasite resistance to DP in clinical isolates over time.
Assess patients’ health-related quality of life, cost-effectiveness, equity and economic implications of using weekly courses of DP vs monthly courses of SP as chemoprevention in SCA.
5. Assess acceptability of weekly courses of DP for malaria chemoprevention in SCA vs monthly courses of SP as chemoprevention in SCA.
6. Conduct policy advocacy to engage key stakeholders on policy decisions on using weekly courses of DP or monthly courses of SP for the chemoprevention of malaria in SCA.
 Uganda 2020-10-02 2023-10-02 Medical and Health Sciences Non-degree Award
Richard Idro
ID: UNCST-2021-R013599
 Hydroxyurea therapy for Neurological and Cognitive Protection in Pediatric Sickle Cell Anemia in Uganda: A single arm open label trial, “BRAIN SAFE II”
REFNo: HS846ES

The primary objective is to determine the impact of daily oral hydroxyurea therapy, 20- 30mg/kg/day, on the frequency and severity of Sickle Cell Vasculopathy(SCV) in a cohort of children treated for three years, as measured by 3 distinct outcomes: abnormal TCD, neurocognitive impairment and primary stroke, compared with baseline.

Secondary objectives
1.Evaluate the impact of Hydroxyurea therapy on structural SCV using MRI and MRA in a randomly selected subset of this cohort.
2.Assess changes to anemia, CRP and malnutrition status during hydroxyurea therapy, over time, compared with baseline levels.


 Uganda 2020-10-02 2023-10-02 Medical and Health Sciences Non-degree Award
Sarah Kiguli
ID: UNCST-2021-R013020
 Nutritional Treatment in Pneumonia Trial. (NuTiP)
REFNo: HS911ES

To establish whether supplementary feeding for 56-days (8 weeks) using Ready to Use Therapeutic Feeds (RUTAFA) in children between 6 months and 12 years with respiratory distress complicated by hypoxia versus usual standard care will improve outcome at 90-days.
 Uganda 2020-10-02 2023-10-02 Medical and Health Sciences Non-degree Award
mariam Namutebi
ID:
TEENAGE FIRST TIME MOTHERS’ PERCEPTIONS ABOUT THEIR HEALTH CARE NEEDS AND THE GAPS IN POSTPARTUM CARE.
REFNo: HS780ES

General objective:
To explore the teenage first time mothers’ perceptions about their postpartum care needs and the gaps in the facility based postpartum care
Specific Objectives:
1. To explore the teenage first time mothers’ perceptions about their postpartum care needs.
2. To identify the current gaps in the facility based postpartum care provided to teenage first time mothers.

 Uganda 2020-10-01 2023-10-01 Medical and Health Sciences Non-degree Award
Joseph Kagaayi
ID: UNCST-2024-R015946
 Impact of COVID-19 Lockdown on HIV and Reproductive, Maternal, Neonatal and Child Health services in Masaka region, Uganda
REFNo: HS865ES

1 Goal
The overall goal of the study is to assess the effect of the COVID-19 lockdown on demand and utilization of RMNCH and HIV services and assess coping mechanisms in order to make evidence-based recommendations for mitigation of the impact during the COVID-19 epidemic and future health emergencies and disasters.

Specific aims
1) To determine the effect of COVID-19 lockdown on discontinuation of Antiretroviral therapy (ART) among patients receiving antiretroviral drugs in 12 districts of the Masaka region.
2) To determine the effect of COVID-19 lockdown on Antenatal care (ANC) attendance, facility deliveries, contraception, immunization, EID, HIV testing among all pregnant women and initiation of option B+ among HIV-positive ANC attendees.
3) To determine the effect of the COVID-19 response on viral load monitoring, intensive adherence counseling and HIV viral suppression among clients in the Masaka region,.
4)To explore clients’, district, and health facility knowledge, attitude and experiences (KAE) and coping mechanisms for sustained ART, and RMNCH services. Qualitative exploration of KAE will provide useful pathways for the effect of lockdown measures on demand and utilization of services.

Uganda 2020-10-01 2023-10-01 Medical and Health Sciences Non-degree Award
Cissy  Kityo
ID: UNCST-2021-R013663
 Validation of SARS-CoV-2 detection by Rapid AirJump RNA Amplification (RARA) COVID Test method
REFNo: HS888ES

We will carry out validation of RARA assay in the laboratory before the field evaluation in testing of SARS-CoV-2.
We intend to understand the inherent characteristics of this assay with regard to accuracy (diagnostic sensitivity, diagnostic specificity), Precision (reproducibility), Limit of detection (LOD), Predictive value (negative and positive), and Assay Efficiency.
Uganda 2020-10-01 2023-10-01 Medical and Health Sciences Non-degree Award
KarenBeth Bohan Heikkinen
ID:
Assessment of Online Modules to Increase Knowledge of Geriatric Care in Health Care Professionals RefNo: MAKSHSREC-2020-6
REFNo: HS727ES

To determine the pharmacists’ satisfaction with pharmacy geriatric online training.,To determine the learning preference in terms of online compared to live educational sessions before and after using the online modules for professional development,To determine the retention of knowledge of geriatric care at three months after completion of all five online educational modules.,To assess the improvement of pharmacy professionals’ knowledge of geriatric care after participating in online educational modules.,
 USA 2020-09-29 2023-09-29 Medical and Health Sciences Non-degree Award
Ignatius Odongo Odongo
ID:
Youth Entrepreneurship in South Africa and Uganda: An Investigation of the Influence of Mental Triggers
REFNo: SS487ES

To contribute to the existing discourse on youth entrepreneurship, by introducing a new applied framework from which youth entrepreneurship can be developed based on the influences of mental triggers. The new framework will include, inter alia, a description of the following:
• the environment that can potentially stimulate youth entrepreneurship;
• the kind of entrepreneurship education that will stimulate and provide requisite skills for the nascent youth entrepreneur; and
• the personal characteristics that can be nurtured for entrepreneurial success.
Armed with this new framework, the stakeholders that areresponsible for youth development, particularly in developing countries, will be able to deal with the psychological and other barriers that impede the youth from venturing and succeeding in entrepreneurship.

 Uganda 2020-09-29 2023-09-29 Social Science and Humanities Degree Award
Victoria Nankabirwa
ID: UNCST-2021-R011871
 Preventing Infant Malnutrition with Early Supplementation (PRIMES)
REFNo: HS825ES

Aim 1. To describe local experiences and beliefs related to breastfeeding, breast milk expression, non-maternal food sources and infant weight and health.

Aim 2. To determine the range of newborn weight changes, the typical age at which a newborn returns to birth weight, and any association of newborn weight change with early dietary intake, clinical and demographic characteristics, and breastfeeding behaviors.

 Uganda 2020-09-29 2023-09-29 Medical and Health Sciences Non-degree Award
Fred Bulamba
ID: UNCST-2019-R000026
 Mapping perioperative care pathways to support surgical treatment in Low-and-Middle Income Countries
REFNo: HS642ES

The aim of this project is to understand the context of perioperative health systems in Uganda, including the main barriers encountered in the delivery of care.

Objectives:
1. Develop a collaborative approach to perioperative care pathway mapping
2. Carry out a rapid appraisal to map 5 pathways (three “Bellwether procedures and two elective procedures) in Uganda.
3. Refine the process and extend to three low- and middle-income countries

 Uganda 2020-09-28 2023-09-28 Medical and Health Sciences Non-degree Award
marie nanyanzi
ID: UNCST-2019-R001553
 Point Of Entry Sauti Za Wananchi (Voices of the citizens)Extension Survey
REFNo: SS468ES

To understand the COVID-19 effects on the citizens’ experience and key services they receive during this era of COVID-19 especially ▪ Establish citizen access to safe water; ▪ Establish citizen access and usage of health services and knowledge, Attitudes and Practices (KAPs); ▪ Find out level of participation/involvement/interaction in development and public activities /institutions; ▪ Find out access and usage of financial services amongst citizens; ▪ Find out how; what and when citizen access different type of information including government and development information. ▪ Establish the knowledge, Attitudes and Practices (KAPs) of citizens on different guidelines, policies; laws and regulations etc
 Uganda 2020-09-28 2023-09-28 Social Science and Humanities Non-degree Award
mariam Namutebi
ID:
POSTPARTUM CARE: FACILITY READINESS, MIDWIVES’ PERSPECTIVES AND THE EFFECT OF USING INDIVIDUALIZED CARE PLANS ON POSTPARTUM OUTCOMES.
REFNo: HS773ES

General Objective

To assess the facility readiness for the provision of Postpartum care, explore the midwives’ perspectives about postpartum care and evaluate the effect of using individualized care plans on the postpartum outcomes in the greater Mpigi region.
Specific objectives
1. To assess the facility readiness to provide postpartum care in selected facilities in the greater Mpigi region.
2. To explore the midwives’ perspectives towards postpartum care in the greater Mpigi region.
3. To evaluate the effect of using individualized care plans in the immediate and early postpartum period on the monitoring assessments, physical examination and health education of postpartum women in the greater Mpigi region.
4. To describe the postpartum women’s perspectives and midwives’ experiences of postpartum care provided using individualized care plans

 Uganda 2020-09-28 2023-09-28 Medical and Health Sciences Degree Award
Esther Buregyeya
ID: UNCST-2020-R014116
 Using the human-centred design model to inform local adaptation of COVID-19 prevention measures among high-risk populations in Malaba and Mutukula points of entry in Uganda
REFNo: HS848ES

1. To determine knowledge and risk-perceptions on COVID-19 measures among high-risk populations in Malaba and Mutukula points of entry.
2. To assess uptake of recommended COVID-19 prevention measures measures among high-risk populations in Malaba and Mutukula points of entry.
3. To explore the facilitators and barriers to uptake of the COVID-19 prevention measures measures among high-risk populations in Malaba and Mutukula points of entry.
4. To design, pilot and evaluate localized behavioural interventions to foster uptake of the COVID-19 prevention measures measures among high-risk populations in Malaba and Mutukula points of entry.
 Uganda 2020-09-28 2023-09-28 Medical and Health Sciences Non-degree Award
Kirsten Beyer M
ID: UNCST-2021-R013472
 Geospatial Analysis of Kampala Cancer Registry Data
REFNo: HS873ES

Objective 1: Identify spatial and spatiotemporal patterns of cancer in Uganda. a) Use geospatial mapping techniques to estimate cancer burdens across geographic space and through time. b) Create visual representations of cancer patterns (maps, graphs). Objective 2: Examine relationships between social and environmental factors and cancer outcomes in Uganda. a) Use statistical analysis techniques to determine associations between environmental factors and cancer outcomes. Objective 3: Pilot the collection of new KCR variables a) For each new case, we will attempt to acquire marital status, education level, occupation, religion, national Identification number (NIN) (new in Uganda), and precise geographic location information. Objective 4: Determine the true spatial extent of KCR data collection potential. a) Identify the number of cases that are discovered and excluded under current practice, as well as the individual’s parish of residence.
USA 2020-09-28 2023-09-28 Medical and Health Sciences Non-degree Award
Catherine Mwesigwa
ID: UNCST-2019-R000988
 THE DENTAL WORKFORCE IN UGANDA: A SITUATION ANALYSIS
REFNo: HS532ES

1. To take a census of the dental professionals in Uganda
2. To determine the recruitment levels into public/private employment and retention rates of dental surgeons and specialists in Uganda.
3. To determine the factors which influence attraction to, retention within and attrition from the health care system among dental surgeons and specialists
4. To examine the spatial distribution of actively practising dental professionals and public health dental officers relative to urban- rural and public-private characteristics

 Uganda 2020-09-23 2023-09-23 Medical and Health Sciences Non-degree Award
John Tabuti Robert Stephen
ID: UNCST-2024-R002181
 Development of a Safe and Efficacious Anti-malarial drug from Traditional medicine (DESAT)
REFNo: HS685ES

The aim of this study is to develop an effective anti-malarial phytomedicine. The specific objective are 1) to prioritize malaria treating plants, and to determine 2) efficacy of commonly used herbal medicines, 3) safety of commonly used herbal medicines, and 4) the active compounds in the selected phytomedicines.
 Uganda 2020-09-23 2023-09-23 Medical and Health Sciences Non-degree Award
Thereza Piloya Were
ID: UNCST-2019-R000491
 Effect of the COVID-19 pandemic on access to community health care services for common childhood illnesses among children under five years in Wakiso District, Uganda
REFNo: HS802ES

Primary Objectives 1. To determine the utilisation of Integrated childhood community Management (ICCM) services for children aged under 5 years seeking care at the VHTs in three sub-counties in Wakiso district between January and June 2020
2. To determine the outcomes of the sick children under 5 years seen by the VHTS in three sub-counties in Wakiso district.
Secondary objective
3. To determine the utilisation of health facility level services for sick children aged under 5 years referred from the VHTS in Wakiso district during the period of January to June 2020


Uganda 2020-09-23 2023-09-23 Medical and Health Sciences Non-degree Award
Eve  Namisango
ID: UNCST-2021-R014038
 Preparedness to face the COVID-19 pandemic in African hospices and palliative care services: A rapid assessment
REFNo: HS806ES

To determine the preparedness and capacity of palliative care service providers in Africa to respond to the COVID-19 pandemic

To explore the potential consequences of the COVID-19 pandemic on palliative care services and service providers in Africa.

 Uganda 2020-09-23 2023-09-23 Medical and Health Sciences Non-degree Award
FLORENCE NALIMU
ID: UNCST-2024-R002900
 Toxicological Evaluation of Aloe Vera Linn and Aloe Ferox Miller Aqueous Leaf and Green Grind Extracts in Wistar Rats.
REFNo: NS138ES

1. To determine the phytochemical groups in the aqueous leaf and green grind extracts of Aloe ferox and Aloe vera.
2. To determine acute oral toxicity effects of Aloe ferox and Aloe vera aqueous whole leaf and green grind extracts in Wistar rats.
3. To determine sub-acute toxicity effects of Aloe ferox and Aloe vera aqueous leaf and green grind decoctions in Wistar rats.

Uganda 2020-09-23 2023-09-23 Natural Sciences Degree Award
JOSAPHAT KAYOGOZA BYAMUGISHA
ID: UNCST-2019-R001680
 Pooled screening of SARS-CoV-2 in the surrounding communities of Makerere University as a cost-effective strategy for reopening.
REFNo: HS912ES

General Objective
To assess the prevalence of SARS-CoV-2 and practices towards its prevention in the surrounding communities of Makerere University and the cost-effectiveness of pooled screening testing strategy to inform reopening of Makerere University.

Specific aims
1.To assess Knowledge, attitudes and practices of people living in areas surrounding Makerere University towards SARS CoV-2 prevention

2.Rapid assessment of high-risk populations around Makerere University for SARS CoV 2 by multi sample pool COVID-19 qRT-PCR technique

 Uganda 2020-09-23 2023-09-23 Medical and Health Sciences Non-degree Award
Nelson Kaulukusi Sewankambo
ID:
CRITICAL THINKING ABOUT HEALTH CLAIMS AND CHOICES AMONG SECONDARY SCHOOL STUDENTS IN UGANDA
REFNo: HS916ES

SUB-STUDY 1: Systematic Reviews
General objective:
Our first sub-study addressing main research question 1 above will be a review of existing evidence about strategies for enabling non-professional students to learn to think critically.
Specific objectives:
The primary objective is to provide an overview of what is known from systematic reviews about the effects of strategies to help primary and secondary school students learn to think critically. Secondary objectives are:
i. To map the characteristics of systematic reviews of teaching strategies
ii. To identify needs and priorities for evaluations of teaching strategies based on the findings of the included systematic reviews
iii. To identify needs and priorities for systematic reviews of the effects of teaching strategies for which we are unable to find reliable, up-to-date systematic reviews
iv. To inform the development of a framework for types of teaching strategies
SUB-STUDY 2: Context Analysis
General objective:
The second sub-study will be a context analysis whose main aim will be to establish existing organizational and individual conditions for teaching critical thinking to lower secondary school students in Uganda.
Specific objectives:
i. To explore what demand there is for learning resources for teaching critical thinking about health in secondary schools in Uganda.
ii. To map where teaching critical thinking about health best fits in the national curriculum
iii. To identify and examine relevant resources already in use
iv. To explore conditions for introducing new learning resources
v. To describe what ICT facilities are likely to be accessible in Ugandan secondary schools for teaching and learning purposes, and what, if any, national plans there are for improvements
vi. To identify opportunities and challenges for developing and using digital learning resources to promote critical thinking about treatments

SUB-STUDY 3: Prioritising and sequencing of Informed Health Choices (IHC) Key concepts
The third sub-study will focus on identifying the ideals or key concepts that will be prioritised and ordered for students in lower secondary schools of Uganda for which then learning resources will be developed.
General objective:
To prioritize and sequence the key concepts relevant to recognizing treatment claims and making informed health choices.
Specific objectives:
i. To establish the number of IHC key concepts from a list of 49 to include in learning resources that will be developed for lower secondary school in Uganda.
ii. To determine the order in which the concepts should be learned, and the competencies and dispositions needed to use those key concepts

SUB-STUDY 4: Design and Development of learning resources
General objective:
The fourth sub-study will aim to design learning-resources for teachers and students that they experience positively, that are feasible to use in Uganda, and that lend themselves to translation and adaptation to other contexts.
Specific objectives:
i. To develop learning resources that are relevant, understandable, credible, desirable, well suited in classroom settings and compatible with existing digital resources for improving critical thinking about treatments.

SUB-STUDY 5: Develop, Test and validate of the outcome evaluation tools
General objective:
To develop and test a flexible bank with multiple-choice questions for use as the claim evaluation tools as well as assess the test-taker’s ability to identify claims.
Specific objectives:
i. To develop and test a flexible bank of multiple-choice questions (MCQs) that will constitute the claim evaluation tools.
ii. To assess the validity, reliability and responsiveness of several items addressing prioritised key concepts using Rasch analysis.

SUB-STUDY 6: Evaluation of the learning materials
General objective:
We will seek to evaluate the short-term effects of the learning-resources on lower secondary students’ and teachers’ ability to make individual and policy health choices.
Specific objectives:
i. To evaluate learning-resources designed to teach lower secondary school students and teachers to assess claims about effects of treatments and their ability to make individual and policy health choices.


SUB-STUDY 7: Process Evaluation during the trials
General objective:
To assess the factors that influence the impact of the developed learning resources and how the use of the learning-resources if found to be effective can be scaled up, adapted and translated for use in other contexts.

Specific objectives:
i. To determine the extent to which the intervention was delivered as intended
ii. To document the barriers and facilitators that might influence the implementation and impact of the intervention
iii. To establish factors that might influence its scaling up
iv. To document any additional adverse or beneficial effects as observed.
v. To establish how the use of the learning-resources if found to be effective can be scaled up, adapted and translated for use in other contexts

SUB-STUDY 8: One-year follow -up
General objective:
The seventh sub-study question will seek to evaluate the long-term effects of the learning-resources on lower secondary students’ and teachers’ ability to make individual and policy health choices.
Specific objectives:
i. To evaluate learning-resources one year post the short-term evaluation in the RCT designed to teach lower secondary school students and teachers to assess claims about effects of treatments and their ability to make individual and policy health choices.

 Uganda 2020-09-23 2023-09-23 Medical and Health Sciences Non-degree Award
Martin Chebet
ID: UNCST-2021-R013909
 A cluster randomised trial to evaluate the effectiveness of household alcohol-based handrub for the prevention of sepsis, diarrhoea and pneumonia in Ugandan infants
REFNo: HS919ES

Primary objectives
The principal objective of this study is to determine whether the provision of
alcohol-based hand rub (ABHR) to pregnant women for postnatal household use
is effective for the prevention of severe illness or death during the first 3 months
of life.
Secondaryobjectives
• To determine the impact of ABHR use by the carer on clinical omphalitis.
• To determine the cost and cost-effectiveness of providing ABHR to pregnant
women in rural Eastern Uganda as a way of preventing early childhood severe
illness and death in the first 3 months of life.
• To assess health inequities in participants by comparing the study outcomes in
each wealth quintile.
• To explore current hand hygiene practices and options of improving practice in
rural Ugandan villages
• To explore the mechanisms of action (mediators and moderators) of
caregiver ABHR training on prevention of severe illness or death during the
first 3 months of life.
• To explore the mechanisms of action (mediators and moderators) of caregiver
ABHR training on depression and ABHR use.

 Uganda 2020-09-23 2023-09-23 Medical and Health Sciences Non-degree Award
Bjorn Van Campenhout -
ID: UNCST-2020-R014080
 Demand and supply factors constraining the emergence and sustainability of an efficient seed system in Uganda.
REFNo: SS603ES

The proposed study aims to provide innovative, evidence-based insights on the: i. Mechanisms that encourage more efficient marketing and distribution of seed and traits at various levels of commercialization and across heterogeneous populations and agro-ecologies (“improving seed supply”), and; ii. Mechanisms that nudge farmers—youth, women, and smallholders—into using improved varieties and quality seed, including varieties and seed for climate-smart and nutrient-dense crops and traits (“enhancing seed demand”).
 Belgium 2020-09-23 2023-09-23 Social Science and Humanities Non-degree Award
Charles Drago Kato Drago
ID: UNCST-2021-R012897
 Clinical evaluation of novel plasma biomarkers for stage diagnosis among sleeping sickness patients in Uganda
REFNo: HS520ES

1. To identify plasma biomarkers associated with either early or late stage T. b. gambiense disease using proteomics methods and compare with those previously identified for T. b. rhodesiense.
2. To determine the potential of plasma biomarkers identified using proteomics methods in discriminating between early and late stage patients for both T. b. rhodesiense and T. b. gambiense sleeping sickness.
3. To initiate the setup of a biomarker research team and laboratory at Makerere University.

Uganda 2020-09-18 2023-09-18 Medical and Health Sciences Non-degree Award
Sarah Nanzigu
ID:
Effects of Co-administration of HAART and Antiepileptic drugs on pharmacokinetics, seizure control and ART outcomes among Ugandans aged 0-24 years. Short title: Study of Co-medication with HAART and antiEpileptic Drugs Acronym: Co-HED
REFNo: HS546ES


General Study Objective: To evaluate the pharmacokinetics and clinical effects of HIV and antiepileptic co-medication among Ugandan patients aged 0-24 years.

SUB-STUDY I
This will be a cross-sectional, evaluating short and long-term effects of HAART-AED co-medication on the pharmacokinetics and treatment outcomes of HAART among Ugandans aged 0-24 years.

Specific objectives for sub-study 1
The specific objectives to be addressed during this sub-study will include the following:
1. To determine the effect of combined treatment with HAART and antiepileptic agents on virological control among HIV infected Ugandans aged 0-24 years, attending Baylor HIV clinic.
2. To determine the effect of combined treatment with HAART and antiepileptic agents on the immunological outcomes of HIV infected Ugandans aged 0-24 years, attending Baylor HIV clinic.
3. To determine the effect of combined treatment with HAART and antiepileptic agents on the safety of Ugandans aged 0-24 years, attending Baylor HIV clinic.

The study shall as well address secondary objectives that include the following:
1. To determine the effect of combined treatment with HAART and antiepileptic agents on efavirenz plasma concentrations, among HIV infected Ugandans aged 0-24 years attending Baylor HIV clinic.
2. To determine the effect of combined treatment with HAART and antiepileptic agents on lopinavir plasma concentrations, among Ugandans aged 0-24 years attending Baylor HIV clinic.

SUB-STUDY II
The main objective of this sub-study will be to evaluate the effect of HAART on the pharmacokinetics and clinical outcomes of carbamazepine and sodium valproate among Ugandans aged 0-24 years during 6 months of combined treatments for HIV and epileptic conditions.

Specific Objectives for sub-study II
1. To determine the effect of HAART on the pharmacokinetics of carbamazepine among Ugandans aged 0-24 years, during 6 months of combined treatment for HIV and epilepsy
2. To determine the effect of HAART on the pharmacokinetics of sodium valproate among Ugandans aged 0-24 years, during 6 months of combined treatment for HIV and epilepsy
3. To determine the effect of HAART on seizure control among Ugandans aged 0-24 years, during 6 months of combined treatment for HIV and epilepsy
4. To determine the effect of HAART on the safety of antiepileptic agents among Ugandans aged 0-24 years, during 6 months of co-medication with HAART and either carbamazepine or sodium valproate
Secondarily, we shall determine concentrations of the respective antiretroviral agents (efavirenz or lopinavir). The concentrations of the antiretroviral drugs estimated from study 11, will be compared to those obtained in study 1 in an attempt to establish a direct link of the effect of AEDs on the pharmacokinetics of antiretroviral agents. In addition, we shall attempt to evaluate the likelihood of a concentration-dependent effect of efavirenz on the pharmacokinetics and treatment outcomes of antiretroviral agents.





 Uganda 2020-09-18 2023-09-18 Medical and Health Sciences Non-degree Award
Lucas Ampaire
ID:
Microbial contamination of locally prepared beverages vended in Kisenyi parish, Kampala: Prevalence, associated factors and utility of rapid diagnostic tests
REFNo: HS586ES

1. To determine the prevalence and factors associated with microbial contamination of locally prepared beverages vended in Kisenyi Parish, Kampala, Uganda.
2. To determine the common contaminating microbial agents in the locally prepared beverages and their antibiotic sensitivity patterns.
3. To assess the performance of MaxSignal® E. coli O157 Strip Test Kit and MaxSignal® Salmonella Strip Test Kit on food-borne pathogens in locally prepared beverages vended in Kisenyi Parish, Kampala , Uganda
4. To develop and evaluate the performance of a local multiplexed strip/cassette for rapid detection of common food contaminants

 Uganda 2020-09-18 2023-09-18 Medical and Health Sciences Degree Award
Jane Achan Edwin
ID: UNCST-2023-R005498
 Malaria among patients admitted with COVID-19: a case series
REFNo: HS666ES

General Objective: To understand the burden and clinical consequences of malaria among COVID-19 patients Specific objectives 1. To determine the prevalence of malaria among patients with COVID-19 and to evaluate the risk of malaria following hospital discharge. 2. To determine the magnitude of previous exposure to malaria among patients with COVID-19 3. To document the impact of malaria on clinical outcomes of patients with COVID-19 4. To assess the potential impact of currently used antimalarial drugs (artemether-lumefantrine and dihydroartemisinin-piperaquine) on clinical outcomes among COVID-19 patients prescribed these drugs as per current clinical indications 5. To document the clinical spectrum of malaria among patients with COVID-19 6. To evaluate the potential interactions between COVID-19 and other infectious diseases including HIV/AIDS and TB 7. To describe health worker perspectives on the management of malaria in COVID-19 patients
Uganda 2020-09-16 2023-09-16 Medical and Health Sciences Non-degree Award
Nathan Fiala
ID: UNCST-2022-R009060
 The Long-term Impacts of a cash-based Employment Program in Northern Uganda
REFNo: SS501ES

1.To evaluate the long-term effectiveness of a cash-based youth employment program using a randomized controlled trial.
2. To understand the effect of COVID-19 and restrictions on youth employment
 USA 2020-09-16 2023-09-16 Social Science and Humanities Non-degree Award
JANE  AMUGE
ID:
Upholding Cooperative Identity as a crucial determinant of Cooperative Resilience: A case study of cooperatives in Uganda
REFNo: SS544ES

1. To identify how cooperatives have optimised their unique character enshrined in their definition, principles and values to cope, remain stable, adapt to situations, innovate and remain resilient in the face of adversity.
2. To establish how adherence or non-adherence to the definition, principles and values of cooperatives have increased their risks, vulnerabilities and contributed to their instability, limited adaptation and innovation thus their lack of resilience.
3. To find out the influence of other factors apart from cooperative identity, on cooperative resilience or the lack of it.

 Uganda 2020-09-16 2023-09-16 Social Science and Humanities Non-degree Award
Gladys Nakalema
ID:
DECISIONAL CAPACITY AND COERCION AMONG PATIENTS ENROLLED IN RESEARCH AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: SS479ES

i. To assess the decisional capacity of research participants at Mbarara Regional Referral Hospital (MRRH) ii. To assess the level of coercion to consent to study participation among research participants at MRRH iii. To determine the association between decisional capacity and level of coercion to consent to study participation among research participants at MRRH
Uganda 2020-09-15 2023-09-15 Social Science and Humanities Degree Award
Annet Nakaganda
ID:
Developing a Standardized tool for cancer risk factors Surveillance: A case study of the prevalence of cancer risk factors in Eastern Uganda (CARIFAS)
REFNo: HS754ES

1. Developing a standardized tool for assessing cancer risk factors in Uganda.
2. Estimating the prevalence of cancer risk factors in Mayuge district (Eastern Uganda

 Uganda 2020-09-15 2023-09-15 Medical and Health Sciences Non-degree Award
Dennis Muhanguzi
ID: UNCST-2019-R001101
 EVALUATION OF THE SAFETY AND EFFICACY OF VECTOCLORÃ’-PLUS EMULSIFIABLE CONCENTRATE [E.C.]: A RANDOMISED SINGLE-BLINDED POSITIVE CONTROLLED MULTI-SITE ACARICIDE FIELD TRIAL
REFNo: NS129ES

General objectives
To determine the efficacy and safety of Vectoclor®-Plus E.C. (Ceva Santé Animale, Libourne) hereinafter called Vectoclor®-Plus when used on cattle for tick control.

Specific objectives
-To determine the efficacy of Vectoclor®-Plus when used on cattle for tick control
-To determine the safety of Vectoclor®-Plus when used on cattle for tick control
 Uganda 2020-09-15 2023-09-15 Natural Sciences Non-degree Award
George Lugalambi William
ID:
UNICEF Handwashing with Soap
REFNo: SS551ES

What factors constrain and prevent individuals and households from washing their hands with soap?

What knowledge, attitudes and practices are prevalent regarding handwashing with soap?

What needs to be done to scale up handwashing with soap initiatives?

Establish barriers to change and how the strategy can efficiently and effectively address them.
 Uganda 2020-09-15 2023-09-15 Social Science and Humanities Non-degree Award
Numa Memisevic
ID:
Breaking stereotypes and remodeling the concept of sexual violence prevention by building resiliency and defense skills among vulnerable women
REFNo: SS542ES

The aim of the foregoing proposal is to test a novel empowerment-based sexual assault prevention
training initiative targeting women at high risk for sexual violence in Uganda. This intervention
focuses on both non-physical and physical measures.
 Yugoslavia 2020-09-10 2023-09-10 Social Science and Humanities Degree Award
Hesbon  Owilla Hansen
ID:
QUANTITATIVE AND QUALITATIVE STUDY ON INNOVATION FOR MEDIA VIABILITY IN EAST AFRICA
REFNo: SS417ES

1. To bolster the viability of media outlets
2. To galvanize media innovation in East Africa, with a focus not just on creative content but on new and sustainable business models for the future.
Kenya 2020-09-08 2023-09-08 Social Science and Humanities Non-degree Award
Fatuma  Namusoke University
ID:
Barriers, knowledge and antimalarial antibodies in relation to Intermittent Preventive Treatment in pregnancy use in Kawempe National Referral Hospital
REFNo: HS620ES

1. Explore the barriers of IPTp implementation in Kawempe National Referral Hospital
2. To describe the knowledge and perceptions of IPTp among mothers Kawempe National Referral Hospital
3. To determine the association between quantity and quality of antimalarial antibodies in puerperium and use of IPTp during pregnancy

 Uganda 2020-09-04 2023-09-04 Medical and Health Sciences Non-degree Award
Mark Jordans
ID: UNCST-2020-R014861
 Increasing the efficiency of an education programme to facilitate rapid adoption and sustainable scale-up.
REFNo: SS451ES

Aim: To increase the efficiency and scalability of the Can’t Wait to Learn (CWTL) programme, through increasing access, attendance, retention and facilitating programme adoption.

The specific objectives of the present research studies are:
1) To develop and test a caregiver engagement intervention to increase children’s equitable access to, attendance of and retention in CWTL;
2) To assess and optimise the CWTL implementation team model to facilitate rapid adoption and scale up of the programme;
3) To evaluate the value for money of CWTL and identify drivers and drainers of value for money.
 Netherlands 2020-09-04 2023-09-04 Social Science and Humanities Non-degree Award
Pauline Byakika-Kibwika
ID: UNCST-2019-R001206
 Optimizing malaria treatment for HIV-malaria co-infected individuals by addressing drug interactions between Artemether-Lumefantrine and Efavirenz.; a randomized trial
REFNo: HS820ES

General Objective: To utilize innovative interventions to overcome drug interactions between artemether-lumefantrine and efavirenz to guide malaria treatment for individuals co-infected with HIV and malaria.
Specific objectives:
1. To determine the safety and Pharmacokinetics of the double dose artemether-lumefantrine when administered with efavirenz based ART among healthy volunteers (malaria negative and HIV negative individuals).
2. To determine the safety and Pharmacokinetics of the 5-day course of artemether-lumefantrine when administered with efavirenz based ART among healthy volunteers (malaria negative and HIV negative individuals).
3. To determine the safety, pharmacokinetics and malaria treatment outcome of a standard dose of artemether-lumefantrine compared to double of the standard dose for weight and a 5-day course of artemether-lumefantrine for treatment of uncomplicated malaria among HIV-Malaria co-infected individuals receiving efavirenz-based ART.
4. To determine the safety and Pharmacokinetics of artemether-lumefantrine when administered with Dolutegravir based ART among HIV-malaria co-infected individuals

 Uganda 2020-09-04 2023-09-04 Medical and Health Sciences Non-degree Award
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"A prosperous Science and Technology Led Ugandan Society."

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